Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4851 - 4900 OF 15390 RESULTS

Interfering with the chronic immune response rescues chronic degeneration after traumatic brain injury
Journal of Neuroscience, ISSN: 15292401 02706474
Ali Ertürk; Susanne Mentz; Erik E. Stout; Maj Hedehus; Sara L. Dominguez; Lisa Neumaier; Franziska Krammer; Gemma Llovera; Karpagam Srinivasan; David V. Hansen; Arthur Liesz; Kimberly Scearce-Levie; Morgan Sheng
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Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride
Synlett, ISSN: 14372096 09365214
Haili Liao; Aimin Li; Xingsong Chen; Kun Liang; Yang Shen; Qingfeng Liang; Kewei Xu; Daniel G. Shore; Elisia Villemure; Michael Siu; Malcolm P. Huestis
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Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)-H Bonds
Journal of Organic Chemistry, ISSN: 15206904 00223263
Georgette M. Castanedo; Yanzhou Liu; James J. Crawford; Marie-Gabrielle Braun
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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Olivier René; Benjamin P. Fauber; Adrian Barnard; Kerry Chapman; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Adam R. Johnson; Hank La; Maxine Norman; Gary Salmon; Susan Summerhill; Harvey Wong
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Recent progress on nuclear receptor RORγ modulators
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Patrick Cyr; Sarah M. Bronner; James J. Crawford
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Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Peter Dragovich; Richard T Cummings; Gauri Deshmukh; Amy Gustafson; Ning Han; Jean-Christophe Harmange; James R. Kiefer; Yue Li; Jun Liang; Bianca M. Liederer; Yichin Liu; Wanda Manieri; Weifeng Mao; Lesley J. Murray; Daniel F. Ortwine; Patrick Trojer; Erica Vanderporten; Maia Vinogradova; Li Wen
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Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge
Journal of Infectious Diseases, ISSN: 15376613 00221899
Sinthujan Jegaskanda; Catherine Luke; Heather D. Hickman; Mark Y. Sangster; Wendy F. Wieland-Alter; Jacqueline McBride; Jon W. Yewdell; Peter Wright; John Treanor; Carrie M. Rosenberger; Kanta Subbarao
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A phase i dose-escalation study evaluating the safety tolerability and pharmacokinetics of CUDC-427, a potent, oral, monovalent IAP antagonist, in patients with refractory solid tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Anthony W. Tolcher; Bendell; Kyriakos P. Papadopoulos; Howard A. Burris; Amita Patnaik; Wayne J. Fairbrother; Harvey Wong; Nageshwar Budha; Darbonne; Franklin V. Peale Jr.; Michael Mamounas; Stephanie Royer-Joo; Ron Yu; Chia C. Portera; Jeffery R. Infante
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Validation of a treatment satisfaction questionnaire in non-hodgkin lymphoma: Assessing the change from intravenous to subcutaneous administration of rituximab
Patient Preference and Adherence, ISSN: 1177889X
Christina Theodore-Oklota; Louise Humphrey; Christof Wiesner; Gabriel Schnetzler; Stacie Hudgens; Alicyn K. Campbell
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Fast and Efficient non-reduced Lys-C digest using pressure cycling technology for antibody disulfide mapping by LC–MS
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Ying Cheng; Yonghong Chen; X. Christopher Yu
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Rapid, semi-automated protein terminal characterization using ISDetect
Nature Biotechnology, ISSN: 15461696 10870156
Corey Bakalarski; Yutian Gan; Ingrid E. Wertz; Jennie R. Lill; Wendy N. Sandoval
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Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Oncogene, ISSN: 14765594 09509232
Franciosa; Diluvio; Del Gaudio; Giuli; Palermo; Grazioli; Campese; Talora; Bellavia; D'Amati; Besharat; Nicoletti; Christian W. Siebel; Lisa Choy; Rustighi; G Del Sal; Screpanti; Checquolo
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High cell-surface density of HER2 deforms cell membranes
Nature Communications, ISSN: 20411723
Inhee Chung; Mike Reichelt; Lily Shao; Robert W. Akita; Koeppen; Linda Rangell; Gabriele Schaefer; Ira Mellman; Mark X. Sliwkowski
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Characterization of the pH and temperature in the rabbit, pig, and monkey eye: Key parameters for the development of long-acting delivery ocular strategies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Florence Lorget; Audrey Parenteau; Michel Carrier; Daniel Lambert; Ana Gueorguieva; Chris Schuetz; Vlad Bantseev; Evan A Thackaberry
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Contribution of antibody hydrodynamic size to vitreal clearance revealed through rabbit studies using a species-matched fab
Molecular Pharmaceutics, ISSN: 15438392 15438384
Whitney Shatz; Hass; Mary Mathieu; Hok Seon Kim; Kimberly D. Leach; Michelle Zhou; Yongping Crawford; Amy Shen; Kathryn Wang; Debby P. Chang; Mauricio Maia; Susan R. Crowell; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley
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Ocular therapeutics: Drug delivery and pharmacology
Molecular Pharmaceutics, ISSN: 15438392 15438384
Leslie Dickmann
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Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Kelly Zhang; Xiaodong Liu
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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
