Scientists / Publications

Publications

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DISPLAYING 7801 - 7850 OF 15578 RESULTS

Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Gregory Z. Ferl; Ruediger E. Port
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Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity
Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851
Meng-Yun Chou; Cary D. Austin; Kim
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC
Nature Immunology, ISSN: 15292908 15292916
Jianming Xie; Johannes B. Huppa; Evan W. Newell; Jun Huang; Peter J. R. Ebert; Qi-Jing Li; Mark M. Davis
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Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Clement L. Ren; Michael W. Konstan; Ashley Yegin; Lawrence Rasouliyan; Benjamin L. Trzaskoma; Morgan; Warren E. Regelmann
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Antibodies against the gh/gl/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (Anti-CMV) neutralizing antibody response in CMV hyperimmune globulin
Journal of Virology, ISSN: 0022538X 10985514
Ashley Fouts; Pamela Chan; Jean-Philippe Stephan; Richard L. Vandlen; Becket Feierbach
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The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients
British Journal of Pharmacology, ISSN: 00071188 14765381
Andrew G. Polson; Reina N. Fuji
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Androgen hormone action in prostatic carcinogenesis: Stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis
Carcinogenesis, ISSN: 01433334 14602180
Emily A. Ricke; Karin Williams; Yi-Fen Lee; Suzana Couto; Yuzhuo Wang; Simon W. Hayward; Gerald R. Cunha; William A. Ricke
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Ultrasensitive detection of cellular protein interactions using bioluminescence resonance energy transfer quantum dot-based nanoprobes
Journal of Cellular Biochemistry, ISSN: 07302312 10974644
Gabriel Quinones; Steven C. Miller; Sukanta Bhattacharyya; Daniel Sobek; Jean-Philippe Stephan
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The effect of fellow eye visual acuity on visual acuity of study eyes receiving ranibizumab for age-related macular degeneration
Retina, ISSN: 0275004X 15392864
Sandrine A. Zweifel; Namrata Saroj; Howard Shapiro; K. Bailey Freund
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Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
mAbs, ISSN: 19420862 19420870
Marcella Yu; Darren Brown; Chae Reed; Shan Chung; Jeff Lutman; Stefanich; Anne Wong; Jean-Philippe Stephan; Robert Bayer
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Drug-drug interaction potential of marketed oncology drugs: In vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction
Pharmaceutical Research, ISSN: 07248741 1573904X
Jane R. Kenny; Sophie Mukadam; Chenghong Zhang; Suzanne Tay; Carol Collins; Aleksandra Galetin; S. Cyrus Khojasteh
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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Daniel P. Sutherlin; Stewart Baker; Angelina Bisconte; Paul M. Blaney; Anthony Brown; Bryan K. Chan; David Chantry; Georgette M. Castanedo; Paul Depledge; Paul Goldsmith; David M. Goldstein; Timothy Hancox; Jasmit Kaur; David Knowles; Rama Kondru; John Lesnick; Matthew C. Lucas; Lewis; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Brian S. Safina; Laurent Salphati; Steven T. Staben; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Ultsch; Bohdan Waszkowycz; Binqing Wei
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Simultaneous, sequential quantitative achiral-chiral analysis by two-dimensional liquid chromatography
Journal of Separation Science, ISSN: 16159306 16159314
Venkatramani; Larry Wigman; Kavita Mistry; Nicholas Chetwyn
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Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
British Journal of Clinical Pharmacology, ISSN: 03065251 13652125
