Scientists / Publications

Publications

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DISPLAYING 4901 - 4950 OF 15390 RESULTS

Application of 19F quantitative NMR to pharmaceutical analysis
Concepts in Magnetic Resonance Part A: Bridging Education and Research, ISSN: 15525023 15466086
Allison O. Mattes; David J. Russell; Evgeny Tishchenko; Yanzhou Liu; Robert H. Cichewicz; Sarah J. Robinson
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First-Line Treatment with Bevacizumab and Platinum Doublet Combination in Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Cohort Study in US Oncology Community Practices
Drugs - Real World Outcomes, ISSN: 21989788 21991154
Orsolya Lunacsek; Arliene Ravelo; Anna D. Coutinho; Sebastien J. Hazard; Mark R. Green; Joanne Willey; Michael Eaddy; Hans-Peter Goertz
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Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Cell Reports, ISSN: 22111247
Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert
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Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
Nature Communications, ISSN: 20411723
Jill M. Spoerke; Steven Gendreau; Kimberly Walter; Jiaheng Qiu; Wilson; Heidi Savage; Junko Aimi; Mika K. Derynck; Meng Chen; Iris Chan; Lukas Amler; Garret M. Hampton; Stephen Johnston; Ian E. Krop; Schmid; Lackner
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Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
Nature Communications, ISSN: 20411723
Jeffery J. Wallin; Bendell; Roel Funke; Mario Sznol; Konstanty Korski; Suzanne Jones; Genevive Hernandez; James Mier; Xian He; F. Stephen Hodi; Mitchell Denker; Vincent Leveque; Marta Cañamero; Galina Babitski; Koeppen; James Ziai; Neeraj Sharma; Fabien Gaire; Daniel S. Chen; Waterkamp; Priti Hegde; David McDermott
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Manufacturing Development and Genotoxic Impurity Control Strategy of the Hedgehog Pathway Inhibitor Vismodegib
Organic Process Research and Development, ISSN: 1520586X 10836160
Remy Angelaud; Mark E. Reynolds; Venkatramani; Scott Savage; Huldreich Trafelet; Thomas Landmesser; Peter Demel; Michael Levis; Olivier Ruha; Baerbel Rueckert; Heinz Jaeggi
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Improvement of sleep in patients with chronic idiopathic/spontaneous urticaria treated with omalizumab: Results of three randomized, double-blind, placebo-controlled studies
Clinical and Translational Allergy, ISSN: 20457022
Ana Gimenéz-Arnau; Sheldon Spector; Evgeniya Antonova; Benjamin L. Trzaskoma; Karin Rosén; Theodore A. Omachi; Donald Stull; Maria-Magdalena Balp; Thomas R. Murphy
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Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation
mAbs, ISSN: 19420870 19420862
Qian Gong; Meredith Hazen; Brett Marshall; Susan R. Crowell; Qinglin Ou; Athena W. Wong; Wilson Phung; Jean-Michel Vernes; Meng; Max L. Tejada; Dana C. Andersen; Robert F. Kelley
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Toxicokinetic and toxicodynamic considerations when deriving health-based exposure limits for pharmaceuticals
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
John F. Reichard; M. Andrew Maier; Naumann; Alison M. Pecquet; Pfister; Sandhu; Sargent; Streeter; Patricia A. Weideman
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A harmonization effort for acceptable daily exposure derivation – Considerations for application of adjustment factors
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Sussman; Naumann; Pfister; Sehner; Seaman; Patricia A. Weideman
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Special endpoint and product specific considerations in pharmaceutical acceptable daily exposure derivation
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Gould; Callis; Dolan; Stanard; Patricia A. Weideman
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Point of departure (PoD) selection for the derivation of acceptable daily exposures (ADEs) for active pharmaceutical ingredients (APIs)
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Joel P. Bercu; Eric Morinello; Sehner; Bryan K. Shipp; Patricia A. Weideman
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Using default methodologies to derive an acceptable daily exposure (ADE)
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Ellen C. Faria; Joel P. Bercu; Dolan; Eric Morinello; Alison M. Pecquet; Seaman; Sehner; Patricia A. Weideman
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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement
Cell Reports, ISSN: 22111247
Seung-Hye Lee; Claire E. Le Pichon; Oskar Adolfsson; Valerie Gafner; Maria Pihlgren; Han Lin; Hilda Solanoy; Robert Brendza; Hai Ngu; Oded Foreman; Ruby Chan; James A. Ernst; Danielle DiCara; Isidro Hötzel; Karpagam Srinivasan; David V. Hansen; Jasvinder K. Atwal; Yanmei Lu; Daniela Bumbaca; Andrea Pfeifer; Ryan J. Watts; Andreas Muhs; Kimberly Scearce-Levie; Gai Ayalon
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Response to comment on "sumo deconjugation is required for arsenic-triggered ubiquitylation of PML"
Science Signaling, ISSN: 19379145 19450877
