Scientists / Publications

Publications

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DISPLAYING 6851 - 6900 OF 15578 RESULTS

2013 White Paper on recent issues in bioanalysis: 'Hybrid' - The best of LBA and LCMS
Bioanalysis, ISSN: 17576180 17576199
Lauren Stevenson; Fabio Garofolo; Binodh DeSilva; Isabelle Dumont; Suzanne Martinez; Mario Rocci; Lakshmi Amaravadi; Margarete Brudny-Kloeppel; Adrien Musuku; Brian Booth; Catherine Dicaire; Laura Wright; Laurence Mayrand-Provencher; Mike Losauro; Dominique Gouty; Mark Arnold; Surendra Bansal; Sherri Dudal; Dawn Dufield; Jeff Duggan; Christopher Evans; Eric Fluhler; Stephanie Fraser; Boris Gorovits; Sam Haidar; Roger Hayes; Stacy Ho; Richard Houghton; Rafiqul Islam; Rand Jenkins; Noriko Katori; Surinder Kaur; Marian Kelley; Magnus Knutsson; Jean W. Lee; Hanlan Liu; Steve Lowes; Mark Ma; Alvydas Mikulskis; Heather Myler; Bob Nicholson; Timothy Olah; Eric Ormsby; Shefali Patel; Vincenzo Pucci; Chad Ray; Gary Schultz; Judy Shih; Ronald Shoup; Craig Simon; An Song; João Tavares Neto; Valerie Theobald; Theingi Thway; Jason Wakelin-Smith; Jian Wang; Laixin Wang; Jan Welink; Emma Whale; Eric Woolf; Raymond Xu
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Patterns of delivery of chemoimmunotherapy to patients with follicular lymphoma in the United States: Results of the National LymphoCare Study
Cancer, ISSN: 0008543X 10970142
Peter Martin; Michelle Byrtek; Keith Dawson; Ryan Ziemiecki; Jonathan W. Friedberg; James R. Cerhan; Christopher R. Flowers; Brian K. Link
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Modulating caspase activity: Beyond the active site
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Jeremy Murray; Adam R. Renslo
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The role of ubiquitination in TWEAK-stimulated signaling
Frontiers in Immunology, ISSN: 16643224
Domagoj Vucic
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Allosteric inhibition of BACE1 by an exosite-binding antibody
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Weiru Wang; Yichin Liu; Lazarus
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Regulation of deubiquitinase proteolytic activity
Current Opinion in Structural Biology, ISSN: 0959440X 1879033X
Oscar W Huang; Andrea G Cochran
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IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity
Journal of Experimental Medicine, ISSN: 00221007 15409538
Giorgia Simonetti; Amanda Carette; Kathryn Silva; Haowei Wang; Nilushi S. De Silva; Nicole Heise; Christian W. Siebel; Mark J. Shlomchik; Ulf Klein
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Erratum: Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes (Current Atherosclerosis Reports (2013) 15:6 (327) DOI: 10.1007/s11883-013-0327-7)
Current Atherosclerosis Reports, ISSN: 15233804 15346242
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Colin H. Mackinnon; Kevin Lau; Jason D. Burch; Yuan Chen; Jonathon Dines; Xiao Ding; Eigenbrot; Alexander Heifetz; Allan Jaochico; Adam R. Johnson; Joachim Kraemer; Susanne Kruger; Thomas M. Krülle; Marya Liimatta; Justin Ly; Rosemary Maghames; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Steven Shia; Daniel B. Stein; Giancarlo Trani; Darshan G. Vaidya; Xiaolu Wang; Steven M. Bromidge; Lawren C. Wu; Zhonghua Pei
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Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333
Kirsten Achilles Poon; Kelly Flagella; Joseph Beyer; Jay Tibbitts; Surinder Kaur; Ola M. Saad; Joo-Hee Yi; Sandhya Girish; Noel Dybdal; Theresa Reynolds
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Learning and confirming with preclinical studies: Modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Harvey Wong; Stephen Gould; Nageshwar Budha; Darbonne; Edward E. Kadel III; Hank La; Bruno Alicke; Jason S Halladay; Rebecca Erickson; Chia C. Portera; Anthony W. Tolcher; Jeffery R. Infante; Michael Mamounas; Flygare; Cornelis E. Hop; Wayne J. Fairbrother
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Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis
Birth Defects Research Part B - Developmental and Reproductive Toxicology, ISSN: 15429733 15429741
Christopher J. Bowman; William J. Breslin; Anu V. Connor; Pauline L. Martin; Graeme J. Moffat; Lakshmi Sivaraman; M. Belen Tornesi; Simon Chivers
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A phase 1B study of dulanermin in combination with modified FOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer
Clinical Colorectal Cancer, ISSN: 15330028 19380674
Zev A. Wainberg; Wells A. Messersmith; Parvin F. Peddi; Amy V. Kapp; Avi Ashkenazi; Stephanie Royer-Joo; Chia C. Portera; Kozloff
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Potential drug interventions for diabetic retinopathy
Drug Discovery Today, ISSN: 13596446 18785832
Qin Shen; Jim Zhen Wu; Jason C. Wong
