Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells
Biotechnology Progress, ISSN: 15206033 87567938
Cynthia Lam; Santell; Blair Wilson; Mandy Yim; Salina Louie; Danming Tang; David Shaw; Pamela Chan; Lazarus; Snedecor; Shahram Misaghi
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Burden of illness of people with persistent symptoms of schizophrenia: A multinational cross-sectional study
International Journal of Social Psychiatry, ISSN: 17412854 00207640
Anna-Lena Nordstroem; Darren Talbot; Corrado Bernasconi; Carmen Galani Berardo; Justine Lalonde
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Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch
Clinical and Translational Science, ISSN: 17528062 17528054
Heleen Scheerens; Malong; Bassett; Zachary Boyd; Vinita Gupta; Harris; Mesick; Simnett; Stevens; Houston N. Gilbert; Risser; Kalamegham; Jordan; Engel; Chen; Essioux; Williams
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iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
The Lancet Oncology, ISSN: 14745488 14702045
Lesley Seymour; Jan Bogaerts; Andrea Perrone; Robert Ford; Lawrence Schwartz; Sumithra Mandrekar; Lin; Saskia Litière; Janet Dancey; Alice Chen; F. Stephen Hodi; Patrick Therasse; Otto S. Hoekstra; Lalitha K Shankar; Jedd D Wolchok; Ballinger; Caroline Caramella; Elisabeth G. E. De Vries
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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
Nature Communications, ISSN: 20411723
Eugene Y. Chiang; Tianbo Li; Surinc Er Jeet; Ivan Peng; Juan Zhang; Wyne P. Lee; Jason Devoss; Patrick Caplazi; Jun Chen; Søren Warming; David Hackos; Susmith Mukund; Christopher M. Koth; Jane L. Grogan
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A phase II randomized trial (GO27827) of first-line FOLFOX plus bevacizumab with or without the MET inhibitor onartuzumab in patients with metastatic colorectal cancer
Oncologist, ISSN: 1549490X 10837159
Bendell; Hochster; Lowell Hart; Irfan Firdaus; Joseph R. Mace; Joshua J. McFarlane; Kozloff; Daniel V.T. Catenacci; Jessie Hsu; Stephen P. Hack; David S. Shames; See Phan; Koeppen; Cohn
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Phase i study of the anti-CD22 antibody-drug conjugate pinatuzumab vedotin with/without rituximab in patients with relapsed/refractory B-cell non-hodgkin lymphoma
Clinical Cancer Research, ISSN: 15573265 10780432
Ranjana H. Advani; Lebovic; Chen; Mark Brunvand; Andre Goy; Julie E. Chang; Ephraim Hochberg; Sreeni Yalamanchili; Robert S. Kahn; Dan Lu; Priya Agarwal; Randall Dere; Hsin-Ju Hsieh; Surai Jones; Yu-Waye Chu; Bruce D. Cheson
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Cutting edge: Notch signaling promotes the plasticity of group-2 innate lymphoid cells
Journal of Immunology, ISSN: 15506606 00221767
Kangning Zhang; Xingyuan Xu; Muhammad Asghar Pasha; Christian W. Siebel; Angelica Costello; Angela Haczku; Katherine MacNamara; Tingbo Liang; Jinfang Zhu; Avinash Bhandoola; Ivan Maillard; Qi Yang
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Survival gains from first-line systemic therapy in metastatic non-small cell lung cancer in the U.S., 1990-2015: Progress and opportunities
Oncologist, ISSN: 1549490X 10837159
Joshua A. Roth; Bernardo H. L. Goulart; Arliene Ravelo; Holli Kolkey; Scott D. Ramsey
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Determination of a no-observable effect level for endotoxin following a single intravitreal administration to dutch belted rabbits
