Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7151 - 7200 OF 15578 RESULTS

Characterization of antibody-polyol interactions by static light scattering: Implications for physical stability of protein formulations
International Journal of Pharmaceutics, ISSN: 03785173 18733476
Shermeen A. Abbas; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia
View on Scopus
A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays
PLoS ONE, ISSN: 19326203
Grace Chan; Tracy L. Kleinheinz; David Peterson; John Moffat
View on Scopus
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
Cancer Research, ISSN: 00085472 15387445
Ted Lau; Emily Chan; Marinella G. Callow; Jo Waaler; Jason Boggs; Robert A. Blake; Steven Magnuson; Amy Sambrone; Melissa Schutten; Ron Firestein; Ondrej Machon; Vladimir Korinek; Edna F. Choo; Dolores Diaz; Mark Merchant; Paul G. Polakis; Daniel D. Holsworth; Stefan Krauss; Michael Costa
View on Scopus
Total antibody quantification for MMAE-conjugated antibody-drug conjugates: Impact of assay format and reagents
Bioconjugate Chemistry, ISSN: 15204812 10431802
Katherine R. Kozak; Siao Ping Tsai; Aimee Fourie-O'Donohue; Josefa Dela Cruz Chuh; Roth; Ryan Cook; Elton Chan; Pamela Chan; Martine Darwish; Rachana Ohri; Helga Raab; Crystal Zhang; Kedan Lin; Wai Lee T. Wong
View on Scopus
Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors
PLoS ONE, ISSN: 19326203
Christiaan N. Klijn; Marco J. Koudijs; Jaap Kool; Jelle ten Hoeve; Mandy Boer; Joost de Moes; Waseem Akhtar; Martine van Miltenburg; Annabel Vendel-Zwaagstra; Marcel J. T. Reinders; David J. Adams; Maarten van Lohuizen; John Hilkens; Lodewyk F. A. Wessels; Jos Jonkers
View on Scopus
Oncogenic ERBB3 Mutations in Human Cancers
Cancer Cell, ISSN: 18783686 15356108
Bijay S. Jaiswal; Noelyn Kljavin; Eric Stawiski; Emily Chan; Chaitali Parikh; Durinck; Subhra Chaudhuri; Kanan Pujara; Joseph Guillory; Kyle A. Edgar; Vasantharajan Janakiraman; Rolf-Peter Scholz; Krista K. Bowman; Maria N. Lorenzo; Hong Li; Jiansheng Wu; Yuan; Brock A. Peters; Zhengyan Kan; Stinson; Michelle Mak; Zora Modrusan; Eigenbrot; Ron Firestein; Howard M. Stern; Krishnaraj Rajalingam; Gabriele Schaefer; Mark Merchant; Mark X. Sliwkowski; FredericJ. deSauvage; Somasekar Seshagiri
View on Scopus
G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hong Xin; Rongze Lu; Heehyoung Lee; Wang Zhang; Chunyan Zhang; Jiehui Deng; Yong Liu; Shudan Shen; Kay-Uwe Wagner; Stephen Forman; Richard Jove; Hua Yu
View on Scopus
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Kerstin Trunzer; Anna Pavlick; Lynn Schuchter; Rene Gonzalez; McArthur; Thomas E. Hutson; Stergios J. Moschos; Keith Flaherty; Kevin B. Kim; Jeffrey S. Weber; Peter Hersey; Georgina V. Long; Donald Lawrence; Patrick A. Ott; Ravi K. Amaravadi; Karl Lewis; Igor Puzanov; Roger S. Lo; Astrid Koehler; Mark Kockx; Olivia Spleiss; Annette Schell-Steven; Houston N. Gilbert; Louise Cockey; Gideon Bollag; Richard J. Lee; Andrew K. Joe; Jeffrey A. Sosman; Antoni Ribas
View on Scopus
Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes
Archives of Biochemistry and Biophysics, ISSN: 00039861 10960384
Camille M. Konopnicki; Leslie Dickmann; Jeffrey M. Tracy; Robert H. Tukey; Larry C. Wienkers; Robert S. Foti
View on Scopus
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lillian Cohn; Bithi Chatterjee; Filipp Esselborn; Anna Smed-Sörensen; Norihiro Nakamura; Cecile Chalouni; Byoung-Chul Lee; Richard L. Vandlen; Tibor Keler; Peter Lauer; Dirk Brockstedt; Ira Mellman; Lélia Delamarre
View on Scopus
Vascular physiology and protein disposition in a preclinical model of neurodegeneration
