Genentech: Publications

July 6, 2015

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations

Molecular Pharmaceutics, ISSN: 15438392 15438384

Paroma Chakravarty; Sanjeev Kothari; Alan Deese; Joseph W. Lubach

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July 3, 2015

Understanding and Addressing the Unbounded “Likelihood” Problem

American Statistician, ISSN: 15372731 00031305

Shiyao Liu; Huaiqing Wu; William Q. Meeker

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July 3, 2015

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: Comparative analysis, molecular docking, bioactivation and toxicological implications

Drug Metabolism Reviews, ISSN: 10979883 03602532

Kevin A. Ford; Gregory Ryslik; Jasleen K. Sodhi; Jason S Halladay; Dolores Diaz; Donna M. Dambach; Melisa Masuda

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott C. Kogan

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott Kogan

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July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Wojciech Jurczak; Sandra J. Horning; Ranjana H. Advani

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July 1, 2015

Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Ada Hui; Lam; Christopher Kuehl; Ulla Grauschopf; Y. John Wang

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July 1, 2015

Projected clinical, resource use, and fiscal impacts of implementing low-dose computed tomography lung cancer screening in Medicare

Journal of Oncology Practice, ISSN: 1935469X 15547477

Joshua A. Roth; Sean D. Sullivan; Bernardo H. L. Goulart; Arliene Ravelo; Joanna C. Sanderson; Scott D. Ramsey

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July 1, 2015

Notch receptor-ligand engagement maintains hematopoietic stem cell quiescence and niche retention

Stem Cells, ISSN: 15494918 10665099

Weihuan Wang; Shuiliang Yu; Grant Zimmerman; Yiwei Wang; Jay Myers; Vionnie W. C. Yu; Dan Huang; Xiaoran Huang; Jeongsup Shim; Yuanshuai Huang; William Xin; Peter Qiao; Minhong Yan; Wei Xin; David T. Scadden; Pamela Stanley; John Lowe; Alex Y. Huang; Christian W. Siebel; Lan Zhou

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July 1, 2015

Effectiveness of rituximab for the treatment of rheumatoid arthritis in patients with prior exposure to anti-TNF: Results from the CORRONA registry

Journal of Rheumatology, ISSN: 14992752 0315162X

Leslie R. Harrold; Reed; Ashwini Shewade; Robert Magner; Katherine C. Saunders; Ani John; Joel M. Kremer; Jeffrey D. Greenberg

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July 1, 2015

Hydrophobic interaction chromatography for antibody drug conjugate drug distribution analysis

American Pharmaceutical Review, ISSN: 10998012

Tao Chen; Kelly Zhang; Jason Gruenhagen; Colin D. Medley

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July 1, 2015

Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States

British Journal of Haematology, ISSN: 13652141 00071048

Chadi Nabhan; Michelle Byrtek; Ashish Rai; Keith Dawson; Zhou; Brian K. Link; Jonathan W. Friedberg; Zelenetz; Matthew J. Maurer; James R. Cerhan; Christopher R. Flowers

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July 1, 2015

Changes in asthma control, work productivity, and impairment with omalizumab: 5-year EXCELS study results

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Karina Raimundo; Benjamin L. Trzaskoma; Karin Rosén; Michael Schatz

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July 1, 2015

A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma

Journal of the American Academy of Dermatology, ISSN: 10976787 01909622

Howard Sofen; Kenneth G. Gross; Leonard Goldberg; Harry Sharata; Tiffani K. Hamilton; Barbara Egbert; Benjamin Lyons; Jeannie Hou; Ivor Caro

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July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Brad Kahl; Sandra J. Horning; Ranjana H. Advani

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July 1, 2015

Risk of corticosteroid-related adverse events in asthma patients with high oral corticosteroid use

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Michael S. Broder; Theodore A. Omachi; Eunice Chang; Gordon H. Sun; Karina Raimundo

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July 1, 2015

The Cost-Effectiveness of Ranibizumab for the Treatment of Diabetic Macular Edema

Ophthalmology, ISSN: 15494713 01616420

Gary C. Brown; Melissa M. Brown; Adam Turpcu; Yamina Rajput

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July 1, 2015

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Diabetologia, ISSN: 14320428 0012186X

Samantha L. Hocking; Rebecca L. Stewart; Amanda E. Brandon; Eurwin Suryana; Ella Stuart; Emily M. Baldwin; Ganesh Kolumam; Zora Modrusan; Jagath R. Junutula; Jenny E. Gunton; Michael Medynskyj; Sinead P. Blaber; Elisabeth Karsten; Benjamin R. Herbert; David E. James; Gregory J. Cooney; Michael M. Swarbrick

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July 1, 2015

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

Pharmacology and Therapeutics, ISSN: 1879016X 01637258

Deepak Sampath; Tanja S. Zabka; Misner; Thomas O'Brien; Peter Dragovich

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July 1, 2015

Sulfonic Acid Salts of Donepezil and Stabilization of Amorphous Donepezil via Formation of Amorphous Salts