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Vlad Bantseev; Paul Miller; Ellison Bentley; Chris Schuetz; Tim M. Streit; Brian J. Christian; Cindy A. Farman; Helen Booler; Evan A Thackaberry
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BPOG five-year vision for single-use technologies
American Pharmaceutical Review, ISSN: 10998012
Ken Wong; Jeffrey Johnson; Sally Kline; Robert Repetto; Ekta Mahajan
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An improved method of predicting extinction coefficients for the determination of protein concentration
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Eric Hilario; Alan Stern; Charlie H. Wang; Yenny W. Vargas; Charles Morgan; Trevor E. Swartz; Thomas W. Patapoff
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Mixed matrix method provides a reliable metabolite exposure comparison for assessment of metabolites in safety testing (MIST)
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; S. Cyrus Khojasteh; Matthew Wright; Cornelis E. Hop; Shuguang Ma
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HER2-Positive Metastatic Breast Cancer Patients Receiving Pertuzumab in a Community Oncology Practice Setting: Treatment Patterns and Outcomes
Drugs - Real World Outcomes, ISSN: 21989788 21991154
Nicholas J. Robert; Hans-Peter Goertz; Pooja Chopra; Xiaolong Jiao; Bongin Yoo; Debra Patt; Vincent Antao
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Correspondence
Nature Methods, ISSN: 15487105 15487091
Elior Rahmani; Noah Zaitlen; Yael Baran; Celeste Eng; Donglei Hu; Joshua Galanter; Sam S. Oh; Esteban G. Burchard; Eleazar Eskin; James Zou; Eran Halperin
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Correcting for cell-type heterogeneity in DNA methylation: A comprehensive evaluation
Nature Methods, ISSN: 15487105 15487091
Elior Rahmani; Noah Zaitlen; Yael Baran; Celeste Eng; Donglei Hu; Joshua Galanter; Sam S. Oh; Esteban G. Burchard; Eleazar Eskin; James Zou; Eran Halperin
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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
Cell, ISSN: 10974172 00928674
Michael R. Burgess; Eugene Hwang; Rana Mroue; Craig M. Bielski; Anica M. Wandler; Benjamin J. Huang; Ari J. Firestone; Amy Young; Jennifer A. Lacap; Lisa Crocker; Saurabh Asthana; Elizabeth M. Davis; Jin Xu; Keiko Akagi; Michelle M. Le Beau; Qing Li; Benjamin Haley; David Stokoe; Deepak Sampath; Barry S. Taylor; Marie Evangelista; Kevin Shannon
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Improving Stepwise Assembly of a Bispecific F(ab′)2 from Two Different Fab′ Molecules
Industrial and Engineering Chemistry Research, ISSN: 15205045 08885885
Ambrose Jon Williams; Robert Ovadia; Glen Giese
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Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Nature Communications, ISSN: 20411723
Janet Lau; Jeanne Cheung; Armando Navarro; Steve Lianoglou; Benjamin Haley; Klara Totpal; Laura A. Strickland; Koeppen; Patrick Caplazi; Jacqueline McBride; Chiu; Rebecca Hong; Jane L. Grogan; Vincent Javinal; Robert Yauch; Bryan Irving; Marcia Belvin; Ira Mellman; Kim; Maike Schmidt
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Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data
mAbs, ISSN: 19420870 19420862
Xiangdan Wang; McKay; Liliana T. Yee; George Dutina; Hass; Ihsan Nijem; David E. Allison; Kyra J. Cowan; Kevin Lin; Quarmby; Yang
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Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells
mAbs, ISSN: 19420870 19420862
