Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4851 - 4900 OF 15477 RESULTS

Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody–drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer
Annals of Oncology, ISSN: 15698041 09237534
Joyce F. Liu; Kevin L. Moore; Michael J. Birrer; Berlin; Ursula A. Matulonis; Jeffery R. Infante; Wolpin; Kirsten Achilles Poon; Ron Firestein; Jian Xu; Robert S. Kahn; Wang; Katie Wood; Darbonne; Lackner; Kelley; Xuyang Lu; Younjeong Choi; Daniel Maslyar; Eric W. Humke; Howard A. Burris
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In vivo evaluation of retinal ganglion cells degeneration in eyes with branch retinal vein occlusion
British Journal of Ophthalmology, ISSN: 14682079 00071161
Rayan A. Alshareef; Giulio Barteselli; Qisheng You; Abhilash Goud; Asiya Jabeen; Harsha L. Rao; Asiya Jabeen; Jay Chhablani
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GluN2A-selective pyridopyrimidinone series of nmdar positive allosteric modulators with an improved in vivo profile
ACS Medicinal Chemistry Letters, ISSN: 19485875
Elisia Villemure; Matthew Volgraf; Yu Jiang; Guosheng Wu; Cuong Q. Ly; Po-Wai Yuen; Aijun Lu; Xifeng Luo; Mingcui Liu; Shun Zhang; Patrick J. Lupardus; Heidi J. A. Wallweber; Bianca M. Liederer; Gauri Deshmukh; Emile G. Plise; Suzanne Tay; Tzu-Ming Wang; Jesse E. Hanson; David Hackos; Kimberly Scearce-Levie; Jacob B. Schwarz; Benjamin D. Sellers
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Randomized phase II study of duligotuzumab (MEHD7945A) vs. cetuximab in squamous cell carcinoma of the head and neck (MEHGAN study)
Frontiers in Oncology, ISSN: 2234943X
Jérôme Fayette; Lori Wirth; Cristina Marinela Oprean; Anghel Udrea; Antonio Jimeno; Danny Rischin; Christopher Nutting; Paul M. Harari; Tibor Csoszi; Dana Cernea; Paul O'Brien; William D. Hanley; Amy V. Kapp; Maria Anderson; Elicia M. Penuel; Bruce Mccall; Andrea Pirzkall; Jan B. Vermorken
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The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Nature Communications, ISSN: 20411723
Kwok Ho Yip; Natasha Kolesnikoff; Nicholas Hauschild; Lisa Biggs; Angel F. Lopez; Stephen J. Galli; Kumar; Michele A. Grimbaldeston
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Introduction
Analysis of Post-Translational Modifications Using Mass Spectrometry,
Rebecca R. Pferdehirt; Florian Gnad; Jennie R. Lill
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Reprint of “Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications”
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Kelly Zhang; Xiaodong Liu
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Health care resource use and costs associated with possible side effects of high oral corticosteroid use in asthma: A claims-based analysis
ClinicoEconomics and Outcomes Research, ISSN: 11786981
Allan T. Luskin; Evgeniya Antonova; Michael S. Broder; Eunice Chang; Theodore A. Omachi; Dennis Ledford
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Battling Btk Mutants with Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations
ACS Chemical Biology, ISSN: 15548937 15548929
Adam R. Johnson; Pawan Bir Kohli; Arna Katewa; Emily Gogol; Lisa D. Belmont; Regina Choy; Elicia M. Penuel; Luciana Burton; Eigenbrot; Christine Yu; Daniel F. Ortwine; Krista K. Bowman; Yvonne Franke; Christine Tam; Alberto Estevez; Kyle Mortara; Jiansheng Wu; Hong Li; May Lin; Philippe Bergeron; James J. Crawford; Wendy B. Young
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Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations
Cell, ISSN: 10974172 00928674
Hélène Quach; Maxime Rotival; Julien Pothlichet; Yong-Hwee Eddie Loh; Michael Dannemann; Nora Zidane; Guillaume Laval; Etienne Patin; Christine Harmant; Marie Lopez; Matthieu Deschamps; Nadia Naffakh; Darragh Duffy; Anja Coen; Geert Leroux-Roels; Frederic Clément; Anne Boland; Jean-François Deleuze; Janet Kelso; Matthew L. Albert; Lluis Quintana-Murci
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IL-27 directly enhances germinal center b cell activity and potentiates lupus in sanroque mice
Journal of Immunology, ISSN: 15506606 00221767
Dipti Vijayan; Norhanani Mohd Redzwan; Danielle T. Avery; Rushika C. Wirasinha; Robert Brink; Giles Walters; Stephen Adelstein; Masao Kobayashi; Paul Gray; Michael Elliott; Melanie Wong; Cecile King; Carola G. Vinuesa; Nico Ghilardi; Cindy S. Ma; Stuart G. Tangye; Marcel Batten
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Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking
Scientific Reports, ISSN: 20452322
