Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8101 - 8150 OF 15578 RESULTS

Treatment of HER2-positive breast cancer: Current status and future perspectives
Nature Reviews Clinical Oncology, ISSN: 17594774 17594782
Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni
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Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria
Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436
Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini
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Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus
Infection and Immunity, ISSN: 00199567 10985522
Melissa A. Gessner; Jessica L. Werner; Lauren M. Lilly; Michael P. Nelson; Allison E. Metz; Chad W. Dunaway; Yvonne R. Chan; Wenjun Ouyang; Gordon D. Brown; Casey T. Weaver; Chad Steele
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Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials
Pancreatology, ISSN: 14243911 14243903
Rebecca J. Brais; Susan E. Davies; Maria O'Donovan; Ben W. Simpson; Natalie Cook; Darbonne; Sian Chilcott; Martijn P. Lolkema; Albrecht Neesse; Michelle Lockley; Pippa G. Corrie; Duncan I. Jodrell; Raaj K. Praseedom; Emmanuel L. Huguet; Asif Jah; Neville V. Jamieson; Frederic J. De Sauvage; David Tuveson; Nicholas R. Carroll
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Erratum: Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres (Bioorganic and Medicinal Chemistry Letters (2010) 20 (2229-2233))
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother
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Tenecteplase for the improvement of blood flow rate in dysfunctional hemodialysis catheters
Clinical Nephrology, ISSN: 03010430
Jesse Goldman; Steven Fishbane; Matthew J. Oliver; Martha Blaney; Joan R. Jacobs; Susan M. Begelman
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Differentiation programs in development and cancer
Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing,
Hosein Kouros-Mehr
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Neuropilin-1 expression in cancer and development
Journal of Pathology, ISSN: 00223417 10969896
Adrian M. Jubb; Laura A. Strickland; Scot D. Liu; Judy Mak; Maike Schmidt; Koeppen
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High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency
PLoS Genetics, ISSN: 15537390 15537404
Ricardo C. Ferreira; Qiang Pan-Hammarström; Robert R. Graham; Gumersindo Fontán; Annette T. Lee; Ward Ortmann; Ning Wang; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R. Ludviksson; Sinikka Koskinen; Katri Haimila; Leonid Padyukov; Peter K. Gregersen; Lennart Hammarström; Timothy W. Behrens
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An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription
Nucleic Acids Research, ISSN: 03051048 13624962
Emily C. Knouf; Kavita Garg; Jason D. Arroyo; Yesenia Correa; Deepayan Sarkar; Rachael K. Parkin; Kaitlyn Wurz; Kathy C. O'Briant; Andrew K. Godwin; Nicole D. Urban; Walter L. Ruzzo; Robert Gentleman; Charles W. Drescher; Elizabeth M. Swisher; Muneesh Tewari
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Internet and print resources to facilitate pathology analysis when phenotyping genetically engineered rodents
Veterinary Pathology, ISSN: 03009858 15442217
Brad Bolon; Suzana Couto; Laurence Fiette; la Perle
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The authors' reply
American Journal of Clinical Pathology, ISSN: 00029173 19437722
Mark H. Stoler; Teresa L. Wright
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Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jun Luo; Natarajan Vijayasankaran; Jennifer Autsen; Rodell Santuray; Terry Hudson; Ashraf Amanullah; Feng Li
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Costs and clinical outcomes among patients with second-line non-small cell lung cancer in the outpatient community setting
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Eric Nadler; Michael Forsyth; Sacha Satram-Hoang; Carolina Reyes
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Profiling cellular myristoylation and palmitoylation using ω-alkynyl fatty acids
Methods in Molecular Biology, ISSN: 10643745
Rami N. Hannoush
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The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether
Protein Science, ISSN: 09618368 1469896X
Ping Liu; Samuel Bouyain; Eigenbrot; Daniel J. Leahy
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Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays
Methods in Molecular Biology, ISSN: 10643745
Gabriela Lavezzari; Lackner
