Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4801 - 4850 OF 15477 RESULTS

Risk of Infection Associated With Subsequent Biologic Agent Use After Rituximab: Results From a National Rheumatoid Arthritis Patient Registry
Arthritis Care and Research, ISSN: 21514658 2151464X
Leslie R. Harrold; Reed; Chitra Karki; Robert Magner; Ashwini Shewade; Ani John; Joel M. Kremer; Jeffrey D. Greenberg
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
Nature Neuroscience, ISSN: 15461726 10976256
Hieab H. H. Adams; Derrek P. Hibar; Vincent Chouraki; Jason L. Stein; Paul Nyquist; Miguel E. Renteria; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Ashley H Beecham; Neda Jahanshad; Katharina Wittfeld; Sven J. Van Der Lee; Lucija Abramovic; Saud Alhusaini; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Lavinia Athanasiu; Tomas Axelsson; Alexa Beiser; Manon Bernard; Joshua C. Bis; Laura M E Blanken; Susan H Blanton; Marc M. Bohlken; Marco P. Boks; Janita Bralten; Adam M Brickman; Owen Carmichael; Mallar Chakravarty; Ganesh Chauhan; Qiang Chen; Christopher R. K. Ching; Gabriel Cuellar-Partida; Anouk Den Braber; Nhat Trung Doan; Stefan Ehrlich; Irina Filippi; Tian Ge; Sudheer Giddaluru; Aaron L. Goldman; Rebecca F Gottesman; Corina U Greven; Oliver Grimm; Michael E Griswold; Tulio Guadalupe; Johanna Hass; Unn K. Haukvik; Saima Hilal; Edith Hofer; David Hoehn; Avram J. Holmes; Martine Hoogman; Deborah Janowitz; Tianye Jia; Dalia Kasperaviciute; Sungeun Kim; Marieke Klein; Bernd Kraemer; Phil H Lee; Jiemin Liao; David C. M. Liewald; Lorna M. Lopez; Michelle Luciano; Christine MacAre; Andre Marquand; Mar Matarin; Mather; Manuel Mattheisen; Bernard Mazoyer; David R McKay; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Allison C. Nugent; Loes M. Olde Loohuis; Jaap Oosterlaan; Martina Papmeyer; Irene Pappa; Lukas Pirpamer; Sara Pudas; Benno Pütz; Kumar B Rajan; Adaikalavan Ramasamy; Jennifer S Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Natalie A. Royle; Tatjana Rundek; Philipp G. Sämann; Claudia L. Satizabal; Lianne Schmaal; Andrew J. Schork; Li Shen; Jean Shin; Elena Shumskaya; Albert V Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutierrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen Van Der Grond; Dennis Van Der Meer; Marjolein M. J. Van Donkelaar; Kristel R. Van Eijk; Theo G M Van Erp; Daan Van Rooij; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Lisa Yanek; Jingyun Yang; Alex Zijdenbos; Marcel P. Zwiers; Ingrid Agartz; Neelum T Aggarwal; Laura Almasy; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Amelia A. Assareh; Sandra Barral; Mark E. Bastin; Diane M Becker; James T. Becker; David A. Bennett; John Blangero; Hans Van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Han G Brunner; Randy L. Buckner; Jan K Buitelaar; Kazima B. Bulayeva; Wiepke Cahn; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Anders M. Dale; Gareth E. Davies; Eco J. C. De Geus; Philip L. De Jager; Greig I. De Zubicaray; Norman Delanty; Chantal Depondt; Anita L Destefano; Allissa Dillman; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Ravi Duggirala; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A Evans; Iryna O. Fedko; Guillén Fernández; Luigi Ferrucci; Simon E. Fisher; Debra A Fleischman; Ian Ford; Tatiana M. Foroud; Peter T. Fox; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; David C. Glahn; Randy L. Gollub; Harald H.H. Göring; Hans-Jörgen Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Sebastian Guelfi; Narelle K. Hansell; John Hardy; Catharina A. Hartman; Ryota Hashimoto; Katrin Hegenscheid; Andreas Heinz; Stephanie Le Hellard; Dena G. Hernandez; Dirk J. Heslenfeld; Beng-Choon Ho; Pieter J. Hoekstra; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Norbert