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DISPLAYING 4301 - 4350 OF 15477 RESULTS

Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)
Annals of Oncology, ISSN: 15698041 09237534
Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte
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TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
Annals of Oncology, ISSN: 15698041 09237534
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yagai Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles
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Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)
Annals of Oncology, ISSN: 15698041 09237534
Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte
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Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis
Rheumatology and Therapy, ISSN: 21986584 21986576
Leslie R. Harrold; Ani John; Reed; Tmirah Haselkorn; Chitra Karki; Youfu Li; Jennie Best; Steve Zlotnick; Joel M. Kremer; Jeffrey D. Greenberg
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Discrepancies between patient-reported outcomes, and endoscopic and histological appearance in UC
Gut, ISSN: 14683288 00175749
Jean-Frédéric Colombel; Mary E. Keir; Alexis Scherl; Rui Zhao; Gert De Hertogh; William A. Faubion Jr.; Timothy T. Lu
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 1 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
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What evidence do we need for biomarker qualification?
Science Translational Medicine, ISSN: 19466242 19466234
Chris Leptak; Joseph P. Menetski; John A. Wagner; Jiri Aubrecht; Linda Brady; Martha Brumfield; William W. Chin; Steven Hoffmann; Gary J. Kelloff; Gabriela Lavezzari; Rajesh Ranganathan; John-Michael Sauer; Frank D. Sistare; Tanja S. Zabka; David Wholley
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Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals
mAbs, ISSN: 19420870 19420862
Sharmila Rajan; Danielle Mandikian; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Junichiro Sonoda; Kyra J. Cowan; C. Andrew Boswell; Stefanich
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Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye
mAbs, ISSN: 19420870 19420862
Devin B. Tesar; Jacob Luoma; Emily A. Wyatt; Catherine Shi; Whitney Shatz; Hass; Mary Mathieu; Li Yi; Jacob E. Corn; Katie F. Maass; Kathryn Wang; Michelle Z. Dion; Nisana Andersen; Kelly M. Loyet; Menno Van Lookeren Campagne; Karthikan Rajagopal; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley
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Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Patrick Weiss; Beryl X. Li; Christina H. McCulley; Stephanie R. Hare; Bronwyn L. Bensema; Teresa A. Palazzo; Dean J. Tantillo; Haiming Zhang; Francis Gosselin
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Thomas Januario; Ye; Russell Bainer; Bruno Alicke; Tunde Smith; Benjamin Haley; Zora Modrusan; Stephen Gould; Robert Yauch
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Patients' priorities in selecting chronic lymphocytic leukemia treatments
Blood advances, ISSN: 24739537 24739529
Carol Mansfield; Anthony Masaquel; Jessie Sutphin; Elisa Weiss; Meghan Gutierrez; Jennifer Wilson; Marco Boeri; Jia Li; Carolina Reyes
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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Yong Ma; Yue Fu; S. Cyrus Khojasteh; Deepak Dalvie; Donglu Zhang
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Blood, ISSN: 15280020 00064971
Jonathan C. Poe; Wei Jia; Hsuan Su; Sarah Anand; Jeremy J. Rose; Prasanthi V. Tata; Amy N. Suthers; Corbin D. Jones; Pei Fen Kuan; Benjamin G. Vincent; Jonathan S. Serody; Mitchell E. Horwitz; Vincent T. Ho; Steve Pavletic; Fran Hakim; Kouros Owzar; Dadong Zhang; Bruce R. Blazar; Christian W. Siebel; Nelson J. Chao; Ivan Maillard; Stefanie Sarantopoulos
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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Cell Metabolism, ISSN: 19327420 15504131
Tian Lan; Donald A. Morgan; Kamal Rahmouni; Junichiro Sonoda; Xiaorong Fu; Shawn C. Burgess; William L. Holland; Steven A. Kliewer; David J. Mangelsdorf
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Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control
Cell, ISSN: 10974172 00928674
Richard G. Yau; Kerstin Doerner; Erick R. Castellanos; Diane L. Haakonsen; Achim Werner; Nan Wang; X. William Yang; Nadia Martinez-Martin; Marissa L. Matsumoto; Vishva M. Dixit; Michael Rape
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B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement
JCI insight, ISSN: 23793708
Alfred H.J. Kim; Jun-Jae Chung; Shreeram Akilesh; Ania Koziell; Sanjay Jain; Jeffrey B. Hodgin; Mark J. Miller; Thaddeus S. Stappenbeck; Jeffrey H. Miner; Andrey S. Shaw
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A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Wei-Ting Hsu; Abigail F.J. Pynn; Domingos Ng; Donna Quicho; Yilma T. Adem; Zephie Kwong; Brad Mauger; John C. Joly; Snedecor; Mike Laird; Dana C. Andersen; Amy Shen
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Access to Cancer Specialist Care and Treatment in Patients With Advanced Stage Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Apar Kishor Ganti; Fred R. Hirsch; Murry W. Wynes; Arliene Ravelo; Suresh Ramalingam; Raluca Ionescu-Ittu; Irina Pivneva; Hossein Borghaei
