Genentech: Publications

March 1, 2015

Differential effects of targeting Notch receptors in a mouse model of liver cancer

Hepatology, ISSN: 15273350 02709139

Erik G. Huntzicker; Kathy Hötzel; Lisa Choy; Li Che; Ross; Gregoire Pau; Neeraj Sharma; Christian W. Siebel; Xin Chen; French

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March 1, 2015

Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox)

American Journal of Cardiology, ISSN: 18791913 00029149

Vanessa S. Reddy; Quang T. Bui; Joan R. Jacobs; Susan M. Begelman; Dave P. Miller; William J. French

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March 1, 2015

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Toxicological Sciences, ISSN: 10960929 10966080

Tanja S. Zabka; Jatinder Singh; Preeti Dhawan; Bianca M. Liederer; Jason Oeh; Ariel Kauss; Yang Xiao; Mark Zak; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Joseph Beyer; Cindy A. Farman; Hirdesh Uppal; Peter Dragovich; Thomas O'Brien; Deepak Sampath; Misner

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March 1, 2015

Necroptosis: Pathway diversity and characteristics

Seminars in Cell and Developmental Biology, ISSN: 10963634 10849521

Maria Cristina De Almagro; Domagoj Vucic

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March 1, 2015

Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Laura M. Paulin; Gregory B. Diette; Paul D. Blanc; Nirupama Putcha; Mark D. Eisner; Richard E. Kanner; Andrew J. Belli; Stephanie Christenson; Donald P. Tashkin; MeiLan Han; Graham Barr; Nadia N. Hansel

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March 1, 2015

The Consequences of Diminishing Industry Support on the Independent Education Landscape: An Evidence-Based Analysis of the Perceived and Realistic Impact on Professional Development and Patient Care Among Oncologists

Journal of Cancer Education, ISSN: 15430154 08858195

Caroline Robinson; John Ruggiero; Mazi Abdolrasulnia; B. Stephen Burton

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March 1, 2015

Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis

Value in Health, ISSN: 15244733 10983015

Josh J. Carlson; Sarika Ogale; Fred Dejonckheere; Sean D. Sullivan

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March 1, 2015

Incidence of giant cell arteritis and characteristics of patients: Data-driven analysis of comorbidities

Arthritis Care and Research, ISSN: 21514658 2151464X

Hans Petri; Alan Nevitt; Khaled Sarsour; Pavel Napalkov; Neil Collinson

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March 1, 2015

Author reply

Ophthalmology, ISSN: 15494713 01616420

Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai

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March 1, 2015

Bioprocessing roundtable

American Pharmaceutical Review, ISSN: 10998012

Todd Kapp; Nick Hutchinson; Melvin G. Whitehead; Michael Hodgkinson; Jerry Martin

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March 1, 2015

In response to L.N. Newcomer et al

Journal of Oncology Practice, ISSN: 1935469X 15547477

Art Small; Melissa Brammer

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March 1, 2015

Primary tumor location as a prognostic factor in metastatic colorectal cancer

Journal of the National Cancer Institute, ISSN: 14602105 00278874

Fotios Loupakis; Dongyun Yang; Linda Yau; Shibao Feng; Chiara Cremolini; Wu Zhang; Martin K. H. Maus; Carlotta Antoniotti; Christiane Langer; Stefan J. Scherer; Thomas Müller; Herbert Hurwitz; Leonard Saltz; Alfredo Falcone; Heinz-Josef Lenz

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March 1, 2015

Catch-up growth during tocilizumab therapy for systemic juvenile idiopathic arthritis: Results from a phase iii trial

Arthritis and Rheumatology, ISSN: 23265205 23265191

Fabrizio De Benedetti; Hermine Brunner; Nicolino Ruperto; Rayfel Schneider; Ricardo Xavier; Roger Allen; Diane E. Brown; Jeffrey Chaitow; Manuela Pardeo; Graciela Espada; Valeria Gerloni; Barry L. Myones; James W. Frane; Jianmei Wang; Terri H. Lipman; Kamal N. Bharucha; Alberto Martini; Daniel Lovell

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March 1, 2015

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Toxicology Mechanisms and Methods, ISSN: 15376524 15376516