Hosten; Jouke-Jan Hottenga; Hilleke E Hulshoff Pol; Masashi Ikeda; M Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J Wouter Jukema; René S. Kahn; Ryota Kanai; Iwona Kloszewska; David Knopman; Peter Kochunov; John B. Kwok; Stephen M. Lawrie; Hervé Lemaître; Xinmin Liu; Dan L. Longo; Longstreth; Oscar L. Lopez; Simon Lovestone; Oliver Martinez; Jean-Luc Martinot; Venkata S. Mattay; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Grant W. Montgomery; Derek W. Morris; Thomas H Mosley; Thomas W. Mühleisen; Bertram Müller-Myhsok; Michael A. Nalls; Matthias Nauck; Thomas E. Nichols; Wiro J Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Rene L. Olvera; Roel A. Ophoff; Massimo Pandolfo; Tomas Paus; Zdenka Pausova; Brenda W. J. H. Penninx; Bruce Pike; Steven G. Potkin; Bruce M. Psaty; Simone Reppermund; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Jerome I. Rotter; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Sigurdur Sigurdsson; Andy Simmons; Andy Singleton; Sanjay M. Sisodiya; Colin Smith; Jordan W. Smoller; Hilkka Soininen; Velandai Srikanth; Vidar M. Steen; David J Stott; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Maria C. Valdés Hernández; Marcel P Van Der Brug; Aad Van Der Lugt; Nic J. A. Van Der Wee; Cornelia M. Van Duijn; Neeltje E. M. Van Haren; Dennis Van 'T Ent; Marie-Jose Van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Michael W. Weiner; Wei Wen; Eric Westman; Tonya White; Andrew K. Wong; Clinton B. Wright; Ronald H. Zielke; Alan B. Zonderman; Ian J. Deary; Charles DeCarli; Helena Schmidt; Nicholas G. Martin; Anton J M De Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Myriam Fornage; Barbara Franke; Stéphanie Debette; Sarah E. Medland; M Arfan Ikram; Paul M. Thompson
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RIPK1 inhibits ZBP1-driven necroptosis during development
Nature, ISSN: 14764687 00280836
Kim Newton; Katherine E. Wickliffe; Maltzman; Dugger; Andreas Strasser; Victoria Pham; Jennie R. Lill; Merone Roose-Girma; Søren Warming; Margaret Solon; Hai Ngu; Webster; Vishva M. Dixit
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Integrated Two-Analyte Population Pharmacokinetic Model for Antibody-Drug Conjugates in Patients: Implications for Reducing Pharmacokinetic Sampling
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Dan Lu; Leonid Gibiansky; Priya Agarwal; Randall Dere; Chunze Li; Yu-Waye Chu; Jamie Hirata; Amita Joshi; Jin Y. Jin; Sandhya Girish
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The RAS/MAPK Axis Gets Stressed Out
Molecular Cell, ISSN: 10974164 10972765
Scott A. Foster; Shiva Malek
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Tissue-Specific Mutations in BRAF and EGFR Necessitate Unique Therapeutic Approaches
Trends in Cancer, ISSN: 24058033
Scott A. Foster; Christiaan N. Klijn; Shiva Malek
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The Role of Next-Generation Sequencing in Enabling Personalized Oncology Therapy
Clinical and Translational Science, ISSN: 17528062 17528054
Cummings; Peters; Lacroix; Fabrice Andre; Lackner
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Validation of synthetic CRISPR reagents as a tool for arrayed functional genomic screening
PLoS ONE, ISSN: 19326203
Jenille Tan; Scott E. Martin
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Balancing blood sample volume with 3Rs: Implementation and best practices for small molecule toxicokinetic assessments in rats
ILAR Journal, ISSN: 19306180 10842020
Eric Harstad; Roxanne Andaya; Jessica A. Couch; Xiao Ding; Xiaorong Liang; Bianca M. Liederer; Kirsten Messick; Trung Nguyen; Michelle G. Schweiger; Jacqueline M. Tarrant; Shelly Zhong; Brian J. Dean