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Eduardo E. Mundo; Bernadette Johnstone; Sheila Ulufatu; Michelle G. Schweiger; Daniela Bumbaca; Fielder; Saileta Prabhu; Leslie A. Khawli
View on Scopus
Drug delivery across the blood-brain barrier
Molecular Pharmaceutics, ISSN: 15438392 15438384
Leslie A. Khawli; Saileta Prabhu
View on Scopus
Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a large North American cooperative group trial
Blood, ISSN: 15280020 00064971
Jennifer A. Kanakry; Hailun Li; Lan L. Gellert; M. Victor Lemas; Wen-Son Hsieh; Fangxin Hong; King L. Tan; Randy D. Gascoyne; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Ranjana H. Advani; Thomas P. Miller; Brad Kahl; Sandra J. Horning; Richard F. Ambinder
View on Scopus
Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Blood, ISSN: 15280020 00064971
Annika Dufour; Palermo; Evelyn Zellmeier; Gudrun Mellert; Guillemette Duchateau-Nguyen; Stephanie Schneider; Tobias Benthaus; Purvi M. Kakadia; Karsten Spiekermann; Wolfgang Hiddemann; Jan Braess; Sim Truong; Nancy Patten; Lin Wu; Sabine Lohmann; David Dornan; Debraj GuhaThakurta; Ru-Fang Yeh; Galina Salogub; Philippe Solal-Celigny; Anna Dmoszynska; Tadeusz Robak; Marco Montillo; John Catalano; Christian H. Geisler; Martin Weisser; Stefan K. Bohlander
View on Scopus
Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a large North American cooperative group trial
Blood, ISSN: 15280020 00064971
Jennifer A. Kanakry; Hailun Li; Lan L. Gellert; M. Victor Lemas; Wen-Son Hsieh; Fangxin Hong; King L. Tan; Randy D. Gascoyne; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Ranjana H. Advani; Thomas P. Miller; Wojciech Jurczak; Sandra J. Horning; Richard F. Ambinder
View on Scopus
GPU-accelerated nonparametric kinetic analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
Magnetic Resonance Imaging, ISSN: 0730725X 18735894
Yu-Han H. Hsu; Gregory Z. Ferl; Chee Ng
View on Scopus
PK assays for antibody-drug conjugates: Case study with ado-trastuzumab emtansine
Bioanalysis, ISSN: 17576180 17576199
Randall Dere; Joo-Hee Yi; Corinna Lei; Ola M. Saad; Catherine Huang; Yanhong Li; Jakub Baudys; Surinder Kaur
View on Scopus
Immunogenicity assays for antibody-drug conjugates: Case study with ado-trastuzumab emtansine
Bioanalysis, ISSN: 17576180 17576199
Montserrat Carrasco-Triguero; Joo-Hee Yi; Randall Dere; Zhihua Julia Qiu; Corinna Lei; Yanhong Li; Connie Mahood; Wang; Douglas Leipold; Kirsten Achilles Poon; Surinder Kaur
View on Scopus
Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images
Neuro-Oncology, ISSN: 15228517 15235866
Kourosh M. Naeini; Whitney B. Pope; Timothy Cloughesy; Robert J. Harris; Albert Lai; Ascia Eskin; Reshmi Chowdhury; Phillips; Phioanh L. Nghiemphu; Yalda Behbahanian; Benjamin M. Ellingson
View on Scopus
Use of "MGE Enhancers" for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons
PLoS ONE, ISSN: 19326203
Ying-Jiun J. Chen; Daniel Vogt; Yanling Wang; Axel Visel; Shanni N. Silberberg; Cory Nicholas; Teruko Danjo; Joshua L. Pollack; Len A. Pennacchio; Stewart Anderson; Yoshiki Sasai; Scott C. Baraban; Arnold R. Kriegstein; Arturo Alvarez-Buylla; John L. R. Rubenstein
View on Scopus
Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production
Biotechnology Progress, ISSN: 87567938 15206033
Shahram Misaghi; Yan Qu; Andrew Snowden; Chang; Snedecor
View on Scopus
Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages
Journal of Experimental Medicine, ISSN: 00221007 15409538