Domenico Fasci; Veronica G. Anania; Jennie R. Lill; Guy S. Salvesen
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Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics
AAPS Journal,
Bonnie Wu; Shan Chung; Xu-Rong Jiang; Jim McNally; Joao Pedras-Vasconcelos; Renuka Pillutla; Joleen T. White; Yuanxin Xu; Shalini Gupta
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Occurrence and outcome of de novo metastatic breast cancer by subtype in a large, diverse population
Cancer Causes and Control, ISSN: 09575243
Li Tao; Laura Chu; Lisa Wang; Lisa Moy; Melissa Brammer; Chunyan Song; Marjorie Green; Allison W. Kurian; Scarlett Lin Gomez; Christina A. Clarke
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Synthesis of Indole-2-carboxylate Derivatives via Palladium-Catalyzed Aerobic Amination of Aryl C-H Bonds
Organic Letters, ISSN: 15237052 15237060
Kyle Clagg; Haiyun Hou; Adam B. Weinstein; David J. Russell; Shannon S. Stahl; Stefan G. Koenig
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Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
Nature Communications, ISSN: 20411723
Nisebita Sahu; Jean-Philippe Stephan; Darlene Dela Cruz; Mark Merchant; Benjamin Haley; Richard Bourgon; Marie Classon; Jeffrey Settleman
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Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
Nature Communications,
Nisebita Sahu; Jean-Philippe Stephan; Darlene Dela Cruz; Mark Merchant; Benjamin Haley; Richard Bourgon; Marie Classon; Jeffrey Settleman
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Effects of antiviral treatment on influenza-related complications over four influenza seasons: 2006–2010
Current Medical Research and Opinion, ISSN: 14734877 03007995
Philip Spagnuolo; Mengxi Zhang; Yaping Xu; Jian Han; Shuqian Liu; Jinan Liu; Maureen Lichtveld; Lizheng Shi
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Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation
Structure, ISSN: 18784186 09692126
Lionel Rouge; Travis W. Bainbridge; Michael Kwok; Raymond K. Tong; Paola Di Lello; Ingrid E. Wertz; Till Maurer; James A. Ernst; Jeremy Murray
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Expression, purification, and characterization of recombinant human and murine milk fat globule-epidermal growth factor-factor 8
Protein Expression and Purification, ISSN: 10465928
Erick R. Castellanos; Claudio Ciferri; Wilson Phung; Wendy N. Sandoval; Marissa L. Matsumoto
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Predictors of Diabetic Macular Edema Treatment Frequency with Ranibizumab During the Open-Label Extension of the RIDE and RISE Trials
Ophthalmology, ISSN: 15494713 01616420
Charles C. Wykoff; Michael J. Elman; Carl D. Regillo; Beiying Ding; Na Lu; Ivaylo Stoilov
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Properties and mechanisms of drug release from matrix tablets containing poly(ethylene oxide) and poly(acrylic acid) as release retardants
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Feng Zhang; Fan Meng; Joseph W. Lubach; Joseph Koleng; Watson
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Population pharmacokinetics of bevacizumab in cancer patients with external validation
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Kelong Han; Thomas Peyret; Mathilde Marchand; Angelica Quartino; Nathalie H. Gosselin; Sandhya Girish; David E. Allison; Jin Y. Jin
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Going beyond common drug metabolizing enzymes: Case studies of biotransformation involving aldehyde oxidase, γ-glutamyl transpeptidase, cathepsin B, flavin-containing monooxygenase, and ADP-ribosyltransferase
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Peter W. Fan; Donglu Zhang; Jason S Halladay; James Driscoll; S. Cyrus Khojasteh
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Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States
American Journal of Hematology, ISSN: 10968652 03618609
Chadi Nabhan; Zhou; Bann-Mo Day; Keith Dawson; Zelenetz; Jonathan W. Friedberg; James R. Cerhan; Brian K. Link; Christopher R. Flowers
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Interpolymer Complexation Between Polyox and Carbopol, and Its Effect on Drug Release From Matrix Tablets
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Feng Zhang; Joseph W. Lubach; Watson Na; Samad Momin
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Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development
Toxicologic Pathology, ISSN: 15331601 01926233
Wendy Halpern; Mehrdad Ameri; Christopher J. Bowman; Michael R. Elwell; Michael L. Mirsky; Julian Oliver; Karen S. Regan; Amera K. Remick; Vicki L. Sutherland; Kary E. Thompson; Claudine Tremblay; Midori Yoshida; Lindsay Tomlinson
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Validation of a biotherapeutic immunoaffinity-LC-MS/MS assay in monkey serum: 'plug-And-play' across seven molecules
Bioanalysis, ISSN: 17576199 17576180
Surinder Kaur; Luna Liu; Diego F. Cortes; Junlong Shao; Rand Jenkins; William R. Mylott; Keyang Xu
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Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision
British Journal of Ophthalmology, ISSN: 00071161
