Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9051 - 9100 OF 15578 RESULTS

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother
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A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
Developmental Biology, ISSN: 1095564X 00121606
Setsu Endoh-Yamagami; Kameel M. Karkar; Scott R. May; Inma Cobos; Myo T. Thwin; Jason E. Long; Amir M. Ashique; Konstantinos Zarbalis; John L. R. Rubenstein; Andrew S. Peterson
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Characteristics of rhVEGF release from topical hydrogel formulations
Pharmaceutical Research, ISSN: 07248741 1573904X
Junyan A. Ji; Jun Liu; Steven J. Shire; Tim J. Kamerzell; Sung Hong; Karen L Billeci; Ye Shen; Y. John Wang
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Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
Nature Cell Biology, ISSN: 14657392
Yaron Pereg; Bob Y. Liu; Karen M. O'Rourke; Meredith Sagolla; Anwesha Dey; László Kömüves; French; Vishva M. Dixit
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The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility
Journal of Immunology, ISSN: 00221767 15506606
Sharon Celeste Morley; Chen Wang; Wan-Lin Lo; Chan-Wang J. Lio; Bernd H. Zinselmeyer; Mark J. Miller; Eric J. Brown; Paul M. Allen
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An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G
Current Opinion in Structural Biology, ISSN: 0959440X
Devin B. Tesar; Pamela J. Bjorkman
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Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jin I. Lee; Damien M. O'Halloran; Jeffrey Eastham-Anderson; Bi-Tzen Juang; Julia A. Kaye; O. Scott Hamilton; Bluma Lesch; Andrei Goga; Noelle D. L'Etoile
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Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Desiree H. Fong; Christopher T. Lemke; Jiyoung Hwang; Bing Xiong; Albert M. Berghuis
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Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Nature, ISSN: 00280836 14764687
Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek
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Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the abl-related gene (Arg) tyrosine kinase and N-WASp
Biochemistry, ISSN: 00062960 15204995
Matthew M. Miller; Stefanie Lapetina; Stacey M. MacGrath; Mindan K. Sfakianos; Thomas D. Pollard; Anthony J. Koleske
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The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching
Developmental Cell, ISSN: 18781551 15345807
Joe C. Hao; Carolyn E. Adler; Leslie Mebane; Frank B. Gertler; Cornelia I. Bargmann; Marc Tessier-Lavigne
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A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles
Molecular Biology of the Cell, ISSN: 10591524
Jorge Z. Torres; Kenneth H. Ban; Peter K Jackson
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Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Xiao Ding; Bilin Chou; Richard A. Graham; Sravanthi Cheeti; Percey; Matassa; Reuschel; Meng; Liu; Voelker; Bert L. Lum; Patrick J. Rudewicz; Cornelis E. Hop
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Using precipitation by polyamines as an alternative to chromatographic separation in antibody purification processes
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Junfen Ma; Hai Hoang; Thomas Myint; Thanmaya Peram; Fahrner; Judy H. Chou
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Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors
Cancer, ISSN: 0008543X 10970142
Faye M. Johnson; Shruti Agrawal; Howard A. Burris; Lee Rosen; Navneet Dhillon; David Hong; Anne Blackwood-Chirchir; Feng R. Luo; Oumar Sy; Sanjeev Kaul; Alberto A. Chiappori
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Restriction of receptor movement alters cellular response: Physical force sensing by EphA2
Science, ISSN: 00368075 10959203
Khalid Salaita; Pradeep Nair; Rebecca S. Petit; Richard M. Neve; Debopriya Das; Joe W. Gray; Jay T. Groves
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CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus
Blood, ISSN: 15280020 00064971
Daniel A. Zlotoff; Arivazhagan Sambandam; Theodore D. Logan; J. Jeremiah Bell; Benjamin A. Schwarz; Avinash Bhandoola
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Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor
Biochemistry, ISSN: 00062960 15204995
Christopher M. Koth; Norzehan Abdul-Manan; Christopher A. Lepre; Peter J. Connolly; Sanghee Yoo; Arun K. Mohanty; Judith A. Lippke; Jacque Zwahlen; Joyce T. Coll; John D. Doran; Miguel Garcia-Guzman; Jonathan M. Moore
