Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7101 - 7150 OF 15578 RESULTS

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS ONE, ISSN: 19326203
Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton
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Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop
AAPS Journal, ISSN: 15507416
Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou
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Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread
Virology, ISSN: 00426822 10960341
Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach
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Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
eLife, ISSN: 2050084X
Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati
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Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis
Journal of Medical Economics, ISSN: 13696998 1941837X
Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder
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Population pharmacokinetics of cyclosporine in transplant recipients
AAPS Journal, ISSN: 15507416
Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich
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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Cancer Research, ISSN: 00085472 15387445
Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)
American Journal of Cardiology, ISSN: 00029149 18791913
Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French
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Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale
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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski
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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
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Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia
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miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer
PLoS ONE, ISSN: 19326203
Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan
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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant
Chemical Communications, ISSN: 1364548X 13597345
Laura M. Dornan; Qun Cao; James C.A. Flanagan; James J. Crawford; Matthew J. Cook; Mark J. Muldoon
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Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno
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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD41 T-cell recovery: A randomized trial
Blood, ISSN: 15280020 00064971
Peter W. Hunt; Nancy Shulman; Timothy L. Hayes; Viktor Dahl; Ma Somsouk; Nicholas T. Funderburg; Bridget McLaughlin; Alan L. Landay; Oluwatoyin Adeyemi; Lee E. Gilman; Brian Clagett; Benigno Rodriguez; Jeffrey N. Martin; Timothy W. Schacker; Barbara L. Shacklett; Sarah Palmer; Michael M. Lederman; Steven G. Deeks
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Early effects of tocilizumab in the treatment of moderate to severe active rheumatoid arthritis: A one-week sub-study of a randomised controlled trial (Rapid Onset and Systemic Efficacy [ROSE] Study)
Clinical and Experimental Rheumatology, ISSN: 0392856X 1593098X
Yazici; Jeffrey R. Curtis; Ince; Baraf; Lepley; Jenny Devenport; Arthur Kavanaugh
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Turning on lanthanide luminescence via nanoencapsulation
Inorganic Chemistry, ISSN: 00201669 1520510X
Boris Makhinson; Alexandra K. Duncan; Ashley R. Elam; Ana De Bettencourt-Dias; Colin D. Medley; Joshua E. Smith; Eric J. Werner
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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Jaehak Oh; Nan Wu; Günther Baravalle; Benjamin Cohn; Jessica K. Ma; Bryan Lo; Ira Mellman; Satoshi Ishido; Mark S. Anderson; Jeoung-Sook Shin
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Drug products for biological medicines: Novel delivery devices, challenging formulations, and combination products, part 2
BioProcess International, ISSN: 15426319
Mire-Sluis; Donna French; Jennifer Mercer; Gerd Kleemann; John Dougherty
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On assay robustness: the importance of early determination and science-driven decision-making
Bioanalysis, ISSN: 17576180 17576199
Kyra J. Cowan
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Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals
Biophysical Reviews, ISSN: 18672469 18672450
Sandeep Yadav; Jun Liu; Thomas M. Scherer; Yatin Gokarn; Barthélemy Demeule; Sonoko Kanai; Andya; Steven J. Shire
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Anti-inflammatory strategies for plaque stabilization after acute coronary syndromes topical collection on vascular biology
Current Atherosclerosis Reports, ISSN: 15346242 15233804
Amos Baruch; Nicholas Van Bruggen; Juyong Brian Kim; Joshua E. Lehrer-Graiwer
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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Peter Dragovich; Benjamin P. Fauber; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Shiva Malek; Borlan Pan; David Peterson; Keith Pitts; Hans E. Purkey; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang
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Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
Molecular Cancer Research, ISSN: 15417786 15573125
Sato; Larsen; Woochang Lee; Han Sun; David S. Shames; Maithili P. Dalvi; Ruben D. Ramirez; Hao Tang; John Michael DiMaio; Boning Gao; Yang Xie; Ignacio I. Wistuba; Adi Gazdar; Jerry W. Shay; Minna
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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Nature Reviews Cancer, ISSN: 1474175X 14741768
Morgan O'Hayre; José Vázquez-Prado; Irina Kufareva; Eric Stawiski; Tracy M. Handel; Somasekar Seshagiri; J. Silvio Gutkind
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Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients