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Refinement, reduction, and replacement of animal toxicity tests by computational methods
ILAR Journal, ISSN: 19306180 10842020
Kevin A. Ford
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
Nature Neuroscience, ISSN: 15461726 10976256
Hieab H. H. Adams; Derrek P. Hibar; Vincent Chouraki; Jason L. Stein; Paul Nyquist; Miguel E. Renteria; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Ashley H Beecham; Neda Jahanshad; Katharina Wittfeld; Sven J. Van Der Lee; Lucija Abramovic; Saud Alhusaini; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Lavinia Athanasiu; Tomas Axelsson; Alexa Beiser; Manon Bernard; Joshua C. Bis; Laura M E Blanken; Susan H Blanton; Marc M. Bohlken; Marco P. Boks; Janita Bralten; Adam M Brickman; Owen Carmichael; Mallar Chakravarty; Ganesh Chauhan; Qiang Chen; Christopher R. K. Ching; Gabriel Cuellar-Partida; Anouk Den Braber; Nhat Trung Doan; Stefan Ehrlich; Irina Filippi; Tian Ge; Sudheer Giddaluru; Aaron L. Goldman; Rebecca F Gottesman; Corina U Greven; Oliver Grimm; Michael E Griswold; Tulio Guadalupe; Johanna Hass; Unn K. Haukvik; Saima Hilal; Edith Hofer; David Hoehn; Avram J. Holmes; Martine Hoogman; Deborah Janowitz; Tianye Jia; Dalia Kasperaviciute; Sungeun Kim; Marieke Klein; Bernd Kraemer; Phil H Lee; Jiemin Liao; David C. M. Liewald; Lorna M. Lopez; Michelle Luciano; Christine MacAre; Andre Marquand; Mar Matarin; Mather; Manuel Mattheisen; Bernard Mazoyer; David R McKay; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Allison C. Nugent; Loes M. Olde Loohuis; Jaap Oosterlaan; Martina Papmeyer; Irene Pappa; Lukas Pirpamer; Sara Pudas; Benno Pütz; Kumar B Rajan; Adaikalavan Ramasamy; Jennifer S Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Natalie A. Royle; Tatjana Rundek; Philipp G. Sämann; Claudia L. Satizabal; Lianne Schmaal; Andrew J. Schork; Li Shen; Jean Shin; Elena Shumskaya; Albert V Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutierrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen Van Der Grond; Dennis Van Der Meer; Marjolein M. J. Van Donkelaar; Kristel R. Van Eijk; Theo G M Van Erp; Daan Van Rooij; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Lisa Yanek; Jingyun Yang; Alex Zijdenbos; Marcel P. Zwiers; Ingrid Agartz; Neelum T Aggarwal; Laura Almasy; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Amelia A. Assareh; Sandra Barral; Mark E. Bastin; Diane M Becker; James T. Becker; David A. Bennett; John Blangero; Hans Van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Han G Brunner; Randy L. Buckner; Jan K Buitelaar; Kazima B. Bulayeva; Wiepke Cahn; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Anders M. Dale; Gareth E. Davies; Eco J. C. De Geus; Philip L. De Jager; Greig I. De Zubicaray; Norman Delanty; Chantal Depondt; Anita L Destefano; Allissa Dillman; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Ravi Duggirala; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A Evans; Iryna O. Fedko; Guillén Fernández; Luigi Ferrucci; Simon E. Fisher; Debra A Fleischman; Ian Ford; Tatiana M. Foroud; Peter T. Fox; Clyde Francks; Masaki Fukunaga; J Raphael Gibbs; David C. Glahn; Randy L. Gollub; Harald H.H. Göring; Hans-Jörgen Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Sebastian Guelfi; Narelle K. Hansell; John Hardy; Catharina A. Hartman; Ryota Hashimoto; Katrin Hegenscheid; Andreas Heinz; Stephanie Le Hellard; Dena G. Hernandez; Dirk J. Heslenfeld; Beng-Choon Ho; Pieter J. Hoekstra; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Norbert Hosten; Jouke-Jan Hottenga; Hilleke E Hulshoff Pol; Masashi Ikeda; M Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J Wouter Jukema; René S. Kahn; Ryota Kanai; Iwona Kloszewska; David Knopman; Peter Kochunov; John B. Kwok; Stephen