Genentech: Publications

October 10, 2012

Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin

Journal of Neuroscience, ISSN: 02706474 15292401

Constantine P. Firme; Ryan G. Natan; Neema Yazdani; Eduardo R. Macagno; Michael W. Baker

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October 8, 2012

Role of myeloid cells in tumor angiogenesis

Milestones in Drug Therapy,

Napoleone Ferrara

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October 5, 2012

Calcium-independent inhibition of PCSK9 by affinity-improved variants of the LDL receptor EGF(A) domain

Journal of Molecular Biology, ISSN: 10898638 00222836

Yingnan Zhang; Lijuan Zhou; Monica Kong-Beltran; Wei Li; Paul Moran; Jianyong Wang; Quan; Jeffrey Tom; Ganesh Kolumam; J. Michael Elliott; Nicholas J. Skelton; Andrew S. Peterson; Daniel Kirchhofer

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October 5, 2012

Population genetic inference from personal genome data: Impact of ancestry and admixture on human genomic variation

American Journal of Human Genetics, ISSN: 00029297 15376605

Jeffrey M. Kidd; Gravel; Jake Byrnes; Andres Moreno-Estrada; Shaila Musharoff; Katarzyna Bryc; Jeremiah D. Degenhardt; Abra Brisbin; Vrunda Sheth; Rong Chen; Stephen F. McLaughlin; Heather E. Peckham; Larsson Omberg; Christina A. Bormann Chung; Sarah Stanley; Kevin Pearlstein; Elizabeth Levandowsky; Suehelay Acevedo-Acevedo; Adam Auton; Alon Keinan; Victor Acuña-Alonzo; Rodrigo Barquera-Lozano; Samuel Canizales-Quinteros; Celeste Eng; Esteban G. Burchard; Archie Russell; Andy Reynolds; Andrew G. Clark; Martin G. Reese; Stephen E. Lincoln; Atul J. Butte; Francisco M. De La Vega; Carlos D. Bustamante

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October 1, 2012

Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications

Journal of Nanoscience and Nanotechnology, ISSN: 15334880 15334899

Po-Chang Chiang; Yuzhong Deng; Savita Ubhayakar; Hank La; Yong Cui; Kang-Jye Chou; Yingqing Ran; Harvey Wong

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October 1, 2012

Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: Results from the 24-week randomized controlled radiate study

Rheumatology, ISSN: 14620324 14620332

Vibeke Strand; Gerd R. Burmester; Sarika Ogale; Jenny Devenport; Ani John; Paul Emery

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October 1, 2012

Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography

Biotechnology Journal, ISSN: 18606768 18607314

Vikram N. Sisodiya; Joshua Lequieu; Maricel Rodriguez; Paul McDonald; Kathlyn P. Lazzareschi

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October 1, 2012

Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry

Journal of Virology, ISSN: 0022538X 10985514

Jingyu Diao; Homer Pantua; Hai Ngu; László Kömüves; Laurie Diehl; Gabriele Schaefer; Sharookh B. Kapadia

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October 1, 2012

Omalizumab and the risk of malignancy: Results from a pooled analysis

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

William W. Busse; Roland Buhl; Carlos Fernandez Vidaurre; Martin Blogg; Jin Zhu; Mark D. Eisner; Janice Canvin

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October 1, 2012

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

Nature Genetics, ISSN: 10614036 15461718

Charles M. Rudin; Durinck; Eric Stawiski; John T. Poirier; Zora Modrusan; David S. Shames; Emily A. Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Rivers; Catherine K. Foo; Deepali Bhatt; Stinson; Florian Gnad; Matthias Peter; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S. Jaiswal; Chaitali Parikh; Yuan; Zemin Zhang; Koeppen; Thomas D Wu; Howard M. Stern; Robert Yauch; Kenneth E. Huffman; Diego D. Paskulin; Peter B. Illei; Marileila Varella-Garcia; Adi Gazdar; Frederic J. De Sauvage; Richard Bourgon; Minna; Malcolm V. Brock; Somasekar Seshagiri

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October 1, 2012

European genetic ancestry is associated with a decreased risk of lupus nephritis

Arthritis and Rheumatism, ISSN: 00043591 15290131

Ilana B. Richman; Kimberly E. Taylor; Sharon A. Chung; Laura Trupin; Michelle Petri; Edward Yelin; Robert R. Graham; Annette T. Lee; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell

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October 1, 2012

Cost utility of palivizumab prophylaxis among pre-term infants in the United States: A national policy perspective