Clinical Cancer Research, ISSN: 10780432 15573265
Manish R. Sharma; Theodore G. Karrison; Bethany Kell; Kehua Wu; Michelle Turcich; David Geary; S. Peter Kang; Naoko Takebe; Richard A. Graham; Michael Maitland; Richard L. Schilsky; Ratain; Ezra E W Cohen
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Next generation therapeutics
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Paul J. Carter; Daria Hazuda; James A. Wells
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Structure-guided design of a selective BCL-XL inhibitor
Nature Chemical Biology, ISSN: 15524450 15524469
Guillaume Lessene; Czabotar; Brad E Sleebs; Zobel; Kym N Lowes; Jerry M Adams; Jonathan B Baell; Colman; Deshayes; Wayne J. Fairbrother; Flygare; Paul Gibbons; Wilhelmus J A Kersten; Sanji Kulasegaram; Rebecca M Moss; John P Parisot; Brian J. Smith; Ian P Street; Hong Yang; David C.S. Huang; Keith G Watson
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Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas
Cancer Letters, ISSN: 03043835 18727980
Nadia Lounnas; Célia Rosilio; Marielle Nebout; Didier Mary; Emmanuel Griessinger; Zouhour Neffati; Johanna Chiche; Hergen Spits; Thijs Hagenbeek; Vahid Asnafi; Sally-Ann Poulsen; Claudiu T. Supuran; Jean-François Peyron; Véronique Imbert
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GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior
Neuropsychopharmacology, ISSN: 0893133X 1740634X
Jesse E. Hanson; Martin Weber; William J. Meilandt; Tiffany Wu; Tom Luu; Lunbin Deng; Mehrdad Shamloo; Morgan Sheng; Kimberly Scearce-Levie; Qiang Zhou
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Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Xiaojing Wang; Steven Magnuson; Richard Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi J. A. Wallweber; John Moffat; Jason H. Drummond; Grace Chan; Eric Harstad; Allen Ebens
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Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Kathryn Chapman; Henry Holzgrefe; Lauren E. Black; Marilyn Brown; Gary Chellman; Christine Copeman; Jessica A. Couch; Stuart Creton; Sean Gehen; Alan M. Hoberman; Lewis B. Kinter; Stephen Madden; Charles Mattis; Hugh A. Stemple; Stephen Wilson
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A requirement for wild-type Ras isoforms in mutant KRas-driven signaling and transformation
Biochemical Journal, ISSN: 02646021 14708728
Carolyn Bentley; Stefanie S. Jurinka; Noelyn Kljavin; Steffan Vartanian; Sree R. Ramani; Lino C. Gonzalez Jr.; Kebing Yu; Zora Modrusan; Pan Du; Richard Bourgon; Richard M. Neve; David Stokoe
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Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo
American Journal of Pathology, ISSN: 00029440 15252191
Alejandro Rodriguez; Tomas Friman; Marcin Kowanetz; Tijs Van Wieringen; Renata Gustafsson; Christian Sundberg
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Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Nguyen Tan; Maureen Wong; Michelle Nannini; Rebecca Hong; Leslie Lee; Stephen Price; Karen Williams; Pierre Pascal Savy; Peng Yue; Deepak Sampath; Jeffrey Settleman; Wayne J. Fairbrother; Lisa D. Belmont
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Kif3a is necessary for initiation and maintenance of medulloblastoma
Carcinogenesis, ISSN: 01433334 14602180
Monique T. Barakat; Eric W. Humke; Matthew P. Scott
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Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Karen Rowland-Yeo; Jane R. Kenny; Amin Rostami-Hodjegan
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Two-in-One antibodies with dual action Fabs
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Eigenbrot; Fuh
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Bispecific antibodies for delivery into the brain
Current Opinion in Chemical Biology, ISSN: 13675931 18790402
Ryan J. Watts; Dennis
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HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Elicia M. Penuel; Congfen Li; Vaishali Parab; Luciana Burton; Kyra J. Cowan; Mark Merchant; Robert Yauch; Premal Patel; Amy Peterson; Garret M. Hampton; Lackner; Priti Hegde
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Ranibizumab treatment outcomes in phakic versus pseudophakic eyes: An individual patient data analysis of 2 phase 3 trials
Ophthalmology, ISSN: 01616420 15494713
David V. Weinberg; Howard Shapiro; Jason S. Ehrlich
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Monoclonal antibody self-association, cluster formation, and rheology at high concentrations
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Wayne G. Lilyestrom; Sandeep Yadav; Steven J. Shire; Thomas M. Scherer
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Pharmacological brake-release of mRNA translation enhances cognitive memory
eLife, ISSN: 2050084X
Carmela Sidrauski; Diego Acosta-Alvear; Arkady Khoutorsky; Punitha Vedantham; Brian R. Hearn; Han Li; Karine Gamache; Ciara M. Gallagher; Kenny K.-H. Ang; Chris Wilson; Voytek Okreglak; Avi Ashkenazi; Byron Hann; Karim Nader; Michelle R. Arkin; Adam R. Renslo; Nahum Sonenberg; Peter Walter
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Antagonists of IAP proteins as cancer therapeutics
Cancer Letters, ISSN: 18727980 03043835
Jasmin N. Dynek; Domagoj Vucic
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Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christian Bowman-Colin; Bing Xia; Samuel Bunting; Christiaan N. Klijn; Rinske Drost; Peter Bouwman; Laura Fineman; Xixi Chen; Aedin C. Culhane; Hong Cai; Scott J. Rodig; Roderick T. Bronson; Jos Jonkers; Andre Nussenzweig; Chryssa Kanellopoulou; David M. Livingston
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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
Nature Communications, ISSN: 20411723
Bridget E. Lamonica; Jan H. Lui; David V. Hansen; Arnold R. Kriegstein
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