Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9501 - 9550 OF 15578 RESULTS

The art of making an exit
Science, ISSN: 00368075 10959203
Fredric Carlsson; Eric J. Brown
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Death receptor signal transducers: Nodes of coordination in immune signaling networks
Nature Immunology, ISSN: 15292908 15292916
Nicholas S. Wilson; Vishva M. Dixit; Avi Ashkenazi
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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
Journal of Medicinal Chemistry, ISSN: 00222623
Frederick Cohen; Bruno Alicke; Linda O. Elliott; Flygare; Tatiana Goncharov; Stephen F. Keteltas; Matthew C Franklin; Stacy Frankovitz; Jean-Philippe Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne J. Fairbrother
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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, ISSN: 00368075 10959203
Jenny Bostrom; Shang-Fan Yu; David Kan; Brent A. Appleton; Chingwei V. Lee; Karen L Billeci; Wenyan Man; Franklin V. Peale Jr.; Ross; Wiesmann; Fuh
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Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab
Journal of Clinical Oncology, ISSN: 0732183X
Alan Sandler; Joan H. Schiller; Robert Gray; Isaiah Dimery; Julie Brahmer; Meghna Samant; Lisa I. Wang; David H. Johnson
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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hua Tian; Christopher Callahan; Kelly J. DuPree; Darbonne; Christina Ahn; Suzie J. Scales; Frederic J. De Sauvage
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Neuropilins in tumor biology
Clinical Cancer Research, ISSN: 10780432
Anil Bagri; Marc Tessier-Lavigne; Ryan J. Watts
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production
Journal of Immunology, ISSN: 00221767 15506606
Carla A. Da Silva; Cecile Chalouni; Adam Williams; Dominik Hartl; Chun G. Lee; Jack A. Elias
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Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
Cancer Research, ISSN: 00085472 15387445
Andrew G. Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley S. Chang; Erin Christensen; Suzanna Clark; Frederic J. De Sauvage; Dan L. Eaton; Kristi Elkins; J. Michael Elliott; Gretchen D. Frantz; Reina N. Fuji; Gray; Kristin Harden; Gladys S. Ingle; Noelyn Kljavin; Koeppen; Nelson; Saileta Prabhu; Helga Raab; Ross; Jean-Philippe Stephan; Suzie J. Scales; Spencer; Richard L. Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens
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Yas3p, an opi1 family transcription factor, regulates Cytochrome P450 expression in response to n-alkanes inYarrowia lipolytica
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kiyoshi Hirakawa; Satoshi Kobayashi; Takuro Inoue; Setsu Endoh-Yamagami; Ryouichi Fukuda; Akinori Ohta
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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
Journal of Medicinal Chemistry, ISSN: 00222623
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V. Rahavendran; Heather Skor; Robert Hunter; Stephanie Shi; Koleen J. Herlihy; Hans Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Lewis
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Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms
Oncogene, ISSN: 09509232 14765594
Hollmén; Jorma Määttä; Bald; Mark X. Sliwkowski; Elenius
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William L. Ince; Novotny; Oliver Rosen
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William Ince; Novotny; Oliver Rosen
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Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
J. Michael Elliott; Lionel Rouge; Wiesmann; Justin M. Scheer
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dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants
EMBO Journal, ISSN: 02614189 14602075
Ryuya Fukunaga; Jennifer A. Doudna
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Two-state selection of conformation-specific antibodies
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Junjun Gao; Sachdev S. Sidhu; James A. Wells
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Selective antibody precipitation using polyelectrolytes: A novel approach to the purification of monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Paul McDonald; Corazon Victa; Jayme N. Carter-Franklin; Fahrner
