Genentech: Publications

January 1, 2016

Bitpacking techniques for indexing genomes: II. Enhanced suffix arrays

Algorithms for Molecular Biology, ISSN: 17487188

Thomas D Wu

January 1, 2016

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Chemical Science, ISSN: 20416539 20416520

Thomas H. Pillow; Jack D. Sadowsky; Donglu Zhang; Shang-Fan Yu; Geoffrey Del Rosario; Keyang Xu; Jintang He; Sunil Bhakta; Rachana Ohri; Katherine R. Kozak; Edward Ha; Jagath R. Junutula; Flygare

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January 1, 2016

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

BMC Pulmonary Medicine, ISSN: 14712466

Jodie L. Simpson; Ian A. Yang; John W. Upham; Paul N. Reynolds; Sandra Hodge; Alan L. James; Christine Jenkins; Matthew J. Peters; Guiquan Jia; Cécile T.J. Holweg; Peter G. Gibson

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January 1, 2016

Discovery and Process Development of Class i PI3K and Class i PI3K/mTOR Inhibitors GDC-0941 and GDC-0980

ACS Symposium Series, ISSN: 19475918 00976156

Srinivasan Babu; Francis Gosselin; Theresa Humphries; Alan G. Olivero; Daniel P. Sutherlin; Qingping Tian

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January 1, 2016

The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR

ACS Symposium Series, ISSN: 19475918 00976156

Timothy P. Heffron; Andrew McClory; Andreas Stumpf

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January 1, 2016

The Medicinal Chemistry and Commercial Manufacturing behind the Discovery and Development of the Hedgehog Inhibitor Vismodegib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Daniel P. Sutherlin; Mark E. Reynolds; Scott Savage; Andreas Stumpf

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January 1, 2016

Human monoclonal antibody 81.39a effectively neutralizes emerging influenza A viruses of group 1 and 2 hemagglutinins

Journal of Virology, ISSN: 10985514 0022538X

Henju Marjuki; Vasiliy P. Mishin; Ning Chai; Man-Wah Tan; Elizabeth Newton; John Tegeris; Karl Erlandson; Melissa Willis; Joyce Jones; Todd Davis; James Stevens; Larisa V. Gubareva

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January 1, 2016

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma

Oncotarget, ISSN: 19492553

Anne Lynn S. Chang; Karl Lewis; Sarah T. Arron; Michael R. Migden; James A. Solomon; Simon Yoo; Bann-Mo Day; Edward McKenna; Aleksandar Sekulic

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January 1, 2016

Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones

Tetrahedron Letters, ISSN: 18733581 00404039

Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang

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January 1, 2016

Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody–drug conjugates

Bioorganic and Medicinal Chemistry, ISSN: 14643391 09680896

Anna C. Giddens; Ho H. Lee; Guo-Liang Lu; Christian K. Miller; Jun Guo; Gail L. Phillips; Thomas H. Pillow; Moana Tercel

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January 1, 2016

Application of LCMS in small-molecule drug development

European Pharmaceutical Review, ISSN: 13608606

Chunang Gu; David J. Russell; Peter M. Yehl

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January 1, 2016

Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab

RMD Open, ISSN: 20565933

Rubbert-Roth; Anthony Sebba; Laura Brockwell; Ariella Kelman; Benjamin Porter-Brown; Jennifer Pulley; Pavel Napalkov; Ronald Van Vollenhoven

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January 1, 2016

Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies

Journal of Immunology Research, ISSN: 23147156 23148861

Michael A. Partridge; Shobha Purushothama; Chinnasamy Elango; Yanmei Lu

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January 1, 2016

Knockout and humanised animal models to study membrane transporters in drug development

RSC Drug Discovery Series, ISSN: 20413211 20413203

Nico Scheer; Xiaoyan Chu; Laurent Salphati; Zamek-Gliszczynski

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January 1, 2016

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Journal of Immunology Research, ISSN: 23147156 23148861

Yanmei Lu; Leslie A. Khawli; Shobha Purushothama; Frank-Peter Theil; Michael A. Partridge

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January 1, 2016

HER2-targeted polyinosine/polycytosine therapy inhibits tumor growth and modulates the tumor immune microenvironment