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Phospho-regulation of DDA3 function in mitosis
Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104
Chang-Young Jang; Judith A. Coppinger; John R. Yates; Guowei Fang
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Mature dendritic cells use endocytic receptors to capture and present antigens
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Craig D. Platt; Jessica K. Ma; Cecile Chalouni; Melanie Ebersold; Hani Bou-Reslan; Richard A. D. Carano; Ira Mellman; Lélia Delamarre
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The zebrafish as a model organism for the study of apoptosis
Apoptosis, ISSN: 13608185 1573675X
Eimon; Avi Ashkenazi
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Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab
Clinical Cancer Research, ISSN: 10780432
Howard M. Stern; Mary Padilla; Klaus W. Wagner; Lukas Amler; Avi Ashkenazi
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The IL-17 family cytokines in immunity and disease
Journal of Clinical Immunology, ISSN: 02719142 15732592
Rajita Pappu; Vladimir Ramirez-Carrozzi; Naruhisa Ota; Wenjun Ouyang; Yan Hu
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Genetic dissection of the function of hindbrain axonal commissures
PLoS Biology, ISSN: 15449173 15457885
Nicolas Renier; Martijn Schonewille; Fabrice Giraudet; Aleksandra Badura; Marc Tessier-Lavigne; Paul Avan; Chris I. de Zeeuw; Alain Chedotal
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Binding to the extracellular matrix and proteolytic processing: Two key mechanisms regulating vascular endothelial growth factor action
Molecular Biology of the Cell, ISSN: 10591524
Napoleone Ferrara
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Inferring the functional effects of mutation through clusters of mutations in homologous proteins
Human Mutation, ISSN: 10597794 10981004
Peng Yue; William F. Forrest; Joshua S. Kaminker; Scott Lohr; Zemin Zhang; Guy Cavet
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Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis
Neurosurgery, ISSN: 0148396X
Mutsumi Nagai; Cigdem Erkuran Yilmaz; Daniel Kirchhofer; Charles T. Esmon; Nigel Mackman; D. Neil Granger
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Metabolic flux analysis and pharmaceutical production
Metabolic Engineering, ISSN: 10967176 10967184
Brett A. Boghigian; Gargi Seth; Robert Kiss; Blaine A. Pfeifer
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Molecular mechanism of the synaptotagmin-SNARE interaction in Ca 2+-triggered vesicle fusion
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Marija Vrljic; Pavel Strop; James A. Ernst; R Bryan Sutton; Steven Chu; Axel T. Brünger
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Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation
Metabolic Engineering, ISSN: 10967176 10967184
Adam L. Meadows; Rahi Karnik; Harry Lam; Sean Forestell; Snedecor
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Triple light chain antibodies: Factors that influence its formation in cell culture
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Natalia Gomez; Abigail R Vinson; Jun Ouyang; Mary D. H. Nguyen; Xiaoying Chen; Vikas Sharma; Inn H. Yuk
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Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
Journal of Neuro-Oncology, ISSN: 0167594X 15737373
Sean McBride; Daniel A. Perez; Mei-Yin Polley; Scott R. VandenBerg; Justin S. Smith; Shichun Zheng; Kathleen R. Lamborn; John K. Wiencke; Susan Chang; Michael D. Prados; Mitchel S. Berger; David Stokoe; Daphne A. Haas-Kogan
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Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy
Journal of Clinical Investigation, ISSN: 15588238 00219738
John F. O'Toole; Yangjian Liu; Erica E. Davis; Christopher J. Westlake; Massimo Attanasio; Edgar A. Otto; Dominik Seelow; Gudrun Nürnberg; Christian Becker; Matti Nuutinen; Mikko Kärppä; Jaakko Ignatius; Johanna Uusimaa; Salla Pakanen; Elisa Jaakkola; Lambertus P. Van Den Heuvel; Henry Fehrenbach; Roger Wiggins; Meera Goyal; Weibin Zhou; Matthias T. F. Wolf; Eric Wise; Juliana Helou; Susan J. Allen; Carlos A Murga-Zamalloa; Shazia Ashraf; Moumita Chaki; Saskia Heeringa; Gil Chernin; Bethan E. Hoskins; Hassan Chaib; Joseph G. Gleeson; Takehiro Kusakabe; Takako Suzuki; R. Elwyn Isaac; Lynne M. Quarmby; Bryan Tennant; Hisashi Fujioka; Hannu Tuominen; Ilmo Hassinen; Hellevi Lohi; Judith L. Van Houten; Agnes Rotig; John A. Sayer; Boris Rolinski; Peter Freisinger; Sethu M. Madhavan; Martina Herzer; Florence Madignier; Holger Prokisch; Peter Nürnberg; Peter K Jackson; Hemant Khanna; Nicholas Katsanis; Friedhelm Hildebrandt
