Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9151 - 9200 OF 15578 RESULTS

RTM3, which controls long-distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology domain-containing protein
Plant Physiology, ISSN: 15322548 00320889
Patrick Cosson; Luc Sofer; Quang Hien Le; Valérie Léger; Valérie Schurdi-Levraud; Steven A. Whitham; Miki L. Yamamoto; Suresh Gopalan; Olivier le Gall; Thierry Candresse; James C. Carrington; Frédéric Revers
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Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Ruediger E. Port; Lisa J. Bernstein; Daniel P. Barboriak; Lu Xu; Timothy P.L. Roberts; Nicholas Van Bruggen
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Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy
Nature Medicine, ISSN: 1546170X 10788956
Napoleone Ferrara
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Molecular dynamics simulations of hydrotropic solubilization and self-aggregation of nicotinamide
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Chenyue Xing; Yingqing Ran
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The chemical toolbox for monitoring protein fatty acylation and prenylation
Nature Chemical Biology, ISSN: 15524469 15524450
Rami N. Hannoush; Jinglucy Sun
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O-fucose modulates notch-controlled blood lineage commitment
American Journal of Pathology, ISSN: 15252191 00029440
Quanjian Yan; David Yao; Lebing L. Wei; Yuanshuai Huang; Jay Myers; Lihua Zhang; Wei Xin; Jeongsup Shim; Yunfang Man; Bronislawa Petryniak; Stanton Gerson; John Lowe; Lan Zhou
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Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients Treated in the MARINA and ANCHOR Trials
American Journal of Ophthalmology, ISSN: 00029394
Irene Barbazetto; Namrata Saroj; Howard Shapiro; Pamela Wong; Allen C. Ho; K. Bailey Freund
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Ranibizumab for Macular Edema following Central Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study
Ophthalmology, ISSN: 01616420
David M. Brown; Peter A. Campochiaro; Rishi Singh; Zhengrong Li; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Roman G. Rubio; Wendy Yee Murahashi
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Early menstrual characteristics associated with subsequent diagnosis of endometriosis
American Journal of Obstetrics and Gynecology, ISSN: 00029378
Susan A. Treloar; Tanya A. Bell; Christina M. Nagle; David M. Purdie; Adèle C. Green
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Ranibizumab for Macular Edema following Branch Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study
Ophthalmology, ISSN: 01616420
Peter A. Campochiaro; Jeffrey S. Heier; Leonard Feiner; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Wendy Yee Murahashi; Roman G. Rubio
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Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
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Manipulation of host cell death pathways during microbial infections
Cell Host and Microbe, ISSN: 19346069 19313128
Lamkanfi; Vishva M. Dixit
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An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Gregory Z. Ferl; Lu Xu; Michel Friesenhahn; Lisa J. Bernstein; Daniel P. Barboriak; Ruediger E. Port
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Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Carlos Iribarren; Irina V. Tolstykh; Mary K. Miller; Mark D. Eisner
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Two lab tests help clinicians diagnose and predict ischemic stroke.
