Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6951 - 7000 OF 15578 RESULTS

Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies
Journal of Experimental Medicine, ISSN: 00221007 15409538
Kim; Avi Ashkenazi
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Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control
BMC Genomics, ISSN: 14712164
Emanuele De Rinaldis; Patrycja Gazinska; Anca Mera; Zora Modrusan; Grazyna Fedorowicz; Brian Burford; Cheryl Gillett; Pierfrancesco Marra; Anita Grigoriadis; David Dornan; Lars Holmberg; Sarah Pinder; Andrew Tutt
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Journal of Cell Biology, ISSN: 00219525 15408140
Sarah Huntwork-Rodriguez; Bei Wang; Trent A. Watkins; Arundhati Sengupta Ghosh; Christine D. Pozniak; Daisy J. Bustos; Kim Newton; Donald S. Kirkpatrick; Joe Lewcock
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Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Manishkumar D. Joshi; Tianhao Li; Qiqing Zhong; Jared L. Anderson
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Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses
PLoS ONE, ISSN: 19326203
Peter S. Askovich; Catherine J. Sanders; Carrie M. Rosenberger; Alan H. Diercks; Pradyot Dash; Garnet Navarro; Peter Vogel; Peter C. Doherty; Paul G. Thomas; Alan Aderem
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Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
Frontiers in Immunology, ISSN: 16643224
Yili Li; Yiyuan Yin; Roy A. Mariuzza
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Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells
Nature Immunology, ISSN: 15292908 15292916
Kamalakannan Rajasekaran; Pawan Kumar; Kristina M. Schuldt; Erik J. Peterson; Bart Vanhaesebroeck; Vishva M. Dixit; Monica S. Thakar; Subramaniam Malarkannan
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Peripherally induced Tregs-role in immune homeostasis and autoimmunity
Frontiers in Immunology, ISSN: 16643224
Mahesh Yadav; Stephen Stephan; Jeffrey A. Bluestone
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SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin
Gene, ISSN: 03781119 18790038
Mariano Oppikofer; Stephanie Kueng; Susan M. Gasser
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A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Wendy Lee; Daniel F. Ortwine; Philippe Bergeron; Kevin Lau; Lichuan Liu; Shiva Malek; Jim Nonomiya; Zhonghua Pei; Kirk D. Robarge; Stephen Schmidt; Steve Sideris; Joseph P. Lyssikatos
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Onartuzumab (MetMab): Using nonclinical pharmacokinetic and concentration-effect data to support clinical development
Clinical Cancer Research, ISSN: 10780432 15573265
Hong Xiang; Brendan C. Bender; Arthur Reyes; Mark Merchant; Nelson L. Shasha Jumbe; Mally Romero; Teresa Davancaze; Ihsan Nijem; Elaine Mai; Judy Young; Amy Peterson; Lisa A. Damico
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Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Christoph Spiess; Jack Bevers; Janet Jackman; Nancy Y. Chiang; Nakamura; Michael Dillon; Hongbin Liu; Patricia Molina; J. Michael Elliott; Whitney Shatz; Justin M. Scheer; Glen Giese; Josefine Persson; Yin Zhang; Dennis; James Giulianotti; Prateek Gupta; Dorothea Reilly; Enzo Palma; Jianyong Wang; Stefanich; Heleen Scheerens; Fuh; Lawren C. Wu
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GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2
PLoS ONE, ISSN: 19326203
Nelson; Morgan Sheng
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Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function
PLoS ONE, ISSN: 19326203
John P. Clancy; Rhonda D. Szczesniak; Melissa A. Ashlock; Sarah E. Ernst; Lijuan Fan; Douglas B. Hornick; Philip H. Karp; Umer Khan; James Lymp; Alicia J. Ostmann; Amir Rezayat; Timothy D. Starner; Shajan P. Sugandha; Hongtao Sun; Nancy Quinney; Scott H. Donaldson; Steven M. Rowe; Sherif E. Gabriel
