Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5201 - 5250 OF 15578 RESULTS

In Vitro Skin Models and Their PredictabilProliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Ratsng Normal and Disease Biology, Pharmacology, and Toxicity
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko; Gail L. Phillips; Dolores Diaz
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Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: Prospective placebo-controlled clinical studies
EMBO Molecular Medicine, ISSN: 17574684 17574676
Jérémie Decalf; Kristin V. Tarbell; Armanda Casrouge; Jeffrey D. Price; Grace Linder; Estelle Mottez; Philippe Sultanik; Vincent Mallet; Stanislas Pol; Darragh Duffy; Matthew L. Albert
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Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Jürgen Behr; Elisabeth Bendstrup; Bruno Crestani; Andreas Günther; Horst Olschewski; C Magnus Sköld; Athol Wells; Wim Wuyts; Dirk Koschel; Michael Kreuter; Benoît Wallaert; Chin-Yu Lin; Jürgen Beck; Carlo Albera
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Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Ian E. Krop; Ingrid A. Mayer; Vinod Ganju; Maura N. Dickler; Stephen Johnston; Serafin Morales; Denise A. Yardley; Melichar; Andres Forero; Soo Chin Lee; Richard de Boer; Katarina Petrakova; Susanne Vallentin; Edith A. Perez; Martine Piccart; Matthew Ellis; Eric P. Winer; Steven Gendreau; Mika K. Derynck; Lackner; Gallia Levy; Jiaheng Qiu; Jing He; Schmid
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An Overview of the Pathogenesis of Immune-mediated Skin Injury
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko
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Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Yuan Chen; Fang Ma; Tong Lu; Nageshwar Budha; Jin Y. Jin; Jane R. Kenny; Harvey Wong; Cornelis E. Hop; Jialin Mao
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Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Dong U. Lee; Paula Katavolos; Gopinath S. Palanisamy; Arna Katewa; Charly Sioson; Janice Corpuz; Jodie Pang; Kevin Dement; Edna F. Choo; Nico Ghilardi; Dolores Diaz; Dimitry Danilenko
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Relationship between Baseline and Early Changes in C-Reactive Protein and Interleukin-6 Levels and Clinical Response to Tocilizumab in Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Jianmei Wang; Jenny Devenport; Jason M. Low; Dale Yu; Hitraya
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Examining Manufacturing Readiness for Breakthrough Drug Development
AAPS PharmSciTech, ISSN: 15309932
Earl S. Dye; Annie Sturgess; Gargi Maheshwari; Kimberly May; Colleen Ruegger; Usha Ramesh; Heow Tan; Keith Cockerill; John Groskoph; Emanuela Lacana; Sau L. Lee; Sarah Pope Miksinski
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Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study with the PI3K-δ Inhibitor
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Daniel P. Sutherlin; Jodie Pang; Laurent Salphati
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Prediction of drug-drug interactions arising from CYP3A induction using a physiologically based dynamic models
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Lisa M. Almond; Sophie Mukadam; Iain Gardner; Krystle Okialda; Susan C. Wong; Oliver Hatley; Suzanne Tay; Karen Rowland-Yeo; Masoud Jamei; Amin Rostami-Hodjegan; Jane R. Kenny
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Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye
Biophysical Chemistry, ISSN: 18734200 03014622
Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga
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Serum periostin is associated with type 2 immunity in severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Mats W. Johansson; Michael D. Evans; Gina M. Crisafi; Cécile T.J. Holweg; Matthews; Jarjour
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Age-related macular degeneration: Complement in action
Immunobiology, ISSN: 18783279 01712985
Menno Van Lookeren Campagne; Erich C. Strauss; Brian L. Yaspan
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Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care
British Journal of Ophthalmology, ISSN: 14682079 00071161
Hema L. Ramkumar; Azadeh Khatibi; William R. Freeman; Giulio Barteselli; Isaac C. Ezon; Payam Amini; Lucie Sharpsten; Cheryl A. Arcinue; Joseph T. Nezgoda; Henry A. Ferreyra; Michael H. Goldbaum
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Visual and Anatomic Outcomes in Patients with Diabetic Macular Edema with Limited Initial Anatomic Response to Ranibizumab in RIDE and RISE Presented in part at: American Academy of Ophthalmology Annual Meeting, October 2014, Chicago, Illinois; And 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.