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On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744
Leonid M. Berezhkovskiy; Susan C. Wong; Jason S Halladay
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Ferumoxytol enhanced resting state fMRI and relative cerebral blood volume mapping in normal human brain
NeuroImage, ISSN: 10538119 10959572
Helen D'Arceuil; Alexandre Coimbra; Pamela Triano; Margaret Dougherty; Julie Mello; Michael Moseley; Gary Glover; Maarten Lansberg; Francis Blankenberg
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PTEN loss mitigates the response of medulloblastoma to hedgehog pathway inhibition
Cancer Research, ISSN: 00085472 15387445
Ciara Metcalfe; Bruno Alicke; Ailey Crow; Marlea Lamoureux; Gerrit J. P. Dijkgraaf; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage
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A novel method for high throughput lipophilicity determination by microscale shake flask and liquid chromatography tandem mass spectrometry
Combinatorial Chemistry and High Throughput Screening, ISSN: 13862073 18755402
Baiwei Lin; Joseph H. Pease
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Endocytosis and cancer
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Ira Mellman; Yarden
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Pharmacokinetic interactions between lersivirine and zidovudine, tenofovir disoproxil fumarate/ emtricitabine and abacavir/lamivudine
Antiviral Therapy, ISSN: 13596535 20402058
Manoli Vourvahis; John Davis; Grant Langdon; Gary Layton; Juanzhi Fang; Heng Wee Choo; Arne G. Hansson; Margaret Tawadrous
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Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Stanley A. Roberts; Paul A. Andrews; Diann Blanset; Kelly Flagella; Boris Gorovits; Carmel M. Lynch; Pauline L. Martin; Kimberly Kramer-Stickland; Stephane Thibault; Garvin Warner
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Process lifecycle validation: Applying risk management
BioPharm International, ISSN: 1542166X 19391862
Anurag S. Rathore; Scott Bozzone; A. Hamid Mollah
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Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Nandini C. Patel; Jacob B. Schwarz; Xinjun J. Hou; Dennis J. Hoover; Longfei Xie; Anton J. Fliri; Randall J. Gallaschun; John T. Lazzaro; Dianne K. Bryce; William E. Hoffmann; Ashley N. Hanks; Dina F. McGinnis; Eric S. Marr; Justin L. Gazard; Mihály Hajós; Renato J. Scialis; Raymond S. Hurst; Christopher L. Shaffer; Jayvardhan Pandit; Christopher J. O'Donnell
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Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Donald S. Kirkpatrick; Daisy J. Bustos; Taner Dogan; Jocelyn Chan; Lilian Phu; Amy Young; Lori S. Friedman; Marcia Belvin; Qinghua Song; Corey Bakalarski; Klaus P. Hoeflich
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A Nobel Prize for membrane traffic: Vesicles find their journey's end
Journal of Cell Biology, ISSN: 00219525 15408140
Ira Mellman; Scott D. Emr
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RASIP1 regulates vertebrate vascular endothelial junction stability through EPAC1-RAP1 signaling
Blood, ISSN: 15280020 00064971
Christopher W. Wilson; Leon Parker; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Merone Roose-Girma; Søren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christian S. Lobsiger; Severine Boillée; Christine Pozniake; Amir M. Khan; Melissa McAlonis-Downes; Joe Lewcock; Don W. Cleveland
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Subcutaneous versus intravenous administration of rituximab: Pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys
PLoS ONE, ISSN: 19326203
Cheng-Ping Mao; Martin R. Brovarney; Karim Dabbagh; Herbert F. Birnböck; Wolfgang F. Richter; Christopher J. Del Nagro
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Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755
David Spigel; Thomas J. Ervin; Rodryg Ramlau; Davey B Daniel; Jerome H Goldschmidt; George R. Blumenschein; Maciej J Krzakowski; Gilles Robinet; Benoit Godbert; Fabrice Barlesi; Ramaswamy Govindan; Taral Patel; Sergey Orlov; Michael Wertheim; Wei Yu; Jiping Zha; Robert Yauch; Premal Patel; See Phan; Amy Peterson
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Improved crystallographic structures using extensive combinatorial refinement
Structure, ISSN: 09692126 18784186
Jerome C. Nwachukwu; Mark R. Southern; James R. Kiefer; Pavel V. Afonine; Paul D. Adams; Thomas C. Terwilliger; Kendall W. Nettles
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Systemic concentrations can limit the oral absorption of poorly soluble drugs: An investigation of non-sink permeation using physiologically based pharmacokinetic modeling
Molecular Pharmaceutics, ISSN: 15438384 15438392
Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong
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Characterization of a water-solid interaction in a partially ordered system