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Visualization techniques for assessing design factors that affect the interaction between pharmaceutical vials and stoppers
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Philippe Lam; Al Stern
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Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale
Trends in Molecular Medicine, ISSN: 14714914
Anil Bagri; Hosein Kouros-Mehr; Kevin G. Leong; Greg D. Plowman
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Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Deepak Sampath; Megan Berry; Georgette M. Castanedo; Zhigang Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Richard Goldsmith; Timothy P. Heffron; Leslie Lee; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Wiesmann; Susan C. Wong; Bing-Yan Zhu
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Practical applications of quality risk management
BioProcess International, ISSN: 15426319
Mire-Sluis; Emma Ramnarine; Joseph Siemiatkoski; Dan Weese; Patrick Swann; Richard O'Keeffe; Joe Kutza; Julia Edwards; Lorna McLeod
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Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation
DMM Disease Models and Mechanisms, ISSN: 17548403 17548411
Nathalie Ortega; Ke Wang; Napoleone Ferrara; Zena Werb; Thiennu H. Vu
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Membrane transporters in drug development
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Kathleen M. Giacomini; Huang; Donald J. Tweedie; Leslie Z. Benet; Kim L.R. Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M. Hillgren; Keith Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B. Kim; Caroline A. Lee; Mikko Niemi; Polli; Yuichi Sugiyama; Peter W. Swaan; Joseph A. Ware; Stephen H. Wright; Sook Wah Yee; Zamek-Gliszczynski; Lei Zhang
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ALK1 signaling regulates early postnatal lymphatic vessel development
Blood, ISSN: 15280020 00064971
Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Minhong Yan
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Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
Cell, ISSN: 00928674
Baris Bingol; Chi-Fong Wang; David Arnott; Dongmei Cheng; Junmin Peng; Morgan Sheng
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IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo
PLoS Pathogens, ISSN: 15537374 15537366
Cheryl A. Stoddart; Mary E. Keir; Joseph M. McCune
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Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy
Blood, ISSN: 15280020 00064971
Saul J. Priceman; James L. Sung; Zory Shaposhnik; Jeremy B. Burton; Antoni X. Torres-Collado; Diana L. Moughon; Mai Johnson; Aldons J. Lusis; Donald A. Cohen; M. Luisa Iruela-Arispe; Lily Wu
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Rere controls retinoic acid signalling and somite bilateral symmetry
Nature, ISSN: 00280836 14764687
Gonçalo C. Vilhais-Neto; Mitsuji Maruhashi; Karen T. Smith; Mireille Vasseur-Cognet; Andrew S. Peterson; Jerry L. Workman; Olivier Pourquié
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A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies
Clinical Cancer Research, ISSN: 10780432
D. Ross Camidge; Roy S. Herbst; Michael S. Gordon; Gail Eckhardt; Razelle Kurzrock; Blythe Durbin; Josephine Ing; Tanyifor M. Tohnya; Jason Sager; Avi Ashkenazi; Gordon L. Bray; David Mendelson
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From the authors
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Prescott G. Woodruff; Joseph R. Arron; John V. Fahy
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Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Natasha K Crellin; Sara Trifari; Charles D. Kaplan; Tom Cupedo; Hergen Spits
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Activation of epithelial STAT3 regulates intestinal homeostasis
Cell Cycle, ISSN: 15514005 15384101
Clemens Neufert; Geethanjali Pickert; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Alexei Nikolaev; Wenjun Ouyang; Markus F. Neurath; Christoph Becker
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Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display
Journal of Molecular Biology, ISSN: 00222836
Nathaniel C. Gordon; Samantha Lien; Jeremy Johnson; Heidi J. A. Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Quan; Melissa A. Starovasnik; Sarah G. Hymowitz; Robert F. Kelley
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