M. Lawrie; Hervé Lemaître; Xinmin Liu; Dan L. Longo; Longstreth; Oscar L. Lopez; Simon Lovestone; Oliver Martinez; Jean-Luc Martinot; Venkata S. Mattay; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Grant W. Montgomery; Derek W. Morris; Thomas H Mosley; Thomas W. Mühleisen; Bertram Müller-Myhsok; Michael A. Nalls; Matthias Nauck; Thomas E. Nichols; Wiro J Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Rene L. Olvera; Roel A. Ophoff; Massimo Pandolfo; Tomas Paus; Zdenka Pausova; Brenda W. J. H. Penninx; Bruce Pike; Steven G. Potkin; Bruce M. Psaty; Simone Reppermund; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Jerome I. Rotter; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Sigurdur Sigurdsson; Andy Simmons; Andy Singleton; Sanjay M. Sisodiya; Colin Smith; Jordan W. Smoller; Hilkka Soininen; Velandai Srikanth; Vidar M. Steen; David J Stott; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Maria C. Valdés Hernández; Marcel P Van Der Brug; Aad Van Der Lugt; Nic J. A. Van Der Wee; Cornelia M. Van Duijn; Neeltje E. M. Van Haren; Dennis Van 'T Ent; Marie-Jose Van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Michael W. Weiner; Wei Wen; Eric Westman; Tonya White; Andrew K. Wong; Clinton B. Wright; Ronald H. Zielke; Alan B. Zonderman; Ian J. Deary; Charles DeCarli; Helena Schmidt; Nicholas G. Martin; Anton J M De Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Myriam Fornage; Barbara Franke; Stéphanie Debette; Sarah E. Medland; M Arfan Ikram; Paul M. Thompson
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Thaw-and-use target cells pre-labeled with calcein AM for antibody-dependent cell-mediated cytotoxicity assays
Journal of Immunological Methods, ISSN: 00221759
Shan Chung; Van Nguyen; Yuwen L. Lin; Lynn Kamen; An Song
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Incidence of Gastrointestinal Perforations in Patients with Rheumatoid Arthritis Treated with Tocilizumab from Clinical Trial, Postmarketing, and Real-World Data Sources
Rheumatology and Therapy, ISSN: 21986584 21986576
Sharareh Monemi; Erhan Berber; Khaled Sarsour; Jianmei Wang; Kathy Lampl; Kamal N. Bharucha; Attila Pethoe-Schramm
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Long-Term Safety and Efficacy of Subcutaneously Administered Tocilizumab for Adult Rheumatoid Arthritis: A Multicenter Phase 3b Long-term Extension Study
Rheumatology and Therapy, ISSN: 21986584 21986576
Alan Kivitz; Thomas Wallace; Ewa Olech; Michael Borofsky; Jenny Devenport; Jinglan Pei; Margaret Michalska
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Evading pre-existing anti-hinge antibody binding by hinge engineering
mAbs, ISSN: 19420870 19420862
Hok Seon Kim; Ingrid Kim; Linda Zheng; Jean-Michel Vernes; Meng; Christoph Spiess
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Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11–15, 2016, San Diego, CA
mAbs, ISSN: 19420870 19420862
James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; Cynthia A. Lemere; Anne Messer; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; Janine Schuurman; Gregory P. Adams; Janice M. Reichert
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Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice
mAbs, ISSN: 19420870 19420862
Chenguang Zhou; Sophie M. Lehar; Johnny Gutierrez; Carrie M. Rosenberger; Nina Ljumanovic; Jason Dinoso; Neelima Koppada; Kyu Hong; Amos Baruch; Montserrat Carrasco-Triguero; Ola M. Saad; Sanjeev Mariathasan; Amrita Kamath
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Quality by Design risk assessments supporting approved antibody products
mAbs, ISSN: 19420870 19420862
Kelley
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Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry
