Genentech: Publications

March 1, 2014

Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy

Virology, ISSN: 00426822 10960341

John R. Teijaro; Kevin B. Walsh; James P. Long; Kevin P. Tordoff; Gregory V. Stark; Amie J. Eisfeld; Yoshihiro Kawaoka; Hugh Rosen; Michael B.A. Oldstone

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March 1, 2014

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

Infection and Immunity, ISSN: 00199567 10985522

Shrinivas Bishu; Nydiaris Herna´ndez-Santos; Michelle R. Simpson-Abelson; Anna R. Huppler; Heather R. Conti; Nico Ghilardi; Anna J. Mamo; Sarah L. Gaffen

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March 1, 2014

Patient-reported outcomes from EMILIA, a randomized phase 3 study of trastuzumab emtansine (T-DM1) versus capecitabine and lapatinib in human epidermal growth factor receptor 2-positive locally advanced or metastatic breast cancer

Cancer, ISSN: 0008543X 10970142

Manfred Welslau; Diéras; Joo-Hyuk Sohn; Sara A. Hurvitz; Deepa Lalla; Liang Fang; Betsy Althaus; Ellie Guardino; David W. Miles

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February 25, 2014

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: Retrospective testing of specimens from the EURTAC trial

PLoS ONE, ISSN: 19326203

Susana Benlloch; Maria F. Botero; Jordi Beltran-Alamillo; Clara Mayo; Ana Gimenez-Capitán; Itziar De Aguirre; Cristina Queralt; Jose Luis Ramirez; Santiago Ramón Y Cajal; Barbara Klughammer; Mariette Schlegel; Walter Bordogna; David Chen; Guili Zhang; Barbara Kovach; Felice Shieh; John F. Palma; Lin Wu; H. Jeffrey Lawrence; Miquel Taron

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February 21, 2014

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

Nature, ISSN: 00280836 14764687

Aditya Murthy; Yun Li; Ivan Peng; Mike Reichelt; Anand K. Katakam; Rajkumar Noubade; Merone Roose-Girma; Jason Devoss; Laurie Diehl; Robert R. Graham; Menno Van Lookeren Campagne

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February 20, 2014

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Immunity, ISSN: 10747613 10974180

Judith Behnsen; Stefan Jellbauer; Christina P. Wong; Robert A. Edwards; Michael D. George; Wenjun Ouyang; Manuela Raffatellu

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February 20, 2014

Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

Immunity, ISSN: 10747613 10974180

Tetsuya Honda; Jackson G. Egen; Tim Lämmermann; Wolfgang Kastenmüller; Parizad Torabi-Parizi; Ronald N. Germain

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February 19, 2014

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

Nature Communications, ISSN: 20411723

Hyunjoo Kim; Ho-June Lee; Yumin Oh; Seon-Guk Choi; Se-Hoon Hong; Hyo-Jin Kim; Song-Yi Lee; Ji-Woo Choi; Deog Su Hwang; Key-Sun Kim; Hyo-Joon Kim; Jianke Zhang; Hyun-Jo Youn; Dong-Young Noh; Yong-Keun Jung

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February 19, 2014

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Sandra M. Swain; Baselga; Sung-Bae Kim; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Sarah Heeson; Emma Clark; Graham Ross; Benyunes; Javier Cortés

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February 18, 2014

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Monica Gostissa; Bjoern Schwer; Amelia Chang; Junchao Dong; Robin M. Meyers; Gregory T. Marecki; Vivian W. Choi; Roberto Chiarle; Ali A. Zarrin; Frederick W. Alt

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February 18, 2014

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

Tetrahedron, ISSN: 00404020 14645416

Brian Wong; Xin Linghu; James J. Crawford; Joy Drobnick; Wendy Lee; Haiming Zhang

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February 18, 2014

Further insights into the effects of pre-organizing the BimBH3 Helix

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; David Segal; Zobel; Anna V. Fedorova; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

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February 15, 2014

Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung

Journal of Immunology, ISSN: 00221767 15506606

Parizad Torabi-Parizi; Nienke Vrisekoop; Wolfgang Kastenmüller; Michael Y. Gerner; Jackson G. Egen; Ronald N. Germain

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February 13, 2014

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors

Cell, ISSN: 10974172 00928674

Diego O. Croci; Juan P. Cerliani; Tomas Dalotto-Moreno; Santiago P. Méndez-Huergo; Ivan D. Mascanfroni; Sebastián Dergan-Dylon; Marta A. Toscano; Julio J. Caramelo; Juan J. García-Vallejo; Jing Ouyang; Enrique A. Mesri; Melissa Junttila; Carlos Bais; Margaret A. Shipp; Mariana Salatino; Gabriel A. Rabinovich