Xinxin Gao; Karen Stanger; Harini Kaluarachchi; Till Maurer; Paulina Ciepla; Cecile Chalouni; Yvonne Franke; Rami N. Hannoush
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Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Bryan K. Chan; Emily J. Hanan; Krista K. Bowman; Marian C. Bryan; Burdick; Emily Chan; Yuan Chen; Saundra Clausen; Trisha Dela Vega; Jennafer Dotson; Eigenbrot; Richard Elliott; Robert Heald; Philip Jackson; Jamie Knight; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Lily Shao; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Christine Yu; Timothy P. Heffron
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Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice
ACS Medicinal Chemistry Letters, ISSN: 19485875
Hans E. Purkey; Kirk D. Robarge; Jinhua Chen; Zhongguo Chen; Laura B. Corson; Charles Z. Ding; Antonio G. DiPasquale; Peter Dragovich; Eigenbrot; Marie Evangelista; Benjamin P. Fauber; Zhenting Gao; Hongxiu Ge; Anna Hitz; Qunh Ho; Sharada Labadie; Kwong Wah Lai; Wenfeng Liu; Yajing Liu; Chiho Li; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Huihui Zhang; Aihe Zhou
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A Method to Measure Protein Unfolding at an Air-Liquid Interface
Langmuir, ISSN: 15205827 07437463
Danielle L. Leiske; Ian C. Shieh; Martha Lovato Tse
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Economic burden related to chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system
Breast Cancer: Targets and Therapy, ISSN: 11791314
Nazia Rashid; Han A. Koh; Hilda C. Baca; Kathy J. Lin; Susan Malecha; Anthony Masaquel
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Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons’ Referrals
Annals of Surgical Oncology, ISSN: 15344681 10689265
Eleftherios P. Mamounas; Christine Poulos; Hans-Peter Goertz; Juan Marcos González; Amy Pugh; Vincent Antao
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Characterization of therapeutic antibodies and related products by two-dimensional liquid chromatography coupled with UV absorbance and mass spectrometric detection
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Dwight R. Stoll; John Danforth; Kelly Zhang; Alain Beck
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Development of a rapid RP-UHPLC–MS method for analysis of modifications in therapeutic monoclonal antibodies
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Bing Zhang; Justin Jeong; Braydon Burgess; Mansour Jazayri; Yun Tang; Taylor Zhang
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Probing the Distribution of Water in a Multi-Component System by Solid-State NMR Spectroscopy
Pharmaceutical Research, ISSN: 1573904X 07248741
Pinal Mistry; Paroma Chakravarty; Joseph W. Lubach
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Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion—reversed phase two dimensional-liquid chromatography
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Yi Li; Cinzia Stella; Laura Zheng; Charity Bechtel; Jason Gruenhagen; Fred Jacobson; Colin D. Medley
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Tocilizumab use in pregnancy: Analysis of a global safety database including data from clinical trials and post-marketing data
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Maria Hoeltzenbein; Evelin Beck; Richa Rajwanshi; Carina Gøtestam Skorpen; Erhan Berber; Christof Schaefer; Monika Østensen
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A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors
Investigational New Drugs, ISSN: 15730646 01676997
Lee Rosen; Patricia M. LoRusso; Wen Wee Ma; Jonathan W. Goldman; Amy Weise; A. Dimitrios Colevas; Alex Adjei; Salim Yazji; Angela Shen; Stuart H. Johnston; Hsin-Ju Hsieh; Iris Chan; Branimir I. Sikic
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Angioedema in the omalizumab chronic idiopathic/spontaneous urticaria pivotal studies
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
James L. Zazzali; Allen P. Kaplan; Marcus Maurer; Karina Raimundo; Benjamin L. Trzaskoma; Paul G. Solari; Evgeniya Antonova; Meryl Mendelson; Karin Rosén
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Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Tao Chen; Yan Chen; Cinzia Stella; Colin D. Medley; Jason Gruenhagen; Kelly Zhang
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
Nature Chemical Biology, ISSN: 15524469 15524450