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Severity of asthma score predicts clinical outcomes in patients with moderate to severe persistent asthma
Chest, ISSN: 19313543 00123692
Mark D. Eisner; Ashley Yegin; Benjamin L. Trzaskoma
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Impact of baseline virologic, immunologic, and demographic characteristics on virologic responses in the Gemini study
HIV Clinical Trials, ISSN: 15284336 19455771
Anchalee Avihingsanon; Kiat Ruxrungtham; Harold Katner; Carol Jean Guittari; Sharon Walmsley
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Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Aarti Shikotra; David F. Choy; Chandra M. Ohri; Emma Doran; Claire A. Butler; Beverley Hargadon; Maria Shelley; Abbas Alexander; Cary D. Austin; Janet Jackman; Lawren C. Wu; Liam G. Heaney; Joseph R. Arron; Peter Bradding
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Intermittent administration of MEK inhibitor GDC-0973 plus pi3k inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Mark Merchant; Christine Orr; Jocelyn Chan; Doug Den Otter; Berry; Ian Kasman; Koeppen; Ken Rice; Nai-Ying Yang; Stefan Engst; Stuart H. Johnston; Lori S. Friedman; Marcia Belvin
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The Role of Pharmaceutical Medical Information in Promotional Review: Three Benchmarking Surveys
Drug Information Journal, ISSN: 00928615
Lisa Bonk; Madhuri Kothari; Alyson Sous Andrikanich; Ellen Yang
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Interdependence of drug substance physical properties and corresponding quality control strategy
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; Mark E. Reynolds; King Chuang; Minli Xie
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Culture temperature modulates aggregation of recombinant antibody in cho cells
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Natalia Gomez; Jayashree Subramanian; Jun Ouyang; Mary D. H. Nguyen; Matthew Hutchinson; Vikas Sharma; Andy Lin; Inn H. Yuk
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Stability of IgG1 monoclonal antibodies in intravenous infusion bags under clinical in-use conditions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Alavattam Sreedhara; Zephania Kwong Glover; Nicole Piros; Nina Xiao; Ankit Patel; Bruce Kabakoff
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Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Sharlene R. Lim; Xiaoli Qin; Simone Susser; John B. Nicholas; Christian Lange; Eva Herrmann; Jin Hong; Ann Elizabeth Arfsten; Lisa Hooi; Williamson Bradford; Nájera; Patrick F. Smith; Stefan Zeuzem; Karl Kossen; Christophe Sarrazin; Scott D. Seiwert
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Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney
Toxicological Sciences, ISSN: 10960929 10966080
Dolores Diaz; Krishna P. Allamneni; Jacqueline M. Tarrant; Sock-Cheng Lewin-Koh; Rama Pai; Preeti Dhawan; Cain; Cleopatra Kozlowski; Hajime Hiraragi; Nghi La; Dylan P. Hartley; Xiao Ding; Brian J. Dean; Sheila Bheddah; Donna M. Dambach
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Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
Nature Chemical Biology, ISSN: 15524469 15524450
Karen Stanger; Micah Steffek; Lijuan Zhou; Christine D. Pozniak; Quan; Yvonne Franke; Jeffrey Tom; Christine Tam; J. Michael Elliott; Joe Lewcock; Yingnan Zhang; Jeremy Murray; Rami N. Hannoush
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Consistency of the novel equations for determination of hepatic clearance and drug time course in liver that account for the difference in drug ionization in extracellular and intracellular tissue water
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy; Ning Liu; Jason S Halladay
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The Yin and Yang of Immunomodulatory Biologics: Assessing the Delicate Balance between Benefit and Risk
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko; Hong Wang
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Signaling: An oxysterol ligand for Smoothened
Nature Chemical Biology, ISSN: 15524469 15524450
Hayley J. Sharpe; Frederic J. De Sauvage
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Evaluation of the National Heart, Lung, and Blood Institute guidelines impairment domain for classifying asthma control and predicting asthma exacerbations
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Robert S. Zeiger; Ashley Yegin; F. Estelle R. Simons; Tmirah Haselkorn; Lawrence Rasouliyan; Stanley J. Szefler; Bradley E. Chipps
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DEGAS: Sharing and tracking target compound ideas with external collaborators