Journal of Medical Economics, ISSN: 13696998 1941837X

Parthiv J. Mahadevia; Anthony Masaquel; Mark J. Polak; Leonard B. Weiner

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October 1, 2012

Risk of Significant Infection in Rheumatoid Arthritis Patients Switching Anti-Tumor Necrosis Factor-α Drugs

Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X

Bao-Anh Nguyen-Khoa; Earl L. Goehring; Kimberly Alexander; Wei Dong; Pavel Napalkov; Judith K. Jones

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October 1, 2012

The genetics of type I interferon in systemic lupus erythematosus

Current Opinion in Immunology, ISSN: 09527915 18790372

Paola G. Bronson; Christina Chaivorapol; Ward Ortmann; Timothy W. Behrens; Robert R. Graham

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October 1, 2012

Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in Vivo

Infection and Immunity, ISSN: 00199567 10985522

Brigitte Y. Watkins; Shilpa A. Joshi; David A. Ball; Hadley Leggett; Summer Park; Janice Kim; Cary D. Austin; Andres Paler Martinez; Min Xu; Kenneth H. Downing; Eric J. Brown

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October 1, 2012

Genomic landscape of liver cancer

Nature Genetics, ISSN: 10614036 15461718

Zemin Zhang

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October 1, 2012

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model

Thrombosis Research, ISSN: 00493848 18792472

Anna L. Hampton; Jose A. Diaz; Angela E. Hawley; Shirley K. Wrobleski; Jian-Guo Wang; Rebecca D. Lee; Daniel Kirchhofer; Robert E. Sigler; Thomas W. Wakefield; Nigel Mackman; Daniel D. Myers Jr.

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October 1, 2012

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials

Retina, ISSN: 0275004X 15392864

Neil M. Bressler; David S. Boyer; David F. Williams; Steven Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio

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October 1, 2012

Immuno-PET of the hepatocyte growth factor receptor met using the 1-armed antibody onartuzumab

Journal of Nuclear Medicine, ISSN: 01615505

Elaine M. Jagoda; Lixin Lang; Veerendra Bhadrasetty; Stephanie Histed; Mark Williams; Gabriela Kramer-Marek; Esther Mena; Lauren Rosenblum; Jan Marik; Jeff N. Tinianow; Mark Merchant; Lawrence Szajek; Chang Paik; Fabiola Cecchi; Kristen Raffensperger; Joe-Marie Jose-Dizon; Donald P. Bottaro; Peter Choyke

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October 1, 2012

A phase i study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors

Investigational New Drugs, ISSN: 01676997 15730646

Andrea Wang-Gillam; William P. Tew; MacE L. Rothenberg; Jakob Dupont; Wendy Cooper; Lars Sternas; Giliane Buzenet; Jeffrey A. Sosman; David R. Spriggs; Albert Craig Lockhart

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October 1, 2012

Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Chudasama; Franziska Schaedeli-Stark; Harrold; Jay Tibbitts; Sandhya Girish; Manish Gupta; Frey; Donald E. Mager

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October 1, 2012

Intracellular-signaling tumor-regression modeling of the pro-apoptotic receptor agonists dulanermin and conatumumab

Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744

Brittany P. Kay; Cheng-Pang Hsu; Jian-Feng Lu; Sun; Shuang Bai; Yan Xin; David Z. D'Argenio

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October 1, 2012

Modulation of caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein

Cellular Microbiology, ISSN: 14625814 14625822

Xiaohui Sem; Jason F. Kreisberg; Trupti Kawli; Man-Wah Tan; Mikael Rhen; Patrick Tan

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October 1, 2012

TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes

Traffic, ISSN: 13989219 16000854

Jonathan R. Davey; Sean J. Humphrey; Jagath R. Junutula; Ashwini K. Mishra; David G. Lambright; David E. James; Jacqueline Stöckli

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October 1, 2012

Pyrazolopyridine inhibitors of B-RafV600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; David Moreno; Ellen R. Laird; Susan L. Gloor; Li Ren; Tyler Risom; Joachim Rudolph; Hillary L. Sturgis; Walter C. Voegtli

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October 1, 2012

FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Kristi Elkins; Bing Zheng; MaryAnn Go; Dionysos S. Slaga; Du; Suzie J. Scales; Shang-Fan Yu; Jacqueline McBride; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Allen Ebens; Andrew G. Polson

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October 1, 2012

Single-stranded microRNA mimics

RNA, ISSN: 13558382 14699001

Guillaume Chorn; Molly Klein-Mcdowell; Lihong Zhao; Matthew A. Saunders; W. Michael Flanagan; Aarron T. Willingham; Lee P. Lim

