Genentech: Publications

June 1, 2012

Protease activity of MALT1: A mystery unravelled

Biochemical Journal, ISSN: 02646021 14708728

Daniel Kirchhofer; Domagoj Vucic

June 1, 2012

Differential gene expression in glioblastoma defined by ADC histogram analysis: Relationship to extracellular matrix molecules and survival

American Journal of Neuroradiology, ISSN: 01956108 1936959X

Whitney B. Pope; Mirsadraei; Albert Lai; Ascia Eskin; Qiao; Kim; Benjamin M. Ellingson; Phioanh L. Nghiemphu; Samir Kharbanda; Robert Soriano; Nelson; William H. Yong; Phillips; Timothy Cloughesy

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June 1, 2012

FOXO3a and β-catenin co-localization: Double trouble in colon cancer?

Nature Medicine, ISSN: 10788956 1546170X

Yibing Yan; Lackner

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June 1, 2012

Economic evaluation of tocilizumab combination in the treatment of moderate-to-severe rheumatoid arthritis in Italy

Journal of Medical Economics, ISSN: 13696998 1941837X

Alex Diamantopoulos; Maurizio Benucci; Stefano Capri; Wolfgang Berger; Neil Wintfeld; Giovanni Giuliani; Walter Ricciardi

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June 1, 2012

Capillary electrophoresis-mass spectrometry methods for tryptic peptide mapping of therapeutic antibodies

Electrophoresis, ISSN: 01730835 15222683

Colin D. Whitmore; Lynn Gennaro

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June 1, 2012

The cost-effectiveness of primary stroke centers for acute stroke care

Stroke, ISSN: 00392499 15244628

Gregory F. Guzauskas; Denise M. Boudreau; Kathleen F. Villa; Steven R. Levine; David L. Veenstra

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June 1, 2012

Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: An analysis of GDC-0973, a MEK inhibitor

Clinical Cancer Research, ISSN: 10780432 15573265

Harvey Wong; Laurent Vernillet; Amy Peterson; Joseph A. Ware; Lillian Lee; Jean-Francois Martini; Peiwen Yu; Congfen Li; Geoffrey Del Rosario; Edna F. Choo; Klaus P. Hoeflich; Yongchang Shi; Blake T. Aftab; Ron Aoyama; Sanh Tan Lam; Marcia Belvin; John Prescott

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June 1, 2012

Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: Key role of Stat3 signaling

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Xueping Qu; Guanglei Zhuang; Lanlan Yu; Meng; Napoleone Ferrara

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June 1, 2012

Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD

Primary Care Respiratory Journal, ISSN: 14714418 14751534

Moshe Zutler; Jonathan P. Singera; Theodore A. Omachia; Mark D. Eisner; Carlos Iribarren; Patricia Katz; Paul D. Blanc

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June 1, 2012

Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery

AAPS PharmSciTech, ISSN: 15309932

Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Amy Sambrone; Connie Chan; Ryan Hart

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June 1, 2012

Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone

Haematologica, ISSN: 03906078 15928721

Daniel O. Persky; David Dornan; Bryan H. Goldman; Rita M. Braziel; Richard I. Fisher; Michael LeBlanc; David G. Maloney; Oliver W. Press; Thomas P. Miller; Lisa M. Rimsza

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June 1, 2012

Issues and challenges of subvisible and submicron particulate analysis in protein solutions

AAPS Journal, ISSN: 15507416

Thomas M. Scherer; Stephenie Leung; Laura Owyang; Steven J. Shire

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June 1, 2012

Genetically engineered mouse models: Closing the gap between preclinical data and trial outcomes

Cancer Research, ISSN: 00085472 15387445

Mallika Singh; Christopher L. Murriel; Leisa Johnson

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June 1, 2012

Developmental genetics of secretory vesicle acidification during caenorhabditis Elegans spermatogenesis