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Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Song-Hua Lee; Rui-Rui Wong; Chui-Yoke Chin; Tian-Yeh Lim; Su-Anne Eng; Cin Kong; Nur Afifah Ijap; Ming-Seong Lau; Mei-Perng Lim; Yunn-Hwen Gan; Fang-Lian He; Man-Wah Tan; Sheila Nathan
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Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Cancer Cell, ISSN: 18783686 15356108
Krishna P.L. Bhat; Veerakumar Balasubramaniyan; Brian Vaillant; Ravesanker Ezhilarasan; Karlijn Hummelink; Faith Hollingsworth; Khalida Wani; Lindsey Heathcock; Johanna D. James; Lindsey D. Goodman; Siobhan Conroy; Lihong Long; Nina Lelic; Suzhen Wang; Joy Gumin; Divya Raj; Yoshinori Kodama; Aditya Raghunathan; Adriana Olar; Kaushal Joshi; Christopher E. Pelloski; Amy Heimberger; SeHoon Kim; Daniel P. Cahill; Ganesh Rao; Wilfred F. A. DenDunnen; Hendrikus W.G.M. Boddeke; Phillips; Ichiro Nakano; Frederick F. Lang; Howard Colman; Erik P. Sulman; Kenneth D. Aldape
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Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region
Journal of Molecular Biology, ISSN: 10898638 00222836
Kittichoat Tiyanont; Thomas E. Wales; Christian W. Siebel; John R. Engen; Stephen C. Blacklow
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CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice
Journal of Virology, ISSN: 0022538X 10985514
Kevin B. Walsh; John Sidney; Megan J. Welch; Daniel M. Fremgen; Alessandro Sette; Michael B.A. Oldstone
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A Role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway
Cell Stem Cell, ISSN: 19345909 18759777
Kai Kessenbrock; Gerrit J. P. Dijkgraaf; Devon A. Lawson; Laurie E. Littlepage; Payam Shahi; Ursula Pieper; Zena Werb
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A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
Journal of General Physiology, ISSN: 00221295 15407748
Tamer M. Gamal El-Din; Gilbert Q. Martinez; Jian Payandeh; Todd Scheuer; William A. Catterall
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Protein microarrays for identification of novel extracellular protein-protein interactions
Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343655 19343663
Irene Tom; Nicholas Lewin-Koh; Sree R. Ramani; Lino C. Gonzalez Jr.
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NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition
Oncogenesis, ISSN: 21579024
Osborne; Larsen; Gonzales; David S. Shames; Sato; Ignacio I. Wistuba; Girard; Minna; Cobb
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Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
Journal of Clinical Investigation, ISSN: 15588238 00219738
Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Anthony Lima; Stacey Yeung; Jason H. Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yin Zhang; Dennis; Jeffrey Eastham-Anderson; Adrian M. Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai H. Barck; Richard A. D. Carano; William F. Forrest; Qinghua Song; Daniel S. Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde
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Go with the flow
Innovations in Pharmaceutical Technology, ISSN: 14717204
Juan Colberg; Stefan G. Koenig; David Leahy; Peter Poechlauer
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Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Barbara J. Brennan; Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Jiney Asthappan; Petra Goelzer; Paul Weigl; Patrick F. Smith
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Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection
Journal of Separation Science, ISSN: 16159306 16159314
Kelly Zhang; Yi Li; Midco Tsang; Nik P. Chetwyn
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Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
Nature Immunology, ISSN: 15292908 15292916
Ansuman T. Satpathy; Carlos G. Briseño; Jacob S. Lee; Dennis Ng; Nicholas A. Manieri; Wumesh Kc; Xiaodi Wu; Stephanie R. Thomas; Wan-Ling Lee; Mustafa Turkoz; Keely G. McDonald; Matthew M. Meredith; Christina Song; Cynthia J. Guidos; Rodney D. Newberry; Wenjun Ouyang; Theresa L. Murphy; Thaddeus S. Stappenbeck; Jennifer L. Gommerman; Michel Nussenzweig; Marco Colonna; Raphael Kopan; Kenneth M. Murphy
