Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6501 - 6550 OF 15578 RESULTS

January 7, 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Nature, ISSN: 00280836 14764687

Yukinori Okada; Di Wu; Gosia Trynka; Towfique Raj; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Shinji Yoshida; Robert R. Graham; Arun Manoharan; Ward Ortmann; Tushar Bhangale; Joshua C. Denny; Robert J. Carroll; Anne E. Eyler; Greenberg; Joel M. Kremer; Dimitrios A. Pappas; Lei Jiang; Jian Yin; Lingying Ye; Ding-Feng Su; Jian Yang; Gang Xie; Edward Keystone; Harm-Jan Westra; Toñu Esko; Andres Metspalu; Xuezhong Zhou; Namrata Gupta; Daniel B. Mirel; Eli A. Stahl; Dorothée Diogo; Jing Cui; Katherine P. Liao; Michael H. Guo; Keiko Myouzen; Takahisa Kawaguchi; Marieke J.H. Coenen; Piet L.C.M. Van Riel; Mart A. F. J. Van De Laar; Henk-Jan Guchelaar; Tom W. J. Huizinga; Philippe Dieudé; Xavier Mariette; S. Louis Bridges Jr.; Alexandra Zhernakova; Toes; Paul P. Tak; Corinne Miceli-Richard; So-Young Bang; Hye-Soon Lee; Javier Martin; Miguel A. Gonzalez-Gay; Luis Rodriguez-Rodriguez; Solbritt Rantapää-Dahlqvist; Lisbeth Ärlestig; Hyon Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Steve Eyre; John Bowes; Anne Barton; Niek De Vries; Larry W. Moreland; Lindsey A. Criswell; Elizabeth W. Karlson; Atsuo Taniguchi; Ryo Yamada; Michiaki Kubo; Jun S. Liu; Sang-Cheol Bae; Jane Worthington; Leonid Padyukov; Lars Klareskog; Peter K. Gregersen; Soumya Raychaudhuri; Barbara E. Stranger; Philip L. De Jager; Lude Franke; Peter M. Visscher; Matthew A. Brown; Hisashi Yamanaka; Tsuneyo Mimori; Atsushi Takahashi; Huji Xu; Timothy W. Behrens; Katherine A. Siminovitch; Shigeki Momohara; Fumihiko Matsuda; Kazuhiko Yamamoto; Robert M. Plenge

January 7, 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Nature, ISSN: 00280836 14764687

Cecilia M. Lindgren; Di Wu; Gosia Trynka; Towfique Raj; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Shinji Yoshida; Robert R. Graham; Arun Manoharan; Ward Ortmann; Tushar Bhangale; Joshua C. Denny; Robert J. Carroll; Anne E. Eyler; Greenberg; Joel M. Kremer; Dimitrios A. Pappas; Lei Jiang; Jian Yin; Lingying Ye; Ding-Feng Su; Jian Yang; Gang Xie; Edward Keystone; Harm-Jan Westra; Toñu Esko; Andres Metspalu; Xuezhong Zhou; Namrata Gupta; Daniel B. Mirel; Eli A. Stahl; Dorothée Diogo; Jing Cui; Katherine P. Liao; Michael H. Guo; Keiko Myouzen; Takahisa Kawaguchi; Marieke J.H. Coenen; Piet L.C.M. Van Riel; Mart A. F. J. Van De Laar; Henk-Jan Guchelaar; Tom W. J. Huizinga; Philippe Dieudé; Xavier Mariette; S. Louis Bridges Jr.; Alexandra Zhernakova; Toes; Paul P. Tak; Corinne Miceli-Richard; So-Young Bang; Hye-Soon Lee; Javier Martin; Miguel A. Gonzalez-Gay; Luis Rodriguez-Rodriguez; Solbritt Rantapää-Dahlqvist; Lisbeth Ärlestig; Hyon Choi; Yoichiro Kamatani; Pilar Galan; Mark Lathrop; Steve Eyre; John Bowes; Anne Barton; Niek De Vries; Larry W. Moreland; Lindsey A. Criswell; Elizabeth W. Karlson; Atsuo Taniguchi; Ryo Yamada; Michiaki Kubo; Jun S. Liu; Sang-Cheol Bae; Jane Worthington; Leonid Padyukov; Lars Klareskog; Peter K. Gregersen; Soumya Raychaudhuri; Barbara E. Stranger; Philip L. De Jager; Lude Franke; Peter M. Visscher; Matthew A. Brown; Hisashi Yamanaka; Tsuneyo Mimori; Atsushi Takahashi; Huji Xu; Timothy W. Behrens; Katherine A. Siminovitch; Shigeki Momohara; Fumihiko Matsuda; Kazuhiko Yamamoto; Robert M. Plenge