Crystal Growth and Design, ISSN: 15287505 15287483

Sun Hye Lee; Jae Ho Bae; Yeojin Park; Bishal Raj Adhikari; Chen Mao; Daeyoung Kim; Kyung Im Kim; Sung Kwon Kang; Eun Hee Lee

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July 1, 2015

Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Lisa Ryner; Yinghui Guan; Ron Firestein; Yuanyuan Xiao; Younjeong Choi; Christina Rabe; Shan Lu; Eloisa Fuentes; Huw; Lackner; Ling Fu; Lukas Amler; Carlos Bais; Wang

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July 1, 2015

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

EBioMedicine, ISSN: 23523964

Ganesh Kolumam; Mark Chen; Raymond K. Tong; Jose Zavala-Solorio; Lance Kates; Nicholas Van Bruggen; Ross; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Diana Ronai Dunshee; Ai-Luen Wu; Benjamin Haley; Keith R. Anderson; Søren Warming; Xin Y. Rairdan; Nicholas Lewin-Koh; Yingnan Zhang; Johnny Gutierrez; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Sharmila Rajan; Travis W. Bainbridge; Jean-Michel Vernes; Meng; James Ziai; Robert Soriano; Matthew J. Brauer; Yongmei Chen; Scott Stawicki; Hok Seon Kim; Laetitia Comps-Agrar; Luis; Christoph Spiess; Yan Wu; James A. Ernst; Owen P. McGuinness; Andrew S. Peterson; Junichiro Sonoda

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July 1, 2015

Intratumoral heterogeneity: From diversity comes resistance

Clinical Cancer Research, ISSN: 15573265 10780432

Ariel Pribluda; Cecile C. de la Cruz; Erica L. Jackson

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July 1, 2015

Conformational Isomerism in Solid State of AMG 853 - Structure Studies Using Solid-State Nuclear Magnetic Resonance and X-ray Diffraction

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Kiang; Karthik Nagapudi; Tian Wu; Matthew L. Peterson; Janan Jona; Richard J. Staples; Peter W. Stephens

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July 1, 2015

Use of cassette dosing to enhance the throughput of rat brain microdialysis studies

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Gauri Deshmukh; Kefeng Sun; Bianca M. Liederer; Xiao Ding; Xingrong Liu

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July 1, 2015

Comparative Study of Analytical Techniques for Determining Protein Charge

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Dana I. Filoti; Steven J. Shire; Sandeep Yadav; Thomas M. Laue

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July 1, 2015

Health-related quality of life in a randomized phase III study of bevacizumab, temozolomide, and radiotherapy in newly diagnosed glioblastoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Martin J. B. Taphoorn; Roger Henriksson; Andrew Bottomley; Timothy Cloughesy; Wick; Warren Mason; Frank Saran; Ryo Nishikawa; Magalie Hilton; Christina Theodore-Oklota; Arliene Ravelo; Olivier L. Chinot

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July 1, 2015

Predictors of Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Ranibizumab

Ophthalmology, ISSN: 15494713 01616420

Raafay Sophie; Na Lu; Peter A. Campochiaro

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July 1, 2015

Vented Spikes Improve Delivery from Intravenous Bags with No Air Headspace

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

William J. Galush; Travis A. Horst

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June 30, 2015

The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive

Temperature, ISSN: 23328959 23328940

Jun Chen

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June 30, 2015

Joint modeling of survival and longitudinal non-survival data: Current methods and issues. Report of the DIA Bayesian joint modeling working group

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

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June 30, 2015

Responses to discussants of 'Joint modeling of survival and longitudinal non-survival data: Current methods and issues. report of the DIA Bayesian joint modeling working group'

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

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June 29, 2015

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

Journal of Experimental Medicine, ISSN: 15409538 00221007

Derek A. Holmes; Eric Suto; Wyne P. Lee; Qinglin Ou; Qian Gong; Hamish R.C. Smith; Patrick Caplazi; Andrew A. Chan

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June 26, 2015

The role of FcεRI expressed in dendritic cells and monocytes

Cellular and Molecular Life Sciences, ISSN: 14209071 1420682X

Jeoung-Sook Shin; Alexandra M. Greer

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June 26, 2015

Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine

Vaccine, ISSN: 18732518 0264410X

Mary Ann Goss; Fabio Lievano; Karyn M. Buchanan; Margaret M. Seminack; Michael L. Cunningham; Adrian Dana

