Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6901 - 6950 OF 15578 RESULTS

November 1, 2013

A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials

Contemporary Clinical Trials, ISSN: 15517144 15592030

Wei Zhong; Joseph S. Koopmeiners; Bradley P. Carlin

November 1, 2013

Using registries to identify adverse events in rheumatic diseases

Pediatrics, ISSN: 00314005 10984275

Geraldina Lionetti; Yukiko Kimura; Laura E. Schanberg; Timothy Beukelman; Carol A. Wallace; Norman T. Ilowite; Jane Winsor; Kathleen Fox; Marc Natter; John S. Sundy; Eric Brodsky; Jeffrey R. Curtis; Vincent Del Gaizo; Solomon Iyasu; Angelika Jahreis; Ann Meeker-O'connell; Barbara B. Mittleman; Bernard M. Murphy; Eric D. Peterson; Sandra C. Raymond; Soko Setoguchi; Jeffrey N. Siegel; Rachel E. Sobel; Daniel Solomon; Taunton R. Southwood; Richard Vesely; Patience H. White; Nico M. Wulffraat; Christy I. Sandborg

November 1, 2013

Population pharmacokinetic analysis from phase i and phase ii studies of the humanized monovalent antibody, onartuzumab (metmab), in patients with advanced solid tumors

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Yan Xin; Denise Jin; Stephen M. Eppler; Lisa A. Damico; Amita Joshi; John Davis; Surinder Kaur; Ihsan Nijem; John Bothos; Amy Peterson; Premal Patel; Shuang Bai

November 1, 2013

Sample size and threshold estimation for clinical trials with predictive biomarkers

Contemporary Clinical Trials, ISSN: 15517144 15592030

Howard M. Mackey; Thomas Bengtsson

November 1, 2013

Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel

Anti-Cancer Drugs, ISSN: 09594973 14735741

Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga

November 1, 2013

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

Acta Neuropathologica, ISSN: 00016322 14320533

Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus

November 1, 2013

Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography

Biotechnology Progress, ISSN: 87567938 15206033

Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel

November 1, 2013

Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments

Journal of Chromatography A, ISSN: 18733778 00219673

Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete

November 1, 2013

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

Journal of Experimental Medicine, ISSN: 00221007 15409538

Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock

November 1, 2013

ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller

November 1, 2013

Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum

November 1, 2013

Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X

Glen Giese; Adam Myrold; Gorrell; Josefine Persson

November 1, 2013

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak

November 1, 2013

Vehicle selection for nonclinical oral safety studies

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607

Evan A Thackaberry

October 24, 2013

IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes

PLoS ONE, ISSN: 19326203

Yaiza Diaz-de-Durana; Janet Lau; Deborah Knee; Christophe Filippi; Marco Londei; Peter McNamara; Marc Nasoff; Michael Didonato; Richard Glynne; Ann E. Herman

October 23, 2013

Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

Tetrahedron Letters, ISSN: 00404039 18733581

Malcolm P. Huestis; Wendy Liu; Matthew Volgraf; Hans E. Purkey; Christine Yu; Weiru Wang; Darin Smith; Guy Vigers; Darrin Dutcher; Kevin W. Hunt; Michael Siu

October 22, 2013

Methylglyoxal Evokes Pain by Stimulating TRPA1

PLoS ONE, ISSN: 19326203

David A. Andersson; Clive Gentry; Emily Light; Nisha Vastani; Julie Vallortigara; Angelika Bierhaus; Thomas Fleming; Stuart Bevan

October 18, 2013

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism

Journal of Experimental Medicine, ISSN: 00221007 15409538

Nathan E. Welty; Christopher Staley; Nico Ghilardi; Michael J. Sadowsky; Botond Z. Igyártó; Daniel H. Kaplan

October 18, 2013

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

Journal of Cell Science, ISSN: 00219533 14779137

Abitha Jacob; Jian Jing; James Lee; Pepper Schedin; Simon M. Gilbert; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris

October 18, 2013

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Journal of Experimental Medicine, ISSN: 00221007 15409538

Adriana Soler; Helena Serra; Wayne Pearce; Ana Angulo; Julie Guillermet-Guibert; Lori S. Friedman; Francesc Viñals; Holger Gerhardt; Oriol Casanovas; Mariona Graupera; Bart Vanhaesebroeck