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Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: Results from a randomized, double-blind, phase III study
Arthritis and Rheumatism, ISSN: 15290131 00043591
Eduardo F. Mysler; Alberto J. Spindler; Renato Guzman; Marc Bijl; David Jayne; Richard A. Furie; Frédéric A. Houssiau; Jorn Drappa; David Close; Romeo MacIuca; Kajal Rao; Saba Shahdad; Paul Brunetta
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Dendritic cells: master regulators of the immune response
Cancer immunology research, ISSN: 23266074
Ira Mellman
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PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
Brain Pathology, ISSN: 10156305 17503639
Joanna J. Phillips; Derick Aranda; David W. Ellison; Alexander R. Judkins; Sidney E. Croul; Daniel J. Brat; Keith L. Ligon; Craig Horbinski; Sriram Venneti; Gelareh Zadeh; Mariarita Santi; Shengmei Zhou; Christina L. Appin; Stefano Sioletic; Lisa M. Sullivan; Maria Martinez-Lage; Aaron E. Robinson; William H. Yong; Timothy Cloughesy; Albert Lai; Phillips; Roxanne Marshall; Sabine Mueller; Daphne A. Haas-Kogan; Annette M. Molinaro; Arie Perry
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An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
Nature Medicine, ISSN: 10788956 1546170X
Alicia S Chung; Xiumin Wu; Guanglei Zhuang; Hai Ngu; Ian Kasman; Jianhuan Zhang; Jean-Michel Vernes; Zhaoshi Jiang; Meng; Franklin V. Peale Jr.; Wenjun Ouyang; Napoleone Ferrara
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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Brian S. Safina; Zachary K. Sweeney; Jun Li; Bryan K. Chan; Angelina Bisconte; Diane Carrera; Georgette M. Castanedo; Michael Flagella; Robert Heald; Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Steve Price; Karin Reif; Laurent Salphati; Eileen Seward; Binqing Wei; Daniel P. Sutherlin
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The association of cytopenias and weight loss with hepatitis C virus virologic response in HIV/HCV-coinfected patients treated with PEG-IFN and RBV
Journal of the International Association of Providers of AIDS Care, ISSN: 23259574 23259582
Jihad Slim; Donna Mildvan; Jian Han; Korner
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Comparison of standard laminectomy with an optimized ejection method for the removal of spinal cords from rats and mice
Journal of Histotechnology, ISSN: 01478885 20460236
Heather S. Kennedy; Charles Jones III; Patrick Caplazi
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Impact of MET expression on outcome in BRAFV600E/K advanced melanoma
Histopathology, ISSN: 03090167 13652559
Adrian M. Jubb; Antoni Ribas; Jeffrey A. Sosman; McArthur; Yibing Yan; Sandra Rost; Sherry Zhao; Koeppen
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Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer
Clinical Colorectal Cancer, ISSN: 15330028 19380674
Bendell; Thomas J. Ervin; David Gallinson; Jaswinder Singh; James A. Wallace; Mansoor Saleh; Marcy Vallone; See Phan; Stephen P. Hack
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Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Peter Dragovich; Kenneth W. Bair; Timm Baumeister; Yen-Ching Ho; Bianca M. Liederer; Xiongcai Liu; Yongbo Liu; Thomas O'Brien; Jason Oeh; Deepak Sampath; Nicholas J. Skelton; Leslie Wang; Weiru Wang; Hongxing Wu; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng
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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Michael Siu; Richard Pastor; Wendy Liu; Kathy Barrett; Megan Berry; Wade S. Blair; Christine Chang; Jacob Z. Chen; Eigenbrot; Nico Ghilardi; Paul Gibbons; Haiying He; Christopher A. Hurley; Jane R. Kenny; S. Cyrus Khojasteh; Hoa Le; Leslie Lee; Joseph P. Lyssikatos; Steven Magnuson; Rebecca Pulk; Vickie Tsui; Ultsch; Yisong Xiao; Bing-Yan Zhu; Deepak Sampath
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A hybrid approach to achieving both marginal and conditional balances for stratification variables in sequential clinical trials
