Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9351 - 9400 OF 15578 RESULTS

August 20, 2009

A highly annotated whole-genome sequence of a Korean individual

Nature, ISSN: 00280836 14764687

Jong-Il Kim; Young Seok Ju; Hansoo Park; Sheehyun Kim; Seonwook Lee; Jae-Hyuk Yi; Joann Mudge; Neil A. Miller; Dongwan Hong; Callum J. Bell; Hye-Sun Kim; In-Soon Chung; Woo-Chung Lee; Ji-Sun Lee; Seung-Hyun Seo; Ji-Young Yun; Hyun Nyun Woo; Heewook Lee; Dongwhan Suh; Seungbok Lee; Hyun-Jin Kim; Maryam Yavartanoo; Minhye Kwak; Ying Zheng; Mi Kyeong Lee; Hyunjun Park; Jeong Yeon Kim; Omer Gokcumen; Ryan E. Mills; Alexander Wait Zaranek; Joseph Thakuria; Xiaodi Wu; Ryan W. Kim; Jim J. Huntley; Shujun Luo; Gary P. Schroth; Thomas D Wu; Hyeran Kim; Kap-Seok Yang; Woong-Yang Park; Hyungtae Kim; George M. Church; Charles Lee; Stephen F. Kingsmore; Jeong-Sun Seo

August 18, 2009

Validation of tangential flow filtration in biopharmaceutical applications task force

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Chris Antoniou; Neil Bingham; Glen Bolton; Chris Bussineau; Michael Dosmar; Chithkala Harinarayan; Robert W. Juffras; James Klein; Peter Levy; Richard V. Levy; Mike Mulcare; Jon Petrone; Jon Romero; Ganesh Vedantham; Robert Velcheck

August 15, 2009

BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells

International Journal of Cancer, ISSN: 00207136 10970215

Saritha Kusam; Veerendra Munugalavadla; Deepali Sawant; Alexander Dent

August 15, 2009

Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Martin Gawlitzek; Michael Estacio; Tobias Fürch; Robert Kiss

August 15, 2009

Investigation of sample preparation artifacts formed during the enzymatic release of N-linked glycans prior to analysis by capillary electrophoresis

Analytical Chemistry, ISSN: 00032700

Yong Liu; Oscar Salas-Solano; Lynn Gennaro

August 12, 2009

A multi-tiered analytical approach for the analysis and quantitation of high-molecular-weight aggregates in a recombinant therapeutic glycoprotein

AAPS Journal, ISSN: 15507416

Heather Hughes; Charles Morgan; Elizabeth Brunyak; Kristen Barranco; Emily Cohen; Tim Edmunds; Karen Lee

August 11, 2009

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

Current Biology, ISSN: 09609822

Setsu Endoh-Yamagami; Marie Evangelista; Deanna G. Wilson; Xiaohui Wen; Jan-Willem Theunissen; Khanhky Phamluong; Matti Davis; Suzie J. Scales; Mark J. Solloway; Frederic J. De Sauvage; Andrew S. Peterson

August 5, 2009

High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

BMC Medical Genomics, ISSN: 17558794

Matthias Peter; Lawrence S. Hon; Joshua S. Kaminker; John Chant; Zemin Zhang

August 5, 2009

Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas

BMC Medical Genomics, ISSN: 17558794

Grazyna Fedorowicz; Steve Guerrero; Thomas D Wu; Zora Modrusan

August 1, 2009

FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes

Journal of Cell Science, ISSN: 00219533

Hui Zhu; Kayleen Fang; Guowei Fang

August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Hu; Lukas Amler; Lackner

August 1, 2009

Oncogenic activating mutations are associated with local copy gain

Molecular Cancer Research, ISSN: 15417786

Barmak Modrek; Lin Ge; Ajay Pandita; Eva Lin; Sankar Mohan; Peng Yue; Steve Guerrero; William M. Lin; Thinh Q. Pham; Zora Modrusan; Somasekar Seshagiri; Howard M. Stern; Waring; Levi A. Garraway; John Chant; David Stokoe; Guy Cavet

August 1, 2009

A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma

Cancer Investigation, ISSN: 07357907 15324192

Agop Y. Bedikian; Nicholas E. Papadopoulos; Kevin B. Kim; Wen-Jen Hwu; Jade Homsi; Michelle R. Glass; Suzanne Cain; Patrick J. Rudewicz; Laurent Vernillet; Patrick Hwu