Ophthalmology, ISSN: 15494713 01616420
Dante Joseph Pieramici; Pin-Wen Wang; Beiying Ding; Shamika Gune
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Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Gerd R. Burmester; William F. Rigby; Ronald Van Vollenhoven; Jonathan Kay; Rubbert-Roth; Ariella Kelman; Sophie Dimonaco; Nina Mitchell
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Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Sebastian Unizony; Villarreal; Miloslavsky; Na Lu; Merkel; Spiera; Seo; Langford; Hoffman; Kallenberg; E. William St. Clair; Iklé; Tchao; Linna Ding; Paul Brunetta; Hyon Choi; Paul A. Monach; Fervenza; John H. Stone; Specks
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Assessment of disease-related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaohui Wei; Jane R. Kenny; Leslie Dickmann; Romeo MacIuca; Looney; Meina Tao Tang
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Cost-Effectiveness Model for Chemoimmunotherapy Options in Patients with Previously Untreated Chronic Lymphocytic Leukemia Unsuitable for Full-Dose Fludarabine-Based Therapy
Value in Health, ISSN: 15244733 10983015
Ursula Becker; Andrew Briggs; Santiago G. Moreno; Joshua A. Ray; Phuong Ngo; Kunal Samanta
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Cycling in the nucleus: Regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Valentina Romeo; Daniel Schümperli
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Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Ernst Ahlberg; Alexander Amberg; Lisa Beilke; Dave Bower; Kevin P. Cross; Laura Custer; Kevin A. Ford; Jacky Van Gompel; James Harvey; Masamitsu Honma; Robert A. Jolly; Elisabeth Joossens; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Lara Kuhnke; Penny Leavitt; Russell Naven; Claire Neilan; Donald P. Quigley; Dana Shuey; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Angela White; Joerg Wichard; Craig Zwickl; Glenn J. Myatt
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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Alexander Amberg; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Kevin P. Cross; Laura Custer; Krista Dobo; Eric Dowdy; Kevin A. Ford; Susanne Glowienke; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; John Nicolette; Andreja Plaper; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; Glenn J. Myatt
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NLRP3 recruitment by NLRC4 during Salmonella infection
Journal of Experimental Medicine, ISSN: 15409538 00221007
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight,
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates
mAbs, ISSN: 19420870 19420862
Yi Li; Christine Gu; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley
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Reproducible pharmacogenomic profiling of cancer cell line panels
Nature, ISSN: 14764687 00280836
Matthias Peter; Eva Lin; Jenille Tan; Yihong Yu; Billy Lam; Steve Lianoglou; Richard M. Neve; Scott E. Martin; Jeffrey Settleman; Robert Yauch; Richard Bourgon
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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
ACS Medicinal Chemistry Letters, ISSN: 19485875
Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Richard Pastor; Yves Leblanc; Christopher G. Nasveschuk; F. Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; E. Megan Flynn; Oscar W Huang; Susan Kaufman; Patricia J. Keller; James R. Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea G Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht
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Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations
Journal of Physical Chemistry A, ISSN: 15205215 10895639
Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; John Wang; Bernhardt L. Trout
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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander Heifetz; Giancarlo Trani; Matteo Aldeghi; Colin H. Mackinnon; Paul A. McEwan; Frederick A. Brookfield; Ewa I. Chudyk; Mike Bodkin; Zhonghua Pei; Jason D. Burch; Daniel F. Ortwine
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Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of rapamycin pathway, versus everolimus in patients with metastatic renal cell carcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Thomas Powles; Lackner; Stephane Oudard; Bernard Escudier; Christy Ralph; Janet E. Brown; Robert E. Hawkins; Daniel Castellano; Brian I. Rini; Michael D. Staehler; Alain Ravaud; Wei Lin; Bridget O'Keeffe; Wang; Shan Lu; Jill M. Spoerke; Huw; Michelle Byrtek; Rui Zhu; Joseph A. Ware; Robert J. Motzer
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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms
Cell Reports, ISSN: 22111247
Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev
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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
The Lancet, ISSN: 1474547X 01406736
Jonathan E. Rosenberg; Jean Hoffman-Censits; Thomas Powles; Michiel S Van Der Heijden; Arjun V. Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M. Retz; Petros Grivas; Richard W. Joseph; Matthew D. Galsky; Mark T. Fleming; Petrylak; Jose Luis Perez-Gracia; Howard A. Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D. Fine; Robert Dreicer
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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
Nature, ISSN: 14764687 00280836
Jianhua Li; Erick Lu; Tangsheng Yi; Jason G. Cyster
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The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nature Communications, ISSN: 20411723
Nadia Martinez-Martin; Sree R. Ramani; Jason A. Hackney; Irene Tom; Bernd Wranik; Michelle Chan; Johnny Wu; Maciej Paluch; Kentaro Takeda; Hass; Hilary F. Clark; Lino C. Gonzalez Jr.