Pharmaceutical Statistics, ISSN: 15391604 15391612
Yunzhi Lin; Zheng Su
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Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
European Journal of Human Genetics, ISSN: 10184813 14765438
Chuan Wang; Annika Ahlford; Tiina M. Järvinen; Gunnel Nordmark; Maija-Leena Eloranta; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Christopher Sjöwall; Heikki Julkunen; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Juha Kere; Lars Rönnblom; Ann-Christine Syvänen; Johanna K. Sandling
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Restricted access media as a streamlined approach toward on-line sample preparation: Recent advancements and applications
Journal of Separation Science, ISSN: 16159306 16159314
Samuel H. Yang; Hui Fan; Robert J. Classon; Kevin A. Schug
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Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways
Microbes and Infection, ISSN: 12864579 1769714X
Tamara Veiga-Parga; Fernanda Giménez; Sachin Mulik; Eugene Y. Chiang; Jane L. Grogan; Barry T. Rouse
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Commentary: Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C - Authors' reply
Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036
Talal; Joanne Lafleur; Hoop; Prashant K. Pandya; Martin; Ira M. Jacobson; Jian Han; Korner
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DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues
Regulatory Peptides, ISSN: 01670115 18731686
Eric Harstad; Jonathan S. Rosenblum; Mark D. Gorrell; William E. Achanzar; Lauro Minimo; Jiangyue Wu; Laura Rosini-Marthaler; Russell Gullo; Nicole D. Ordway; Mark S. Kirby; Kristina D. Chadwick; Gregory N. Cosma; Carolyn F. Moyer
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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors
Journal of Immunology, ISSN: 00221767 15506606
Sue J. Sohn; Kathy Barrett; Anne Van Abbema; Christine Chang; Pawan Bir Kohli; Hidenobu Kanda; Janice Smith; Yingjie Lai; Aihe Zhou; Birong Zhang; Wenqian Yang; Karen Williams; Calum Macleod; Christopher A. Hurley; Janusz J. Kulagowski; Nicholas Lewin-Koh; Hart S. Dengler; Adam R. Johnson; Nico Ghilardi; Mark Zak; Jun Liang; Wade S. Blair; Steven Magnuson; Lawren C. Wu
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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
Nature Chemical Biology, ISSN: 15524450 15524469
Paola Magnaghi; Roberto D'Alessio; Barbara Valsasina; Nilla Avanzi; Simona Rizzi; Daniela Asa; Fabio Gasparri; Liviana Cozzi; Ulisse Cucchi; Christian Orrenius; Paolo Polucci; Dario Ballinari; Claudia Perrera; Antonella Leone; Giovanni Cervi; Elena Casale; Yang Xiao; Wong; Daniel J Anderson; Arturo Galvani; Daniele Donati; Thomas O'Brien; Peter K Jackson; Antonella Isacchi
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High resolution reversed phase analysis of recombinant monoclonal antibodies by ultra-high pressure liquid chromatography column coupling
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
Szabolcs Fekete; Michael W. Dong; Taylor Zhang; Davy Guillarme
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Assessing the potential cost-effectiveness of retesting IHC0, IHC1+, or FISH-negative early stage breast cancer patients for HER2 status
Cancer, ISSN: 0008543X 10970142
Louis P. Garrison Jr.; Deepa Lalla; Melissa Brammer; Joseph B. Babigumira; Bruce Wang; Edith A. Perez
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Demonstrating measurement equivalence of the electronic and paper formats of the urticaria patient daily diary in patients with chronic idiopathic urticaria
Patient, ISSN: 11781653 11781661
Emuella M. Flood; James L. Zazzali; Jennifer Devlen
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Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies
Biotechnology Progress, ISSN: 87567938 15206033
Yongping Crawford; Michelle Zhou; Zhilan Hu; John C. Joly; Snedecor; Amy Shen; Albert Gao
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