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Josee Cote; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jincai Li; Wei Gu; Diane G. Edmondson; Connie Lu; Natarajan Vijayasankaran; Bruno Figueroa; Dave Stevenson; Thomas Ryll; Feng Li
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A single-dose study of denosumab in patients with various degrees of renal impairment
Journal of Bone and Mineral Research, ISSN: 08840431 15234681
Geoffrey A. Block; Henry G. Bone; Liang Fang; Edward Lee; Desmond Padhi
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The transcription factor ZNF217 Is a prognostic biomarker and therapeutic target during breast cancer progression
Cancer Discovery, ISSN: 21598274 21598290
Laurie E. Littlepage; Adam S. Adler; Hosein Kouros-Mehr; Guiqing Huang; Jonathan Chou; Sheryl R. Krig; Obi L. Griffith; James E. Korkola; Kun Qu; Devon A. Lawson; Qing Xue; Mark D. Sternlicht; Gerrit J. P. Dijkgraaf; Paul Yaswen; Hope S. Rugo; Colleen A. Sweeney; Colin C. Collins; Joe W. Gray; Howard Y. Chang; Zena Werb
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Regulation of epithelial immunity by IL-17 family cytokines
Trends in Immunology, ISSN: 14714906 14714981
Rajita Pappu; Sascha Rutz; Wenjun Ouyang
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A Randomized, phase II trial of standard triweekly compared with dose-dense biweekly capecitabine plus oxaliplatin plus bevacizumab as first-line treatment for metastatic colorectal cancer: XELOX-A-DVS (dense versus standard)
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Edith Mitchell; Thomas Cartwright; Ambrose Kwok; Hu; Edward McKenna; Yehuda Z. Patt
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Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
Nature Biotechnology, ISSN: 10870156 15461696
Mallika Singh; Napoleone Ferrara
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Navitoclax (ABT-263) reduces Bcl-x L-mediated chemoresistance in ovarian cancer models
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Maureen Wong; Nguyen Tan; Jiping Zha; Franklin V. Peale Jr.; Peng Yue; Wayne J. Fairbrother; Lisa D. Belmont
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CD28 costimulation regulates genome-wide effects on alternative splicing
PLoS ONE, ISSN: 19326203
Manish J. Butte; Sun Jung Lee; Jonathan Jesneck; Mary E. Keir; W. Nicholas Haining; Arlene H. Sharpe
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Bystanders Not So Innocent after All
Immunity, ISSN: 10747613 10974180
Marcel Batten; Nico Ghilardi
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ERK inhibition overcomes acquired resistance to MEK Inhibitors
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Georgia Hatzivassiliou; Bonnie Liu; Carol O'Brien; Jill M. Spoerke; Klaus P. Hoeflich; Matthias Peter; Robert Soriano; William F. Forrest; Sherry Heldens; Huifen Chen; Toy; Connie Ha; Wei Zhou; Kyung Song; Lori S. Friedman; Lukas Amler; Garret M. Hampton; John Moffat; Marcia Belvin; Lackner
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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Hans Erickson; Gail L. Phillips; Douglas Leipold; Carmela A. Provenzano; Elaine Mai; Holly A. Johnson; Bert Gunter; Charlene A. Audette; Manish Gupta; Jan Pinkas; Jay Tibbitts
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Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Janusz J. Kulagowski; Wade S. Blair; Richard J. Bull; Christine Chang; Gauri Deshmukh; Hazel J. Dyke; Eigenbrot; Nico Ghilardi; Paul Gibbons; Trevor K. Harrison; Peter R. Hewitt; Marya Liimatta; Christopher A. Hurley; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Robert J. Maxey; Rohan Mendonca; Kyle Mortara; Jeremy Murray; Raman Narukulla; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Discovery of novel PI3-Kinase δ specific inhibitors for the treatment of rheumatoid arthritis: Taming CYP3A4 time-dependent inhibition