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February 13, 2014

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type i 1/2 kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Steven T. Staben; Jianwen A. Feng; Karen Lyle; Marcia Belvin; Jason Boggs; Jason D. Burch; Ching-Ching Chua; Haifeng Cui; Antonio G. DiPasquale; Lori S. Friedman; Christopher E. Heise; Koeppen; Adrian Kotey; Robert Mintzer; Angela Oh; David Allen Roberts; Lionel Rouge; Joachim Rudolph; Christine Tam; Weiru Wang; Yisong Xiao; Amy Young; Yamin Zhang; Klaus P. Hoeflich

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February 13, 2014

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl) cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Anthony M. Giannetti; Xiaozhang Zheng; Nicholas J. Skelton; Weiru Wang; Brandon Bravo; Kenneth W. Bair; Timm Baumeister; Eric Cheng; Lisa Crocker; Yezhen Feng; Janet Gunzner; Yen-Ching Ho; Rongbao Hua; Bianca M. Liederer; Yongbo Liu; Xiaolei Ma; Thomas O'Brien; Jason Oeh; Deepak Sampath; Youming Shen; Chengcheng Wang; Leslie Wang; Hongxing Wu; Yang Xiao; Po-Wai Yuen; Mark Zak; Guiling Zhao; Qiang Zhao; Peter Dragovich

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February 12, 2014

Integrative biology approach identifies cytokine targeting strategies for psoriasis

Science Translational Medicine, ISSN: 19466242 19466234

Gayathri K. Perera; Chrysanthi Ainali; Ekaterina Semenova; Christian Hundhausen; Guillermo Barinaga; Deepika Kassen; Andrew E. Williams; Muddassar M. Mirza; Mercedesz Balazs; Xiaoting Wang; Robert Sanchez Rodriguez; Andrej Alendar; Jonathan Barker; Sophia Tsoka; Wenjun Ouyang; Frank Nestle

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February 10, 2014

Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers

PLoS ONE, ISSN: 19326203

Erica Schleifman; Rupal Desai; Jill M. Spoerke; Yuanyuan Xiao; Cheryl Wong; Ilma Abbas; Carol O'Brien; Rajesh Patel; Teiko Sumiyoshi; Ling Fu; Rachel Tam; Koeppen; Wilson; Rajiv Raja; Garret M. Hampton; Lackner

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February 10, 2014

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Journal of Experimental Medicine, ISSN: 00221007 15409538

Nga Bien-Ly; Y. Joy Yu; Daniela Bumbaca; Justin Elstrott; C. Andrew Boswell; Yin Zhang; Wilman Luk; Yanmei Lu; Dennis; Robby M. Weimer; Inhee Chung; Ryan J. Watts

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February 6, 2014

Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

Cell Stem Cell, ISSN: 19345909 18759777

Ciara Metcalfe; Noelyn Kljavin; Ryan Ybarra; Frederic J. De Sauvage

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February 6, 2014

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Benjamin P. Fauber; Steven Magnuson

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February 4, 2014

A general approach to site-specific antibody drug conjugates

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Feng Tian; Yingchun Lu; Anthony Manibusan; Aaron Sellers; Hon Tran; Ying Sun; Trung Phuong; Richard Barnett; Brad Hehli; Frank Song; Michael J. DeGuzman; Semsi Ensari; Jason K. Pinkstaff; Lorraine M. Sullivan; Sandra L. Biroc; Ho Cho; Peter G. Schultz; John Di Joseph; Maureen Dougher; Dangshe Ma; Russell Dushin; Mauricio Leal; Lioudmila Tchistiakova; Eric Feyfant; Hans-Peter Gerber; Puja Sapra

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February 1, 2014

Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Nature Reviews Immunology, ISSN: 14741733 14741741

Marcus R. Clark; Malay Mandal; Kyoko Ochiai; Harinder Singh

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February 1, 2014

Continued benefit of tocilizumab plus disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis and inadequate clinical responses by week 8 of treatment

Journal of Rheumatology, ISSN: 0315162X 14992752

Edward Keystone; Andrew Anisfeld; Sarika Ogale; Jenny Devenport; Jeffrey R. Curtis

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February 1, 2014

Hexyl glucoside and hexyl maltoside inhibit light-induced oxidation of tryptophan

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yilma T. Adem; Patricia Molina; Hongbin Liu; Thomas W. Patapoff; Alavattam Sreedhara; Osigwe Esue

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February 1, 2014

Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Edward J. Gane; Régine Rouzier; Alicja Wiercinska-Drapalo; Dominique Larrey; Peter N. Morcos; Barbara J. Brennan; Sophie Le Pogam; Nájera; Rosemary Petric; Jonathan Q. Tran; Rohit Kulkarni; Ying Zhang; Patrick F. Smith; Ellen S. Yetzer; Nancy Shulman