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June 25, 2015

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

Cell Death and Disease, ISSN: 20414889

Maria Cristina De Almagro; Tatiana Goncharov; Kim Newton; Domagoj Vucic

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June 25, 2015

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Lewis Gazzard; Karen Williams; Huifen Chen; Lorraine Axford; Elizabeth M. Blackwood; Brenda Burton; Kerry Chapman; Peter H. Crackett; Joy Drobnick; Charles Ellwood; Jennifer A. Epler; Michael Flagella; Emanuela Gancia; Matthew Gill; Simon Goodacre; Jason S Halladay; Joanne F. M. Hewitt; Hazel Hunt; Samuel Kintz; Joseph P. Lyssikatos; Calum Macleod; Sarah Major; Guillaume Médard; Raman Narukulla; Judi Ramiscal; Stephen Schmidt; Eileen Seward; Wiesmann; Ping Wu; Sharon Fong Yee; Ivana Yen; Shiva Malek

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June 25, 2015

Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

James J. Crawford; Wendy Lee; Ignacio Aliagas; Simon Mathieu; Klaus P. Hoeflich; Wei Zhou; Weiru Wang; Lionel Rouge; Lesley J. Murray; Hank La; Ning Liu; Peter W. Fan; Jonathan Cheong; Christopher E. Heise; Sreemathy Ramaswamy; Robert Mintzer; Yanzhou Liu; Qi Chao; Joachim Rudolph

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June 23, 2015

Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Kanika Bajaj Pahuja; Jinzhi Wang; Anastasia Blagoveshchenskaya; Lillian Lim; Madhusudhan; Peter Mayinger; Randy Schekman

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June 19, 2015

Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425

Organic Process Research and Development, ISSN: 1520586X 10836160

Andreas Stumpf; Zhigang Cheng; Brian Wong; Mark E. Reynolds; Remy Angelaud; James Girotti; Alan Deese; Christine Gu; Lewis Gazzard

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June 18, 2015

Drugs versus placebo for dysthymia

Cochrane database of systematic reviews (Online : Update Software), ISSN: 1469493X

Mauricio Silva de Lima; Joanna Moncrieff; Bernardo G. O Soares

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June 18, 2015

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

BMC Genomics, ISSN: 14712164

Florian Gnad; Sophia Doll; Gerard Manning; David Arnott; Zemin Zhang

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June 18, 2015

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Nature Chemical Biology, ISSN: 15524469 15524450

Elayne Chan-Penebre; Kristy G. Kuplast; Christina R. Majer; P Ann Boriack-Sjodin; Tim J. Wigle; L Danielle Johnston; Nathalie Rioux; Michael J. Munchhof; Lei Jin; Suzanne L. Jacques; Kip A. West; Trupti Lingaraj; Kimberly Stickland; Scott A. Ribich; Alejandra Raimondi; Margaret Porter Scott; Nigel J. Waters; Roy M. Pollock; Jesse J. Smith; Olena Barbash; Melissa Pappalardi; Thau F. Ho; Kelvin Nurse; Khyati P. Oza; Kathleen T. Gallagher; Ryan Kruger; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth; Kenneth W. Duncan

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June 18, 2015

Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress

PLoS ONE, ISSN: 19326203

Andrea D'Osualdo; Veronica G. Anania; Kebing Yu; Jennie R. Lill; Randal J. Kaufman; Shu-Ichi Matsuzawa; John C. Reed

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June 15, 2015

Histopathology in mouse models of rheumatoid arthritis

Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development,

Patrick Caplazi; Laurie Diehl

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June 15, 2015

Baculovirus display for discovery of low-affinity extracellular receptor-ligand interactions using protein microarrays

Analytical Biochemistry, ISSN: 10960309 00032697

Irene Tom; Alberto Estevez; Krista K. Bowman; Lino C. Gonzalez Jr.

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June 15, 2015

Ig Repertoire Constructor: A novel algorithm for antibody repertoire construction and immunoproteogenomics analysis

Bioinformatics, ISSN: 14602059 13674803

Yana Safonova; Stefano Bonissone; Eugene Kurpilyansky; Ekaterina Starostina; Alla Lapidus; Stinson; Laura DePalatis; Wendy N. Sandoval; Jennie R. Lill; Pavel A. Pevzner

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June 15, 2015

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Ankush Argade; Somasekhar Bhamidipati; Hui Li; Catherine Sylvain; Jeffrey Clough; David Carroll; Holger Keim; Sylvia Braselmann; Vanessa Taylor; Haoran Zhao; Ellen Herlaar; Sarkiz D. Issakani; Brian R. Wong; Esteban S. Masuda; Donald G. Payan; Rajinder Singh

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June 15, 2015

Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Ankush Argade; Somasekhar Bhamidipati; Hui Li; David Carroll; Jeffrey Clough; Holger Keim; Catherine Sylvain; Alexander B. Rossi; Christina Coquilla; Sarkiz D. Issakani; Esteban S. Masuda; Donald G. Payan; Rajinder Singh

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June 13, 2015

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Jianwen A. Feng; Ignacio Aliagas; Philippe Bergeron; Jeff Blaney; Erin K. Bradley; Michael F. T. Koehler; Man-Ling Lee; Daniel F. Ortwine; Vickie Tsui; Johnny Wu; Alberto Gobbi

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