Jacqueline M. Tarrant; Preeti Dhawan; Jatinder Singh; Tanja S. Zabka; Emer Clarke; Garry Dossantos; Peter Dragovich; Deepak Sampath; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Ariel Kauss; Donna M. Dambach; Misner; Dolores Diaz; Hirdesh Uppal

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March 1, 2015

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayerss

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Tianxiang Han; William R. Proctor; Chester L. Costales; Hao Cai; Ruth S. Everett; Dhiren R. Thakker

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March 1, 2015

Symptom burden and quality of life among women with HER2+ metastatic breast cancer

Breast Journal, ISSN: 15244741 1075122X

Musa Mayer; Kathleen Lang; Sara A. Hurvitz; Deepa Lalla; Victoria Federico; Melissa Brammer; Joseph Menzin; Debasish Tripathy

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March 1, 2015

Efficacy of Hedgehog pathway inhibitors in basal cell carcinoma

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Nicole Basset-Seguin; Hayley J. Sharpe; Frederic J. De Sauvage

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March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Brad Kahl

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March 1, 2015

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

AAPS Journal, ISSN: 15507416

Edgar Schuck; Tonika Bohnert; Arijit Chakravarty; Valeriu Damian-Iordache; Christopher Gibson; Cheng-Pang Hsu; Tycho Heimbach; Anu Shilpa Krishnatry; Bianca M. Liederer; Jing Lin; Tristan Maurer; Jerome T Mettetal; Daniel R Mudra; Marjoleen JMA Nijsen; Joseph Raybon; Patricia Schroeder; Virna Schuck; Satyendra Suryawanshi; Yaming Su; Patrick Trapa; Alice Tsai; Majid Vakilynejad; Shining Wang; Harvey Wong

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March 1, 2015

A prospective observational study of oseltamivir safety and tolerability in infants and young children ≤24 months

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Barbara A. Rath; William A. Blumentals; Mary K. Miller; Kathryn Starzyk; Boguslaw Tetiurka; Martina Wollenhaupt

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March 1, 2015

Comparison of statistical and operational properties of subject randomization procedures for large multicenter clinical trial treating medical emergencies

Contemporary Clinical Trials, ISSN: 15592030 15517144

Wenle Zhao; Yunming Mu; Darren Tayama; Sharon D. Yeatts

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March 1, 2015

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Xuejun Fan; Randall J. Brezski; Hui Deng; Pooja M. Dhupkar; Yun Shi; Anneliese Gonzalez; Songlin Zhang; Michael Rycyzyn; William R. Strohl; Robert E. Jordan; Ningyan Zhang; Zhiqiang An

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March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Wojciech Jurczak

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February 26, 2015

Inhibiting the deubiquitinating enzymes (DUBs)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Chudi O. Ndubaku; Vickie Tsui

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February 26, 2015

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Li Ren; Jonas Grina; David Moreno; James F. Blake; John J. Gaudino; Rustam Garrey; Andrew T. Metcalf; Michael Burkard; Matthew Martinson; Kevin Rasor; Huifen Chen; Brian J. Dean; Stephen Gould; Patricia Pacheco; Sheerin Shahidi-Latham; Jianping Yin; Kristina West; Weiru Wang; John Moffat; Jacob B. Schwarz

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February 25, 2015

Human biosample authentication using the high-throughput, cost-effective SNPtraceTM system

PLoS ONE, ISSN: 19326203

May M. Y. Liang-Chu; Mamie Yu; Matthias Peter; Julie Koeman; Janet Ziegle; Marie Lee; Richard Bourgon; Richard M. Neve

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February 19, 2015

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Nature, ISSN: 14764687 00280836

Sascha Rutz; Nobuhiko Kayagaki; Qui Phung; Celine Eidenschenk; Rajkumar Noubade; Xiaoting Wang; Justin Lesch; Rongze Lu; Kim Newton; Oscar W Huang; Andrea G Cochran; Vasser; Benjamin P. Fauber; Jason Devoss; Webster; Laurie Diehl; Zora Modrusan; Donald S. Kirkpatrick; Jennie R. Lill; Wenjun Ouyang; Vishva M. Dixit