Riku Kiviranta; Kei Yamana; Hiroaki Saito; Daniel K. Ho; Julius Laine; Kati Tarkkonen; Vappu Nieminen-Pihala; Eric Hesse; Diego Correa; Jorma Määttä; Lino Tessarollo; Evan D. Rosen; William C. Horne; Nancy A. Jenkins; Neal G. Copeland; Søren Warming; Roland Baron
View on Scopus
Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
Ophthalmology, ISSN: 15494713 01616420
Brandon G. Busbee; Allen C. Ho; David M. Brown; Jeffrey S. Heier; Ivan J. Suñer; Zhengrong Li; Roman G. Rubio; Phillip Lai
View on Scopus
P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma
Journal of the National Cancer Institute, ISSN: 00278874 14602105
Christy C. Ong; Adrian M. Jubb; Diana Jakubiak; Wei Zhou; Joachim Rudolph; Matthias Peter; Marcin Kowanetz; Yibing Yan; Jarrod Tremayne; Richard Lisle; Adrian L. Harris; Lori S. Friedman; Marcia Belvin; Mark R. Middleton; Elizabeth M. Blackwood; Koeppen; Klaus P. Hoeflich
View on Scopus
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants
Journal of Comparative Neurology, ISSN: 00219967 10969861
Bei Wang; Jason E. Long; Pierre Flandin; Ramon Pla; Ronald R. Waclaw; Kenneth Campbell; John L. R. Rubenstein
View on Scopus
A note on variance estimation in the Cox proportional hazards model
Journal of Applied Statistics, ISSN: 02664763 13600532
Jiong Luo; Zheng Su
View on Scopus
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
DMM Disease Models and Mechanisms, ISSN: 17548403 17548411
Cleopatra Kozlowski; Surinc Er Jeet; Joseph Beyer; Steve Guerrero; Justin Lesch; Xiaoting Wang; Jason Devoss; Laurie Diehl
View on Scopus
First-line treatment patterns and clinical outcomes in patients with HER2-positive and hormone receptor-positive metastatic breast cancer from registHER
Oncologist, ISSN: 10837159 1549490X
Debasish Tripathy; Peter A. Kaufman; Adam Brufsky; Musa Mayer; Marianne Ulcickas Yood; Bongin Yoo; Quah; Denise A. Yardley; Hope S. Rugo
View on Scopus
Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum
Bioanalysis, ISSN: 17576180 17576199
Keyang Xu; Luna Liu; Randall Dere; Elaine Mai; Rebecca Erickson; Angela Hendricks; Kedan Lin; Jagath R. Junutula; Surinder Kaur
View on Scopus
Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Inna Y. Gong; Wendy A. Teft; Justin Ly; Yunghsiang Chen; Bruno Alicke; Richard B. Kim; Edna F. Choo
View on Scopus
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Chudi O. Ndubaku; Nicole Blaquiere; Marcia Belvin; Richard J. Bull; Danette Dudley; Kyle A. Edgar; Daniel C. Gray; Robert Heald; Timothy P. Heffron; Graham Jones; Mark Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Neville J. McLean; Jim Nonomiya; Alan G. Olivero; Rachel Ord; Jodie Pang; Stephen Price; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Jeffery J. Wallin; Lan Wang; Binqing Wei; Christian Weismann; Ping Wu
View on Scopus
A likelihood and resampling based approach to dichotomizing a continuous biomarker in medical research
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Min Su; Liang Fang; Zheng Su
View on Scopus
8th annual european antibody congress 2012: November 27-28, 2012, Geneva, Switzerland
mAbs, ISSN: 19420862 19420870
Alain Beck; Paul J. Carter; Hans-Peter Gerber; Alexey A. Lugovskoy; Thierry Wurch; Jagath R. Junutula; Roland Kontermann; Robert Mabry
View on Scopus
Predictive value in retinal vein occlusions of early versus late or incomplete ranibizumab response defined by optical coherence tomography
Ophthalmology, ISSN: 01616420 15494713
Robert B. Bhisitkul; Peter A. Campochiaro; Howard Shapiro; Roman G. Rubio
View on Scopus
Safety of rituximab in combination with other biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: An open-label study
Journal of Rheumatology, ISSN: 0315162X 14992752
