Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4151 - 4200 OF 15477 RESULTS

February 1, 2018

IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Nirav R. Bhakta; Stephanie Christenson; Srilaxmi Nerella; Owen D. Solberg; Christine Nguyen; David F. Choy; Kyle L. Jung; Suresh Garudadri; Luke R. Bonser; Joshua L. Pollack; Lorna T. Zlock; David J. Erle; Charles Langelier; Joseph L. Derisi; Joseph R. Arron; John V. Fahy; Prescott G. Woodruff

February 1, 2018

Peak purity in liquid chromatography, part 1: Basic concepts, commercial software, and limitations

LC-GC Europe, ISSN: 14716577

Sarah C. Rutan; Venkatramani; Dwight R. Stoll

February 1, 2018

Clinicopathologic Correlation of Anti–Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration

Ophthalmology, ISSN: 15494713 01616420

Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Lan Wang; Richard M. Feist; Christopher A. Girkin; Sarra Gattoussi; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund

January 31, 2018

Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups

Journal of the American Chemical Society, ISSN: 15205126 00027863

Arismel Tena Meza; Thomas Wurm; Lewis Smith; Seung Wook Kim; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

January 30, 2018

DEM based computational model to predict moisture induced cohesion in pharmaceutical powders

International Journal of Pharmaceutics, ISSN: 18733476 03785173

Raj Mukherjee; Chen Mao; Sayantan Chattoraj; Bodhisattwa Chaudhuri

January 30, 2018

Trace level determination of chloroacetyl chloride and degradation products by derivatization gas chromatography

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Marie-France Morissette; Larry Wigman; Jerry Tso

January 30, 2018

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors

Breast Cancer Research, ISSN: 1465542X 14655411

Anneleen Daemen; Gerard Manning

January 26, 2018

Process Design for Bispecific Antibodies

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes,

Ambrose Jon Williams; Glen Giese; Andreas Schaubmar; Thomas von Hirschheydt

January 26, 2018

Post-Licensure Purification Process Improvements for Therapeutic Antibodies: Current and Future States

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes,

Kelley; Annika Kleinjans; Philip M. Lester

January 23, 2018

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Tania Chernov-Rogan; Tianbo Li; Gang Lu; Henry Verschoof; Kuldip Khakh; Steven W Jones; Beresini; Chang Liu; Daniel F. Ortwine; Steven J. McKerrall; David Hackos; Daniel P. Sutherlin; Charles J. Cohen; Jun Chen

January 20, 2018

Reply to M. Mo et al

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Manish A. Shah; Luis A. Herráez-Baranda; Amit Garg; Tabernero

January 19, 2018

Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Tao Huang; Mary Mathieu; Sophia Lee; Xinhua Wang; Yee Seir Kee; Jack Bevers; Claudio Ciferri; Alberto Estavez; Manda Wong; Nancy Y. Chiang; Nakamura; Randall J. Brezski

January 16, 2018

Monoclonal Antibody Interfaces: Dilatation Mechanics and Bubble Coalescence

Langmuir, ISSN: 15205827 07437463

Aadithya Kannan; Ian C. Shieh; Danielle L. Leiske; Gerald G. Fuller

January 16, 2018

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models

Cell Reports, ISSN: 22111247

Brad A. Friedman; Karpagam Srinivasan; Gai Ayalon; William J. Meilandt; Han Lin; Melanie A. Huntley; Yi Cao; Seung-Hye Lee; Patrick C. G. Haddick; Hai Ngu; Zora Modrusan; Jessica L. Larson; Joshua S. Kaminker; Marcel P Van Der Brug; David V. Hansen

January 16, 2018

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Barbara Piasecka; Darragh Duffy; Alejandra Urrutia; Hélène Quach; Etienne Patin; Céline Posseme; Jacob Bergstedt; Bruno Charbit; Vincent Rouilly; Cameron R. MacPherson; Milena Hasan; Benoit Albaud; David Gentien; Jacques Fellay; Matthew L. Albert; Lluis Quintana-Murci

January 12, 2018

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Nature Communications, ISSN: 20411723

Hans D. Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette M. Castanedo; Benjamin T. Jackson; Youngsu C. Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leonid M. Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael J. Townsend; Jason Devoss; Adam R. Johnson; Robert Godemann; Wyne P. Lee; Cary D. Austin; Brent Mckenzie; Jason A. Hackney; James J. Crawford; Steven T. Staben; Moulay Hicham Alaoui-Ismaili; Lawren C. Wu; Nico Ghilardi

January 2, 2018

Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation

Structure, ISSN: 18784186 09692126

Ayşegül Özen; Lionel Rouge; Charlene Bashore; Brian R. Hearn; Nicholas J. Skelton; Erin C. Dueber

January 2, 2018

Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations

Molecular Pharmaceutics, ISSN: 15438392 15438384

Balakrishnan S. Moorthy; Isidro E. Zarraga; Lokesh Kumar; Benjamin T. Walters; Pierre Goldbach; Elizabeth M. Topp; Andrea Allmendinger