August 1, 2009

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus

Arthritis and Rheumatism, ISSN: 00043591 15290131

Sharon A. Chung; Tian; Kimberly E. Taylor; Annette T. Lee; Ward Ortmann; Geoffrey Hom; Robert R. Graham; Joanne Nititham; Jennifer A. Kelly; Jean Morrisey; Hui Wu; Hong Yin; Marta E. Alarcón-Riquelme; Betty P. Tsao; John B. Harley; Patrick M. Gaffney; Kathy L. Moser; Manzi; Michelle Petri; Peter K. Gregersen; Carl D. Langefeld; Timothy W. Behrens; Michael F. Seldin; Lindsey A. Criswell

August 1, 2009

Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

FEBS Journal, ISSN: 1742464X 17424658

Niko Föger; Silvia Bulfone-Paus; Andrew A. Chan; Kyeong-Hee Lee

August 1, 2009

Paracrine hedgehog signaling in cancer

Cancer Research, ISSN: 00085472 15387445

Jan-Willem Theunissen; Frederic J. De Sauvage

August 1, 2009

Churg-Strauss syndrome in patients treated with omalizumab

Chest, ISSN: 19313543 00123692

Michael E. Wechsler; Dennis A. Wong; Mary K. Miller; Lisa Lawrence-Miyasaki

August 1, 2009

Antibody binding to a tethered vesicle assembly using QCM-D

Analytical Chemistry, ISSN: 00032700

Ankit Patel; Kay K. Kanazawa; Curtis W. Frank

August 1, 2009

Health benefit costs and absenteeism due to insomnia from the employer's perspective: A retrospective, case-control, database study

Journal of Clinical Psychiatry, ISSN: 01606689

Nathan L. Kleinman; Richard A. Brook; Justin Doan; Arthur K. Melkonian; Robert W. Baran

August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Xiaolan Hu; Lukas Amler; Lackner

July 31, 2009

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Ching Ching Leow; Bu-Er Wang; Ross; Sara M. Chan; Jiping Zha; Richard A. D. Carano; Gretchen D. Frantz; Michael M. Shen; Frederic J. De Sauvage; Gao

July 28, 2009

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

PLoS ONE, ISSN: 19326203

Galia Blum; Robby M. Weimer; Laura E. Edgington; Walter Adams; Matthew Bogyo

July 28, 2009

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation

Biochemistry, ISSN: 00062960

Eric Bourhis; Andreas Lingel; Qui Phung; Wayne J. Fairbrother; Andrea G Cochran

July 28, 2009

Development of a microarray platform for FFPET profiling: Application to the classification of human tumors

Journal of Translational Medicine, ISSN: 14795876

Sven Duenwald; Mingjie Zhou; Yanqun Wang; Serguei Lejnine; Amit Kulkarni; Jaime Graves; Ryan Smith; John C. Castle; George Tokiwa; Bernard M. Fine; Hongyue Dai; Thomas Fare; Matthew Marton

July 27, 2009

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells

Journal of Cell Biology, ISSN: 00219525 00219525

Glen A. Farr; Mike Hull; Ira Mellman; Michael J. Caplan

July 24, 2009

Two-dimensional liquid chromatographic methods to examine phenylboronate interactions with recombinant antibodies

Journal of Chromatography A, ISSN: 00219673

Boyan Zhang; Sean Mathewson; Huifen Chen

July 23, 2009

Navigating the Deubiquitinating Proteome with a CompPASS

Cell, ISSN: 00928674

Peter K Jackson

July 22, 2009

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

Arthritis Research and Therapy, ISSN: 14786354 14786362

Donna L. Thibault; Kareem L. Graham; Lowen Y. Lee; Imelda Balboni; Paul J. Hertzog; Paul J. Utz

July 17, 2009

Assigning large proteins in the solid state: A MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins

Journal of Biomolecular NMR, ISSN: 09252738 15735001

Victoria A. Higman; Jeremy Flinders; Matthias Hiller; Stefan Jehle; Stefan Markovic; Sebastian Fiedler; Barth-Jan van Rossum; Hartmut Oschkinat

July 17, 2009

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

ACS Chemical Biology, ISSN: 15548929

Chudi O. Ndubaku; Eugene Varfolomeev; Lan Wang; Zobel; Kevin Lau; Linda O. Elliott; Brigitte Maurer; Anna V. Fedorova; Jasmin N. Dynek; Michael F. T. Koehler; Sarah G. Hymowitz; Vickie Tsui; Deshayes; Wayne J. Fairbrother; Flygare; Domagoj Vucic

July 17, 2009

Imaging the lipidome: ω-alkynyl fatty acids for detection and cellular visualization of lipid-modified proteins

ACS Chemical Biology, ISSN: 15548929

Rami N. Hannoush; Natalia Arenas-Ramirez

July 17, 2009

IL-33 Raises Alarm

Immunity, ISSN: 10747613

Lamkanfi; Vishva M. Dixit

July 15, 2009

Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates

Cell Cycle, ISSN: 15514005 15384101

Liyun Sang; Hilary A. Coller

July 15, 2009

Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis

Arthritis Care and Research, ISSN: 21514658

Michael M. Ward; Matthew R. Hendrey; James D. Malley; Thomas J. Learch; John C. Davis; John D. Reveille; Michael Weisman