William F. Rigby; Philip J. Mease; Ewa Olech; Ashby; Swati Tole
View on Scopus
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
The Lancet Oncology, ISSN: 14702045 14745488
Sandra M. Swain; Sung-Bae Kim; Javier Cortés; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Adam Knott; Emma Clark; Graham Ross; Benyunes; Baselga
View on Scopus
Dr. Keystone, et al, reply
Journal of Rheumatology, ISSN: 0315162X 14992752
Edward Keystone; Stanley B. Cohen; Paul Emery; Joel M. Kremer; Maxime Dougados; James E. Loveless; Carol Y. Chung; Pamela Wong; Lehane; Helen Tyrrell
View on Scopus
Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Gargi Seth; Robert W. Hamilton; Stapp; Lisa Zheng; Angela Meier; Krista Petty; Stephenie Leung; Srikanth Chary
View on Scopus
Bioanalysis special focus issue on antibody-drug conjugates
Bioanalysis, ISSN: 17576180 17576199
Surinder Kaur
View on Scopus
Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper
Bioanalysis, ISSN: 17576180 17576199
Boris Gorovits; Stephen C. Alley; Sanela Bilic; Brian Booth; Surinder Kaur; Phillip Oldfield; Shobha Purushothama; Chetana Rao; Stacy Shord; Patricia Siguenza
View on Scopus
Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS
Bioanalysis, ISSN: 17576180 17576199
Shuguang Ma; Swapan K. Chowdhury
View on Scopus
Newer developments in HPLC impacting pharmaceutical analysis: A brief review
American Pharmaceutical Review, ISSN: 10998012
Michael W. Dong; Davy Guillarme
View on Scopus
Recapitulating human cancer in a mouse
Nature Biotechnology, ISSN: 10870156 15461696
Lynda Chin; Frederic J. De Sauvage; Mikala Egeblad; Kenneth P. Olive; David Tuveson; William Weiss
View on Scopus
Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
Science Translational Medicine, ISSN: 19466234 19466242
Jessica A. Couch; Y. Joy Yu; Yin Zhang; Jacqueline M. Tarrant; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Raymond K. Tong; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kapil Gadkar; Saileta Prabhu; Benjamin A. Ordonia; Quyen Nguyen; Yuwen L. Lin; Zhonghua Lin; Mercedesz Balazs; Kimberly Scearce-Levie; James A. Ernst; Dennis; Ryan J. Watts
View on Scopus
Strategies to address drug interaction potential for antibody-drug conjugates in clinical development
Bioanalysis, ISSN: 17576180 17576199
Dan Lu; Srikumar Sahasranaman; Yi Zhang; Sandhya Girish
View on Scopus
Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab
Journal of Molecular Biology, ISSN: 10898638 00222836
Ultsch; Jack Bevers; Nakamura; Richard L. Vandlen; Robert F. Kelley; Lawren C. Wu; Eigenbrot
View on Scopus
EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS
PLoS ONE, ISSN: 19326203
Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Hai Ngu; Nicholas Lewin-Koh; Mark Chen; Jeffrey Eastham-Anderson; Ryan J. Watts; Kimberly Scearce-Levie
View on Scopus
Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Kevin W. Hunt; Adam W. Cook; Ryan J. Watts; Christopher T. Clark; Guy Vigers; Darin Smith; Andrew T. Metcalf; Indrani W. Gunawardana; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Allen A. Thomas; Sumeet Rana; Nicholas C. Kallan; Robert K. Delisle; James P. Rizzi; Kelly Regal; Douglas Sammond; Robert Groneberg; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos; Allison Marlow; Xingrong Liu; Tony P. Tang
View on Scopus
Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Simon Allen; Julia M. Richardson; Angela Mehlert; Michael A. J. Ferguson
View on Scopus
Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1
FEBS Letters, ISSN: 00145793 18733468
Elizabeth Helgason; Qui Phung; Erin C. Dueber
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.