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Brian S. Safina; Stewart Baker; Matthew Baumgardner; Paul M. Blaney; Bryan K. Chan; Yunghsiang Chen; Matthew W. Cartwright; Georgette M. Castanedo; Christine Chabot; Arnaud J. Cheguillaume; Paul Goldsmith; David M. Goldstein; Bindu Goyal; Timothy Hancox; Raj K. Handa; Pravin S Iyer; Jasmit Kaur; Rama Kondru; Jane R. Kenny; Sussie L. Krintel; Jun Li; John Lesnick; Matthew C. Lucas; Lewis; Sophie Mukadam; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Fernando Padilla; Wylie S. Palmer; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Laurent Salphati; Pascal P. A. Savy; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Suzanne Tay; Parcharee Tivitmahaisoon; Bohdan Waszkowycz; Binqing Wei; Qin Yue; Chenghong Zhang; Daniel P. Sutherlin
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Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib
Biochemistry, ISSN: 00062960 15204995
Youngjoo Kim; Zhimin Li; Mihaela Apetri; Beibei Luo; Jeffrey Settleman; Karen S. Anderson
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DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina
Cell, ISSN: 10974172 00928674
Joseph M. Zullo; Ignacio A. Demarco; Roger Piqué-Regi; Daniel J. Gaffney; Charles B. Epstein; Chauncey J. Spooner; Teresa R. Luperchio; Bradley E. Bernstein; Jonathan K. Pritchard; Karen L. Reddy; Harinder Singh
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Clinical trial considerations on male contraception and collection of pregnancy information from female partners
Journal of Translational Medicine, ISSN: 14795876
Maria L. Banholzer; Heinrich Buergin; Christoph Wandel; Georg Schmitt; Elmar Gocke; Richard Peck; Thomas Singer; Theresa Reynolds; Marie Mannino; Jonathan Deutsch; Lucette Doessegger
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Pharmacokinetic models for FcRn-mediated IgG disposition
Journal of Biomedicine and Biotechnology, ISSN: 11107243 11107251
Jim J. Xiao
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Charge heterogeneity of monoclonal antibodies by multiplexed imaged capillary isoelectric focusing immunoassay with chemiluminescence detection
Analytical Chemistry, ISSN: 00032700
David A. Michels; Andrea W. Tu; Will McElroy; David Voehringer; Oscar Salas-Solano
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Analysis of Fcγ receptor IIIa and IIa polymorphisms: Lack of correlation with outcome in trastuzumab-treated breast cancer patients
Clinical Cancer Research, ISSN: 10780432 15573265
Sara A. Hurvitz; David J. Betting; Howard M. Stern; Emmanuel Quinaux; Stinson; Somasekar Seshagiri; Ying Zhao; Marc Buyse; John Mackey; Adrian Driga; Sambasivarao Damaraju; Mark X. Sliwkowski; Nicholas J. Robert; Vicente Valero; John Crown; Carla Falkson; Adam Brufsky; Tadeusz Pienkowski; Wolfgang Eiermann; Miguel Martín; Valerie Bée; Omkar Marathe; Dennis J. Slamon; John M. Timmerman
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Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
Blood, ISSN: 15280020 00064971
Delphine Mérino; Seong Lin Khaw; Stefan P. Glaser; Daniel J Anderson; Lisa D. Belmont; Wong; Peng Yue; Mikara Robati; Belinda Phipson; Fairlie; Lee; Kirsteen J. Campbell; Cassandra J. Vandenberg; Suzanne Cory; Andrew W. Roberts; Mary J. C. Ludlam; David C.S. Huang; Bouillet
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Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Huifen Chen; Bryan K. Chan; Jason H. Drummond; Anthony A. Estrada; Janet Gunzner; Xingrong Liu; Yichin Liu; John Moffat; Daniel G. Shore; Zachary K. Sweeney; Thuy Tran; Shumei Wang; Guiling Zhao; Haitao Zhu; Burdick
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Monoclonal antibodies to the V2 domain of MN-rgp120: Fine mapping of epitopes and inhibition of α4β7 binding
PLoS ONE, ISSN: 19326203
Nakamura; Dora P. A. J. Fonseca; Sara M. O'Rourke; Aaron L. Vollrath; Berman
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IL-17-Induced Act1-Mediated signaling is critical for cuprizone-induced demyelination
Journal of Neuroscience, ISSN: 02706474 15292401
Zizhen Kang; Liping Liu; Roo Spangler; Charles Spear; Chenhui Wang; Muhammet Fatih Gulen; Mike Veenstra; Wenjun Ouyang; Richard M. Ransohoff; Xiaoxia Li