Managed Care, ISSN: 10623388
Thomas Morrow
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On developing a process for conducting extractable-leachable assessment of components used for storage of biopharmaceuticals
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Aditya A. Wakankar; Y. John Wang; Eleanor Canova-Davis; Stacey Ma; Dieter Schmalzing; Josh Grieco; Terry Milby; Theresa Reynolds; Mazzarella; Ed Hoff; Stephen Gomez; Sheryl Martin-Moe
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Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli
Protein Expression and Purification, ISSN: 10465928
Jawahar Sudhamsu; Mariam Kabir; Michael V. Airola; Bhumit A. Patel; Syun-Ru Yeh; Denis L. Rousseau; Brian R. Crane
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Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability
American Journal of Pathology, ISSN: 15252191 00029440
Marco Mura; Matthew Binnie; Bing Han; Chengjin Li; Cristiano F. Andrade; Atsushi Shiozaki; Yu Zhang; Napoleone Ferrara; David Hwang; Thomas K. Waddell; Shaf Keshavjee; Mingyao Liu
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Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels
American Journal of Pathology, ISSN: 15252191 00029440
Weon-Kyoo You; Ian Kasman; Dana D. Hu-Lowe; Donald M. McDonald
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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization
Analytical Biochemistry, ISSN: 10960309 00032697
Brian D. Connolly; Thomas W. Patapoff; Y. John Wang; Jamie M. R. Moore; Tim J. Kamerzell
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Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors
American Journal of Pathology, ISSN: 15252191 00029440
Seth B. Coffelt; Claire E. Lewis; Luigi Naldini; J. Martin Brown; Napoleone Ferrara; Michele De Palma
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PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Cell, ISSN: 00928674
Carlos Bais; Xiumin Wu; Jenny Yao; Suya Yang; Yongping Crawford; Krista McCutcheon; Christine Tan; Ganesh Kolumam; Jean-Michel Vernes; Jeffrey Eastham-Anderson; Peter Haughney; Marcin Kowanetz; Thijs Hagenbeek; Ian Kasman; Hani Bou-Reslan; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Yu-Ju Gloria Meng; Hongo; Jean-Philippe Stephan; Masabumi Shibuya; Napoleone Ferrara
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Vision-Related Function after Ranibizumab Treatment by Better- or Worse-Seeing Eye. Clinical Trial Results from MARINA and ANCHOR
Ophthalmology, ISSN: 01616420
Neil M. Bressler; Tom S. Chang; Ivan J. Suñer; Jennifer T. Fine; Chantal M. Dolan; James Ward; Tsontcho Ianchulev
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On the influence of protein binding on pharmacological activity of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the hedgehog pathway inhibitor GDC-0449 in dogs: An investigation using preclinical studies and physiologically based pharmacokinetic modeling
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Harvey Wong; Frank-Peter Theil; Yong Cui; James C. Marsters Jr.; S. Cyrus Khojasteh; Laurent Vernillet; Hank La; Xiling Song; Hong Wang; Eric Morinello; Yuzhong Deng; Cornelis E. Hop
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Signaling to NF-kappaB: regulation by ubiquitination.
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Ingrid E. Wertz; Vishva M. Dixit
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Secretory Cell Hyperplasia and Defects in Notch Activity in a Mouse Model of Leukocyte Adhesion Deficiency Type II
Gastroenterology, ISSN: 00165085
Christopher C.M. Waterhouse; Steven Johnson; Mia Phillipson; Lori Zbytnuik; Björn Petri; Margaret Kelly; John Lowe; Paul Kubes
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Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Mark A. Socinski; Frank A. Scappaticci; Meghna Samant; Margaret M. Kolb; Kozloff
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Specific interactions in high concentration antibody solutions resulting in high viscosity
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sandeep Yadav; Jun Liu; Steven J. Shire; Devendra S. Kalonia
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Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials
Journal of Rheumatology, ISSN: 0315162X
Ronald Van Vollenhoven; Paul Emery; Bingham; Edward Keystone; Roy Fleischmann; Daniel E. Furst; Katherine Macey; Marianne Sweetser; Ariella Kelman; Rao Ravi
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Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642
Beat A. Kaufmann; Chad L. Carr; J. Todd Belcik; Aris Xie; Yue Qi; Scott Chadderdon; Evan S. Caplan; Jaspreet Khangura; Sherron Bullens; Bunting; Jonathan R. Lindner
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Comparative biotransformation of pyrazinone-containing corticotropin- releasing factor receptor-1 antagonists: Minimizing the reactive metabolite formation
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xiaoliang Zhuo; Richard A. Hartz; Joanne J. Bronson; Harvey Wong; Vijay T. Ahuja; Vivekananda M. Vrudhula; John E. Leet; Stella Huang; John E. Macor; Yue-Zhong Shu
