Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4251 - 4300 OF 15477 RESULTS

Principles of drag force flow sensor
Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,
Valery Sheverev; Vadim Stepaniuk; Ajit S. Narang
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Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation
Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,
Sherif I.F. Badawy; Ajit S. Narang; Keirnan R. LaMarche; Ganeshkumar Subramanian; Sailesh A. Varia
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Hormone-Targeted Therapy and Resistance
Annual Review of Cancer Biology, ISSN: 24723428
Ciara Metcalfe; Lori S. Friedman; Jeffrey H. Hager
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Oncologists' perceptions of drug affordability using NCCN Evidence Blocks: Results from a national survey
Journal of Managed Care and Specialty Pharmacy, ISSN: 23761032 23760540
Bijal Shah-Manek; Wong; Arliene Ravelo; Marco D. Dibonaventura
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The relationship between guideline-recommended initiation of therapy, outcomes, and cost for patients with metastatic non-small cell lung cancer
Journal of Managed Care and Specialty Pharmacy, ISSN: 23761032 23760540
Adrianne Casebeer; Dana Drzayich Antol; Richard W. DeClue; Sari Hopson; Yong Li; Raya Khoury; Todd Michael; Marina Sehman; Aparna R. Parikh; Stephen Stemkowski; Mikele M. Bunce
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Hepatic microphysiological systems: Current and future applications in drug discovery and development
Microfluidic Cell Culture Systems,
Ajit Dash; William R. Proctor
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Inflammation and Hepatotoxicity
Comprehensive Toxicology, Third Edition: Volume 1-15,
James P. Luyendyk; Ganey; Aaron Fullerton; Robert Roth
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Predictive Biomarkers and Targeted Therapies in Immuno-oncology
Predictive Biomarkers in Oncology: Applications in Precision Medicine,
Koeppen; Mark L. McCleland; Marcin Kowanetz
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Immune Signaling in Carcinogenesis
Predictive Biomarkers in Oncology: Applications in Precision Medicine,
Mahesh Yadav; Marcin Kowanetz; Koeppen
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Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Sara A. Hurvitz; Miguel Martin; Cynthia Mayte Villarreal Garza; Kyung Hae Jung; Chiun-Sheng Huang; Alastair Thompson; Nadia Harbeck; Vicente Valero; Daniil Stroyakovskiy; Hans Wildiers; Mario Campone; Jean-François Boileau; Matthias W. Beckmann; Karen Afenjar; Rodrigo Fresco; Hans-Joachim Helms; Xu; Yvonne G. Lin; Joseph Sparano; Dennis J. Slamon
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Intracellular regulation of TNF activity in health and disease
Cytokine, ISSN: 10960023 10434666
Eugene Varfolomeev; Domagoj Vucic
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Mechanistic overview of immune checkpoints to support the rational design of their combinations in cancer immunotherapy
Annals of Oncology, ISSN: 15698041 09237534
Rotte; Jin Y. Jin; Vincent Lemaire
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Understanding heterogeneity in the host response to Staphylococcus aureus infection for prognostic biomarker discovery
Critical Care, ISSN: 1466609X 13648535
Dinoso; Johnny Gutierrez; David F. Choy; Sarah K. Kummerfeld; Amos Baruch; Chambers; Carrie M. Rosenberger
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No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Eva Havrdová; Douglas L. Arnold; Amit Bar-Or; Comi; Hartung; Ludwig Kappos; Lublin; Selmaj; Traboulsee; Belachew; Iain Bennett; Regine Buffels; Hideki Garren; Jian Han; Laura Julian; Julie Napieralski; Stephen L. Hauser; Giovannoni
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A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sarah M. Bronner; Jeremy Murray; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Edna F. Choo; Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson
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Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Paola Di Lello; Richard Pastor; Jeremy Murray; Robert A. Blake; Frederick Cohen; Terry Crawford; Joy Drobnick; Jason H. Drummond; Kategaya; Tracy L. Kleinheinz; Till Maurer; Lionel Rouge; Xianrui Zhao; Ingrid E. Wertz; Chudi O. Ndubaku; Vickie Tsui
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Tumour lymph vessels boost immunotherapy
Nature, ISSN: 14764687 00280836
Christine Moussion; Shannon J. Turley
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Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Wei-Jen Chung; Anneleen Daemen; Jason H. Cheng; Jason E. Long; Jonathan Cooper; Bu-Er Wang; Christopher Tran; Mallika Singh; Florian Gnad; Zora Modrusan; Oded Foreman; Melissa Junttila; Anton Berns
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Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "knob-Into-Hole" Bispecific Antibody
Analytical Chemistry, ISSN: 15206882 00032700