mAbs, ISSN: 19420870 19420862
Yiyuan Yin; Guanghui Han; Jianhui Zhou; Michael Dillon; Luke McCarty; Lou Gavino; Diego Ellerman; Christoph Spiess; Wendy N. Sandoval; Paul J. Carter
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An efficient route to bispecific antibody production using single-reactor mammalian co-culture
mAbs, ISSN: 19420870 19420862
Whitney Shatz; Domingos Ng; George Dutina; Athena W. Wong; Diana Ronai Dunshee; Junichiro Sonoda; Amy Shen; Justin M. Scheer
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Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer
International Journal of Cancer, ISSN: 10970215 00207136
Sung-Bae Kim; Hans Wildiers; Ian E. Krop; Melanie Smitt; Ron Yu; Sanne Lysbet de Haas; Antonio González-Martín
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A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study)
Cancer, ISSN: 10970142 0008543X
Vicky Makker; Fernando O. Recio; Ling Ma; Ursula A. Matulonis; Jennifer O. Lauchle; Hema Parmar; Houston N. Gilbert; Joseph A. Ware; Rui Zhu; Shan Lu; Huw; Wang; Koeppen; Jill M. Spoerke; Lackner; Carol Aghajanian
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Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates
ACS Medicinal Chemistry Letters, ISSN: 19485875
Donglu Zhang; Thomas H. Pillow; Yong Ma; Josefa Dela Cruz-Chuh; Katherine R. Kozak; Jack D. Sadowsky; Gail L. Phillips; Jun Guo; Martine Darwish; Peter W. Fan; Jingtian Chen; Changrong He; Tao Wang; Hui Yao; Zijin Xu; Jinhua Chen; John Wai; Zhonghua Pei; Cornelis E. Hop; S. Cyrus Khojasteh; Peter Dragovich
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Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis
Cell Metabolism, ISSN: 19327420 15504131
Nisebita Sahu; Darlene Dela Cruz; Min Gao; Wendy N. Sandoval; Matthias Peter; Jinfeng Liu; Jean-Philippe Stephan; Benjamin Haley; Marie Classon; Georgia Hatzivassiliou; Jeffrey Settleman
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Bridging End of Discovery to Regulatory Filing: Formulations for IND- and Registration-Enabling Nonclinical Studies
Oral Formulation Roadmap from Early Drug Discovery to Development,
Evan A Thackaberry
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Formulation Strategies for High Dose Toxicology Studies: Case Studies
Oral Formulation Roadmap from Early Drug Discovery to Development,
Dennis H. Leung; Pierre Daublain; Mengwei Hu; Kung-I Feng
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Resolving TYK2 locus genotype-To-phenotype differences in autoimmunity
Science Translational Medicine, ISSN: 19466242 19466234
Calliope A. Dendrou; Adrian Cortes; Lydia Shipman; Hayley G. Evans; Kathrine E. Attfield; Luke Jostins; Thomas Barber; Gurman Kaur; Subita Balaram Kuttikkatte; Oliver A. Leach; Christiane Desel; Soren L. Faergeman; Jane Cheeseman; Matt J. Neville; Stephen J. Sawcer; Alastair Compston; Adam R. Johnson; Christine Everett; John I. Bell; Fredrik Karpe; Ultsch; Eigenbrot; Gilean McVean; Lars Fugger
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Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Nageshwar Budha; Tao Ji; Luna Musib; Stephen M. Eppler; Mark J. Dresser; Yuan Chen; Jin Y. Jin
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Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Free Radical Biology and Medicine, ISSN: 18734596 08915849
Baris Bingol; Morgan Sheng
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The economic burden of end-of-life care in metastatic breast cancer
Journal of Medical Economics, ISSN: 1941837X 13696998
Thomas Bramley; Vincent Antao; Orsolya Lunacsek; Kristin Hennenfent; Anthony Masaquel