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February 18, 2015

Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening

Journal of Neuroscience, ISSN: 15292401 02706474

York Rudhard; Arundhati Sengupta Ghosh; Beatrix Lippert; Alexander Böcker; Mehdi Pedaran; Joachim Krämer; Hai Ngu; Oded Foreman; Yichin Liu; Joe Lewcock

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February 17, 2015

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

Nature Cell Biology, ISSN: 14764679 14657392

Christian N. Cunningham; Joshua M. Baughman; Lilian Phu; Joy S. Tea; Christine Yu; Mary Coons; Donald S. Kirkpatrick; Baris Bingol; Jacob E. Corn

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February 17, 2015

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

Immunity, ISSN: 10974180 10747613

Melba Muñoz; Celine Eidenschenk; Naruhisa Ota; Kit Wong; Uwe Lohmann; Anja A. Kühl; Xiaoting Wang; Paolo Manzanillo; Yun Li; Sascha Rutz; Yan Zheng; Laurie Diehl; Nobuhiko Kayagaki; Menno Van Lookeren Campagne; Oliver Liesenfeld; Markus Heimesaat; Wenjun Ouyang

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February 15, 2015

The cryptophycins as potent payloads for antibody drug conjugates

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Vishal A. Verma; Thomas H. Pillow; Laura DePalatis; Guangmin Li; Gail L. Phillips; Andrew G. Polson; Helga Raab; Spencer; Bing Zheng

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February 15, 2015

Fibroblastic reticular cells: Organization and regulation of the T lymphocyte life cycle

Journal of Immunology, ISSN: 15506606 00221767

Flavian D. Brown; Shannon J. Turley

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February 15, 2015

Vascular patterning regulates interdigital cell death by a ros-mediated mechanism

Development (Cambridge), ISSN: 14779129 09501991

Idit Eshkar-Oren; Sharon Krief; Napoleone Ferrara; Alison M. Elliott; Elazar Zelzer

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February 15, 2015

Ubiquitination profiling identifies sensitivity factors for iap antagonist treatment

Biochemical Journal, ISSN: 14708728 02646021

Eugene Varfolomeev; Anita Izrael-Tomasevic; Kebing Yu; Daisy J. Bustos; Tatiana Goncharov; Lisa D. Belmont; Alexandre Masselot; Corey Bakalarski; Donald S. Kirkpatrick; Domagoj Vucic

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February 13, 2015

A practical, protecting-group-free synthesis of a PI3K/mTOR inhibitor

Organic Process Research and Development, ISSN: 1520586X 10836160

Qingping Tian; Ursula Hoffmann; Theresa Humphries; Zhigang Cheng; Pirmin Hidber; Herbert M. Yajima; Maud Guillemot-Plass; Jane Li; Ulrike Bromberger; Srinivasan Babu; David Askin; Francis Gosselin

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February 10, 2015

Structural and biochemical studies of HCMV gH/gL/gO and pentamer reveal mutually exclusive cell entry complexes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Claudio Ciferri; Sumana Chandramouli; Danilo Donnarumma; Pavel A. Nikitin; Michael A. Cianfrocco; Rachel Gerrein; Adam L. Feire; Susan W. Barnett; Anders E. Lilja; Rino Rappuoli; Nathalie Norais; Ethan C. Settembre; Andrea Carfi

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February 4, 2015

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Science Translational Medicine, ISSN: 19466242 19466234

Reina N. Fuji; Michael Flagella; Miriam Baca; Marco A. S Baptista; Jens Brodbeck; Bryan K. Chan; Brian K. Fiske; Lee Honigberg; Adrian M. Jubb; Paula Katavolos; Donna W. Lee; Sock-Cheng Lewin-Koh; Tori Lin; Xingrong Liu; Shannon Liu; Joseph P. Lyssikatos; Jennifer O'Mahony; Mike Reichelt; Merone Roose-Girma; Zejuan Sheng; Todd Sherer; Ashley Smith; Margaret Solon; Zachary K. Sweeney; Jacqueline M. Tarrant; Alison Urkowitz; Søren Warming; Murat Yaylaoglu; Shuo Zhang; Haitao Zhu; Anthony A. Estrada; Ryan J. Watts