Hui-Min Zhang; Charlene Li; Ming Lei; Victor Lundin; Ho Young Lee; Milady Ninonuevo; Kevin Lin; Guanghui Han; Wendy N. Sandoval; Dongsheng Lei; Gang Ren; Jennifer Zhang; Hongbin Liu
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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Stephen J. Gregson; Luke Masterson; Binqing Wei; Thomas H. Pillow; Spencer; Gyoung-Dong Kang; Shang-Fan Yu; Helga Raab; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Janet Gunzner; Brian S. Safina; Rachana Ohri; Martine Darwish; Katherine R. Kozak; Josefa Dela Cruz Chuh; Andrew G. Polson; Flygare; Philip W. Howard
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TRP’ing up chronic kidney disease
Science, ISSN: 10959203 00368075
Jun-Jae Chung; Andrey S. Shaw
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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance
Cell Stem Cell, ISSN: 18759777 19345909
Samantha Haller; Subir Kapuria; Rebeccah Riley; Monique N. O'Leary; Katherine H. Schreiber; Julie K. Andersen; Simon Melov; Jianwen Que; Thomas A. Rando; Jason Rock; Brian K. Kennedy; Joseph T. Rodgers; Heinrich Jasper
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T Lymphocytes Expressing AlphaE Beta7 Integrin in Ulcerative Colitis: Associations With Cellular Lineage and Phenotype
Journal of Crohn's and Colitis, ISSN: 18764479
Christopher A. Lamb; John A. Kirby; Mary E. Keir; John C. Mansfield
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Real-world Direct Health Care Costs for Metastatic Colorectal Cancer Patients Treated With Cetuximab or Bevacizumab-containing Regimens in First-line or First-line Through Second-line Therapy
Clinical Colorectal Cancer, ISSN: 19380674 15330028
Stephen S. Johnston; Kathleen Wilson; Helen Varker; Elisabetta Malangone-Monaco; Paul Juneau; Ellen Riehle; Sacha Satram-Hoang; Nicolas Sommer; Sarika Ogale
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
Nature Communications, ISSN: 20411723
Vagheesh M. Narasimhan; Raheleh Rahbari; Aylwyn Scally; Arthur Wuster; Dan Mason; Yali Xue; John Wright; Richard C. Trembath; Eamonn R Maher; David A. van Heel; Adam Auton; Matthew E. Hurles; Chris Tyler-Smith; Richard Durbin
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Population pharmacokinetics and exposure–response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shang-Chiung Chen; Angelica Quartino; Daniel Polhamus; Matthew Riggs; Jonathan French; Xin Wang; Shweta Vadhavkar; Melanie Smitt; Silke Hoersch; Alexander Strasak; Jin Y. Jin; Sandhya Girish; Chunze Li
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Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Ilisten Jones; Richa Rajwanshi; Karin Rosén; Dale T. Umetsu
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Photodegradation Pathways of Protein Disulfides: Human Growth Hormone
Pharmaceutical Research, ISSN: 1573904X 07248741
Daniel Steinmann; Olivier Mozziconacci; Rupesh Bommana; John F. Stobaugh; Y. John Wang; Christian Schöneich
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Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 15738744 1567567X
Kagedal; Leonid Gibiansky; Jian Xu; Xin Wang; Divya Samineni; Shang-Chiung Chen; Dan Lu; Priya Agarwal; Wang; Ola M. Saad; Neelima Koppada; Bernard M. Fine; Jin Y. Jin; Sandhya Girish; Chunze Li
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Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Karin Jonstam; Marit Westman; Gabriële Holtappels; Cécile T.J. Holweg; Claus Bachert
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Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Scientific Reports, ISSN: 20452322
Travis W. Bainbridge; Diana Ronai Dunshee; Noelyn Kljavin; Nicholas J. Skelton; Junichiro Sonoda; James A. Ernst
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage
Nature Communications, ISSN: 20411723
Mariano Oppikofer; Meredith Sagolla; Benjamin Haley; Hui-Min Zhang; Sarah K. Kummerfeld; Jawahar Sudhamsu; E. Megan Flynn; Tianyi Bai; Jennifer Zhang; Claudio Ciferri; Andrea G Cochran
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Exposure–response analyses of trastuzumab emtansine in patients with HER2-positive advanced breast cancer previously treated with trastuzumab and a taxane
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chunze Li; Wang; Shang-Chiung Chen; Russell D. Wada; Dan Lu; Xin Wang; Daniel Polhamus; Jonathan French; Shweta Vadhavkar; Alexander Strasak; Melanie Smitt; Amita Joshi; Meghna Samant; Angelica Quartino; Jin Y. Jin; Sandhya Girish
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Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li
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Baseline asthma burden, comorbidities, and biomarkers in omalizumab-treated patients in PROSPERO
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Bradley E. Chipps; Robert S. Zeiger; Allan T. Luskin; William W. Busse; Benjamin L. Trzaskoma; Evgeniya Antonova; Hooman Pazwash; Susan L. Limb; Paul G. Solari; Noelle M. Griffin; Thomas B. Casale