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A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Christina J. Lee; Gargi Seth; Joni Tsukuda; Robert W. Hamilton
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New methods allowing the detection of protein aggregates: A case study on trastuzumab
mAbs, ISSN: 19420862
Barthélemy Demeule; Caroline Palais; Gia Machaidze; Robert Gurny; Tudor Arvinte
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Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children
Pediatrics, ISSN: 00314005 10984275
Gabriele Renzetti; Gaetano Silvestre; Claudio D'Amario; Egidio Bottini; Fulvia Gloria-Bottini; Nunzio Bottini; Alexander Auais; Miriam K. Perez; Giovanni Piedimonte
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The effect of low intensity ultraviolet-c light on monoclonal antibodies
Biotechnology Progress, ISSN: 87567938
Christopher M. Lorenz; Bradley Wolk; Quan; Emily W. Alcala; Eng; Daniel J. McDonald; Timothy Matthews
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Modeling electrostatic exclusion effects during ion exchange chromatography of monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Andrew Zydney; Chithkala Harinarayan; Robert Van Reis
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The double-histone-acetyltransferase complex ATAC is essential for mammalian development
Molecular and Cellular Biology, ISSN: 02707306
Sebastián Guelman; Kenji Kozuka; Yifan Mao; Victoria Pham; Mark J. Solloway; John Wang; Jiansheng Wu; Jennie R. Lill; Jiping Zha
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Extrapituitary and Pituitary Pathological Findings in Horses with Pituitary Pars Intermedia Dysfunction: A Retrospective Study
Journal of Equine Veterinary Science, ISSN: 07370806
Christiana M. Glover; Lisa M. Miller; Noel Dybdal; Alfonso Lopez; Wendy M. Duckett; Dianne McFarlane
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Adherence and persistence with omalizumab and fluticasone/salmeterol within a managed care population
Allergy and Asthma Proceedings, ISSN: 10885412 15396304
Michael S. Broder; Eunice Chang; Caron Ory; Tripthi V. Kamath; Sandhya Sapra
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Trace level analysis of leached Protein A in bioprocess samples without interference from the large excess of rhMAb IgG
Journal of Immunological Methods, ISSN: 00221759
Judith Zhu-Shimoni; Feny Gunawan; Anne Thomas; Vanderlaan; Stults
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Chapter 5 DNA Targets of AID. Evolutionary Link Between Antibody Somatic Hypermutation and Class Switch Recombination
Advances in Immunology, ISSN: 00652776 15578445
Jason A. Hackney; Shahram Misaghi; Kate Senger; Christopher Garris; Yonglian Sun; Maria N. Lorenzo; Ali A. Zarrin
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Genetic deletion of JAM-C reveals a role in myeloid progenitor generation
Blood, ISSN: 15280020 00064971
Asja Praetor; Jacqueline McBride; Chiu; Linda Rangell; Lorena Cabote; Wyne P. Lee; James Cupp; Dimitry Danilenko; Sherman Fong
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Genetic deletion of JAM-C reveals a role in myeloid progenitor generation
Blood, ISSN: 15280020 00064971
Asja Praetor; Jacqueline McBride; Chiu; Linda Rangell; Lorena Cabote; Wyne P. Lee; James Cupp; Dimitry Danilenko; Fong
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Perforin-mediated suppression of B-cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Paul Bolitho; Shayna E. A. Street; Jennifer A. Westwood; Winfried Edelmann; Duncan MacGregor; Waring; William K. Murray; Dale I. Godfrey; Joseph A. Trapani; Ricky W. Johnstone; Mark J. Smyth
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IL-17 receptor signaling inhibits C/EBPb by sequential phosphorylation of the regulatory 2 domain
Science Signaling, ISSN: 19450877 19379145
Fang Shen; Nan Li; Padmaja Gade; Dhananjaya V. Kalvakolanu; Timothy Weibley; Brad Doble; James R. Woodgett; Troy D. Wood; Sarah L. Gaffen
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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Nature, ISSN: 00280836 14764687