Aaron Boudreau; Hans E. Purkey; Anna Hitz; Kirk D. Robarge; David Peterson; Sharada Labadie; Mandy Kwong; Rebecca Hong; Min Gao; Christopher J. Del Nagro; Raju V. Pusapati; Shuguang Ma; Laurent Salphati; Jodie Pang; Aihe Zhou; Tommy Lai; Yingjie Li; Zhongguo Chen; Binqing Wei; Ivana Yen; Steve Sideris; Mark L. McCleland; Ron Firestein; Laura B. Corson; Alexander N. Vanderbilt; Simon P. Williams; Anneleen Daemen; Marcia Belvin; Eigenbrot; Peter K Jackson; Shiva Malek; Georgia Hatzivassiliou; Deepak Sampath; Marie Evangelista; Thomas O'Brien
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1H, 13C and 15N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7)
Biomolecular NMR Assignments, ISSN: 1874270X 18742718
Paola Di Lello; Lionel Rouge; Borlan Pan; Till Maurer
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Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Zhilan Hu; Henry Zhang; Benjamin Haley; Frank D. Macchi; Feng Yang; Shahram Misaghi; Joseph Elich; Renee Yang; Yun Tang; John C. Joly; Snedecor; Amy Shen
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Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease
Clinical and Experimental Allergy, ISSN: 13652222 09547894
Caswell-Smith; Hosking; Cripps; Cécile T.J. Holweg; Matthews; Holliday; Maillot; James Fingleton; Mark Weatherall; Irene Braithwaite; Beasley; Thomas Charles; Leonie Eastlake; Denise Fabian; Tony Mallon; Claire Munro; Janine Pilcher; Alison Pritchard; Michael Richards; Judith Riley; Philippa Shirtcliffe; Maureen Stretch; Mathew Williams; Jochen Brumm; Meghana Handigol; Julie Olsen; Karl Yen
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Clinical development of new drug-radiotherapy combinations
Nature Reviews Clinical Oncology, ISSN: 17594782 17594774
Ricky A. Sharma; Ruth Plummer; Julie K. Stock; Tessa A. Greenhalgh; Ozlem Ataman; Stephen Kelly; Robert Clay; Richard A. Adams; Richard Baird; Lucinda Billingham; Sarah R. Brown; Sean Buckland; Helen Bulbeck; Anthony J. Chalmers; Glen Clack; Aaron N. Cranston; Lars Damstrup; Roberta Ferraldeschi; Martin D. Forster; Julian Golec; Russell M. Hagan; Emma Hall; Axel-R. Hanauske; Kevin J. Harrington; Tom Haswell; Maria A. Hawkins; Tim Illidge; Hazel Jones; Andrew S. Kennedy; Fiona Mcdonald; Thorsten Melcher; James P.B. O'Connor; John R. Pollard; Mark P. Saunders; David Sebag-Montefiore; Melanie Smitt; John Staffurth; Ian J. Stratford; Stephen R. Wedge
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An automated high-throughput metabolic stability assay using an integrated high-resolution accurate mass method and automated data analysis software
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Pranav Shah; Edward Kerns; Dac-Trung Nguyen; R. Scott Obach; Amy Q. Wang; Alexey Zakharov; John C. McKew; Anton Simeonov; Cornelis E. Hop; Xin Xu
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Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Nicola A. Hanania; Phillip Korenblat; Kenneth R Chapman; Eric D Bateman; Petr Kopecky; Pierluigi Paggiaro; Akihito Yokoyama; Julie Olsson; Sarah Gray; Cécile T.J. Holweg; Mark D. Eisner; Charles Asare; Saloumeh Kadkhodayan Fischer; Kun Peng; Wendy Putnam; Matthews
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Isolating the Role of Bevacizumab in Elderly Patients with Previously Untreated Nonsquamous Non-Small Cell Lung Cancer
American Journal of Clinical Oncology: Cancer Clinical Trials, ISSN: 1537453X 02773732
Corey Langer; Mark A. Socinski; Jyoti D. Patel; Alan Sandler; Joan H. Schiller; Larry Leon; Sebastien J. Hazard; Suresh Ramalingam
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Non-cytochrome P450-mediated bioactivation and its toxicological relevance
Drug Metabolism Reviews, ISSN: 10979883 03602532
Jinping Gan; Shuguang Ma; Donglu Zhang
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Ranibizumab Treatment for Pigment Epithelial Detachment Secondary to Neovascular Age-Related Macular Degeneration: Post Hoc Analysis of the HARBOR Study
Ophthalmology, ISSN: 15494713 01616420
David Sarraf; Nikolas J.S. London; Rahul N. Khurana; Pravin U. Dugel; Shamika Gune; Lauren Hill; Lisa Tuomi
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Metabolic response to NAD depletion across cell lines is highly variable
PLoS ONE, ISSN: 19326203
Yang Xiao; Mandy Kwong; Anneleen Daemen; Marcia Belvin; Xiaorong Liang; Georgia Hatzivassiliou; Thomas O'Brien
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Clinical endpoints for the study of geographic atrophy secondary to age-related macular degeneration
Retina, ISSN: 15392864 0275004X
Srinivas Sadda; Usha Chakravarthy; David G. Birch; Giovanni Staurenghi; Erin C. Henry; Christopher Brittain
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Regulation of interleukin-10 expression
Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598
Sascha Rutz; Wenjun Ouyang