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February 1, 2014

Ready-to-use cryopreserved primary cells: A novel solution for QC lot release potency assays

BioProcess International, ISSN: 15426319

Hélène Gazzano-Santoro; Linda G. Chan; Mimmi S. Ballard; Judy Young

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February 1, 2014

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

European Respiratory Journal, ISSN: 09031936 13993003

Joseph R. Arron; David F. Choy; Laviolette; Steven G. Kelsen; Ammar Hatab; Richard Leigh; Neil C. Thomson; Eugene R. Bleecker; Ron Olivenstein; Pedro C. Avila; Jarjour; Mario Castro; Gauvreau; James T. Good; Joel N. Kline; Adel Mansur; Mayers; Liam G. Heaney; Qutayba Hamid; Harris

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February 1, 2014

Underuse of the health care system by persons with diabetes mellitus and diabetic macular edema in the United States

JAMA Ophthalmology, ISSN: 21686165

Neil M. Bressler; Rohit Varma; Quan V. Doan; Michelle Gleeson; Mark Danese; Julie K. Bower; Elizabeth Selvin; Chantal M. Dolan; Jennifer T. Fine; Shoshana Colman; Adam Turpcu

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February 1, 2014

Interview: Experiences targeting B cells for the treatment of multiple sclerosis

Immunotherapy, ISSN: 1750743X 17507448

Andrew A. Chan; Albert Jan Schutte

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February 1, 2014

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Peter Dragovich; Guiling Zhao; Timm Baumeister; Brandon Bravo; Anthony M. Giannetti; Yen-Ching Ho; Rongbao Hua; Guangkun Li; Xiaorong Liang; Xiaolei Ma; Thomas O'Brien; Angela Oh; Nicholas J. Skelton; Chengcheng Wang; Weiru Wang; Yunli Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Qiang Zhao; Xiaozhang Zheng

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February 1, 2014

Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Elaine Mai; Zhong Zheng; Youjun Chen; Jing Peng; Christophe Severin; Ellen H. Filvaroff; Mally Romero; William Mallet; Surinder Kaur; Thomas R. Gelzleichter; Ihsan Nijem; Mark Merchant; Judy Young

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February 1, 2014

A phase ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophy

Retina, ISSN: 0275004X 15392864

Diana V. Do; Dante Joseph Pieramici; Menno Van Lookeren Campagne; Tatiana Beres; Michel Friesenhahn; Yi Zhang; Erich C. Strauss

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February 1, 2014

Exploring concepts of in vitro time-dependent CYP inhibition assays

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607

David M Stresser; Jialin Mao; Jane R. Kenny; Barry C Jones; Kenneth Grime

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February 1, 2014

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

Journal of General Virology, ISSN: 00221317 14652099

Carrie M. Rosenberger; Rebecca L. Podyminogin; Peter S. Askovich; Garnet Navarro; Shari M. Kaiser; Catherine J. Sanders; Jennifer L. McClaren; Vincent C. Tam; Pradyot Dash; Jhoanna G. Noonan; Bart G. Jones; Sherri L. Surman; Jacques J. Peschon; Alan H. Diercks; Julia L. Hurwitz; Peter C. Doherty; Paul G. Thomas; Alan Aderem

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February 1, 2014

The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Edna F. Choo; Jason Boggs; Chunqiang Zhu; Joseph W. Lubach; Nathaniel D. Catron; Gary Jenkins; Andrew J. Souers; Richard Voorman

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February 1, 2014

Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss

Ophthalmology, ISSN: 01616420 15494713

Stephanie J. Loomis; Jae H. Kang; Robert N. Weinreb; Brian L. Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Brian W. Kunkle; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs

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January 29, 2014

Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication

PLoS ONE, ISSN: 19326203

Michael Degtyarev; Mike Reichelt; Kui Lin

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January 22, 2014

Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Tetrahedron Letters, ISSN: 00404039 18733581

Olivier René; Benjamin P. Fauber

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January 17, 2014

Practical nonazide synthesis of a D-amino acid oxidase inhibitor via a sequential erlenmeyer-plöchl reaction and ligand-free copper(I) amination protocol

Organic Process Research and Development, ISSN: 1520586X 10836160

Hang Zhao; Stefan G. Koenig; John W. Dankwardt; Surendra P. Singh

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January 17, 2014

An efficient catalytic asymmetric synthesis of a β2-amino acid on multikilogram scale

Organic Process Research and Development, ISSN: 1520586X 10836160

Travis Remarchuk; Srinivasan Babu; Jeffrey Stults; Antonio Zanotti-Gerosa; Stephen Roseblade; Shaohui Yang; Ping Huang; Chunbo Sha; Youchu Wang