January 2, 2018

Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment

mAbs, ISSN: 19420870 19420862

Frank R. Brennan; Joy A. Cavagnaro; Kathleen McKeever; Patricia C. Ryan; Melissa Schutten; John Vahle; Gerhard F. Weinbauer; Estelle Marrer-Berger; Lauren E. Black

January 1, 2018

An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Jodie Pang; Jia Liu; Laurent Salphati

January 1, 2018

Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System

Biotechnology Journal, ISSN: 18607314 18606768

Danming Tang; Cynthia Lam; Salina Louie; Kam Hon Hoi; David Shaw; Mandy Yim; Snedecor; Shahram Misaghi

January 1, 2018

Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Bradley E. Chipps; Tmirah Haselkorn; Karin Rosén; David R. Mink; Benjamin L. Trzaskoma; Allan T. Luskin

January 1, 2018

IgG Fc engineering to modulate antibody effector functions

Protein and Cell, ISSN: 16748018 1674800X

Xinhua Wang; Mary Mathieu; Randall J. Brezski

January 1, 2018

An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts

Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719

Daniel D. Bravo; Tania Chernov-Rogan; Jun Chen; Jianyong Wang

January 1, 2018

Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Kwong Wah Lai; F. Anthony Romero; Vickie Tsui; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Kevin Chen; Zhongguo Chen; Edna F. Choo; Terry Crawford; Patrick Cyr; Susan Kaufman; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jeremy Murray; Weichao Shen; John Wai; Fei Wang; Caicai Zhu; Xiaoyu Zhu; Steven Magnuson

January 1, 2018

Computational support of medicinal chemistry in industrial settings

Methods in Molecular Biology, ISSN: 10643745

Daniel F. Ortwine

January 1, 2018

Solubilization of a Poorly Soluble B-Raf (Rapidly Accelerated Fibrosarcoma) Inhibitor: From Theory to Application

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Linda Bao; Le An; Yingqing Ran

January 1, 2018

A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective

AAPS Journal, ISSN: 15507416

Allison Given Chunyk; Alison Joyce; Saloumeh Kadkhodayan Fischer; Mark Dysinger; Alvydas Mikulskis; Andreas Jeromin; Rosemary Lawrence-Henderson; Baker; David Yeung

January 1, 2018

A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy

AAPS Journal, ISSN: 15507416

Richard S. Rogers; Michael Abernathy; Douglas D. Richardson; Jason C. Rouse; Justin B. Sperry; Patrick Swann; Jette Wypych; X. Christopher Yu; Li Zang; Rohini Deshpande

January 1, 2018

Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids

Respiratory Medicine, ISSN: 15323064 09546111

Phillip Korenblat; Edwin Kerwin; Igor Leshchenko; Karl Yen; Cécile T.J. Holweg; Judith Anzures-Cabrera; Carmen Martin; Wendy Putnam; Laura Governale; Julie Olsson; Matthews

January 1, 2018

Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition

Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X

Steven Cepa; David M. Potter; Lisa Wong; Leah Schutt; Jacqueline M. Tarrant; Jodie Pang; Xiaolin Zhang; Roxanne Andaya; Laurent Salphati; Yingqing Ran; Le An; Ryan Morgan; Jonathan M. Maher

January 1, 2018

Pathology and Pathogenesis of Immune-Mediated Diseases of Animals

Veterinary Pathology, ISSN: 15442217 03009858

Laurie Diehl; David K. Meyerholz; Michael J. Day; Verena K. Affolter

January 1, 2018

Type 2 immunity in tissue repair and fibrosis

Nature Reviews Immunology, ISSN: 14741741 14741733

Richard L. Gieseck; Mark S. Wilson; Thomas A. Wynn

January 1, 2018

Patient acceptable symptom state in scleroderma: Results from the tocilizumab compared with placebo trial in active diffuse cutaneous systemic sclerosis

Rheumatology, ISSN: 14620332 14620324

Michael B. Arnold; Dinesh Khanna; Christopher P. Denton; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Helen Spotswood; Laura Burke; Jeffrey N. Siegel; Angelika Jahreis; Daniel E. Furst; Janet E. Pope

January 1, 2018

Reply to hunsberger and memoli, "efficacy analysis in healthy-volunteer influenza challenge trials: Intention to treat"

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael A. Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen-Harris; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie M. Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Harris; Jorge A. Tavela

January 1, 2018

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Namrata S. Patil; Luisella Righi; Koeppen; Wei Zou; Stefania Izzo; Federica Grosso; Roberta Libener; Marco Loiacono; Valentina Monica; Consuelo Buttigliero; Silvia Novello; Priti Hegde; Mauro Papotti; Marcin Kowanetz; Giorgio Scagliotti

January 1, 2018

Cardiovascular effects of renal distal tubule deletion of the fgf receptor 1 gene

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Xiaobin Han; Ross; Ganesh Kolumam; Min Pi; Junichiro Sonoda; Gwendalyn King; Darryl Quarles