Cancer immunology research, ISSN: 23266074 23266066

Maya Zigler; Alexei Shir; Salim Joubran; Anna Sagalov; Shoshana Klein; Nufar Edinger; Jeffrey Lau; Shang-Fan Yu; Gabriel Mizraji; Anat Globerson Levin; Mark X. Sliwkowski; Alexander Levitzki

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January 1, 2016

Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for 89Zr4+ and its use for immunoPET imaging of HER2 positive model of ovarian carcinoma in mice

Theranostics, ISSN: 18387640

Jeff N. Tinianow; Darpan N. Pandya; Sylvie L. Pailloux; Annie Ogasawara; Alexander N. Vanderbilt; Herman S. Gill; Simon P. Williams; Thaddeus J. Wadas; Darren Magda; Jan Marik

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January 1, 2016

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Karen E. Parrish; Jialin Mao; Jacob Z. Chen; Allan Jaochico; Justin Ly; Quynh Ho; Sophie Mukadam; Matthew Wright

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January 1, 2016

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Oncotarget, ISSN: 19492553

Sonja C. Lueck; Annika C. Russ; Ursula Botzenhardt; Richard F. Schlenk; Zobel; Deshayes; Domagoj Vucic; Hartmut Doḧner; Konstanze Döhner; Fulda; Lars Bullinger

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January 1, 2016

Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates

Reproductive Toxicology, ISSN: 18731708 08906238

Hong Wang; Chris Schuetz; Akihiro Arima; Yutaka Chihaya; Gerhard F. Weinbauer; Gunnar Habermann; Jim J. Xiao; Cynthia Woods; Jane L. Grogan; Thomas R. Gelzleichter; Cain

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January 1, 2016

Identification of potent, selective KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Victor S Gehling; Steve Bellon; Jean-Christophe Harmange; Yves Leblanc; Florence Poy; Shobu Odate; Shane Buker; Fei Lan; Shilpi Arora; Kaylyn E Williamson; Peter Sandy; Richard T Cummings; Christopher Bailey; Louise Bergeron; Weifeng Mao; Amy Gustafson; Yichin Liu; Erica Vanderporten; James E. Audia; Patrick Trojer; Brian K Albrecht

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January 1, 2016

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Birong Zhang; Sharada Labadie; Daniel F. Ortwine; Maia Vinogradova; James R. Kiefer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

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January 1, 2016

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy Lee; James J. Crawford; Ignacio Aliagas; Lesley J. Murray; Suzanne Tay; Weiru Wang; Christopher E. Heise; Klaus P. Hoeflich; Hank La; Simon Mathieu; Robert Mintzer; Sreemathy Ramaswamy; Lionel Rouge; Joachim Rudolph

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January 1, 2016

De novo guanine biosynthesis but not the riboswitch-regulated purine salvage pathway is required for Staphylococcus aureus infection in vivo

Journal of Bacteriology, ISSN: 10985530 00219193

Eric M. Kofoed; Donghong Yan; Anand K. Katakam; Mike Reichelt; Baiwei Lin; Janice Kim; Summer Park; Shailesh V. Date; Ian R. Monk; Min Xu; Cary D. Austin; Till Maurer; Man-Wah Tan

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January 1, 2016

Preexisting antibodies to an F(ab′)2 Antibody therapeutic and novel method for immunogenicity assessment

Journal of Immunology Research, ISSN: 23147156 23148861

Jane Ruppel; Ann Brady; Rebecca Elliott; Cecilia Leddy; Marco Palencia; Daniel A. Coleman; Jessica A. Couch; Eric Wakshull

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January 1, 2016

Short-Term Efficacy Reliably Predicts Long-Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-Based Meta-Analysis

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yehong Wang; Rui Zhu; Jim J. Xiao; John C. Davis; Jaap W. Mandema; Jin Y. Jin; Meina Tao Tang

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January 1, 2016

Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi

RNA Biology, ISSN: 15558584 15476286

Colin K. Watanabe; Trinna L. Cuellar; Benjamin Haley

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January 1, 2016

VH-VL orientation prediction for antibody humanization candidate selection: A case study

mAbs, ISSN: 19420870 19420862

Alexander Bujotzek; Florian Lipsmeier; Seth F. Harris; Jörg Benz; Andreas Kuglstatter; Guy J. Georges