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The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among patients with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Nina Parikh Thomas; Suellen Curkendall; Amanda M. Farr; Elaine B. Yu; Hurley
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Mismatch repair deficiency testing in clinical practice
Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159
Natalia Buza; James Ziai; Pei Hui
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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
Journal of Clinical Investigation, ISSN: 15588238 00219738
Marianne R. Spalinger; Stephanie Kasper; Claudia Gottier; Silvia Lang; Kirstin Atrott; Stephan R. Vavricka; Sylvie Scharl; Petrus M. Gutte; Markus G. Grütter; Hans-Dietmar Beer; Emmanuel Contassot; Andrew A. Chan; Xuezhi Dai; David J. Rawlings; Florian Mair; Burkhard Becher; Werner Falk; Fried; Gerhard Rogler; Michael Scharl
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Roles of periostin in respiratory disorders
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Kenji Izuhara; Simon J. Conway; Bethany B. Moore; Hisako Matsumoto; Cécile T.J. Holweg; Matthews; Joseph R. Arron
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Clearance of extractables and leachables from single-use technologies via ultrafiltration/diafiltration operations
Biotechnology Progress, ISSN: 15206033
Nicholas Magarian; Kate Lee; Kunal Nagpal; Ken Skidmore; Ekta Mahajan
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Exploring concordance of Patient-Reported information on patientsLikeMe and medical claims data at the patient level
Journal of Medical Internet Research, ISSN: 14388871
Gabriel S. Eichler; Elisenda Cochin; Jian Han; Hu; Timothy E. Vaughan; Paul Wicks; Charles E. Barr; Jenny Devenport
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Expression profile of BCL-2, BCL-XL, and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Elizabeth A. Punnoose; Joel D. Leverson; Franklin V. Peale Jr.; Erwin R. Boghaert; Lisa D. Belmont; Nguyen Tan; Amy Young; Michael J. Mitten; Ellen Ingalla; Darbonne; Anatol Oleksijew; Paul Tapang; Peng Yue; Jason Oeh; Leslie Lee; Maïga; Wayne J. Fairbrother; Amiot; Andrew J. Souers; Deepak Sampath
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Prediction and quantification of splice events from RNA-seq data
PLoS ONE, ISSN: 19326203
Leonard D. Goldstein; Yi Cao; Gregoire Pau; Michael Lawrence; Thomas D Wu; Somasekar Seshagiri; Robert Gentleman
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Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy
International Journal of Toxicology, ISSN: 1092874X 10915818
Prell; Wendy Halpern; Gautham K. Rao
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Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases
Seminars in Nephrology, ISSN: 15584488 02709295
Garg; Domagoj Vucic
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Patterns of early and delayed visual response to ranibizumab treatment for neovascular age-related macular degeneration
JAMA Ophthalmology, ISSN: 21686165
Glenn Stoller; Gregg T. Kokame; Richard F. Dreyer; Howard Shapiro; Lisa Tuomi
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Delay in initiation of adjuvant trastuzumab therapy leads to decreased overall survival and relapse-free survival in patients with HER2-positive non-metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Christopher Gallagher; Kenneth More; Tripthi V. Kamath; Anthony Masaquel; Annie Guérin; Raluca Ionescu-Ittu; Marjolaine Gauthier-Loiselle; Roy Nitulescu; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett
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Prospective design of anti-transferrin receptor bispecific antibodies for optimal delivery into the human brain
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Jitendra Kanodia; Kapil Gadkar; Daniela Bumbaca; Yin Zhang; Raymond K. Tong; Wilman Luk; Kwame Hoyte; Yanmei Lu; Kristin R. Wildsmith; Jessica A. Couch; Ryan J. Watts; Dennis; James A. Ernst; Kimberly Scearce-Levie; Jasvinder K. Atwal; Ramanujan; Sean B. Joseph
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