Genetics, ISSN: 00166731 19432631

Elizabeth J. Gleason; Paul D. Hartley; Melissa Henderson; Katherine L. Hill-Harfe; Paul W. Price; Robby M. Weimer; Tim L. Kroft; Guang-dan Zhu; Suzanne Cordovado; Steven W. L'Hernault

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June 1, 2012

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

Genes and Development, ISSN: 08909369 15495477

Karen Yap; Zhao Qin Lim; Piyush Khandelia; Brad A. Friedman; Eugene V. Makeyev

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June 1, 2012

HORIZON: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration

Ophthalmology, ISSN: 01616420 15494713

Michael Singer; Carl C. Awh; Srinivas Sadda; William R. Freeman; Andrew N. Antoszyk; Pamela Wong; Lisa Tuomi

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June 1, 2012

Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery

Pharmaceutical Research, ISSN: 07248741 1573904X

Elaine E. Peters; Mahmoud Ameri; Xiaomei Wang; Maa; Peter E. Daddona

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June 1, 2012

Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

John I. Trujillo; James R. Kiefer; Wei Huang; Jacqueline E. Day; Joseph Moon; Gina M. Jerome; Christine P. Bono; Christine M. Kornmeier; Melanie L. Williams; Cyrille Kuhn; Glen R. Rennie; Thomas A. Wynn; Christopher P. Carron; Atli Thorarensen

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June 1, 2012

Synaptic structure and function

Current Opinion in Neurobiology, ISSN: 09594388 18736882

Antoine Triller; Morgan Sheng

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June 1, 2012

Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Eric Van Cutsem; Sanne De Haas; Yoon-Koo Kang; Atsushi Ohtsu; Niall C. Tebbutt; Jian M. Xu; Wei Peng Yong; Bernd Langer; Paul Delmar; Stefan J. Scherer; Manish A. Shah

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May 31, 2012

A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies

Blood, ISSN: 15280020 00064971

Laurie H. Sehn; Sarit E. Assouline; Douglas A. Stewart; Joy Mangel; Randy D. Gascoyne; Gregg D. Fine; Susan Frances-Lasserre; David J. Carlile; Michael Crump

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May 30, 2012

Synthesis of cyanoacetyl oxazolidinones

Synthesis (Germany), ISSN: 00397881 1437210X

Kaitlyn M. Weeber; Jacob B. Schwarz

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May 25, 2012

Building a three-dimensional model of CYP2C9 inhibition using the autocorrelator: An autonomous model generator

Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596

Matthew A. Lardy; Laurie Lebrun; Drew Bullard; Charles Kissinger; Alberto Gobbi

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May 25, 2012

Building a three-dimensional model of CYP2C9 inhibition using the autocorrelator: An autonomous model generator

Journal of Chemical Information and Modeling, ISSN: 15499596 15205142

Matthew A. Lardy; Laurie Lebrun; Drew Bullard; Charles Kissinger; Alberto Gobbi

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May 25, 2012

Mapping N-Glycosylation Sites across Seven Evolutionarily Distant Species Reveals a Divergent Substrate Proteome Despite a Common Core Machinery

Molecular Cell, ISSN: 10972765 10974164

Dorota F. Zielińska; Florian Gnad; Katharina Schropp; Jacek R. Wiśniewski; Matthias Mann

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May 24, 2012

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Robert Heald; Philip Jackson; Pascal P. A. Savy; Mark Jones; Emanuela Gancia; Brenda Burton; Richard Newman; Jason Boggs; Emily Chan; Jocelyn Chan; Edna F. Choo; Mark Merchant; Patrick J. Rudewicz; Ultsch; Wiesmann; Qin Yue; Marcia Belvin; Steve Price

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May 22, 2012

Origin of immunoglobulin isotype switching

Current Biology, ISSN: 09609822

Catherine Zhu; Victor Lee; Alyssa Finn; Kate Senger; Ali A. Zarrin; Louis Du Pasquier; Ellen Hsu