January 7, 2014

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Allen A. Thomas; Kevin W. Hunt; Matthew Volgraf; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Douglas Sammond; Tony P. Tang; Susan P. Rhodes; Andrew T. Metcalf; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos; Indrani W. Gunawardana

January 6, 2014

Diagnosis-driven individualization of cancer care

The Bethesda Handbook of Clinical Oncology: Fourth Edition,

Philippe C. Bishop; Chris J. Bowden; Garret M. Hampton; Lukas Amler

January 6, 2014

Defining the ligand specificity of the Deleted in Colorectal Cancer (DCC) receptor

PLoS ONE, ISSN: 19326203

Patrick C. G. Haddick; Irene Tom; Luis; Gabriel Quinones; Bernd Wranik; Sree R. Ramani; Jean-Philippe Stephan; Marc Tessier-Lavigne; Lino C. Gonzalez Jr.

January 6, 2014

Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model

BMC Complementary and Alternative Medicine, ISSN: 14726882

Cin Kong; Wageeh A. Yehye; Noorsaadah Abd Rahman; Man-Wah Tan; Sheila Nathan

January 5, 2014

Long-term depression: A cell biological view

Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 14712970 09628436

Morgan Sheng; Ali Ertürk

January 2, 2014

A versatile annulation route to primary-amino-substituted naphthyridine esters

Synlett, ISSN: 09365214 14372096

Jinhua Chen; Zijin Xu; Tao Wang; Joseph P. Lyssikatos; Chudi O. Ndubaku

January 2, 2014

Depressive, functional status, and neuropsychiatric symptom trajectories before an Alzheimer's disease diagnosis

Aging and Mental Health, ISSN: 13607863 13646915

Joseph E. Gaugler; Martha Hovater; David L. Roth; Joseph A. Johnston; Robert L. Kane; Khaled Sarsour

January 1, 2014

A20-a bipartite ubiquitin editing enzyme with immunoregulatory potential

Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598

Ingrid E. Wertz; Vishva M. Dixit

January 1, 2014

Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: An Eastern Cooperative Oncology Group study (E2404)

Leukemia and Lymphoma, ISSN: 10292403 10428194

Kristen Ganjoo; Fangxin Hong; Sandra J. Horning; Randy D. Gascoyne; Yasodha Natkunam; Lode J. Swinnen; Thomas M. Habermann; Wojciech Jurczak; Ranjana H. Advani

January 1, 2014

A phase I study of PRO131921, a novel anti-CD20 monoclonal antibody in patients with relapsed/refractory CD20+ indolent NHL: Correlation between clinical responses and AUC pharmacokinetics

Clinical Immunology, ISSN: 15217035 15216616

Carla Casulo; Julie Vose; William Y. Ho; Wojciech Jurczak; Mark Brunvand; Andre Goy; Yvette Kasamon; Bruce D. Cheson; Jonathan W. Friedberg

January 1, 2014

Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: An Eastern Cooperative Oncology Group study (E1405)

Blood, ISSN: 15280020 00064971

Julie E. Chang; Hailun Li; Smith; Randy D. Gascoyne; Elisabeth M. Paietta; David T. Yang; Ranjana H. Advani; Sandra J. Horning; Wojciech Jurczak

January 1, 2014

The rheumatoid arthritis treat-to-target trial: A cluster randomized trial within the Corrona rheumatology network

BMC Musculoskeletal Disorders, ISSN: 14712474

Leslie R. Harrold; Reed; J. Timothy Harrington; Christine J. Barr; Katherine C. Saunders; Allan Gibofsky; Jeffrey D. Greenberg; Ani John; Jenny Devenport; Joel M. Kremer

January 1, 2014

Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: Metabolism of nonionizable analogs of tienilic acid

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Suzanne Tay; Hoa Le; Kevin A. Ford; Sidney D. Nelson; S. Cyrus Khojasteh; Peter M. Rademacher

January 1, 2014

Dichotomizing a Continuous Baseline Covariate in Randomized Clinical Trials with Binary Outcomes

Communications in Statistics: Simulation and Computation, ISSN: 15324141 03610918

Boan Zhang; Yunzhi Lin; Zheng Su

January 1, 2014

Steric and electronic factors influence regio-isomeric thiazole formations between substituted benzothioamides and ethyl bromopyruvate

Journal of Heterocyclic Chemistry, ISSN: 19435193 0022152X

Jun Liang; Valerie Dorman Soucy; Vickie Tusi; Yanzhou Liu; Birong Zhang; Yingjie Lai; Steven Magnuson; Bing-Yan Zhu; Fangdao Wang; Jinghao Gu; Qingfen Zhang; Yuan Wu; Wei Deng; Wenqian Yang