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February 3, 2015

Submicrometer particles and slip flow in liquid chromatography

Analytical Chemistry, ISSN: 15206882 00032700

Benjamin A. Rogers; Zhen Wu; Bingchuan Wei; Ximo Zhang; Xiang Cao; Oyeleye Alabi; Mary J. Wirth

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February 2, 2015

Targeting the extrinsic apoptotic pathway in cancer: Lessons learned and future directions

Journal of Clinical Investigation, ISSN: 15588238 00219738

Avi Ashkenazi

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February 1, 2015

Hepatic immune regulation by stromal cells

Current Opinion in Immunology, ISSN: 18790372 09527915

Frank A Schildberg; Arlene H. Sharpe; Shannon J. Turley

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February 1, 2015

Subcutaneous versus intravenous formulation of trastuzumab for HER2-positive early breast cancer: Updated results from the phase III HannaH study

Annals of Oncology, ISSN: 15698041 09237534

Christian Jackisch; Sung-Bae Kim; Vladimir Semiglazov; Melichar; Pivot; Carina Hillenbach; Daniil Stroyakovskiy; Bert L. Lum; Rebecca Elliott; Weber; Gustavo Ismael

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February 1, 2015

Amorphous solid dispersions: A robust platform to address bioavailability challenges

Therapeutic Delivery, ISSN: 20416008 20415990

Ann Newman; Karthik Nagapudi; Robert Wenslow

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February 1, 2015

Current therapy of granulomatosis with polyangiitis and microscopic polyangiitis: the role of rituximab

Journal of Nephrology, ISSN: 17246059 11218428

Duvuru Geetha; Cees Kallenberg; John H. Stone; Alan D. Salama; Gerald B. Appel; George Duna; Paul Brunetta; David Jayne

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February 1, 2015

An evaluation of risk factors for major adverse cardiovascular events during tocilizumab therapy

Arthritis and Rheumatology, ISSN: 23265205 23265191

Vijay U. Rao; Andrey Pavlov; Micki Klearman; David Musselman; Jon T. Giles; Joan Bathon; Naveed Sattar; Janet S. Lee

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February 1, 2015

Modular analysis of peripheral blood gene expression in rheumatoid arthritis captures reproducible gene expression changes in tumor necrosis factor responders

Arthritis and Rheumatology, ISSN: 23265205 23265191

Michaela Oswald; Mark E. Curran; Sarah L. Lamberth; Robert M. Townsend; Jennifer D. Hamilton; David N. Chernoff; John P. Carulli; Michael J. Townsend; Michael E. Weinblatt; Marlena Kern; Cassandra M. Pond; Annette T. Lee; Peter K. Gregersen

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February 1, 2015

Long-term effects of therapy with ranibizumab on diabetic retinopathy severity and baseline risk factors for worsening retinopathy

Ophthalmology, ISSN: 15494713 01616420

Michael S. Ip; Amitha Domalpally; Jennifer K. Sun; Jason S. Ehrlich

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February 1, 2015

A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: A case study of pennyroyal oil

Drug Metabolism Reviews, ISSN: 10979883 03602532

Perry Gordon; S. Cyrus Khojasteh

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February 1, 2015

The Xolair Pregnancy Registry (EXPECT): The safety of omalizumab use during pregnancy

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Jennifer Namazy; Michael D. Cabana; Angela E. Scheuerle; John M. Thorp; Hubert Chen; Gillis Carrigan; Yan Wang; Joachim Veith; Elizabeth Andrews

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February 1, 2015

Primary cervical cancer screening with human papillomavirus: End of study results from the ATHENA study using HPV as the first-line screening test

Gynecologic Oncology, ISSN: 10956859 00908258

Thomas C. Wright; Mark H. Stoler; Catherine M. Behrens; Abha Sharma; Guili Zhang; Teresa L. Wright

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February 1, 2015

Negative symptoms and functioning during the first year after a recent onset of schizophrenia and 8years later

Schizophrenia Research, ISSN: 15732509 09209964

Joseph Ventura; Kenneth L. Subotnik; Michael J. Gitlin; Denise Gretchen-Doorly; Arielle Ered; Kathleen F. Villa; Gerhard S. Hellemann; Keith H. Nuechterlein

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