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Adverse event-related costs for systemic metastatic breast cancer treatment among female Medicaid beneficiaries
Journal of Medical Economics, ISSN: 1941837X 13696998
Debra E. Irwin; Anthony Masaquel; Stephen S. Johnston; Brian Barnett
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Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics
AAPS Journal, ISSN: 15507416
Bonnie Wu; Shan Chung; Xu-Rong Jiang; Jim McNally; Joao Pedras-Vasconcelos; Renuka Pillutla; Joleen T. White; Yuanxin Xu; Shalini Gupta
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A practical guide to assess the Nancy histological index for UC
Gut, ISSN: 14683288 00175749
Aude Marchal-Bressenot; Alexis Scherl; Julia Salleron; Peyrin-Biroulet
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Precision of pharmaceutical powder flow measurement using ring shear tester: High variability is inherent to powders with low cohesion
Powder Technology, ISSN: 1873328X 00325910
Lap Yin Leung; Chen Mao; Li Ping Chen; Yi Yang
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Fit-for-purpose biomarker immunoassay qualification and validation: Three case studies
Bioanalysis, ISSN: 17576199 17576180
Kyra J. Cowan; Xiaoying Gao; Vaishali Parab; Trung Nguy; Lawren C. Wu; Joseph R. Arron; Michael J. Townsend; Jeffery J. Wallin; Melissa Cheu; Alyssa M. Morimoto; Eric Wakshull
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Issues facing the bioanalytical community: Summary of round table discussions
Bioanalysis, ISSN: 17576199 17576180
Neil Spooner; Stephanie Cape; Roger Hayes; Surinder Kaur; John Kolman; Steve Lowes; Scott Summerfield; Amanda Wilson; Eric Woolf
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Characterization of IL-17AA and IL-17FF in rheumatoid arthritis and multiple sclerosis
Bioanalysis, ISSN: 17576199 17576180
Cheryl A. Schofield; Saloumeh Kadkhodayan Fischer; Michael J. Townsend; Mosesova; Kun Peng; A F. Setiadi; An Song; Amos Baruch
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Commercial biomarker assays: Friend and foe
Bioanalysis, ISSN: 17576199 17576180
Saloumeh Kadkhodayan Fischer; Montserrat Carrasco-Triguero; Kyu Hong; Jeremy Good; Teresa Davancaze; Trung Nguy; Jessica Li; Darbonne; Alyssa M. Morimoto; Yuda Zhu
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Rifampin-mediated induction of tamoxifen metabolism in a humanized PXR-CAR-CYP3A4/3A7-CYP2D6 mouse model
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jae H. Chang; John Chen; Liling Liu; Kirsten Messick; Justin Ly
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Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Li Wang; Carol Collins; Edward J. Kelly; Xiaoyan Chu; Adrian S. Ray; Laurent Salphati; Guangqing Xiao; Caroline A. Lee; Yurong Lai; Mingxiang Liao; Anita Mathias; Raymond Evers; W. Griffith Humphreys; Cornelis E. Hop; Sean C. Kumer; Jashvant D. Unadkat
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Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency
Nature Genetics, ISSN: 15461718 10614036
Paola G. Bronson; Diana Chang; Tushar Bhangale; Michael F. Seldin; Ward Ortmann; Ricardo C. Ferreira; Elena Urcelay; Luis Fernández Pereira; Javier Martin; Alessandro Plebani; Vassilios Lougaris; Vanda Friman; Tomáš Freiberger; Jiri Litzman; Vojtech Thon; Qiang Pan-Hammarström; Lennart Hammarström; Robert R. Graham; Timothy W. Behrens
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Measuring experimental cyclohexane-water distribution coefficients for the SAMPL5 challenge
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ariën S. Rustenburg; Justin Dancer; Baiwei Lin; Jianwen A. Feng; Daniel F. Ortwine; David L. Mobley; John D. Chodera