January 1, 2014

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Bhagwat Prasad; Raymond Evers; Anshul Gupta; Cornelis E. Hop; Laurent Salphati; Suneet Shukla; Suresh V. Ambudkar; Jashvant D. Unadkat

January 1, 2014

Molecular beacons for intracellular analysis: Challenges and successes

Molecular Beacons,

Colin D. Medley; Zhi Zhu

January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

January 1, 2014

Etrolizumab as induction therapy for ulcerative colitis: A randomised, controlled, phase 2 trial

The Lancet, ISSN: 1474547X 01406736

Séverine Vermeire; Sharon O'Byrne; Mary E. Keir; Marna Williams; Timothy T. Lu; John C Mansfield; Christopher A. Lamb; Brian G. Feagan; Julián Panés; Azucena Salas; Daniel C. Baumgart; Stefan Schreiber; Iris Dotan; William J. Sandborn; Tew; Diana Luca; Meina Tao Tang; Laurie Diehl; Jeffrey Eastham-Anderson; Gert De Hertogh; Clementine Perrier; Jackson G. Egen; John A. Kirby; Gert Van Assche; Paul J. Rutgeerts

January 1, 2014

Multiplexed ion beam imaging of human breast tumors

Nature Medicine, ISSN: 1546170X 10788956

Michael Angelo; Sean C. Bendall; Rachel Finck; Matthew B. Hale; Chuck Hitzman; Alexander D. Borowsky; Richard M. Levenson; John Lowe; Scot D. Liu; Shuchun Zhao; Yasodha Natkunam; Garry P. Nolan

January 1, 2014

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Heidi J. A. Wallweber; Christine Tam; Yvonne Franke; Melissa A. Starovasnik; Patrick J. Lupardus

January 1, 2014

Model-based meta-analysis for quantifying paclitaxel dose response in cancer patients

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Amita Joshi; Li; Nancy Zhang; Melanie Ren; Yuying Gao; Russell D. Wada; Jin Y. Jin

January 1, 2014

Byproducts of commonly used coupling reagents: Origin, toxicological evaluation and methods for determination

American Pharmaceutical Review, ISSN: 10998012

Larry Wigman; Travis Remarchuk; Stephen Gomez; Archana Kumar; Michael W. Dong; Colin D. Medley; Nik P. Chetwyn

January 1, 2014

New FDA draft guidance on immunogenicity

AAPS Journal, ISSN: 15507416

Ashwin Parenky; Heather Myler; Lakshmi Amaravadi; Karoline Bechtold-Peters; Amy Rosenberg; Susan Kirshner; Quarmby

January 1, 2014

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility, and interindividual variability

Endocrinology, ISSN: 19457170 00137227

Zhican Wang; Timothy Wong; Takanori Hashizume; Leslie Dickmann; Michele Scian; Nicholas J. Koszewski; Jesse P. Goff; Ronald L. Horst; Amarjit S. Chaudhry; Erin G. Schuetz; Kenneth E. Thummel

January 1, 2014

Change notifications for single use components: Criteria from an end user perspective

Pharmaceutical Engineering, ISSN: 02738139

Sally Kline; Ekta Mahajan; Darrell Morrow; Bob Steininger; Nancy Sweeney; Russell Wong

January 1, 2014

Sleeping our Alzheimer's risk away

Journal of Experimental Medicine, ISSN: 15409538 00221007

Ryan J. Watts

January 1, 2014

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

Science, ISSN: 10959203 00368075

Kim Newton; Dugger; Katherine E. Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ron Ferrando; French; Webster; Merone Roose-Girma; Søren Warming; Vishva M. Dixit

January 1, 2014

Evaluation of two commercial omalizumab/free IgE immunoassays: Implications of use during therapy

Current Medical Research and Opinion, ISSN: 14734877 03007995

Baker; Kun Peng; Melissa Cheu; Saloumeh Kadkhodayan Fischer

January 1, 2014

CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

Mucosal Immunology, ISSN: 19353456 19330219

Moshkovits; Shik; Itan; Karo-Atar; Bernshtein; Hershko; Menno Van Lookeren Campagne; Munitz

January 1, 2014

Administration of Anti-CD20 mAb Is Highly Effective in Preventing but Ineffective in Treating Chronic Graft-Versus-Host Disease While Preserving Strong Graft-Versus-Leukemia Effects

Biology of Blood and Marrow Transplantation, ISSN: 15236536 10838791

Heather F. Johnston; Yajing Xu; Jeremy J. Racine; Kaniel Cassady; Xiong Ni; Tao Wu; Andrew A. Chan; Stephen Forman; Defu Zeng

