Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8901 - 8950 OF 15578 RESULTS

Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer
Cancer Research, ISSN: 15387445 00085472
Ciara Metcalfe; Ashraf E. K. Ibrahim; Michael Graeb; Marc De La Roche; Thomas Schwarz-Romond; Marc Fiedler; Douglas J. Winton; Anthony Corfield; Mariann Bienz
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Imbalanced pattern completion vs. separation in cognitive disease: Network simulations of synaptic pathologies predict a personalized therapeutics strategy
BMC Neuroscience, ISSN: 14712202
Jesse E. Hanson; Daniel V. Madison
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β-catenin balances immunity
Science, ISSN: 00368075 10959203
Ira Mellman; Björn E. Clausen
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Diverse somatic mutation patterns and pathway alterations in human cancers
Nature, ISSN: 00280836 14764687
Zhengyan Kan; Bijay S. Jaiswal; Stinson; Vasantharajan Janakiraman; Deepali Bhatt; Howard M. Stern; Peng Yue; Matthias Peter; Richard Bourgon; Jianbiao Zheng; Martin Moorhead; Subhra Chaudhuri; Lynn P. Tomsho; Brock A. Peters; Kanan Pujara; Shaun Cordes; David P. Davis; Victoria E. H. Carlton; Yuan; Li Li; Weiru Wang; Eigenbrot; Joshua S. Kaminker; Eberhard; Waring; Stephan C. Schuster; Zora Modrusan; Zemin Zhang; David Stokoe; Frederic J. De Sauvage; Malek Faham; Somasekar Seshagiri
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Considerations for Successful Lyophilization Process Scale-Up, Technology Transfer, and Routine Production
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Samir Sane; Chung C. Hsu
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The Structure of Biological Therapeutics
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Sheryl Martin-Moe; Tim Osslund; Y. John Wang; Tahir Mahmood; Rohini Deshpande; Susan Hershenson
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Reversible Self-Association of Pharmaceutical Proteins: Characterization and Case Studies
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Vikas Sharma; Harminder Bajaj; Devendra S. Kalonia
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Experimental Detection and Characterization of Protein Aggregates
Aggregation of Therapeutic Proteins,
Vikas Sharma; Devendra S. Kalonia
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High-Concentration Antibody Formulations
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Steven J. Shire; Jun Liu; Wolfgang Friess; Susanne Jörg; Hanns-Christian Mahler
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Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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Preface
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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Construction, MD simulation, and hydrodynamic validation of an all-atom model of a monoclonal IgG antibody
Biophysical Journal, ISSN: 15420086 00063495
J. Paul Brandt; Thomas W. Patapoff; Sergio R. Aragon
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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Journal of Experimental Medicine, ISSN: 15409538 00221007
Petr Broz; Kim Newton; Lamkanfi; Sanjeev Mariathasan; Vishva M. Dixit; Denise M. Monack
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Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer
Biological Chemistry, ISSN: 14316730 14374315
Henry R. Maun; Daniel Kirchhofer; Lazarus
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Effect of trastuzumab on health-related quality of life in patients with HER2-positive metastatic breast cancer: Data from three clinical trials
Clinical Breast Cancer, ISSN: 15268209
Hope S. Rugo; Melissa Brammer; Fan Zhang; Deepa Lalla
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Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing
Clinical Therapeutics, ISSN: 01492918 1879114X
Kay Stubenrauch; Uwe Wessels; Herbert Birnboeck; Francisco Ramirez; Angelika Jahreis; Julia Schleypen
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Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Hanbiao Yang; Robert T. Hendricks; Nidhi Arora; Dov Nitzan; Calvin Yee; Matthew C. Lucas; Yanli Yang; Amy Fung; Sonal Rajyaguru; Seth F. Harris; Vincent J.P. Leveque; Julie Qi Hang; Sophie Le Pogam; Deborah Reuter; Gisele A. Tavares
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High-yield expression of human vascular endothelial growth factor VEGF 165 in Escherichia coli and purification for therapeutic applications
Protein Expression and Purification, ISSN: 10465928
Shelly A. Pizarro; Jane Gunson; Field; Rachel Dinges; Stefanie Khoo; Milind Dalal; Michael Lee; Kimberly A. Kaleas; Kathryn Moiseff; Susan Garnick; Dorothea Reilly; Mike Laird; Charles H. Schmelzer
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Distal regions of the human IFNG locus direct cell type-specific expression
Journal of Immunology, ISSN: 00221767 15506606
Patrick L. Collins; Shaojing Chang; Melodie Henderson; Mohammed Soutto; Georgia M. Davis; Allyson G. McLoed; Michael J. Townsend; Laurie H. Glimcher; Douglas P. Mortlock; Aune
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Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
Modern Pathology, ISSN: 08933952 15300285
Xingxing Zang; Peggy S. Sullivan; Robert A. Soslow; Rebecca Waitz; Victor E. Reuter; Andrew Wilton; Howard T. Thaler; Manonmani Arul; Susan F. Slovin; Joyce Wei; David R. Spriggs; Jakob Dupont; James P. Allison
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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody
Molecular Cell, ISSN: 10972765
Marissa L. Matsumoto; Katherine E. Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy J. Bustos; Lilian Phu; Donald S. Kirkpatrick; Sarah G. Hymowitz; Michael Rape; Robert F. Kelley; Vishva M. Dixit
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A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress
Cancer Research, ISSN: 00085472 15387445
David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont
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The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan
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The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes
Journal of Virology, ISSN: 0022538X 10985514
Sanjay Chandriani; Yiyang Xu; Don Ganem
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Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression
Neuron, ISSN: 08966273
Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano
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A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade
Assay and Drug Development Technologies, ISSN: 1540658X
Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise
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Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly
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Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy
Clinical Cancer Research, ISSN: 10780432 15573265
Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman
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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Nature Immunology, ISSN: 15292908 15292916
Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner
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Avoiding infusion therapy prime benefit of new MS drug: The search for an acceptable oral MS drug may be over if fingolimod (Gilenia) survives an FDA review this fall
Managed Care, ISSN: 10623388
Thomas Morrow
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Vive la science! Vive le hérisson!