Michael Dillon; Yiyuan Yin; Jianhui Zhou; Luke McCarty; Diego Ellerman; Dionysos S. Slaga; Teemu T. Junttila; Guanghui Han; Wendy N. Sandoval; Meric A. Ovacik; Kedan Lin; Zhilan Hu; Amy Shen; Jacob E. Corn; Christoph Spiess; Paul J. Carter
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Brafv600 mutations in solid tumors, other than metastatic melanoma and papillary thyroid cancer, or multiple myeloma: A screening study
OncoTargets and Therapy, ISSN: 11786930
Cohn; Bann-Mo Day; Sarang Abhyankar; Edward McKenna; Todd Riehl; Igor Puzanov
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Trace Analysis of Potentially Mutagenic Boronic Acids and Esters in Drug Substance by ICP-MS
Organic Process Research and Development, ISSN: 1520586X 10836160
Ila Patel; Venkatramani; Andreas Stumpf; Larry Wigman; Peter M. Yehl
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marian C. Bryan; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Shaun Hughes; Luke Humphreys; Paul Richardson; Markus Schober; Alan Steven; Timothy White; Stijn Wuyts; Jingjun Yin
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Domain-specific free thiol variant characterization of an IgG1 by reversed-phase high-performance liquid chromatography mass spectrometry
Analytical Biochemistry, ISSN: 10960309 00032697
Ying Cheng; Matthew T. Chen; Lisa C. Patterson; X. Christopher Yu; Taylor Zhang; Braydon Burgess; Yonghong Chen
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GeneAttribution: Trait agnostic identification of candidate genes associated with noncoding variation
Bioinformatics, ISSN: 14602059 13674803
Arthur Wuster; Diana Chang; Timothy W. Behrens; Tushar Bhangale
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Biomarker analysis of the NeoSphere study: Pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer
Breast Cancer Research, ISSN: 1465542X 14655411
Giampaolo Bianchini; Astrid Kiermaier; Giulia V. Bianchi; Im; Tadeusz Pienkowski; Mei-Ching Liu; Ling-Ming Tseng; Mitch Dowsett; Lila Zabaglo; Sarah Kirk; Szado; Jennifer Eng-Wong; Lukas Amler; Pinuccia Valagussa; Luca Gianni
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Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Cripps; Cécile T.J. Holweg; Matthews; Maillot; James Fingleton; Mark Weatherall; Richard Beasley; Irene Braithwaite; Caswell-Smith; Beasley; Tony Mallon; Judith Riley; Janine Pilcher; Mathew Williams; Philippa Shirtcliffe; Thomas Charles; Holliday; Maureen Stretch; Alison Pritchard; Denise Fabian; Hosking; Meghana Handigol; Cecile Holweg; John Matthews
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Characterization of protein-excipient microheterogeneity in biopharmaceutical solid-state formulations by confocal fluorescence microscopy
Molecular Pharmaceutics, ISSN: 15438392 15438384
Stijn H.S. Koshari; Jean L. Ross; Purnendu K. Nayak; Isidro E. Zarraga; Karthikan Rajagopal; Norman J. Wagner; Abraham M. Lenhoff
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An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
Blood, ISSN: 15280020 00064971
Leong; Siddharth Sukumaran; Maria Hristopoulos; Klara Totpal; Shannon Stainton; Elizabeth Lu; Alfred Wong; Lucinda Tam; Robert J. Newman; Brian R. Vuillemenot; Diego Ellerman; Chen Gu; Mary Mathieu; Dennis; Allen Nguyen; Bing Zheng; Crystal Zhang; Genee Y. Lee; Yu-Waye Chu; Prell; Kedan Lin; Steven T. Laing; Andrew G. Polson
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Clinical translation of ferumoxytol-based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Jill Fredrickson; Natalie J. Serkova; Shelby K. Wyatt; Richard A. D. Carano; Andrea Pirzkall; Ina Rhee; Lee Rosen; Alberto Bessudo; Colin D. Weekes; De Crespigny