January 1, 2014

A mechanistic systems pharmacology model for prediction of LDL cholesterol lowering by PCSK9 antagonism in human dyslipidemic populations

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kapil Gadkar; Nageshwar Budha; Amos Baruch; John Davis; Fielder; Ramanujan

January 1, 2014

When assay format matters: A case study on the evaluation of three assay formats to support a clinical pharmacokinetic study

AAPS Journal, ISSN: 15507416

Kun Peng; Baker; Suzanne Brignoli; Janis Cabuhat; Saloumeh Kadkhodayan Fischer

January 1, 2014

Interrogation of in vivo protein-protein interactions using transgenic mouse models and stable isotope labeling

Methods in Molecular Biology, ISSN: 10643745

Anwesha Dey; Jiansheng Wu; Donald S. Kirkpatrick

January 1, 2014

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms

Journal of Neuroscience, ISSN: 15292401 02706474

Ali Ertürk; Yuanyuan Wang; Morgan Sheng

January 1, 2014

Mechanisms of age-related macular degeneration and therapeutic opportunities

Journal of Pathology, ISSN: 00223417 10969896

Menno Van Lookeren Campagne; Jennifer Lecouter; Brian L. Yaspan; Weilan Ye

January 1, 2014

Ubiquitin in inflammation: The right linkage makes all the difference

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Jacob E. Corn; Domagoj Vucic

January 1, 2014

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Andriy Kryshtafovych; John Moult; Patrick Bales; J.Fernando Bazan; Marco Biasini; Alex Burgin; Chen Chen; Frank V. Cochran; Timothy K. Craig; Rhiju Das; Deborah Fass; Carmela Garcia-Doval; Osnat Herzberg; Donald Lorimer; Hartmut Luecke; Xiaolei Ma; Daniel C. Nelson; Mark J. van Raaij; Forest Rohwer; Anca Segall; Victor Seguritan; Kornelius Zeth; Torsten Schwede

January 1, 2014

Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics

Journal of Immunological Methods, ISSN: 18727905 00221759

Boris Gorovits; Eric Wakshull; Renuka Pillutla; Yuanxin Xu; Marta Starcevic Manning; Jaya Goyal

January 1, 2014

Matrix-assisted laser desorption/ionization time-of-flight mass analysis of peptides

Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343663 19343655

Wendy N. Sandoval

January 1, 2014

β-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells

Journal of Leukocyte Biology, ISSN: 19383673 07415400

Xinjun Liang; Chunmei Fu; Weiguo Cui; Julia L. Ober-Blöbaum; Sonja P. Zahner; Protul A. Shrikant; Björn E. Clausen; Richard A. Flavell; Ira Mellman; Aimin Jiang

January 1, 2014

Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Russell D. Wada; Hans Erickson; Gail L. Phillips; Carmela A. Provenzano; Douglas Leipold; Elaine Mai; Holly A. Johnson; Jay Tibbitts

January 1, 2014

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

mAbs, ISSN: 19420870 19420862

Bing Li; Ashley Fouts; Katharina F. Stengel; Patricia Luhn; Michael Dillon; Wei-Ching Liang; Becket Feierbach; Robert F. Kelley; Isidro Hötzel

January 1, 2014

MHC associations with clinical and autoantibody manifestations in European SLE

Genes and Immunity, ISSN: 14765470 14664879

David L. Morris; Michelle M.A. Fernando; Kimberly E. Taylor; Sharon A. Chung; Joanne Nititham; Marta E. Alarcón-Riquelme; Lisa F. Barcellos; Timothy W. Behrens; Chris Cotsapas; Patrick M. Gaffney; Robert R. Graham; Bernardo A. Pons-Estel; Peter K. Gregersen; John B. Harley; Stephen L. Hauser; Geoffrey Hom; Carl D. Langefeld; Janelle A. Noble; John D. Rioux; Michael F. Seldin; Timothy J. Vyse; Lindsey A. Criswell

January 1, 2014

Therapeutic opportunities of the IL-22-IL-22R1 system

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Robert Sabat; Wenjun Ouyang; Kerstin Wolk

January 1, 2014

Methods for measuring antibody-dependent cell-mediated cytotoxicity in vitro

Methods in Molecular Biology, ISSN: 10643745

Aaron S. Miller; Max L. Tejada; Hélène Gazzano-Santoro

January 1, 2014

Part VII: GMPs for Small-Molecule Drugs in Early Development—Workshop Summary

Pharmaceutical Technology, ISSN: 21507376 15432521

Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

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