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Drugging Wnt signalling in cancer
EMBO Journal, ISSN: 14602075 02614189
Paul G. Polakis
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Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Xiaolei Ma; Elizabeth Helgason; Qui Phung; Quan; Rekha S. Iyer; Michelle W. Lee; Krista K. Bowman; Melissa A. Starovasnik; Erin C. Dueber
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Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): Protein conformational ensemble on HDL
Biochemistry, ISSN: 00062960 15204995
Xuan Gao; Shujun Yuan; Shobini Jayaraman; Olga Gursky
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OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Carol Aghajanian; Stephanie V. Blank; Barbara Goff; Patricia L. Judson; Michael G. Teneriello; Amreen Husain; Mika A. Sovak; Jing Yi; Lawrence R. Nycum
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Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer
Blood, ISSN: 15280020 00064971
Jian-Guo Wang; Julia E. Geddings; Maria M. Aleman; Jessica C. Cardenas; Pichika Chantrathammachart; Julie C. Williams; Daniel Kirchhofer; Vladimir Y. Bogdanov; Ronald R. Bach; Janusz Rak; Frank C. Church; Alisa S. Wolberg; Rafal Pawlinski; Nigel S. Key; Jen Jen Yeh; Nigel Mackman
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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
Nature, ISSN: 00280836 14764687
Jian Payandeh; Tamer M. Gamal El-Din; Todd Scheuer; Ning Zheng; William A. Catterall
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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
New England Journal of Medicine, ISSN: 15334406 00284793
Jean Y. Tang; Julian M. Mackay-Wiggan; Michelle Aszterbaum; Robert Yauch; Joselyn Lindgren; Kris Chang; Carol Coppola; Anita M. Chanana; Jackleen Marji; David R. Bickers; Ervin H. Epstein Jr.
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Efficacy and safety of vismodegib in advanced basal-cell carcinoma
New England Journal of Medicine, ISSN: 15334406 00284793
Aleksandar Sekulic; Michael R. Migden; Anthony E. Oro; Luc Dirix; Karl Lewis; John Hainsworth; James A. Solomon; Simon Yoo; Sarah T. Arron; Philip A. Friedlander; Ellen Marmur; Charles M. Rudin; Anne Lynn S. Chang; Low; Howard M. Mackey; Robert Yauch; Richard A. Graham; Josina C. Reddy; Axel Hauschild
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Structural and functional analysis of HtrA1 and its subdomains
Structure, ISSN: 09692126 18784186
Eigenbrot; Ultsch; Michael T. Lipari; Paul Moran; S. Jack Lin; Rajkumar Ganesan; Quan; Jeffrey Tom; Wendy N. Sandoval; Menno Van Lookeren Campagne; Daniel Kirchhofer
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Impact of low-dose ritonavir on danoprevir pharmacokinetics: Results of computer-based simulations and a clinical drug-drug interaction study
Clinical Pharmacokinetics, ISSN: 03125963 11791926
Micaela B. Reddy; Yuan Chen; Joshua Haznedar; Jennifer Fretland; Steven Blotner; Patrick F. Smith; Jonathan Q. Tran
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MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jessica K. Ma; Mia Y. Platt; Jeffrey Eastham-Anderson; Jeoung-Sook Shin; Ira Mellman
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In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
PLoS ONE, ISSN: 19326203
Kristin R. Wildsmith; Jacob M. Basak; Bruce W. Patterson; Yuriy Pyatkivskyy; Jungsu Kim; Kevin E. Yarasheski; Jennifer X. Wang; Kwasi G. Mawuenyega; Hong Jiang; Maia Parsadanian; Hyejin Yoon; Tom Kasten; Wendy C. Sigurdson; Chengjie Xiong; Alison M. Goate; David M. Holtzman; Randall J. Bateman
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Ligand binding assays in the 21st century laboratory: Recommendations for characterization and supply of critical reagents
AAPS Journal, ISSN: 15507416
Denise M. O'Hara; Valerie Theobald; Adrienne Clements Egan; Joel Usansky; Murli Krishna; Julie TerWee; Mauricio Maia; Frank P. Spriggs; John Kenney; Afshin Safavi; Jeannine Keefe
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