July 10, 2009

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin; Thomas F.J. Martin

July 10, 2009

Wnt signaling is regulated by endoplasmic reticulum retention

PLoS ONE, ISSN: 19326203

J. Susie Zoltewicz; Amir M. Ashique; Youngshik Choe; Gena Lee; Stacy Taylor; Khanhky Phamluong; Mark J. Solloway; Andrew S. Peterson

July 10, 2009

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin

July 8, 2009

Reassessment of corticospinal tract regeneration in Nogo-deficient mice

Journal of Neuroscience, ISSN: 02706474 15292401

Jae K. Lee; Andrea F. Chan; Sen M. Luu; Yuhong Zhu; Carole Ho; Marc Tessier-Lavigne; Binhai Zheng

July 8, 2009

Scalable total synthesis and biological evaluation of haouamine A and its atropisomer

Journal of the American Chemical Society, ISSN: 00027863

Noah Z. Burns; Irina N. Krylova; Rami N. Hannoush; Phil S. Baran

July 6, 2009

Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice

Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836

Jian-Guo Wang; Manly; Daniel Kirchhofer; Rafal Pawlinski; Nigel Mackman

July 6, 2009

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Journal of Experimental Medicine, ISSN: 00221007 15409538

Wei Cao; Laura Bover; Minkwon Cho; Xiaoxia Wen; Shino Hanabuchi; Musheng Bao; David B. Rosen; Yi-Hong Wang; Joanne L. Shaw; Qiumei Du; Chun Li; Naoko Arai; Zhengbin Yao; Lewis L. Lanier; Yong-Jun Liu

July 6, 2009

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

Nature Immunology, ISSN: 15292908 15292916

Sara Trifari; Charles D. Kaplan; Elise H. Tran; Natasha K Crellin; Hergen Spits

July 6, 2009

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Journal of Experimental Medicine, ISSN: 00221007 15409538

Geethanjali Pickert; Clemens Neufert; Moritz Leppkes; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Hans-Anton Lehr; Sebastian Hirth; Benno Weigmann; Stefan Wirtz; Wenjun Ouyang; Markus F. Neurath; Christoph Becker

July 1, 2009

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models

Clinical Cancer Research, ISSN: 10780432

Klaus P. Hoeflich; Carol O'Brien; Zachary Boyd; Guy Cavet; Steve Guerrero; Kenneth Jung; Thomas Januario; Heidi Savage; Elizabeth A. Punnoose; Tom Truong; Wei Zhou; Berry; Lesley J. Murray; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner

July 1, 2009

Differential role of the Ca2+ sensor synaptotagmin VII in macrophages and dendritic cells

Immunobiology, ISSN: 01712985

Steven M. Becker; Lélia Delamarre; Ira Mellman; Norma W. Andrews

July 1, 2009

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Rafael Ponce; Leslie Abad; Lakshmi Amaravadi; Thomas R. Gelzleichter; Elizabeth Gore; Green; Shalini Gupta; Danuta Herzyk; Christopher Hurst; Inge A. Ivens; Thomas Kawabata; Curtis Maier; Barbara Mounho; Bonita Rup; Gopi Shankar; Holly W. Smith; Peter Thomas; Daniel Wierda

July 1, 2009

Unbound brain concentration determines receptor occupancy: A correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Xingrong Liu; Olga Vilenski; Joyce Kwan; Subbu Apparsundaram; Robert Weikert

July 1, 2009

Targeted depletion of lymphotoxin-α-expressing T H 1 and T H 17 cells inhibits autoimmune disease

Nature Medicine, ISSN: 10788956 1546170X

Eugene Y. Chiang; Ganesh Kolumam; Xin Yu; Michelle Francesco; Ivelja; Ivan Peng; Gribling; Jean Shu; Wyne P. Lee; Refino; Mercedesz Balazs; Andres Paler Martinez; Allen Nguyen; Judy Young; Kai H. Barck; Richard A. D. Carano; Ron Ferrando; Laurie Diehl; Devavani Chatterjea; Jane L. Grogan

July 1, 2009

Measurements of birth defect prevalence: Which is most useful as a comparator group for pharmaceutical pregnancy registries?

Birth Defects Research Part A - Clinical and Molecular Teratology, ISSN: 15420752 15420760

Angela E. Scheuerle; Vani X. Vannappagari; Mary K. Miller

July 1, 2009

Player RanKings: Using coefficient of variation to measure MLB players' worth

Quality Progress, ISSN: 0033524X

Julia E. Seaman; Elaine Allen

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