Ronald E.P. Frenkel; Howard Shapiro; Ivaylo Stoilov
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Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis
Journal of the American Geriatrics Society, ISSN: 15325415 00028614
Pei-Jung Lin; Yue Zhong; Howard Fillit; Er Chen; Peter J. Neumann
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Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
Cytokine and Growth Factor Reviews, ISSN: 18790305 13596101
Sascha Rutz; Celine Eidenschenk; James R. Kiefer; Wenjun Ouyang
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Separation science in drug development, part 4: Quality control
LC-GC Europe, ISSN: 14716577
Dawen Kou; Larry Wigman; Peter M. Yehl; Michael W. Dong
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Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision
British Journal of Ophthalmology, ISSN: 14682079 00071161
Ronald E.P. Frenkel; Howard Shapiro; Ivaylo Stoilov
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Immune escape to PD-L1/PD-1 blockade: Seven steps to success (or failure)
Annals of Oncology, ISSN: 15698041 09237534
Kim; Daniel S. Chen
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Precision medicine and oncology: An overview of the opportunities presented by next-generation sequencing and big data and the challenges posed to conventional drug development and regulatory approval pathways
Annals of Oncology, ISSN: 15698041 09237534
Michael Doherty; Metcalfe; Ellie Guardino; Peters; Ramage
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Relationship between tumor biomarkers and efficacy in EMILIA, a phase III study of trastuzumab emtansine in HER2-Positive metastatic breast cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Baselga; Gail L. Phillips; Sunil Verma; Jungsil Ro; Huober; Ellie Guardino; Meghna Samant; Steve Olsen; Sanne De Haas; Pegram
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Pathway analysis by randomization incorporating structure - Paris: An update
Bioinformatics, ISSN: 14602059 13674803
Mariusz Butkiewicz; Jessica Cooke Bailey; Alex Frase; Scott Dudek; Brian L. Yaspan; Marylyn Ritchie; Sarah A. Pendergrass; Jonathan L. Haines
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The Prevalence of Myopic Choroidal Neovascularization in the United States: Analysis of the IRIS® Data Registry and NHANES
Ophthalmology, ISSN: 15494713 01616420
Jeffrey R. Willis; Susan Vitale; Lawrence S. Morse; David W. Parke; William L. Rich; Flora Lum; Ronald A. Cantrell
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Comparison of BALB/c and B6-albino mouse strain blastocysts as hosts for the injection of C57BL6/N-derived C2 embryonic stem cells
Transgenic Research, ISSN: 15739368 09628819
Tuija M. Alcantar; Rhonda Wiler; Xin Y. Rairdan
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A high-throughput hydrophilic interaction liquid chromatography coupled with a charged aerosol detector method to assess trisulfides in IgG1 monoclonal antibodies using tris(2-carboxyethyl)phosphine reaction products: Tris(2-carboxyethyl)phosphine-oxide and tris(2-carboxyethyl)phosphine-sulfide
Journal of Chromatography A, ISSN: 18733778 00219673
Christopher Cornell; Amish Karanjit; Yan Chen; Fred Jacobson
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Reducing the risk of failure: Biomarker-guided trial design
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Michael J. Townsend; Joseph R. Arron
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Comment on "nRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis"
Science Translational Medicine, ISSN: 19466242 19466234
Jérémie Decalf; Rosa Barreira da Silva; Scott Werneke; Matthew L. Albert
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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Jose Ponte; Xiuxia Sun; Nicholas C. Yoder; Nathan Fishkin; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Megan Bogalhas; Lintao Wang; Sharon Wilhelm; Wayne C. Widdison; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert
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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
Neuron, ISSN: 10974199 08966273
Felix L. Yeh; Yuanyuan Wang; Irene Tom; Lino C. Gonzalez Jr.; Morgan Sheng
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The Itch to degrade ROR-γt
Nature Immunology, ISSN: 15292916 15292908
Sascha Rutz; Wenjun Ouyang
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Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions
International Journal of Cardiology, ISSN: 18741754 01675273
Christian Bo Poulsen; Ahmed Ludvigsen Al-Mashhadi; Karin von Wachenfeldt; Jacob Fog Bentzon; Lars Bo Nielsen; Rozh H. Al-Mashhadi; Jesper Thygesen; Lars Tolbod; Jens Rolighed Larsen; Jørgen Frøkiær; Ahmed Tawakol; Esad Vucic; Jill Fredrickson; Amos Baruch; Björn Frendéus; Anna-Karin Robertson; Søren Kragh Moestrup; Ludovic Drouet; Erling Falk
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A simple and sensitive method to analyze genotoxic impurity hydrazine in pharmaceutical materials
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Jennifer Wang; Samuel H. Yang; Kelly Zhang
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