Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8151 - 8200 OF 15578 RESULTS

Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport
EJNMMI Research, ISSN: 2191219X
Simon P. Williams; Judith E. Flores; Ruediger E. Port; Thomas Bengtsson
View on Scopus
The power of FDG PET to detect treatment effects is increased by glucose correction using a Michaelis constant
EJNMMI Research, ISSN: 2191219X
Simon P. Williams; Judith E. Flores; Andreas R. Baudy; Ruediger E. Port; Thomas Bengtsson
View on Scopus
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
Journal of Pathology, ISSN: 10969896 00223417
Mallika Singh; Suzana Couto; William F. Forrest; Anthony Lima; Jason H. Cheng; Rafael Molina; Jason E. Long; Patricia Hamilton; Angela McNutt; Ian Kasman; Michelle Nannini; Hani Bou-Reslan; Tim C. Cao; Calvin Ho; Kai H. Barck; Richard A. D. Carano; Oded Foreman; Jeffrey Eastham-Anderson; Adrian M. Jubb; Napoleone Ferrara; Leisa Johnson
View on Scopus
Mechanisms of acquired resistance to targeted cancer therapies
Future Oncology, ISSN: 17448301 14796694
Lackner; Wilson; Jeffrey Settleman
View on Scopus
Key findings and clinical implications from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Bradley E. Chipps; Robert S. Zeiger; Larry Borish; Sally E. Wenzel; Ashley Yegin; Mary Lou Hayden; Dave P. Miller; Eugene R. Bleecker; F. Estelle R. Simons; Stanley J. Szefler; Weiss; Tmirah Haselkorn
View on Scopus
The potential clinical relevance of visible particles in parenteral drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Lucette Doessegger; Hanns-Christian Mahler; Piotr Szczesny; Helmut Rockstroh; Georg Kallmeyer; Anja Langenkamp; Joerg Herrmann; Joseph Famulare
View on Scopus
An 'all-inclusive' 96-well cytochrome P450 induction method: Measuring enzyme: Activity, mrna levels, protein levels, and cytotoxicity from one well using: Cryopreserved human hepatocytes
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Jason S Halladay; Susan C. Wong; S. Cyrus Khojasteh; Susan Grepper
View on Scopus
Rheumatoid arthritis and the incidence of influenza and influenza-related complications: A retrospective cohort study
BMC Musculoskeletal Disorders, ISSN: 14712474
William A. Blumentals; Anna Arreglado; Pavel Napalkov; Stephen Toovey
View on Scopus
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Guiquan Jia; Erickson; David F. Choy; Mosesova; Lawren C. Wu; Owen D. Solberg; Aarti Shikotra; Richard Carter; Séverine Audusseau; Qutayba Hamid; Peter Bradding; John V. Fahy; Prescott G. Woodruff; Harris; Joseph R. Arron
View on Scopus
Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.
PLoS ONE, ISSN: 19326203
French; Benjamin C. Lin; Manping Wang; Adams; Theresa Shek; Kathy Hötzel; Brad Bolon; Ron Ferrando; Craig Blackmore; Kurt A. Schroeder; Luis A Rodriguez; Maria Hristopoulos; Rayna Venook; Avi Ashkenazi; Luc Desnoyers
View on Scopus
Effects of commercial air travel on patients with pulmonary hypertension
Chest, ISSN: 19313543 00123692
Nareg Roubinian; C. Gregory Elliott; Christopher F. Barnett; Paul D. Blanc; Joan Chen; Teresa De Marco; Hubert Chen
View on Scopus
Determination of hepatic clearance with the account of drug-protein binding kinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
View on Scopus
A phase i study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Sarah B. Goldberg; Jeffrey G. Supko; Joel W. Neal; Alona Muzikansky; Subba Digumarthy; Panos Fidias; Jennifer S. Temel; Rebecca S. Heist; Alice T. Shaw; Patricia O. McCarthy; Thomas J. Lynch; Sreenath Sharma; Jeffrey Settleman; Lecia V. Sequist
View on Scopus
Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin
View on Scopus
Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny
View on Scopus
Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler
View on Scopus
Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
View on Scopus
Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
View on Scopus
Variable selection in multivariate modeling of drug product formula and manufacturing process
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie
View on Scopus
Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Mayumi Bowen; Nick Armstrong; Maa
View on Scopus
Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma
Investigational New Drugs, ISSN: 15730646 01676997
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
View on Scopus
Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach
Drug Metabolism Letters, ISSN: 18723128
Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny
View on Scopus
A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Jeff Blaney
View on Scopus
SpeCond: A method to detect condition-specific gene expression
Genome Biology, ISSN: 14747596 1474760X
Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe
View on Scopus
The A-MYSM Power of Deubiquitinases
Immunity, ISSN: 10747613 10974180
Ignacio A. Demarco; Harinder Singh
View on Scopus
The authors reply
New England Journal of Medicine, ISSN: 00284793 15334406
Joseph R. Arron; Jonathan Corren; Matthews
View on Scopus
Cancer immunotherapy comes of age
Nature, ISSN: 14764687 00280836
Ira Mellman; George Coukos; Glenn Dranoff
View on Scopus
Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria
PLoS ONE, ISSN: 19326203
Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder
View on Scopus
TRAF2 and cellular IAPs: A critical link in TNFR family signaling
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
View on Scopus
Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
View on Scopus
Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
Science Translational Medicine, ISSN: 19466242 19466234
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
View on Scopus
Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition
PLoS ONE, ISSN: 19326203
Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens
View on Scopus
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Science Translational Medicine, ISSN: 19466242
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
View on Scopus
The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
View on Scopus
Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
View on Scopus
Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
British Journal of Cancer, ISSN: 00070920 15321827
Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland
View on Scopus
Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha
View on Scopus
On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format
Analytical Biochemistry, ISSN: 10960309 00032697
Melissa Alvarez; Guillaume Tremintin; Jennifer Wang; Eng; Kao; Justin Jeong; Victor Ling; Oleg V. Borisov
View on Scopus
Role of MetMAb (OA-5D5) in c-MET active lung malignancies
Expert Opinion on Biological Therapy, ISSN: 14712598
Mosmi Surati; Premal Patel; Amy Peterson; Ravi Salgia
View on Scopus
The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
Genes and Immunity, ISSN: 14664879 14765470
Paola G. Bronson; Goldstein; Ramsay; Beckman; Janelle A. Noble; Lane; Michael F. Seldin; Jennifer A. Kelly; John B. Harley; Kathy L. Moser; Patrick M. Gaffney; Timothy W. Behrens; Lindsey A. Criswell; Lisa F. Barcellos
View on Scopus
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
Nature Immunology, ISSN: 15292908 15292916
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Luis; Zhongua Lin; Surinc Er Jeet; Justin Lesch; Jason A. Hackney; Janice Kim; Meijuan Zhou; Joyce Lai; Zora Modrusan; Tao Sai; Wyne P. Lee; Min Xu; Patrick Caplazi; Laurie Diehl; Jason De Voss; Mercedesz Balazs; Lino C. Gonzalez Jr.; Harinder Singh; Wenjun Ouyang; Rajita Pappu
View on Scopus
Proposal for a new protein therapeutic immunogenicity titer assay cutpoint
Bioanalysis, ISSN: 17576180 17576199
Eric Wakshull; Robert Hendricks; Caroline Amaya; Daniel A. Coleman
View on Scopus
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T H17 cells
Nature Immunology, ISSN: 15292908 15292916
Sascha Rutz; Rajkumar Noubade; Celine Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason A. Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
View on Scopus
It takes two to tango: A new couple in the family of ubiquitin-editing complexes
Nature Immunology, ISSN: 15292908 15292916
Ingrid E. Wertz
View on Scopus
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
PLoS Genetics, ISSN: 15537390 15537404
Paula S. Ramos; Lindsey A. Criswell; Kathy L. Moser; Mary E. Comeau; Adrienne H. Williams; Nicholas M. Pajewski; Sharon A. Chung; Robert R. Graham; Raphael Zidovetzki; Jennifer A. Kelly; Kenneth M. Kaufman; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; Robert P. Kimberly; Patrick M. Gaffney; Marta E. Alarcón-Riquelme; John B. Harley; Carl D. Langefeld
View on Scopus
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors
Endocrinology, ISSN: 00137227 19457170
Erik R. Nelson; Carolyn D. DuSell; Xiaojuan Wang; Matthew K. Howe; Glenda Evans; Ryan D. Michalek; Michihisa Umetani; Jeffrey C. Rathmell; Sundeep Khosla; Diane Gesty-Palmer; Donald P. McDonnell
View on Scopus
Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects
AAPS Journal, ISSN: 15507416
Nageshwar Budha; Andreas Kovar; Bernd Meibohm
View on Scopus
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Albert Lai; Samir Kharbanda; Whitney B. Pope; Anh Tran; Orestes E. Solis; Franklin V. Peale Jr.; William F. Forrest; Kanan Pujara; Jose A. Carrillo; Ajay Pandita; Benjamin M. Ellingson; Chauncey W. Bowers; Robert Soriano; Nils-Ole Schmidt; Sankar Mohan; William H. Yong; Somasekar Seshagiri; Zora Modrusan; Zhaoshi Jiang; Kenneth D. Aldape; Paul S. Mischel; Linda M. Liau; Cameron J. Escovedo; Weidong Chen; Phioanh L. Nghiemphu; C. David James; Michael D. Prados; Manfred Westphal; Katrin Lamszus; Timothy Cloughesy; Phillips
View on Scopus
Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans
Psychopharmacology, ISSN: 00333158 14322072
William Cho; Paul Maruff; John Connell; Cindy Gargano; Nicole Calder; Scott Doran; Sabrina Fox-Bosetti; Aizza Hassan; John Renger; Gary Herman; Christopher Lines; Ajay Verma
View on Scopus
Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human
Xenobiotica, ISSN: 00498254 13665928
Laurent Salphati; Jodie Pang; Emile G. Plise; Bilin Chou; Jason S Halladay; Alan G. Olivero; Patrick J. Rudewicz; Qingping Tian; Susan C. Wong; Xiaolin Zhang
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.