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January 1, 2016

Detecting Data Quality Issues in Clinical Trials: Current Practices and Recommendations

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

David Knepper; Christian Fenske; Patrick Nadolny; Alun Bedding; Elena Gribkova; John Polzer; Jennifer Neumann; Brett Wilson; Joanne Benedict; Andy Lawton

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January 1, 2016

Application of a plug-and-play immunogenicity assay in cynomolgus monkey serum for ADCs at early stages of drug development

Journal of Immunology Research, ISSN: 23147156 23148861

Montserrat Carrasco-Triguero; Helen Davis; Yuda Zhu; Daniel A. Coleman; Denise Nazzal; Paul Vu; Surinder Kaur

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January 1, 2016

Estimating the population benefits and costs of Rituximab therapy in the United States from 1998 to 2013 using real-world data

Medical Care, ISSN: 15371948 00257079

Mark Danese; Carolina Reyes; Michelle Gleeson; Marc Halperin; Sandra Skettino; Joseph Mikhael

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January 1, 2016

The INNs and outs of antibody nonproprietary names

mAbs, ISSN: 19420870 19420862

Tim D. Jones; Paul J. Carter; Pluckthun; Max Vásquez; Robert G. E. Holgate; Isidro Hötzel; Andrew G. Popplewell; Paul W. H. I. Parren; Markus Enzelberger; Hendrik J. Rademaker; Michael R. Clark; David C. Lowe; Bassil I. Dahiyat; Victoria Smith; John M. Lambert; Herren Wu; Mary Reilly; John S. Haurum; Stefan Dübel; James S. Huston; Thomas Schirrmann; Richard A. J. Janssen; Martin Steegmaier; Jane A. Gross; Andrew Bradbury; Dennis R. Burton; Dimiter S. Dimitrov; Kerry A. Chester; Martin J. Glennie; Julian Davies; Adam Walker; Steve Martin; John McCafferty; Matthew P. Baker

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January 1, 2016

Multi-site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence

mAbs, ISSN: 19420870 19420862

Ákos Szekrényes; Park; Marcia Santos; Clarence Lew; Aled Jones; Ted Haxo; Michael Kimzey; Shiva Pourkaveh; Zoltán Szabó; Zoran Sosic; Peng Feng; Csaba Váradi; Francois De L'Escaille; Jean-Bernard Falmagne; Preeti Sejwal; Thomas Niedringhaus; David A. Michels; Gordon Freckleton; Melissa Hamm; Anastasiya Manuilov; Melissa Schwartz; Jiann-Kae Luo; Jonathan van Dyck; Pui-King Leung; Marcell Olajos; Yingmei Gu; Kai Gao; Wenbo Wang; Jo Wegstein; Samnang Tep; András Guttman

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January 1, 2016

Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies

mAbs, ISSN: 19420870 19420862

Qing Xie; Benjamin Moore; Richard L Beardsley

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January 1, 2016

Reply

Ophthalmology, ISSN: 15494713 01616420

Raafay Sophie; Na Lu; Peter A. Campochiaro

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January 1, 2016

Image Analysis-Based Approaches for Scoring Mouse Models of Colitis

Veterinary Pathology, ISSN: 15442217 03009858

Rogers; Jeffrey Eastham-Anderson; Jason Devoss; Justin Lesch; Donghong Yan; Min Xu; Margaret Solon; Kathy Hötzel; Laurie Diehl; Webster

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January 1, 2016

Magnetic resonance enterography is feasible and reliable in multicenter clinical trials in patients with Crohn's disease, and may help select subjects with active inflammation

Alimentary Pharmacology and Therapeutics, ISSN: 13652036 02692813

Coimbra; Rimola; Sharon O'Byrne; Timothy T. Lu; Thomas Bengtsson; De Crespigny; Diana Luca; Paul J. Rutgeerts; Bruining; Fidler; William J. Sandborn; Santillan; Higgins; Al-Hawary; Severine Vermeire; Vanbeckevoort; Vanslembrouck; Peyrin-Biroulet; Laurent; Herrmann; Julián Panés