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Corticosteroid-related toxicity in patients with chronic idiopathic urticaria-chronic spontaneous urticaria
Allergy and Asthma Proceedings, ISSN: 15396304 10885412
Dennis Ledford; Michael S. Broder; Evgeniya Antonova; Theodore A. Omachi; Eunice Chang; Allan T. Luskin
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Chromosomal instability estimation based on next generation sequencing and single cell genome wide copy number variation analysis
PLoS ONE, ISSN: 19326203
Stephanie B. Greene; Angel E. Dago; Laura J. Leitz; Yipeng Wang; Jerry Lee; Shannon L. Werner; Steven Gendreau; Premal Patel; Shidong Jia; Liangxuan Zhang; Eric K Tucker; Michael Malchiodi; Ryon P. Graf; Ryan Dittamore; Dena Marrinucci; Mark Landers
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Development and application of a microfluidics-based panel in the basal/luminal transcriptional characterization of archival bladder cancers
PLoS ONE, ISSN: 19326203
Doris Kim; Younjeong Choi; James S. Ireland; Oded Foreman; Rachel Tam; Rajesh Patel; Erica Schleifman; Maipelo Motlhabi; French; Cheryl Wong; Peters; Luciana L. Molinero; Rajiv Raja; Lukas Amler; Garret M. Hampton; Lackner; Omar Kabbarah
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Functional Reading Independence (Fri) index: A new patient-reported outcome measure for patients with geographic atrophy
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Miriam Kimel; Nancy Kline Leidy; Elizabeth Tschosik; Chantal M. Dolan; Eric H. Souied; Rohit Varma; Neil M. Bressler
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An alternative approach to ChIP-Seq normalization enables detection of genome-wide changes in histone H3 lysine 27 trimethylation upon EZH2 inhibition
PLoS ONE, ISSN: 19326203
Brian Egan; Chih-Chi Yuan; Madeleine Lisa Craske; Paul Labhart; Gulfem D. Guler; David Arnott; Tobias Maile; Jennifer Busby; Chisato Henry; Theresa K. Kelly; Charles Tindell; Suchit Jhunjhunwala; Feng Zhao; Charlie Hatton; Barbara M. Bryant; Marie Classon; Patrick Trojer
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Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards
The Lancet Oncology, ISSN: 14745488 14702045
Andrew Bottomley; Madeline Pe; Jeff A. Sloan; Ethan Basch; Franck Bonnetain; Melanie Calvert; Alicyn Campbell; Charles S. Cleeland; Kim Cocks; Laurence Collette; Amylou Dueck; Nancy Devlin; Hans-Henning Flechtner; Carolyn C. Gotay; Eva Greimel; Ingolf Griebsch; Mogens Groenvold; Jean-Francois Hamel; Madeleine King; Paul G Kluetz; Michael Koller; Daniel C Malone; Francesca Martinelli; Sandra A Mitchell; Carol M Moinpour; Jammbe Musoro; Daniel O'Connor; Kathy Oliver; Elisabeth Piault-Louis; Martine Piccart; Francisco L Pimentel; Chantal Quinten; Jaap C Reijneveld; Christoph Schürmann; Ashley Wilder Smith; Katherine M Soltys; Martin J. B. Taphoorn; Galina Velikova; Corneel Coens
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A small-scale model to assess the risk of leachables from single-use bioprocess containers through protein quality characterization
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Nina Xiao; Colin D. Medley; Ian C. Shieh; Gregory Downing; Shelly A. Pizarro; Jun Liu; Ankit Patel
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Pictilisib PI3Kinase inhibitor (a phosphatidylinositol 3-kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative, locally recurrent, or metastatic breast cancer: Interim analysis of the multicentre, placebo-controlled, phase II randomised PEGGY study
Annals of Oncology, ISSN: 15698041 09237534
Peter Vuylsteke; Huizing; Katarina Petrakova; Roylance; Laing; Chan; Abell; Steven Gendreau; Isabelle Rooney; Doris Apt; Jing Zhou; Stina M. Singel; Louis Fehrenbacher
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