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A mouse knockout library for secreted and transmembrane proteins
Nature Biotechnology, ISSN: 15461696 10870156
Tracy Tzu-Ling Tang; Li Li; Zhijun Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark J. Solloway; Leon Parker; Weilan Ye; William F. Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Godowski; Kathleen H. Holt; Andrew S. Peterson; Brian P. Zambrowicz; Frederic J. De Sauvage
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Cardiovascular events associated with ipratropium bromide in COPD
Chest, ISSN: 19313543 00123692
Sarika S. Ogale; Todd A. Lee; David H. Au; Denise M. Boudreau; Sean D. Sullivan
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A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood-tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Psychological effects of patient surge in large-scale emergencies: A quality improvement tool for hospital and clinic capacity planning and response
Prehospital and Disaster Medicine, ISSN: 19451938 1049023X
Lisa S. Meredith; James L. Zazzali; Sandra Shields; David P. Eisenman; Halla Alsabagh
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A multigene predictor of outcome in glioblastoma
Neuro-Oncology, ISSN: 15228517 15235866
Howard Colman; Li Zhang; Erik P. Sulman; J. Matthew McDonald; Nasrin Latif Shooshtari; Andreana Rivera; Sonya Popoff; Catherine L. Nutt; David N. Louis; J. Gregory Cairncross; Mark R. Gilbert; Phillips; Minesh P. Mehta; Arnab Chakravarti; Christopher E. Pelloski; Krishna P.L. Bhat; Burt G. Feuerstein; Robert B. Jenkins; Kenneth D. Aldape
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Cold denaturation of monoclonal antibodies
mAbs, ISSN: 19420862
Kristi L. Lazar; Thomas W. Patapoff; Vikas Sharma
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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
Cancer Cell, ISSN: 15356108
Jian-Bin Wang; Jon W. Erickson; Reina N. Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F. Wilson; Andre L.B. Ambrosio; Sandra M.G. Dias; Chi V. Dang; Richard A. Cerione
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Bevacizumab safety in patients with central nervous system metastases
Clinical Cancer Research, ISSN: 10780432
Benjamin Besse; Susan F. Lasserre; Peter Compton; Jane E. Huang; Stella Augustus; Ulrich-Peter Rohr
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Therapeutic strategies within the ubiquitin proteasome system
Cell Death and Differentiation, ISSN: 13509047 14765403
Adam G. Eldridge; Thomas O'Brien
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Long-term safety of recombinant human growth hormone in children
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Jennifer J. Bell; Parker; Rita D. Swinford; Andrew R. Hoffman; Thomas J. Maneatis; Barbara M. Lippe
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Regulation of death receptor signaling by the ubiquitin system
Cell Death and Differentiation, ISSN: 13509047 14765403
Ingrid E. Wertz; Vishva M. Dixit
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Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: Insights into rational drug design and activity regulation
Chemical Biology and Drug Design, ISSN: 17470285 17470277
Alan K. Kutach; Armando G. Villaseñor; Diana Lam; Charles Belunis; Cheryl Janson; Stephen Lok; Li-Na Hong; Chao-Min Liu; Jerome Deval; Thomas J. Novak; Jim W. Barnett; Wei Chu; David Shaw; Andreas Kuglstatter
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Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
Merrill; C. Michael Neuwelt; Daniel J. Wallace; Joseph C. Shanahan; Latinis; James C. Oates; Tammy O. Utset; Gordon; David A. Isenberg; Hsin-Ju Hsieh; David Zhang; Paul Brunetta
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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells
Trends in Molecular Medicine, ISSN: 14714914
Liyun Sang; James M. Roberts; Hilary A. Coller
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Poor disease control among insured users of high-dose combination therapy for asthma
Allergy and Asthma Proceedings, ISSN: 10885412 15396304
Michael S. Broder; Eunice Chang; Tripthi V. Kamath; Sandhya Sapra
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Purification and characterization of a motility initiating protein from caprine epididymal plasma
Journal of Cellular Physiology, ISSN: 00219541
Bijay S. Jaiswal; Kaushik Das; Sudipta Saha; Sandhya Rekha Dungdung; Gopal C. Majumder
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AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
British Journal of Pharmacology, ISSN: 14765381 00071188
Joel R. Gever; Rothschild Soto; Robert A. Henningsen; Renee S. Martin; David Hackos; Sandip Panicker; Rubas; Ian B. Oglesby; Michael P. Dillon; Marcos E. Milla; Geoffrey Burnstock; Anthony P. D. W. Ford
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Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection
Journal of Drug Targeting, ISSN: 1061186X 10292330
Daugherty; Mrsny
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