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FDG-PET is prognostic and predictive for progression-free survival in relapsed follicular lymphoma: exploratory analysis of the GAUSS study
Leukemia and Lymphoma, ISSN: 10292403 10428194
Lale Kostakoglu; Andre Goy; Giovanni Martinelli; Dolores Caballero; Michael Crump; Gianluca Gaidano; Tara Baetz; Rena Buckstein; Gregg D. Fine; Guenter Fingerle-Rowson; Claude Berge; Deniz Sahin; Oliver W. Press; Laurie H. Sehn
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Health-related quality of life and symptoms in patients with rituximab-refractory indolent non-Hodgkin lymphoma treated in the phase III GADOLIN study with obinutuzumab plus bendamustine versus bendamustine alone
Annals of Hematology, ISSN: 14320584 09395555
Bruce D. Cheson; Peter C. Trask; John G. Gribben; Natalie Dimier; Eva Kimby; Pieternella J. Lugtenburg; Catherine Thieblemont; Elisabeth Wassner-Fritsch; Aino Launonen; Laurie H. Sehn
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Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Meijuan Zhou; Donghong Yan; Jing Kang; Xiumin Wu; Eric Suto; Miriam Baca; Cary D. Austin; Min Xu; Wyne P. Lee; Rajita Pappu
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A Random Forest Approach for Counting Silicone Oil Droplets and Protein Particles in Antibody Formulations Using Flow Microscopy
Pharmaceutical Research, ISSN: 1573904X 07248741
Miguel Saggu; Ankit Patel; Theodoro Koulis
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Pharmacokinetic and exposure–response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Angelica Quartino; Hanbin Li; Jin Y. Jin; D. Russell Wada; Benyunes; Virginia McNally; Lucia Viganò; Ihsan Nijem; Bert L. Lum; Amit Garg
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Antibody–Antibiotic Conjugates: A Novel Therapeutic Platform against Bacterial Infections
Trends in Molecular Medicine, ISSN: 1471499X 14714914
Sanjeev Mariathasan; Man-Wah Tan
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Phase 2 randomized, double-blind, placebo-controlled trial of RG7667, a combination monoclonal antibody, for prevention of cytomegalovirus infection in high-risk kidney transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Julie H. Ishida; Anita Patel; Aneesh K. Mehta; Philippe Gatault; Jacqueline McBride; Tracy Burgess; Michael A. Derby; David R. Snydman; Brinda Emu; Becket Feierbach; Ashley Fouts; Mauricio Maia; Rong Deng; Carrie M. Rosenberger; Lynn Gennaro; Natalee S. Striano; X. Charlene Liao; Jorge A. Tavel
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Five-year Efficacy and safety of tocilizumab monotherapy in patients with rheumatoid arthritis who were methotrexate-And biologic-naive or free of methotrexate for 6 months: The ambition study
Journal of Rheumatology, ISSN: 14992752 0315162X
Graeme Jones; Thomas Wallace; Matthew J. McIntosh; Laura Brockwell; Juan Gomez-Reino; Anthony Sebba
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Mantle cell lymphoma initial therapy with abbreviated R-CHOP followed by 90Y-ibritumomab tiuxetan: 10-year follow-up of the phase 2 ECOG-ACRIN study E1499
Leukemia, ISSN: 14765551 08876924
Smith; Fangxin Hong; Hailun Li; Leo I. Gordon; Randy D. Gascoyne; Elisabeth M. Paietta; Ranjana H. Advani; Andres Forero; Sandra J. Horning; Brad Kahl
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What is the value of conducting a trial of r-tPA for the treatment of mild stroke patients?