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October 1, 2012

A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Brendan C. Bender; Franziska Schaedeli-Stark; Reinhold Koch; Amita Joshi; Yu-Waye Chu; Hope S. Rugo; Ian E. Krop; Sandhya Girish; Lena E. Friberg; Manish Gupta

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October 1, 2012

Quantifying the exact allocation ratios in randomized clinical trials with biased coin randomization

Computer Methods and Programs in Biomedicine, ISSN: 01692607 18727565

Yunzhi Lin; Zheng Su

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October 1, 2012

Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis

Respirology, ISSN: 13237799 14401843

Sato; David S. Shames; Yoshinori Hasegawa

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October 1, 2012

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Nucleic Acids Research, ISSN: 03051048 13624962

Anne Dallas; Heini Ilves; Qing Ge; Pavan Kumar; Joshua Shorenstein; Sergei A. Kazakov; Trinna L. Cuellar; Michael T. McManus; Mark A. Behlke; Brian H. Johnston

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October 1, 2012

Racial differences in presentation and management of follicular non-Hodgkin lymphoma in the United States: Report from the National LymphoCare Study

Cancer, ISSN: 0008543X 10970142

Chadi Nabhan; Michelle Byrtek; Taylor; Jonathan W. Friedberg; James R. Cerhan; John Hainsworth; Thomas P. Miller; Jamie Hirata; Brian K. Link; Christopher R. Flowers

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October 1, 2012

Treatment patterns and clinical outcomes in elderly patients with HER2-positive metastatic breast cancer from the registHER observational study

Breast Cancer Research and Treatment, ISSN: 01676806 15737217

Peter A. Kaufman; Adam Brufsky; Musa Mayer; Hope S. Rugo; Debasish Tripathy; Marianne Ulcickas Yood; Shibao Feng; Lisa I. Wang; Quah; Denise A. Yardley

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October 1, 2012

Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials

Ophthalmology, ISSN: 01616420 15494713

Rohit Varma; Neil M. Bressler; Ivan J. Suñer; Paul P. Lee; Chantal M. Dolan; James Ward; Shoshana Colman; Roman G. Rubio

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October 1, 2012

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials

Retina, ISSN: 0275004X 15392864

Neil M. Bressler; David S. Boyer; David F. Williams; Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio

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September 28, 2012

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

Cell, ISSN: 10974172 00928674

Robert M. Samstein; Aaron Arvey; Steven Z. Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Kim; Will Liao; Ming Li; Christina Leslie; John A. Stamatoyannopoulos; Alexander Y. Rudensky

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September 27, 2012

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Blood, ISSN: 15280020 00064971

Raghuveer Singh Mali; Peilin Ma; Li-Fan Zeng; Holly Martin; Baskar Ramdas; Yantao He; Emily Sims; Sarah Nabinger; Joydeep Ghosh; Namit Sharma; Veerendra Munugalavadla; Anindya Chatterjee; Shuo Li; Sandusky; Andrew W. Craig; Kevin D. Bunting; Gen-Sheng Feng; Rebecca J. Chan; Zhong-Yin Zhang; Reuben Kapur

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September 27, 2012

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton

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September 27, 2012

Cross-neutralization of influenza A viruses mediated by a single antibody loop

Nature, ISSN: 00280836 14764687

Damian C. Ekiert; Arun K. Kashyap; John Steel; Adam Rubrum; Gira Bhabha; Reza Khayat; Jeong Hyun Lee; Michael Dillon; Ryann E. O'Neil; Aleksandr M. Faynboym; Michael Horowitz; Lawrence Horowitz; Andrew B. Ward; Peter Palese; Richard Webby; Richard A. Lerner; Ramesh R. Bhatt; Ian A. Wilson

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September 27, 2012

The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang

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September 27, 2012

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian B. Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton

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September 26, 2012

Spatially coordinated kinase signaling regulates local axon degeneration

Journal of Neuroscience, ISSN: 02706474 15292401

Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts

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September 21, 2012

Loss of the tumor suppressor BAP1 causes myeloid transformation

Science, ISSN: 10959203 00368075

Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit

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September 20, 2012

Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller

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September 19, 2012

Childhood disorders of the synapse: Challenges and opportunities

Science Translational Medicine, ISSN: 19466234 19466242

Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi

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September 18, 2012

Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study

International Journal of Nephrology, ISSN: 2090214X 20902158

Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese

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September 17, 2012

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

PLoS ONE, ISSN: 19326203

Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting

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September 17, 2012

Validity of cost and utility results?

PharmacoEconomics, ISSN: 11707690 11792027

Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere

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September 15, 2012

Ras inhibition via direct Ras binding - Is there a path forward?

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Weiru Wang; Guowei Fang; Joachim Rudolph

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September 13, 2012