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May 22, 2012

BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor

PLoS ONE, ISSN: 19326203

Kateryna Kyrylkova; Sergiy Kyryachenko; Brian Biehs; Ophir D. Klein; Chrissa Kioussi; Mark Leid

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May 21, 2012

Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM)

BMC Microbiology, ISSN: 14712180

Brett A Chromy; Imola K. Fodor; Nancy K Montgomery; Paul A Luciw; Sandra L McCutchen-Maloney

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May 21, 2012

Effect of central nervous system metastases on treatment discontinuation and survival in older women receiving trastuzumab for metastatic breast cancer

Journal of Cancer Epidemiology, ISSN: 16878558 16878566

Mark Danese; Karla Lindquist; Justin Doan; Deepa Lalla; Melissa Brammer; Robert I. Griffiths

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May 15, 2012

Current Technology and Limitation of LC-MS

ADME-Enabling Technologies in Drug Design and Development,

Cornelis E. Hop

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May 15, 2012

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf V600E kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Li Ren; Kateri Ahrendt; Jonas Grina; Ellen R. Laird; Alexandre J. Buckmelter; Joshua D. Hansen; Bradley J. Newhouse; David Moreno; Steve Wenglowsky; Victoria Dinkel; Susan L. Gloor; Gregg Hastings; Sumeet Rana; Kevin Rasor; Tyler Risom; Hillary L. Sturgis; Walter C. Voegtli; Simon Mathieu

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May 15, 2012

Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module

Developmental Cell, ISSN: 15345807 18781551

Matthew Koss; Alexandre Bolze; Andrea Brendolan; Matilde Saggese; Terence D. Capellini; Ekaterina Bojilova; Bertrand Boisson; Owen W.J. Prall; David A. Elliott; Mark J. Solloway; Elisa Lenti; Chisa Hidaka; Ching-Pin Chang; Nizar Mahlaoui; Richard P. Harvey; Jean-Laurent Casanova; Licia Selleri

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May 15, 2012

Caspases in synaptic plasticity

Molecular Brain, ISSN: 17566606

Zheng Li; Morgan Sheng

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May 15, 2012

Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy

Journal of Immunology, ISSN: 00221767 15506606

Maureen A. Su; Dan Davini; Philip Cheng; Karen Giang; Una Fan; Jason Devoss; Kellsey P. A. Johannes; Lorelei Taylor; Anthony K. Shum; Mariella Valenzise; Antonella Meloni; Helene Bour-Jordan; Mark S. Anderson

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May 11, 2012

Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology

BMC Bioinformatics, ISSN: 14712105

Steven M. Hill; Richard M. Neve; Nora Bayani; Wen-Lin Kuo; Safiyyah Ziyad; Paul T. Spellman; Joe W. Gray; Sach Mukherjee

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May 10, 2012

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Flygare; Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Frederick Cohen; Deshayes; Karl Doerner; Gail Eckhardt; Linda O. Elliott; Bainian Feng; Matthew C Franklin; Stacy Frankovitz Reisner; Lewis Gazzard; Jason S Halladay; Sarah G. Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley J. Murray; Emile G. Plise; Quan; Jean-Philippe Stephan; Young G. Shin; Jeffrey Tom; Vickie Tsui; Joanne Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi J. A. Wallweber; Lan Wang; Joseph A. Ware; Zhaoyang Wen; Harvey Wong; Jonathan M. Wong; Melisa Wong; Susan C. Wong; Ron Yu; Zobel; Wayne J. Fairbrother

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May 9, 2012

Challenges and opportunities in the use of CTCs for companion diagnostic development

Recent Results in Cancer Research, ISSN: 00800015

Elizabeth A. Punnoose; Lackner

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May 8, 2012

An ATP-site on-off switch that restricts phosphatase accessibility of Akt

Science Signaling, ISSN: 19450877 19379145

Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber

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May 8, 2012

An ATP-site on-off switch that restricts phosphatase accessibility of Akt

Science Signaling, ISSN: 19450877 19379145

Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian B. Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber

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May 4, 2012

Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Yonglian Sun; Kate Senger; Tomasz K. Baginski; Anita Mazloom; Yvonne Chinn; Homer Pantua; Kajal Hamidzadeh; Sree R. Ramani; Luis; Irene Tom; Andrew Sebrell; Gabriel Quinones; Ma; Kiran Mukhyala; Tao Sai; Jiabing Ding; Benjamin Haley; Hooman Shadnia; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Hass; Ali A. Zarrin

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May 4, 2012

Engineering and structural characterization of a linear polyubiquitin-specific antibody

Journal of Molecular Biology, ISSN: 10898638 00222836

Marissa L. Matsumoto; Ken Dong; Christine Yu; Lilian Phu; Xinxin Gao; Rami N. Hannoush; Sarah G. Hymowitz; Donald S. Kirkpatrick; Vishva M. Dixit; Robert F. Kelley

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May 4, 2012

Complementary proteomic tools for the dissection of apoptotic proteolysis events

Journal of Proteome Research, ISSN: 15353893 15353907

Victoria Pham; Pitti; Veronica G. Anania; Corey Bakalarski; Daisy J. Bustos; Suchit Jhunjhunwala; Qui Phung; Kebing Yu; William F. Forrest; Donald S. Kirkpatrick; Avi Ashkenazi; Jennie R. Lill

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May 3, 2012

Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes

PLoS ONE, ISSN: 19326203

Jeffery J. Wallin; Zhengyu Guan; Kyle A. Edgar; Wei Zhou; Ross Francis; Anthony C. Torres; Matthias Peter; Jeffrey Eastham-Anderson; Sabrina Arena; Alberto Bardelli; Sue Griffin; John E. Goodall; Kyla M. Grimshaw; Klaus P. Hoeflich; Christopher Torrance; Marcia Belvin; Lori S. Friedman

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May 2, 2012

N-Cadherin prodomain processing regulates synaptogenesis

Journal of Neuroscience, ISSN: 02706474 15292401

Analía Reinés; Louis-Philippe Bernier; Robyn McAdam; Wiam Belkaid; Shan; Alexander W. Koch; Philippe Séguéla; David R. Colman; Ajit S. Dhaunchak

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May 1, 2012

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

Journal of Pharmacological and Toxicological Methods, ISSN: 10568719 1873488X

Leishman; Beck; Noel Dybdal; Gallacher; Guth; Holbrook; Brian Roche; Wallis

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May 1, 2012

From the editor

BioProcess International, ISSN: 15426319

Siddharth Advant; Hazel Aranha; Milton J. Axley; R. Lee Buckler; Michel Chartrain; Nancy Chew; Laurel Donahue-Hjelle; John Dougherty; Don R. Durham; Jim Faulkner; Pete Gagnon; Hélène Gazzano-Santoro; Rick Hancock; Timothy K. Hayes; Kenneth Hughes; Susan Dana Jones; Alex D. Kanarek; Dennis M. Kraichely; Vadim Klyushnichenko; Fred Mann; Adriana E. Manzi; Otto-Wilhelm Merten; Thomas J. Pritchett; T. Shantha Raju; Nadine Ritter; Sally Seaver; Robert P. Shaw; Abhinav Shukla; Michiel Ultee; Scott M. Wheelwright; William G. Whitford; Shuichi Yamamoto; Jianguo Yang; Xiaoming Yang

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May 1, 2012

Standardization of single use components' extractable studies for industry

Pharmaceutical Engineering, ISSN: 02738139

Ekta Mahajan; Trishna Ray-Chaudhuri; James Dean Vogel

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May 1, 2012

Online FDA Resources Versus Data on File: Minimizing Data on File in Standard Medical Response Letters

Drug Information Journal, ISSN: 00928615

Nancy Hwang; Graham; Marbel Catolico

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May 1, 2012