January 1, 2018

Opposing roles of dendritic cell subsets in experimental GN

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Sebastian Brähler; Bernd H. Zinselmeyer; Saravanan Raju; Maximilian Nitschke; Hani Suleiman; Brian T. Saunders; Michael W. Johnson; Alexander M.C. Böhner; Susanne F. Viehmann; Derek J. Theisen; Nicole M. Kretzer; Carlos G. Briseño; Konstantin Zaitsev; Olga Ornatsky; Qing Chang; Javier A. Carrero; Jeffrey B. Kopp; Maxim N. Artyomov; Christian Kurts; Kenneth M. Murphy; Jeffrey H. Miner; Andrey S. Shaw

January 1, 2018

CD8+ T cell infiltration in breast and colon cancer: A histologic and statistical analysis

PLoS ONE, ISSN: 19326203

James Ziai; Houston N. Gilbert; Oded Foreman; Jeffrey Eastham-Anderson; Felix Chu; Mahrukh Huseni; Kim

January 1, 2018

A solid-phase approach for the synthesis of α-Aminoboronic acid peptides

RSC Advances, ISSN: 20462069

Blake E. Daniels; Craig E. Stivala

January 1, 2018

Detection of PD-L1 in circulating tumor cells and white blood cells from patients with advanced non-small-cell lung cancer

Annals of Oncology, ISSN: 15698041 09237534

Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Chamorey; Salomé Lalvée; Eric Selva; Leroy; Charles-Hugo Marquette; Marcin Kowanetz; Priti Hedge; Elizabeth A. Punnoose; Paul Hofman

January 1, 2018

Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: Results from the ETOP Lungscape Project

Annals of Oncology, ISSN: 15698041 09237534

Keith M. Kerr; Urania Dafni; Katja Schulze; Erik Thunnissen; Lukas Bubendorf; Hager; Stephen P. Finn; Biernat; Vliegen; Losa; Antonio Marchetti; Richard Cheney; Arne Warth; Ernst Jan M. Speel; Blackhall; Kim Monkhorst; Jantus Lewintre; Verena Tischler; Clark; Bertran-Alamillo; Meldgaard; Gately; Wrona; Vandenberghe; Enriqueta Felip; De Luca; Spasenija Savic; Muley; Smit; Anne-Marie C. Dingemans; Priest; Baas; Carlos Camps; Weder; Polydoropoulou; Thomas R. Geiger; Roswitha Kammler; Teiko Sumiyoshi; Molina; David S. Shames; Rolf A Stahel; Solange Peters; Boss

January 1, 2018

The Integumentary System

Fundamentals of Toxicologic Pathology: Third Edition,

Kelly L. Diegel; Dimitry Danilenko; Zbigniew W. Wojcinski

January 1, 2018

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

PLoS Pathogens, ISSN: 15537374 15537366

Nicole D. Marino; Michael W. Panas; Magdalena Franco; Terence C. Theisen; Adit Naor; Suchita Rastogi; Kerry R. Buchholz; Hernan A. Lorenzi; John C. Boothroyd

January 1, 2018

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

EMBO Reports, ISSN: 14693178 1469221X

Dan Du; Yoko Katsuno; Dominique Meyer; Erine H Budi; Si-Han Chen; Koeppen; Hongjun Wang; Rosemary J Akhurst; Rik Derynck

January 1, 2018

Nonclinical safety assessment of anti-factor d: Key strategies and challenges for the nonclinical development of intravitreal biologics

Journal of Ocular Pharmacology and Therapeutics, ISSN: 15577732 10807683

Vlad Bantseev; Rebecca Erickson; Douglas Leipold; Caroline Amaya; Paul Miller; Helen Booler; Evan A Thackaberry

January 1, 2018

First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; S. Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

January 1, 2018

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: Study protocol for a randomised trial

Trials, ISSN: 17456215

Catherine E. Hanratty; Matthews; Joseph R. Arron; David F. Choy; Ian D. Pavord; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Ratko Djukanovic; Nicola Gallagher; Stephen J. Fowler; Tim Hardman; Timothy Harrison; Cécile T.J. Holweg; Peter Howarth; James Lordan; Adel Mansur; Andrew Menzies-Gow; Mosesova; Robert Niven; Douglas S. Robinson; Dominick E. Shaw; Samantha Walker; Ashley Woodcock; Liam G. Heaney; Ian Adcock; Boriello; Matthew Catley; Kian Fan Chung; Richard W. Costello; Sebastian Johnston; Frank Keane; Richard May; Lisa Pierre; Dirk Smith; Chris Stevenson; Val Hudson; David Supple; Gainsborough; Horn

January 1, 2018

Status and future of 3D cell culture in toxicity testing

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Monicah A. Otieno; Jinping Gan; William R. Proctor

January 1, 2018

Immune-modified response evaluation criteria in solid tumors (imrecist): Refining guidelines to assess the clinical benefit of cancer immunotherapy

Journal of Clinical Oncology, ISSN: 15277755 0732183X

F. Stephen Hodi; Ballinger; Benjamin Lyons; Jean-Charles Soria; Mizuki Nishino; Tabernero; Thomas Powles; David Smith; Axel Hoos; Chris McKenna; Ulrich Beyer; Ina Rhee; Gregg D. Fine; Nathan Winslow; Daniel S. Chen; Jedd D Wolchok

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