International Journal of Stroke, ISSN: 17474949 17474930
Gregory F. Guzauskas; Er Chen; Deepa Lalla; Elaine B. Yu; Darren Tayama; David L. Veenstra
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MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats
Toxicologic Pathology, ISSN: 15331601 01926233
Dolores Diaz; Rama Pai; Cain; Nghi La; Donna M. Dambach; Jacob Schwartz; Jacqueline M. Tarrant
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Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma
Annals of Translational Medicine, ISSN: 23055847 23055839
Kevin M. Hart; David F. Choy; Peter Bradding; Thomas A. Wynn; Joseph R. Arron
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Mantle cell lymphoma initial therapy with abbreviated R-CHOP followed by 90Y-ibritumomab tiuxetan: 10-year follow-up of the phase 2 ECOG-ACRIN study E1499
Leukemia, ISSN: 14765551 08876924
Smith; Fangxin Hong; Hailun Li; Leo I. Gordon; Randy D. Gascoyne; Elisabeth M. Paietta; Ranjana H. Advani; Andres Forero; Sandra J. Horning; Wojciech Jurczak
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
Nature Communications, ISSN: 20411723
Florencia Cayrol; Pannee Praditsuktavorn; Tharu M. Fernando; Nicholas Kwiatkowski; Rossella Marullo; M. Nieves Calvo-Vidal; Jude Phillip; Benet Pera; Shao-Ning Yang; Kaipol Takpradit; Lidia Roman; Marcello Gaudiano; Ramona Crescenzo; Jia Ruan; Giorgio Inghirami; Tinghu Zhang; Graciela Cremaschi; Nathanael S. Gray; Leandro Cerchietti
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Development of a multi-matrix LC–MS/MS method for urea quantitation and its application in human respiratory disease studies
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Jianshuang Wang; Yang Gao; Dorshorst; Fang Cai; Meire C. Bremer; Dennis Milanowski; Tracy Staton; Stephanie Cape; Brian J. Dean; Xiao Ding
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Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Georgette M. Castanedo; Nicole Blaquiere; Beresini; Brandon Bravo; Hans D. Brightbill; Jacob Z. Chen; Haifeng Cui; Eigenbrot; Christine Everett; Jianwen A. Feng; Robert Godemann; Emily Gogol; Sarah G. Hymowitz; Adam R. Johnson; Nobuhiko Kayagaki; Pawan Bir Kohli; Kathleen Knüppel; Joachim Kraemer; Susan Krüger; Pui Loke; Paul A. McEwan; Christian A.G.N. Montalbetti; David Allen Roberts; Myron Smith; Stefan Steinbacher; Swathi Sujatha-Bhaskar; Ryan Takahashi; Xiaolu Wang; Lawren C. Wu; Yamin Zhang; Steven T. Staben
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Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Georgette M. Castanedo; Nicole Blaquiere; Beresini; Brandon Bravo; Hans D. Brightbill; Jacob Z. Chen; Haifeng Cui; Eigenbrot; Christine Everett; Jianwen A. Feng; Robert Godemann; Emily Gogol; Sarah G. Hymowitz; Adam R. Johnson; Nobuhiko Kayagaki; Pawan Bir Kohli; Kathleen Knüppel; Joachim Kraemer; Susanne Kruger; Pui Loke; Paul A. McEwan; Christian A.G.N. Montalbetti; David Allen Roberts; Myron Smith; Stefan Steinbacher; Swathi Sujatha-Bhaskar; Ryan Takahashi; Xiaolu Wang; Lawren C. Wu; Yamin Zhang; Steven T. Staben
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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Patrick Koenig; Chingwei V. Lee; Benjamin T. Walters; Vasantharajan Janakiraman; Stinson; Thomas W. Patapoff; Fuh
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Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
The Lancet, ISSN: 1474547X 01406736
Achim Rittmeyer; Fabrice Barlesi; Waterkamp; Keunchil Park; Fortunato Ciardiello; Joachim Von Pawel; Shirish M. Gadgeel; Toyoaki Hida; Dariusz M Kowalski; Manuel Cobo Dols; Diego L Cortinovis; Joseph W. Leach; Jonathan Polikoff; Carlos H. Barrios; Fairooz F. Kabbinavar; Osvaldo Arén Frontera; Filippo De Marinis; Hande Turna; Jong-Seok Lee; Ballinger; Marcin Kowanetz; Pei He; Daniel S. Chen; Alan Sandler; David R. Gandara
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