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Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses
Journal of the National Cancer Institute, ISSN: 14602105 00278874
Carlos Bais; Barbara Mueller; Mark F. Brady; Robert S. Mannel; Robert. A. Burger; Wei Wei; Koen M. Marien; Mark Kockx; Amreen Husain; Michael J. Birrer
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High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression
Biotechnology Progress, ISSN: 15206033 87567938
Hermann-Josef Meyer; Rebecca Turincio; Shirley Ng; Juan Li; Blair Wilson; Pamela Chan; Mark Zak; Dorothea Reilly; Beresini; Athena W. Wong
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Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space
AAPS Journal, ISSN: 15507416
Eric Wakshull; Quarmby; Hanns-Christian Mahler; Hongwen Rivers; Dhananjay Jere; Meg Ramos; Piotr Szczesny; Karoline Bechtold-Peters; Sharmila Masli; Swati Gupta
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Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin
Pharmaceutical Research, ISSN: 1573904X 07248741
Mariya Pindrus; James L. Cole; Japneet Kaur; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms
AAPS Journal, ISSN: 15507416
Andre Hermans; Andreas M. Abend; Filippos Kesisoglou; Talia Flanagan; Michael J. Cohen; Dorys A. Diaz; Mao; Limin Zhang; Gregory K. Webster; Yiqing Lin; David Hahn; Carrie A. Coutant; Haiyan Grady
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Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound
Pharmaceutical Research, ISSN: 1573904X 07248741
Jialin Mao; Peter W. Fan; Susan C. Wong; Jianshuang Wang; Moulay Hicham Alaoui Ismaili; Brian J. Dean; Cornelis E. Hop; Matthew Wright; Yuan Chen
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Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Thomas M. Monticello; Thomas W. Jones; Donna M. Dambach; David M. Potter; Michael W. Bolt; Maggie Liu; Douglas A. Keller; Timothy K. Hart; Vivek J. Kadambi
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FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Molecular Metabolism, ISSN: 22128778
Mark Chen; Joshua C. Chang; Jose Zavala-Solorio; Lance Kates; Minh Thai; Annie Ogasawara; Xiaobo Bai; Sean Flanagan; Victor Nunez; Khanhky Phamluong; James Ziai; Robert J. Newman; Søren Warming; Ganesh Kolumam; Junichiro Sonoda
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A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced non–small cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Jean-Charles Soria; Alex Adjei; Rastilav Bahleda; Benjamin Besse; Charles Ferte; David Planchard; Jing Zhou; Joseph A. Ware; Kari M. Morrissey; Geetha Shankar; Wei Lin; Jennifer L. Schutzman; Grace Dy; Harry J.M. Groen
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Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies
AAPS Journal, ISSN: 15507416
Zhandong Don Zhong; Adrienne Clements-Egan; Boris Gorovits; Mauricio Maia; Giane Sumner; Valerie Theobald; Yuling Wu; Manoj Rajadhyaksha
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High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Yinghui Guan; Oleg Mayba; Thomas Sandmann; Shan Lu; Younjeong Choi; Darbonne; Vincent Leveque; Lisa Ryner; Eric W. Humke; Nga W.R. Tam; Sundari Sujathasarma; Anna Cheung; Richard Bourgon; Lackner; Wang
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Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large b-cell lymphoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Umberto Vitolo; Marek Trneny; David Belada; John M. Burke; Angelo Michele Carella; Neil Chua; Pau Abrisqueta; Judit Demeter; Ian Flinn; Xiaonan Hong; Won Seog Kim; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Mikkel Z. Oestergaard; Michael Wenger; Guenter Fingerle-Rowson; Olivier Catalani; Tina Nielsen; Maurizio Martelli; Laurie H. Sehn
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Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates
British Journal of Pharmacology, ISSN: 14765381 00071188
Daniela Bumbaca; Janice Maloney; Kristin R. Wildsmith; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Yanmei Lu; Kun Peng; Blair Wilson; Pamela Chan; Kapil Gadkar; Andrew Kosky; Marisa Goo; Daugherty; Jessica A. Couch; Thomas Keene; Karen Hayes; Lisa Jungbauer Nikolas; Deanna Lane; Robert Switzer; Eric L. Adams; Ryan J. Watts; Kimberly Scearce-Levie; Saileta Prabhu; Lisa Shafer; Deepak R Thakker; Keith Hildebrand; Jasvinder K. Atwal
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Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza a virus challenge model
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael A. Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen-Harris; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie M. Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Harris; Jorge A. Tavela
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Silencing of retrotransposons by SET DB1 inhibits the interferon response in acute myeloid leukemia
Journal of Cell Biology, ISSN: 15408140 00219525