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Peripheral blood gene expression predicts clinical benefit from anti–IL-13 in asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
David F. Choy; Guiquan Jia; Abbas Alexander; Katrina B. Morshead; Nicholas Lewin-Koh; Rajiv Dua; Pauline Rivera; Priscilla Moonsamy; Marcel Fontecha; Aarthi Balasubramanyam; Chris Santini; Ekaterina Bassett; Jill M. Ray; Christopher R. Cabanski; Mary S. Bradley; Romeo MacIuca; Mosesova; Heleen Scheerens; Joseph R. Arron
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Corticosteroid-related adverse events in patients with giant cell arteritis: A claims-based analysis
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Michael S. Broder; Khaled Sarsour; Eunice Chang; Neil Collinson; Katie Tuckwell; Pavel Napalkov; Micki Klearman
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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Ian E. Templeton; Yuan Chen; Jialin Mao; Jian Lin; Hongbin Yu; Peters; Shebley; Varma
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Randomized phase 3 study in low-grade lymphoma comparing maintenance anti-CD20 antibody with observation after induction therapy: A trial of the ECOG-ACRIN cancer research group (E1496)
Cancer, ISSN: 10970142 0008543X
Stefan K. Barta; Hailun Li; Hochster; Fangxin Hong; Edie Weller; Randy D. Gascoyne; Thomas M. Habermann; Leo I. Gordon; Natalia Colocci; Elizabeth M. Bengtson; Sandra J. Horning; Brad Kahl
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Using the HistoPress embedding tool to process murine colon samples for histopathology
Journal of Histotechnology, ISSN: 20460236 01478885
Susan Haller; Victor Nunez; Charles Havnar; Noa Safra; Oded Foreman
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Ritonavir-boosted danoprevir plus peginterferon alfa-2a and ribavirin in Asian chronic hepatitis C patients with or without cirrhosis
Journal of Gastroenterology and Hepatology (Australia), ISSN: 14401746 08159319
Jia-Horng Kao; Shui-Yi Tung; Younjae Lee; Satawat Thongsawat; Tanwandee; I.-Shyan Sheen; Jinzi J. Wu; Hui Li; Barbara J. Brennan; Julian Zhou; Sophie Le Pogam; Nájera; James A. Thommes; George Hill
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Considerations on Endpoint Selection, Weighting Determination, and Uncertainty Evaluation in the Benefit-Risk Assessment of Medical Product
Statistics in Biopharmaceutical Research, ISSN: 19466315
Haijun Ma; Qi Jiang; Christy Chuang-Stein; Scott R. Evans; Weili He; George Quartey; John Scott; Shihua Wen; Ramin Arani
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Selecting and Integrating Data Sources in Benefit–Risk Assessment: Considerations and Future Directions
Statistics in Biopharmaceutical Research, ISSN: 19466315
Rachael L. DiSantostefano; Jesse A. Berlin; Christy Chuang-Stein; George Quartey; Gary Eichenbaum; Bennett Levitan
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Practical Analysis and Visualization Tools for Benefit-Risk Assessment in Drug Development: A Review of Recent FDA Advisory Committee Meeting Packages
Statistics in Biopharmaceutical Research, ISSN: 19466315
Shihua Wen; Weili He; Scott R. Evans; George Quartey; Jonathan D. Norton; Christy Chuang-Stein; Qi Jiang; Haijun Ma; Mondira Bhattacharya
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Atezolizumab (atezo) in platinum (plat)-treated locally advanced/metastatic urothelial carcinoma (mUC): Updated OS, safety and biomarkers from the Ph II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Yohann Loriot; Jonathan E. Rosenberg; Thomas Powles; Andrea Necchi; Syed Hussain; Morales; Margitta M. Retz; Günter Niegisch; Ignacio Durán; Christine Théodore; Jose Luis Perez-Gracia; Grande Pulido; AnnChristine Thåström; Bradford Danner; Sanjeev Mariathasan; Oyewale Abidoye; Michiel S Van Der Heijden
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Second-line metastatic urothelial carcinoma treatment and survival in real-world patients in the US
Annals of Oncology, ISSN: 15698041 09237534
Sumanta Kumar Pal; Matthew D. Galsky; Shih Wen Lin; Sarika Ogale; Marko Zivkovic; Simpson; Christina L. Derleth; Guru Sonpavde
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PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
Annals of Oncology, ISSN: 15698041 09237534
De Bono; De Giorgi; Christophe Massard; Sergio Bracarda; Nava Rodrigues; Ivo Kocak; Albert Font; J. Arranz Arija; Shih; George Daniel Radavoi; Yu; Wai Y. Chan; Steven Gendreau; Zhang; Ruth Riisnaes; Matthew Wongchenko; Daniel Maslyar; Viorel Jinga
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