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January 16, 2014

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

Oncogene, ISSN: 09509232 14765594

Veerendra Munugalavadla; Sanjeev Mariathasan; Dionysos S. Slaga; Du; Berry; Geoffrey Del Rosario; Yibing Yan; Boe; Liping L. Sun; Lori S. Friedman; Chesi; P. Lief Bergsagel; Allen Ebens

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January 16, 2014

Th17 cells at the crossroads of autoimmunity, inflammation, and atherosclerosis

Immunity, ISSN: 10747613 10974180

Nicholas Vanbruggen; Wenjun Ouyang

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January 15, 2014

Chk1 inhibition in p53 deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death

Cell Cycle, ISSN: 15514005 15384101

Christopher J. Del Nagro; Jonathan Choi; Yang Xiao; Linda Rangell; Sankar Mohan; Ajay Pandita; Jiping Zha; Peter K Jackson; Thomas O'Brien

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January 15, 2014

Dual targeting of HER2-positive cancer with trastuzumab emtansine and pertuzumab: Critical role for neuregulin blockade in antitumor response to combination therapy

Clinical Cancer Research, ISSN: 10780432 15573265

Gail L. Phillips; Carter Fields; Guangmin Li; Dowbenko; Gabriele Schaefer; Kathy Miller; Fabrice Andre; Howard A. Burris; Kathy S. Albain; Nadia Harbeck; Diéras; Diana Crivellari; Liang Fang; Ellie Guardino; Steve Olsen; Lisa Crocker; Mark X. Sliwkowski

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January 15, 2014

Inhibition of c-kit is not required for reversal of hyperglycemia by imatinib in NOD mice

PLoS ONE, ISSN: 19326203

Janet Lau; Qiang Zhou; Susan E. Sutton; Ann E. Herman; Christian Schmedt; Richard Glynne

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January 15, 2014

Future directions in idiopathic pulmonary fibrosis research an NHLBI workshop report

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Timothy S. Blackwell; Andrew M. Tager; Zea Borok; Bethany B. Moore; David A. Schwartz; Kevin J. Anstrom; Ziv Bar-Joseph; Peter Bitterman; Michael R. Blackburn; Williamson Bradford; Kevin K. Brown; Harold A. Chapman; Harold R. Collard; Gregory P. Cosgrove; Robin Deterding; Ramona Doyle; Kevin R. Flaherty; Christine Kim Garcia; James S. Hagood; Craig A. Henke; Erica Herzog; Cory M. Hogaboam; Jeffrey C. Horowitz; Talmadge E. King Jr.; James E. Loyd; William E. Lawson; Clay B. Marsh; Paul W. Noble; Imre Noth; Dean Sheppard; Julie Olsson; Luis A. Ortiz; Thomas G. O'Riordan; Tim D. Oury; Ganesh Raghu; Jesse Roman; Patricia J. Sime; Thomas H. Sisson; Daniel Tschumperlin; Shelia M. Violette; Timothy E. Weaver; Rebecca G. Wells; Eric S. White; Naftali Kaminski; Fernando J. Martinez; Thomas A. Wynn; Victor J. Thannickal; Jerry P. Eu

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January 15, 2014

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Biochemical Journal, ISSN: 02646021 14708728

James M. Murphy; Qingwei Zhang; Samuel N. Young; Michael L. Reese; Fiona P. Bailey; Patrick A. Eyers; Daniela Ungureanu; Henrik Hammaren; Olli Silvennoinen; Leila N. Varghese; Kelan Chen; Anne Tripaydonis; Natalia Jura; Koichi Fukuda; Jun Qin; Zachary Nimchuk; Mary Beth Mudgett; Sabine Elowe; Christine L. Gee; Ling Liu; Roger J. Daly; Gerard Manning; Jeffrey J. Babon; Isabelle S. Lucet

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January 10, 2014

Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Yingnan Zhang; Eigenbrot; Lijuan Zhou; Steven Shia; Wei Li; Quan; Jeffrey Tom; Paul Moran; Paola Di Lello; Nicholas J. Skelton; Monica Kong-Beltran; Andrew S. Peterson; Daniel Kirchhofer

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January 9, 2014

Small molecule disruptors of the Glucokinase-Glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Kate S. Ashton; Kristin L. Andrews; Marian C. Bryan; Jie Chen; Kui Chen; Michelle Chen; Samer Chmait; Michael Croghan; Rod Cupples; Christopher Fotsch; Joan Helmering; Steve R. Jordan; Robert J. M. Kurzeja; Klaus Michelsen; Lewis D. Pennington; Steve F. Poon; Glenn Sivits; Gwyneth Van; Steve L. Vonderfecht; Robert C. Wahl; Jiandong Zhang; David J. Lloyd; Clarence Hale; David J. St. Jean

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