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January 1, 2016

Slashing the timelines: Opting to generate high-titer clonal lines faster via viability-based single cell sorting

Biotechnology Progress, ISSN: 15206033 87567938

Shahram Misaghi; David Shaw; Salina Louie; Adrian Nava; Laura C. Simmons; Snedecor; Chungkee Poon; Jonathan S. Paw; Laurie L. Gilmour; James Cupp

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January 1, 2016

Evaluation of IgE Antibodies to Omalizumab (Xolair®) and Their Potential Correlation to Anaphylaxis

AAPS Journal, ISSN: 15507416

Baker; Nakamura; Henry B. Lowman; Saloumeh Kadkhodayan Fischer

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January 1, 2016

The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance

Metallomics, ISSN: 1756591X 17565901

Yue Fu; Kevin E. Bruce; Hongwei Wu; David P. Giedroc

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January 1, 2016

The LonA protease regulates biofilm formation, motility, virulence, and the type VI secretion system in Vibrio cholerae

Journal of Bacteriology, ISSN: 10985530 00219193

Andrew Rogers; Loni Townsley; Ana L. Gallego-Hernandez; Sinem Beyhan; Laura Kwuan; Fitnat H. Yildiz

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January 1, 2016

Bevacizumab dosing strategy in paediatric cancer patients based on population pharmacokinetic analysis with external validation

British Journal of Clinical Pharmacology, ISSN: 13652125 03065251

Kelong Han; Thomas Peyret; Angelica Quartino; Nathalie H. Gosselin; Sridharan Gururangan; Michela Casanova; Johannes H. M. Merks; Maura Massimino; Jacques Grill; Najat C. Daw; Fariba Navid; Jin Y. Jin; David E. Allison

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January 1, 2016

Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Daniel Fleck; Matthias Voss; Ben Brankatschk; Camilla Giudici; Heike Hampel; Benjamin Schwenk; Dieter Edbauer; Akio Fukumori; Harald Steiner; Elisabeth Kremmer; Martina Haug-Kröper; Moritz J. Rossner; Regina Fluhrer; Michael Willem; Christian Haass

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January 1, 2016

Recommendations for Use and Fit-for-Purpose Validation of Biomarker Multiplex Ligand Binding Assays in Drug Development

AAPS Journal, ISSN: 15507416

Darshana Jani; John Allinson; Flora Berisha; Kyra J. Cowan; Viswanath Devanarayan; Carol Gleason; Andreas Jeromin; Steve Keller; Masood U. Khan; Bill Nowatzke; Paul Rhyne; Laurie Stephen

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January 1, 2016

Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA)

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Gerd R. Burmester; Rubbert-Roth; Alain Cantagrel; Stephen Hall; Piotr Leszczynski; Daniel Feldman; Madura J. Rangaraj; Georgia Roane; Charles Ludivico; Bao; Lucy Rowell; Claire Davies; Eduardo F. Mysler

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January 1, 2016

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

Journal of Lipid Research, ISSN: 15397262 00222275

Kapil Gadkar; James Lu; Srikumar Sahasranaman; John Davis; Norman A. Mazer; Ramanujan

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January 1, 2016

Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase

Alzheimer's and Dementia, ISSN: 15525279 15525260

Mark Forrest Gordon; William R. Lenderking; Amy Duhig; Julie Chandler; J. Jason Lundy; David S. Miller; Elisabeth Piault-Louis; Rachelle S. Doody; Douglas Galasko; Serge Gauthier; Lori Frank

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January 1, 2016

Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Anja Winter; Anna G. Sigurdardottir; Danielle DiCara; Giovanni Valenti; Tom L. Blundell; Ermanno Gherardi

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January 1, 2016

Effects of enzastaurin and its metabolites on the QT interval in cancer patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Pamela A. Welch; Wee Teck Ng; Christelle L. Darstein; Luna Musib; Thierry Lesimple

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January 1, 2016

Population Pharmacokinetic Model of Cabozantinib in Patients with Medullary Thyroid Carcinoma and Its Application to an Exposure-Response Analysis

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Dale Miles; Nelson L'ntshotsholé Jumbe; Steven Lacy; Linh Nguyen

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