EMBO Reports, ISSN: 1469221X 14693178
Jeremy Reiter; Frederic J. De Sauvage
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Vertebrate Hedgehog signaling: Cilia rule
BMC Biology, ISSN: 17417007
Christopher W. Wilson; Didier Y. R. Stainier
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Managing Successful Product Portfolio Creation and R&D Pipelines
Pharmaceutical and Biomedical Project Management in a Changing Global Environment,
Sue E. Steven
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Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
Journal of Neuroscience, ISSN: 02706474 15292401
Ozlem Bozdagi; Xiaobin Wang; Jessica S. Nikitczuk; Tonya R. Anderson; Erik B. Bloss; Glenn L. Radice; Qiang Zhou; Deanna L. Benson; George W. Huntley
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Preparation and separation of antimicrobial agents derived from capreomycin
Tetrahedron Letters, ISSN: 00404039
D. David Hennings; Daniel J. Watson; Joseph P. Lyssikatos; Andrew Allen
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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy
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Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W. Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco Van Den Akker
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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
Journal of Immunology, ISSN: 00221767 15506606
Allen W. Ho; Fang Shen; Heather R. Conti; Nayan Patel; Erin E. Childs; Alanna C. Peterson; Nydiaris Herna´ndez-Santos; Jay K. Kolls; Lawrence P. Kane; Wenjun Ouyang; Sarah L. Gaffen
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Predictive biomarkers of sensitivity to the phosphatidylinositol 3′ kinase inhibitor GDC-0941 in breast cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Carol O'Brien; Jeffery J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Zhengyu Guan; Berry; Wei Wei Prior; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Merkel; Spiera; Seo; Langford; Hoffman; Cees Kallenberg; St.clair; Anthony Turkiewicz; Tchao; Lisa Webber; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; David Weitzenkamp; Iklé; Vicki Seyfert-Margolis; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Specks
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Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
Journal of Neuroscience, ISSN: 02706474 15292401
Alexander Jaworski; Hua Long; Marc Tessier-Lavigne
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Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
Nature, ISSN: 00280836 14764687
Ira Surolia; Stephan P. Pirnie; Vasant Chellappa; Kendra N. Taylor; Annaiah Cariappa; Jesse Moya; Haoyuan Liu; Daphne W. Bell; David R. Driscoll; Sven Diederichs; Khaleda Haider; Ilka Netravali; Sheila Le; Roberto Elia; Ethan Dow; Annette T. Lee; Jan Freudenberg; Philip L. De Jager; Yves Chretien; Ajit Varki; Marcy E. MacDonald; Tammy Gillis; Timothy W. Behrens; Donald Bloch; Deborah Collier; Joshua Korzenik; Daniel K. Podolsky; David A. Hafler; Mandakolathur Murali; Bruce Sands; John H. Stone; Peter K. Gregersen; Shiv Pillai
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Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Janet Jackman; Yongmei Chen; Arthur Huang; Moffat; Justin M. Scheer; Leong; Wyne P. Lee; Juan Zhang; Navneet Sharma; Yanmei Lu; Suhasini Iyer; Robert L. Shields; Nancy Y. Chiang; Michele Bauer; Diana Jakubiak; Merone Roose-Girma; Richard L. Vandlen; Yansura; Yan Wu; Lawren C. Wu
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Response
Science, ISSN: 10959203 00368075
Levinson
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Prosthetic hand provides nearly normal function: It might seem to be straight out of science fiction, but there's solid science and engineering behind it
Managed Care, ISSN: 10623388
Thomas Morrow
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Unique challenges and opportunities for enabling and supporting preclinical and translational areas of biologic development in India - A perspective
American Pharmaceutical Outsourcing, ISSN: 15296318
Ashwin Datt; Sara Kenkare-Mitra
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US cost burden of ischemic stroke: A systematic literature review
American Journal of Managed Care, ISSN: 10880224
Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung
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Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis
Cytokine, ISSN: 10434666
Judy Young; Xin Yu; Kristen Wolslegel; Allen Nguyen; Catherine Kung; Eugene Y. Chiang; Ganesh Kolumam; Nathan Wei; Wai Lee T. Wong; Laura DeForge; Michael J. Townsend; Jane L. Grogan
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Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H. M. Van Der Helm-van Mil; Joanne Nititham; Laura B. Hughes; Niek De Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Wedren; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J. Bart A. Crusius; Irene E. Van Der Horst-Bruinsma; Marieke Herenius; Michael E. Weinblatt; Nancy A. Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Kimme Hyrich; Michael F. Seldin; Larry W. Moreland; Timothy W. Behrens; Allaart; Lindsey A. Criswell; Tom W. J. Huizinga; Paul P. Tak; S. Louis Bridges Jr.; Toes; Anne Barton; Lars Klareskog; Peter K. Gregersen; Elizabeth W. Karlson; Robert M. Plenge
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Response
Chest, ISSN: 19313543 00123692
Sarika Ogale; Todd A. Lee; Sean D. Sullivan
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