Journal of Chemical Information and Modeling, ISSN: 15205142 15499596
Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron
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Viscosity behavior of high-concentration monoclonal antibody solutions: Correlation with interaction parameter and electroviscous effects
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia
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Transforming the untransformable: Application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis
mBio, ISSN: 21507511
Ian R. Monk; Ishita M. Shah; Min Xu; Man-Wah Tan; Timothy J. Foster
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Viscosity behavior of high-concentration protein mixtures
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
William J. Galush; Lan N. Le; Jamie M. R. Moore
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Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells
PLoS Pathogens, ISSN: 15537374 15537366
Anna Smed-Sörensen; Cecile Chalouni; Bithi Chatterjee; Lillian Cohn; Peter Blattmann; Norihiro Nakamura; Lélia Delamarre; Ira Mellman
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Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab
Annals of Oncology, ISSN: 15698041 09237534
Lenihan; Suter; Melissa Brammer; Neate; Graham Ross; Baselga
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Escherichia coli Serotype O55:H7 Diversity Supports Parallel Acquisition of Bacteriophage at Shiga Toxin Phage Insertion Sites during evolution of the O157:H7 lineage
Journal of Bacteriology, ISSN: 10985530 00219193
Jennifer L. Kyle; Craig A. Cummings; Craig T. Parker; Beatriz Quiñones; Paolo Vatta; Elizabeth Newton; Steven Huynh; Michelle Swimley; Lovorka Degoricija; Melissa Barker; Samar Fontanoz; Kimberly Nguyen; Ronak Patel; Rixun Fang; Robert Tebbs; Olga Petrauskene; Manohar Furtado; Robert E. Mandrell
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Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C
Gastroenterology, ISSN: 15280012 00165085
Tom W. Chu; Rohit Kulkarni; Edward J. Gane; Stuart K. Roberts; Catherine Stedman; Peter Angus; Brett Ritchie; Xiao-Yu Lu; David Ipe; Uri Lopatin; Søren Germer; Victor A. Iglesias; Robert Elston; Patrick F. Smith; Nancy Shulman
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Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Paroma Chakravarty; Raj Suryanarayanan; Ramprakash Govindarajan
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Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma
Thorax, ISSN: 14683296 00406376
Claire A. Butler; Stephen McQuaid; Cliff C. Taggart; Sinead Weldon; Richard Carter; Grzegorz Skibinski; Timothy J. Warke; David F. Choy; Lorcan P. McGarvey; Peter Bradding; Joseph R. Arron; Liam G. Heaney
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Synapses and Alzheimer's disease
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Morgan Sheng; Bernardo L Sabatini; Thomas C. Südhof
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Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain
Current Molecular Medicine, ISSN: 18755666 15665240
Shelby K. Wyatt; H. Charles Manning; Mingfeng Bai; Moneeb Ehtesham; Khubaib Y. Mapara; Reid C. Thompson; Darryl J. Bornhop
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Applying Nonexperimental Study Approach to Analyze Historical Batch Data
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Minli Xie
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Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis
mBio, ISSN: 21507511
Tien-Huei Hsu; Irene W. Althaus; Oded Foreman; Katherine R. Spindlera
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Phase II study of eribulin mesylate (E7389) in patients with metastatic castration-resistant prostate cancer stratified by prior taxane therapy
Annals of Oncology, ISSN: 15698041 09237534
De Bono; Molife; Guru Sonpavde; Pablo Maroto; Calvo; Cartwright; Loesch; Feit; Asha Das; Zang; Wanders; Agoulnik; Petrylak
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On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenate
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Symptom burden & quality of life among patients receiving second-line treatment of metastatic colorectal cancer
BMC Research Notes, ISSN: 17560500
Mark S. Walker; Elaine B. Yu; Jiandong Kerr; Yeun Mi Yim; Edward J. Stepanski; Lee S. Schwartzberg
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FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973
EJNMMI Research, ISSN: 2191219X
Andreas R. Baudy; Taner Dogan; Judith E. Flores; Klaus P. Hoeflich; Fei Su; Nicholas Van Bruggen; Simon P. Williams
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