Cell Death and Differentiation, ISSN: 14765403 13509047
Kim Newton; Dugger; Maltzman; Joan M. Greve; Maj Hedehus; Baby Martin-McNulty; Richard A. D. Carano; Tim C. Cao; Nicholas Van Bruggen; Lisa J. Bernstein; Wyne P. Lee; Xiumin Wu; Jason Devoss; Juan Zhang; Surinc Er Jeet; Ivan Peng; Brent Mckenzie; Merone Roose-Girma; Patrick Caplazi; Laurie Diehl; Webster; Domagoj Vucic
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Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Helen Prior; Anna Bottomley; Pascal Champéroux; Jason Cordes; Eric Delpy; Noel Dybdal; Nick Edmunds; Mike Engwall; Mike Foley; Michael Hoffmann; Robert Kaiser; Ken Meecham; Stéphane Milano; Aileen Milne; Rick Nelson; Brian Roche; Jean-Pierre Valentin; Gemma Ward; Kathryn Chapman
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Anaphylactic reactions associated with omalizumab administration: Analysis of a case-control study
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Dale T. Umetsu; Gillis Carrigan; Abdelkader Rahmaoui
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Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity
AAPS Journal, ISSN: 15507416
Anne-Françoise Aubry; Brian J. Dean; Ulf Diczfalusy; Angela Goodenough; André Iffland; James McLeod; Naidong Weng; Ziping Yang
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Independent radiologic review of AURELIA, a phase 3 trial of bevacizumab plus chemotherapy for platinum-resistant recurrent ovarian cancer
Gynecologic Oncology, ISSN: 10956859 00908258
Amreen Husain; Yan Wang; Lars C. Hanker; Belén Ojeda; Maarit Anttila; Enrico Breda; Peter Vuylsteke; Eric Pujade-Lauraine
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Ethnic sensitivity assessment of the antibody–drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chunze Li; Wang; Dan Lu; Jin Y. Jin; Yuying Gao; Kiyoshi Matsunaga; Yuriko Igawa; Ihsan Nijem; Michael W. Lu; Alexander Strasak; Nataliya Chernyukhin; Sandhya Girish
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Process characterization and Design Space definition
Biologicals, ISSN: 10958320 10451056
Christian Hakemeyer; Nathan McKnight; Rick St. John; Steven Meier; Melody Trexler-Schmidt; Kelley; Frank Zettl; Robert Puskeiler; Annika Kleinjans; Fred Lim; Christine Wurth
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QbD implementation and Post Approval Lifecycle Management (PALM)
Biologicals, ISSN: 10958320 10451056
Ettore Ohage; Raquel Iverson; Lynne Krummen; Ron Taticek; Maria Vega
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Integration of QbD risk assessment tools and overall risk management
Biologicals, ISSN: 10958320 10451056
Kelley; Cromwell; Joe Jerkins
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Chemical structure and concentration of intratumor catabolites determine efficacy of antibody drug conjugates
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Donglu Zhang; Shang-Fan Yu; Yong Ma; Keyang Xu; Peter Dragovich; Thomas H. Pillow; Luna Liu; Geoffrey Del Rosario; Jintang He; Zhonghua Pei; Jack D. Sadowsky; Hans Erickson; Cornelis E. Hop; S. Cyrus Khojasteh
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Occurrence and outcome of de novo metastatic breast cancer by subtype in a large, diverse population
Cancer Causes and Control, ISSN: 15737225 09575243
Li Tao; Laura Chu; Lisa I. Wang; Lisa Moy; Melissa Brammer; Chunyan Song; Marjorie Green; Allison W. Kurian; Scarlett Lin Gomez; Christina A. Clarke
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Survey of Health Care Practitioners’ Preferences for Medical Information: Collective Insights for Impacting Patient Care
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Stacey M. Fung; Dannis Y. Chang; Roshni Patel-Romero; Matt Suchodolski
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Two phase 1, randomized, double-blind, placebo-controlled, single- ascending-dose studies to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza a virus monoclonal antibody, MHAA4549A, in healthy volunteers
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jeremy Lim; Rong Deng; Michael A. Derby; Richard Larouche; Priscilla Horn; Malia Anderson; Mauricio Maia; Stephanie Carrier; Isabelle Pelletier; Tracy Burgess; Priya Kulkarni; Elizabeth Newton; Jorge A. Tavel
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Brief Report: Whole-Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis
Arthritis and Rheumatology, ISSN: 23265205 23265191
Angel C. Y. Mak; Paul L. F. Tang; Clare Cleveland; Melanie H. Smith; Kari Connolly; Tamiko R. Katsumoto; Paul J. Wolters; Pui-Yan Kwok; Lindsey A. Criswell
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Minipiloting Tools for Pharmaceutical Development
AAPS PharmSciTech, ISSN: 19398042 18725120
Julia ZH Gao; Ajit S. Narang; Sailesh A. Varia
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Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: Pooled analysis of two trials
Orphanet Journal of Rare Diseases, ISSN: 17501172
Anne Lynn S. Chang; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic
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Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma
European Respiratory Journal, ISSN: 13993003 09031936
Emma Doran; David F. Choy; Aarti Shikotra; Claire A. Butler; Declan M. O'Rourke; James A. Johnston; Adrien Kissenpfennig; Peter Bradding; Joseph R. Arron; Liam G. Heaney
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Should Therapeutic Drug Monitoring for Monoclonal Antibodies Remain the Exception or Become the Norm?