Molecular Pharmaceutics, ISSN: 15438384 15438392
Paroma Chakravarty; Joseph W. Lubach
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Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects
Molecular Pharmaceutics, ISSN: 15438384 15438392
Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser
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Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Molecular Pharmaceutics, ISSN: 15438384 15438392
Marc R. Yago; Adam Frymoyer; Gillian S. Smelick; Lynda A. Frassetto; Nageshwar Budha; Mark J. Dresser; Joseph A. Ware; Leslie Z. Benet
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Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph W. Lubach; Jacob Z. Chen; Jonathan Hau; Jose Imperio; Melis Coraggio; Lichuan Liu; Harvey Wong
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Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
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Physical chemical drug-drug interactions from drug discovery to registration: New opportunities for the pharmaceutical scientist to impact drug development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel
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Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: Bench to bedside investigation of pH-dependent solubility
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel; Jin Y. Jin; Jackson D. Pellett; Gillian S. Smelick; David A. West; Laurent Salphati; Xiao Ding; Rebecca Sutton; Jane Fridyland; Mark J. Dresser; Glenn Morrisson; Scott N. Holden
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Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs - Reversing the effect of elevated gastric pH with betaine HCl
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jodie Pang; Gena Dalziel; Brian J. Dean; Joseph A. Ware; Laurent Salphati
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More myths in ultrahigh-pressure liquid chromatography
LC-GC Europe, ISSN: 14716577
Michael W. Dong
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Journal of Experimental Medicine, ISSN: 00221007 15409538
Omar Abdel-Wahab; Jie Gao; Mazhar Adli; Anwesha Dey; Thomas Trimarchi; Young Rock Chung; Cem Kuscu; Todd Hricik; Delphine Ndiaye-Lobry; Lindsay M. LaFave; Richard Koche; Alan H. Shih; Olga A. Guryanova; Eunhee Kim; Sheng Li; Suveg Pandey; Joseph Y. Shin; Leon Telis; Jinfeng Liu; Parva K. Bhatt; Sebastien Monette; Xinyang Zhao; Christopher E Mason; Christopher Y. Park; Bradley E. Bernstein; Iannis Aifantis; Ross L. Levine
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Nature Neuroscience, ISSN: 10976256 15461726
David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein
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Two-dimensional HPLC in pharmaceutical analysis
American Pharmaceutical Review, ISSN: 10998012
Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn
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Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation
Biotechnology Progress, ISSN: 87567938 15206033
Joseph Wood; Ekta Mahajan; Masaru Shiratori
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Clinical applications of palifermin: Amelioration of oral mucositis and other potential indications
Journal of Cellular and Molecular Medicine, ISSN: 15821838
Saroj Vadhan-Raj; Jenna D. Goldberg; Miguel-Angel Perales; Dietmar P. Berger; Marcel R.M. van den Brink
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Erratum: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (Journal of Inherited Metabolic Disease DOI: 10.1007/s10545-012-9561-3)
Journal of Inherited Metabolic Disease, ISSN: 01418955 15732665
Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales
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Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct
Developmental Dynamics, ISSN: 10588388 10970177
Yoko Inès Nozawa; Erica Yao; Chuwen Lin; Jehn-Hsiahn Yang; Christopher W. Wilson; Rhodora Gacayan; Pao-Tien Chuang
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A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Peter N. Morcos; Linda Chang; Rohit Kulkarni; Mylene Giraudon; Nancy Shulman; Barbara J. Brennan; Patrick F. Smith; Jonathan Q. Tran
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Age distribution of patients with advanced non-melanoma skin cancer in the United States
Archives of Dermatological Research, ISSN: 03403696 1432069X
Stacey Dacosta Byfield; Diana M. Chen; Yeun Mi Yim; Carolina Reyes
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Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Bradley J. Newhouse; Steve Wenglowsky; Jonas Grina; Ellen R. Laird; Walter C. Voegtli; Li Ren; Kateri Ahrendt; Alexandre J. Buckmelter; Susan L. Gloor; Nathalie Klopfenstein; Joachim Rudolph; Zhaoyang Wen; Xianfeng Li; Bainian Feng
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