October 16, 2013

Incidence of catheter-related complications in patients with central venous or hemodialysis catheters: A health care claims database analysis

BMC Cardiovascular Disorders, ISSN: 14712261

Pavel Napalkov; Diana M. Felici; Laura Chu; Joan R. Jacobs; Susan M. Begelman

October 16, 2013

Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay

BMC Bioinformatics, ISSN: 14712105

Gregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber

October 16, 2013

Investigation into temperature-induced aggregation of an antibody drug conjugate

Bioconjugate Chemistry, ISSN: 15204812 10431802

Nia S. Beckley; Kathlyn P. Lazzareschi; Hung-Wei Chih; Vikas Sharma; Heather Flores

October 16, 2013

Managing technologies in a global drug substance biotech manufacturing network - A case study

Pharmaceutical Outsourcing, ISSN: 19453337

Michael Pohlscheidt; Eric Fallon; David Chang; Dan Stark; Frank Trach

October 16, 2013

IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis

BMJ Open, ISSN: 20446055

Jianmei Wang; Adam Platt; Ruchi Upmanyu; Søren Germer; Guiyuan Lei; Christina Rabe; Ryma Benayed; Andrew Kenwright; Andrew Hemmings; Mitchell Martin; Olivier Harari

October 16, 2013

Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

C. Andrew Boswell; Jan Marik; Michael J. Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Bumbaca; Victor Yip; Eduardo E. Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha N. Goriparthi; Anthony Trias; Herman S. Gill; Simon P. Williams; Jagath R. Junutula; Fielder; Leslie A. Khawli

October 15, 2013

EGFR-activating mutations correlate with a fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity

Cancer Research, ISSN: 00085472 15387445

Heike N. Pfaäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H. Benes; Lecia V. Sequist; Lee Zou; Henning Willers

October 15, 2013

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Yingchun Liu; Shiva Malek; David Peterson; Keith Pitts; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Ivana Yen; Qin Yue

October 15, 2013

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Xiaozhang Zheng; Kenneth W. Bair; Paul Bauer; Timm Baumeister; Krista K. Bowman; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Yezhen Feng; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Hong Li; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Justin Ly; Thomas O'Brien; Jason Oeh; Angela Oh; Dominic J. Reynolds; Deepak Sampath; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jarrod Tremayne; Leslie Wang; Weiru Wang; Zhongguo Wang; Hongxing Wu; Jiansheng Wu; Yang Xiao; Guangxing Yang; Po-Wai Yuen; Mark Zak; Peter Dragovich

October 1, 2013

New paradigms for process validation: A practical approach

BioProcess International, ISSN: 15426319

Mire-Sluis; Vijay Chiruvolu; Kelley; Linda Ng; Reb Russell; Chiang Syin; Victor Vinci; Mats Welin; Nathan McKnight; Bob Kuhn; Christian Klock; Ranjit Deshmukh; Siddharth Advant

October 1, 2013

Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Elizabeth M. Blackwood; Jennifer A. Epler; Ivana Yen; Michael Flagella; Thomas O'Brien; Marie Evangelista; Stephen Schmidt; Yang Xiao; Jonathan Choi; Kaska Kowanetz; Judi Ramiscal; Kenton Wong; Diana Jakubiak; Sharon Fong Yee; Cain; Lewis Gazzard; Karen Williams; Jason S Halladay; Peter K Jackson; Shiva Malek

October 1, 2013

A dual host vector for Fab phage display and expression of native IgG in mammalian cells

Protein Engineering, Design and Selection, ISSN: 17410126 17410134

Devin B. Tesar; Isidro Hötzel

October 1, 2013

SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Rebecca R. Pferdehirt; Barbara J. Meyer

October 1, 2013

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins

PLoS Pathogens, ISSN: 15537366 15537374

Wouter L. W. Hazenbos; Kimberly K. Kajihara; Richard L. Vandlen; J. Hiroshi Morisaki; Sophie M. Lehar; Mark J. Kwakkenbos; Tim Beaumont; Arjen Q. Bakker; Qui Phung; Lee R. Swem; Satish Ramakrishnan; Janice Kim; Min Xu; Ishita M. Shah; Binh An Diep; Tao Sai; Andrew Sebrell; Yana Khalfin; Angela Oh; Christopher M. Koth; S. Jack Lin; Byoung-Chul Lee; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Hergen Spits; Eric J. Brown; Man-Wah Tan; Sanjeev Mariathasan