Trinna L. Cuellar; Anna-Maria Herzner; Xiaotian Zhang; Yogesh Goyal; Colin K. Watanabe; Brad A. Friedman; Vasantharajan Janakiraman; Durinck; Stinson; David Arnott; Tommy K. Cheung; Subhra Chaudhuri; Zora Modrusan; Jonas Martin Doerr; Marie Classon; Benjamin Haley
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A blueprint to advance colorectal cancer immunotherapies
Cancer immunology research, ISSN: 23266074 23266066
Dung T. Le; Vanessa M. Hubbard-Lucey; Michael A. Morse; Christopher R. Heery; Andrea Dwyer; Thomas H. Marsilje; Arthur N. Brodsky; Emily Chan; Dustin A. Deming; Luis A. Diaz; Wolf H. Fridman; Richard M. Goldberg; Stanley R. Hamilton; Franck Housseau; Elizabeth M. Jaffee; S. Peter Kang; Smitha S. Krishnamurthi; Christopher H. Lieu; Wells A. Messersmith; Cynthia L. Sears; Neil H. Segal; Arvin Yang; Rebecca A. Moss; Edward Cha; Jill O'Donnell-Tormey; Roach; Anjelica Q. Davis; Keavy McAbee; Sharyn Worrall; Al B. Benson
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Higher order structure of proteins in biopharmaceutical development
Pharmacopeial Forum, ISSN: 15421945 03634655
Yves Aubin; Michael D. Brenowitz; Edward Chess; Thomas M. Laue; Jasper C. Lin; Donald MacLean; John P. Marino; Linda O. Narhi; William Weiss; Qin Zou
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A new lead to NLRP3 inhibition
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lamkanfi; Vishva M. Dixit
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Combining "bottom-up" and "top-down" approaches to assess the impact of food and gastric pH on pictilisib (GDC-0941) pharmacokinetics
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Tong Lu; Grazyna Fraczkiewicz; Laurent Salphati; Nageshwar Budha; Gena Dalziel; Gillian S. Smelick; Kari M. Morrissey; John Davis; Jin Y. Jin; Joseph A. Ware
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Effect of docetaxel duration on clinical outcomes: Exploratory analysis of CLEOPATRA, a phase III randomized controlled trial
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Im; Fung; Bongin Yoo; Adam Knott; Sarah Heeson; Beattie; Sandra M. Swain
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An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma
Annals of Oncology, ISSN: 15698041 09237534
Stéphane Temam; Spicer; Farzaneh; Jean-Charles Soria; Oppenheim; McGurk; Antoine Hollebecque; Sarini; Hussain; Soehrman Brossard; Manenti; Stefan Evers; Paul Delmar; Di Scala; Christoph Mancao; Feuerhake; Luc Andries; Ott; Passioukov; Delord
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Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Anna Hitz; Maj Hedehus; Jeffrey Eastham-Anderson; Franklin V. Peale Jr.; Patricia Hamilton; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano
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Concordance between plasma-based and tissue-based next-generation sequencing in LOTUS
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Matthew Wongchenko; Stina M. Singel; Baselga
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High-resolution two-dimensional liquid chromatography analysis of key linker drug intermediate used in antibody drug conjugates
Journal of Chromatography A, ISSN: 18733778 00219673
Venkatramani; Shu Rong Huang; Mohammad Al-Sayah; Ila Patel; Larry Wigman
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USP7 small-molecule inhibitors interfere with ubiquitin binding
Nature, ISSN: 14764687 00280836
Kategaya; Paola Di Lello; Lionel Rouge; Richard Pastor; Clark; Jason H. Drummond; Tracy L. Kleinheinz; Eva Lin; John-Paul Upton; Sumit Prakash; Johanna Heideker; Mark L. McCleland; Maria Stella Ritorto; Dario R. Alessi; Matthias Trost; Travis W. Bainbridge; Michael Kwok; Taylur P. Ma; Zachary Stiffler; Bradley Brasher; Yinyan Tang; Priyadarshini Jaishankar; Brian R. Hearn; Adam R. Renslo; Michelle R. Arkin; Frederick Cohen; Kebing Yu; Franklin V. Peale Jr.; Florian Gnad; Matthew T. Chang; Christiaan N. Klijn; Elizabeth M. Blackwood; Scott E. Martin; William F. Forrest; James A. Ernst; Chudi O. Ndubaku; Xiaojing Wang; Beresini; Vickie Tsui; Carsten Schwerdtfeger; Robert A. Blake; Jeremy Murray; Till Maurer; Ingrid E. Wertz
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Grid-Based Surface Generalized Born Model for Calculation of Electrostatic Binding Free Energies
Journal of Chemical Information and Modeling, ISSN: 15205142 15499596
Negin Forouzesh; Saeed Izadi; Alexey V. Onufriev
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Grid-Based Surface Generalized Born Model for Calculation of Electrostatic Binding Free Energies
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Negin Forouzesh; Saeed Izadi; Alexey V. Onufriev
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marian C. Bryan; Andrew Cosbie; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Shaun Hughes; Mark McLaws; Paul Richardson; Gheorghe-Doru Roiban; Markus Schober; Alan Steven; Timothy White; Jingjun Yin
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Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Breanna S. Vollmar; Binqing Wei; Rachana Ohri; Jianhui Zhou; Jintang He; Shang-Fan Yu; Douglas Leipold; Ely Cosino; Sharon Fong Yee; Aimee Fourie-O'Donohue; Guangmin Li; Gail L. Phillips; Katherine R. Kozak; Amrita Kamath; Keyang Xu; Genee Y. Lee; Greg A. Lazar; Hans Erickson
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