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Mark Stroh; Bert L. Lum
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Erratum: Corrigendum to “Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry” (Journal of Chromatography B (2016) 1020 (111–119) (S157002321630188X) (10.1016/j.jchromb.2016.03.039))
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Xiaorong Liang; Michael Van Parys; Xiao Ding; Ning Zeng; Luke Bi; Dorshorst; McKnight; Dennis Milanowski; Jialin Mao; Yuan Chen; Joseph A. Ware; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
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A putative bacterial ABC transporter circumvents the essentiality of signal peptidase
mBio, ISSN: 21507511 21612129
J. Hiroshi Morisaki; Peter A. Smith; Shailesh V. Date; Kimberly K. Kajihara; Chau Linda Truong; Zora Modrusan; Donghong Yan; Jing Kang; Min Xu; Ishita M. Shah; Robert Mintzer; Eric M. Kofoed; Tommy K. Cheung; David Arnott; Michael F. T. Koehler; Christopher E. Heise; Eric J. Brown; Man-Wah Tan; Wouter L. W. Hazenbos
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Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Paolo A. Ascierto; McArthur; Brigitte Dréno; Victoria Atkinson; Gabriella Liszkay; Anna Maria Di Giacomo; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Yibing Yan; Matthew Wongchenko; Ilsung Chang; Jessie Hsu; Daniel Koralek; Isabelle Rooney; Antoni Ribas; James Larkin
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Vemurafenib in patients with BRAFV600E-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Marcia S Brose; Maria E Cabanillas; Ezra E W Cohen; Lori Wirth; Todd Riehl; Huibin Yue; Steven I Sherman; Eric J Sherman
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Determination of critical quality attributes for monoclonal antibodies using quality by design principles
Biologicals, ISSN: 10958320 10451056
Nadja Alt; Taylor Zhang; Paul Motchnik; Ron Taticek; Quarmby; Tilman Schlothauer; Hermann Beck; Thomas Emrich; Reed J. Harris
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Establishing a control system using QbD principles
Biologicals, ISSN: 10958320 10451056
Kepert; Cromwell; Niklas Engler; Christof Finkler; Gerald Gellermann; Lynn Gennaro; Reed J. Harris; Raquel Iverson; Kelley; Lynne Krummen; Nathan McKnight; Paul Motchnik; Volker Schnaible; Ron Taticek
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Introduction to the application of QbD principles for the development of monoclonal antibodies
Biologicals, ISSN: 10958320 10451056
Christof Finkler; Lynne Krummen
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Foreword: Quality by Design for monoclonal antibodies: Description of an integrated system
Biologicals, ISSN: 10958320 10451056
Kelley
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Introduction to the theme ‘technology – translational pharmacology’
Drug Discovery Today: Technologies, ISSN: 17406749
Saileta Prabhu
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Pharmacogenomics in the age of personalized medicine
Drug Discovery Today: Technologies, ISSN: 17406749
Leslie Dickmann; Joseph A. Ware
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Quantitative systems pharmacology: a promising approach for translational pharmacology
Drug Discovery Today: Technologies, ISSN: 17406749
Kapil Gadkar; Kirouac; Neil Parrott; Ramanujan
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Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies
Drug Discovery Today: Technologies, ISSN: 17406749
Amrita Kamath
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Translational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice
Drug Discovery Today: Technologies, ISSN: 17406749
Harvey Wong; Stephen Gould
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Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
Cell Reports, ISSN: 22111247
Leonard D. Goldstein; James Lee; Florian Gnad; Christiaan N. Klijn; Annalisa Schaub; Jens Reeder; Anneleen Daemen; Corey Bakalarski; Thomas Holcomb; David S. Shames; Ryan J. Hartmaier; Juliann Chmielecki; Somasekar Seshagiri; Robert Gentleman; David Stokoe
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Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Cell Reports, ISSN: 22111247
Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Matthew L. Albert; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert
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