October 1, 2013

Considerations for the successful co-development of targeted cancer therapies and companion diagnostics

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Jane Fridlyand; Richard M. Simon; Jessica C. Walrath; Roach; Richard Buller; David P. Schenkein; Keith Flaherty; Jeff D. Allen; Ellen V. Sigal; Scher

October 1, 2013

Spray Drying of Monoclonal Antibodies: Investigating Powder-Based Biologic Drug Substance Bulk Storage

Drying Technology, ISSN: 07373937 15322300

Mayumi Bowen; Robert Turok; Maa

October 1, 2013

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Journal of Clinical Investigation, ISSN: 00219738 15588238

Holly Martin; Raghuveer Singh Mali; Peilin Ma; Anindya Chatterjee; Baskar Ramdas; Emily Sims; Veerendra Munugalavadla; Joydeep Ghosh; Matringly; Valeria Visconte; Ramon V. Tiu; Cornelis P. Vlaar; Suranganie Dharmawardhane; Reuben Kapur

October 1, 2013

The anatomy of successful computational biology software

Nature Biotechnology, ISSN: 10870156 15461696

Stephen Altschul; Barry Demchak; Richard Durbin; Robert Gentleman; Martin Krzywinski; Heng Li; Anton Nekrutenko; James Robinson; Wayne Rasband; James Taylor; Cole Trapnell

October 1, 2013

A high-throughput functional complementation assay for classification of BRCA1 missense variants

Cancer Discovery, ISSN: 21598274 21598290

Peter Bouwman; Hanneke van der Gulden; Ingrid van der Heijden; Rinske Drost; Christiaan N. Klijn; Pramudita Prasetyanti; Mark Pieterse; Ellen Wientjens; Jost Seibler; Frans B.L. Hogervorst; Jos Jonkers

October 1, 2013

Mass spectrometry of antibody-drug conjugates in plasma and tissue in drug development

Characterization of Protein Therapeutics using Mass Spectrometry,

Surinder Kaur; Keyang Xu; Ola M. Saad; Luna Liu; Tim Slattery; Randall Dere

October 1, 2013

Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease

Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036

Gordon; Hamzeh; Pockros; Hoop; Buikema; Korner; Terrault

October 1, 2013

Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36-month results from two phase III trials: RISE and RIDE

Ophthalmology, ISSN: 01616420 15494713

David M. Brown; Quan Dong Nguyen; Dennis Marcus; David S. Boyer; Sunil Patel; Leonard Feiner; Patricio G. Schlottmann; Amy Chen Rundle; Jiameng Zhang; Roman G. Rubio; Anthony P. Adamis; Jason S. Ehrlich; J. Jill Hopkins

October 1, 2013

Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 01676806 15737217

Hope S. Rugo; Adam Brufsky; Marianne Ulcickas Yood; Debasish Tripathy; Peter A. Kaufman; Musa Mayer; Bongin Yoo; Oyewale Abidoye; Denise A. Yardley

October 1, 2013

Bevacizumab confers additional advantage to the combination of trastuzumab plus pertuzumab in trastuzumab-refractory breast cancer model

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Yuliang Sun; Nandini Dey; Melissa Brammer; Pradip De; Brian R. Leyland-Jones

October 1, 2013

In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release

Nature Medicine, ISSN: 10788956 1546170X

Richard H. Scheller

October 1, 2013

B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes

Clinical and Experimental Immunology, ISSN: 00099104 13652249

Rajasekaran; Nan Wang; Hang; Macaubas; Rinderknecht; Beilhack; Shizuru; Mellins

September 27, 2013

The structure and regulation of magnesium selective ion channels

Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642

Jian Payandeh; Roland Pfoh; Emil F. Pai

September 26, 2013

The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone

PLoS ONE, ISSN: 19326203

Ingemar André; Jacob E. Corn

September 25, 2013

Influence of tumour micro-environment heterogeneity on therapeutic response

Nature, ISSN: 00280836 14764687

Melissa Junttila; Frederic J. De Sauvage

September 24, 2013

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; Wei Yu Lin; Zhonghua Lin; Maria N. Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary D. Austin; Mercedesz Balazs; Merone Roose-Girma; Laura DeForge; Søren Warming; Wyne P. Lee; Vishva M. Dixit; Ali A. Zarrin

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