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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Li Di; Christopher Breen; Rob Chambers; Sean T. Eckley; Robert Fricke; Avijit Ghosh; Paul Harradine; Kalvass; Stacy Ho; Caroline A. Lee; Punit H. Marathe; Everett J. Perkins; Mark Qian; Susanna Tse; Zhengyin Yan; Zamek-Gliszczynski
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Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Peter Dragovich; Broccatelli; Jinhua Chen; Peter W. Fan; Hoa Le; Mao; Thomas H. Pillow; Andrew G. Polson; John Wai; Zijin Xu; Hui Yao; Donglu Zhang
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Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology
SALAS Discovery, ISSN: 24725560 24725552
Erica Vanderporten; Michael D. Scholle; John Sherrill; John C. Tran; Yichin Liu
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Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry
SALAS Discovery, ISSN: 24725560 24725552
E. Ellen Jones; Wujuan Zhang; Xueheng Zhao; Cristine Quiason; Stephanie Dale; Sheerin Shahidi-Latham; Gregory A. Grabowski; Kenneth D.R. Setchell; Richard R. Drake; Ying Sun
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Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
Scientific Reports, ISSN: 20452322
Simon Hansen; Jakob C. Stüber; Patrick Ernst; Alexander Koch; Daniel Bojar; Alexander Batyuk; Pluckthun
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Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor venetoclax
Cancer Discovery, ISSN: 21598290 21598274
Joel D. Leverson; Deepak Sampath; Andrew J. Souers; Saul H. Rosenberg; Wayne J. Fairbrother; Amiot; Marina Konopleva; Anthony Letai
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A phase i dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with erlotinib in patients with advanced solid tumors
Oncologist, ISSN: 1549490X 10837159
Stephen Leong; Rebecca A. Moss; Daniel W. Bowles; Joseph A. Ware; Jing Zhou; Jill M. Spoerke; Lackner; Geetha Shankar; Jennifer L. Schutzman; Ruud van der Noll; Emile E. Voest; Jan H. M. Schellens
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2017 White Paper on recent issues in bioanalysis: A global perspective on immunogenicity guidelines & biomarker assay performance (Part 3-LBA: Immunogenicity, biomarkers and PK assays)
Bioanalysis, ISSN: 17576199 17576180
Shalini Gupta; Richards; Lakshmi Amaravadi; Steven Piccoli; Binodh DeSilva; Renuka Pillutla; Lauren Stevenson; Devangi Mehta; Montserrat Carrasco-Triguero; Robert J. Neely; Michael A. Partridge; Roland F Staack; Xuemei Zhao; Boris Gorovits; Gerry Kolaitis; Giane Sumner; Kay Stubenrauch; Zou; Shashi Amur; Chris Beaver; Isabella Berger; Flora Berisha; Herbert Birnboeck; Joe Bower; Seongeun Julia Cho; Isabelle Cludts; Cocea; Lorella Di Donato; Saloumeh Kadkhodayan Fischer; Stephanie Fraser; Fabio Garofolo; Sam Haidar; Jonathan Haulenbeek; Charles Hottenstein; Jenny Hu; Akiko Ishii-Watabe; Rafiqul Islam; Darshana Jani; John Kadavil; John Kamerud; Daniel Kramer; Pekka Kurki; Stephen MacMannis; Jim McNally; Ashley Mullan; Apollon Papadimitriou; Joao Pedras-Vasconcelos; Soma Ray; Afshin Safavi; Yoshiro Saito; Natasha Savoie; Marianne Scheel Fjording; Kara Scheibner; John Smeraglia; An Song; Bruce C. Stouffer; Nilufer Tampal; Barry Van Der Strate; Thorsten Verch; Jan Welink; Yuanxin Xu; Tong-Yuan Yang; Lilian Yengi; Jianing Zeng; Yan Zhang; Yanhua Zhang; Stephen Zoog
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Reversed-phase chromatography with large pore superficially porous particles for high throughput immunoglobulin G2 disulfide isoform separation
Journal of Chromatography A, ISSN: 18733778 00219673
Bingchuan Wei; Bing Zhang; Barry E. Boyes; Taylor Zhang
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Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: Post-progression outcomes from the phase II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Andrea Necchi; Richard W. Joseph; Yohann Loriot; Jean Hoffman-Censits; Jose Luis Perez-Gracia; Petrylak; Christina L. Derleth; Darren Tayama; Qian Zhu; Beiying Ding; Constanze Kaiser; Jonathan E. Rosenberg
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Statistical characterization of therapeutic protein modifications
Scientific Reports, ISSN: 20452322
Tsung-Heng Tsai; Zhiqi Hao; Qiuting Hong; Benjamin Moore; Cinzia Stella; Jeffrey H. Zhang; Yan Chen; Michael Kim; Theo Koulis; Gregory Ryslik; Erik Verschueren; Fred Jacobson; William E. Haskins; Olga Vitek
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Erratum to: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (npj Systems Biology and Applications, (2017), 3, 1, (14), 10.1038/s41540-017-0016-1)
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis: Experience from 92 Sites in an Open-Label US Expanded Access Program
Pulmonary Therapy, ISSN: 23641746 23641754
Lisa H Lancaster; Lake Morrison; Alexander Auais; Beiying Ding; Ahmar Iqbal; Boris Polman; Kevin R. Flaherty
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TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
Annals of Oncology, ISSN: 15698041 09237534
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles
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