Anatoly Nikolaev; Todd McLaughlin; Dennis D.M. O'Leary; Marc Tessier-Lavigne
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Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes
Blood, ISSN: 15280020 00064971
Ralph Tiedt; Jörn Coers; Sandra Ziegler; Adrian Wiestner; Hui Hao-Shen; Caroline Bornmann; Johannes Schenkel; Svetlana Karakhanova; Frederic J. De Sauvage; Carl W. Jackson; Radek C. Skoda
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PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kathleen A. O'Hagan; Sinead Cocchiglia; Alexander V. Zhdanov; Murtaza M. Tambawala; Eoin P. Cummins; Mona Monfared; Terence A. Agbor; John F. Garvey; Dmitri B. Papkovsky; Cormac T. Taylor; Bernard B. Allan
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Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii- I nfected dendritic cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Romina S. Goldszmid; Isabelle Coppens; Avital Lev; Pat Caspar; Ira Mellman; Alan Sher
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Human CD4 + T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christopher J. Haines; Thierry D. Giffon; Li-Sheng Lu; Lu; Marc Tessier-Lavigne; Douglas T. Ross; David B. Lewis
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Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells
Journal of Immunology, ISSN: 00221767 15506606
Iyadh Douagi; Cornelia Gujer; Christopher Sundling; William C. Adams; Anna Smed-Sörensen; Robert A. Seder; Gunilla B. Karlsson Hedestam; Karin Loré
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The impact of protein exclusion on the purity performance of ion exchange resins
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Zeid; Chithkala Harinarayan; Robert Van Reis
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α-actinin and filamin cooperatively enhance the stiffness of actin filament networks
PLoS ONE, ISSN: 19326203
Osigwe Esue; Yiider Tseng; Denis Wirtz
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Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Markus Eser; Lluis Masip; Hiroshi Kadokura; George Georgiou; Jonathan Beckwith
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The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts
Experimental Eye Research, ISSN: 00144835
Claudia M. Garcia; Ying-Bo Shui; Meera Kamath; Justin DeVillar; Randall S. Johnson; Hans-Peter Gerber; Napoleone Ferrara; Michael L. Robinson; David C. Beebe
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A phase I/II trial of trastuzumab plus erlotinib in metastatic HER2-positive breast cancer: A dual ErbB targeted approach
Clinical Breast Cancer, ISSN: 15268209
Carolyn D. Britten; Richard S. Finn; Linda Bosserman; Steven Wong; Michael F. Press; Mubashira Malik; Bert L. Lum; Dennis J. Slamon
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B and T lymphocyte attenuator regulates B cell receptor signaling by targeting Syk and BLNK
Journal of Immunology, ISSN: 15506606 00221767
Andrew C. Vendel; Jill Calemine-Fenaux; Anita Izrael-Tomasevic; Vandana Chauhan; David Arnott; Dan L. Eaton
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Drug-drug interactions mediated through P-glycoprotein: Clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Fenner; Troutman; Kempshall; Cook; Joseph A. Ware; Smith; Caroline A. Lee
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Breaking into bone biology: Target practice
Nature Medicine, ISSN: 10788956 1546170X
Yongwon Choi; Matthew C. Walsh; Joseph R. Arron
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Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population
Arthritis and Rheumatism, ISSN: 00043591 15290131
Ikue Ito; Aya Kawasaki; Satoshi Ito; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Akito Tsutsumi; Geoffrey Hom; Robert R. Graham; Yoshinari Takasaki; Hiroshi Hashimoto; Jun Ohashi; Timothy W. Behrens; Takayuki Sumida; Naoyuki Tsuchiya
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Construction and application of a zebrafish array comparative genomic hybridization platform
Genes Chromosomes and Cancer, ISSN: 10452257 10982264
Jennifer L. Freeman; Craig Ceol; Hui Feng; David M. Langenau; Cassandra Belair; Howard M. Stern; Anhua Song; Barry H. Paw; A. Thomas Look; Yi Zhou; Leonard I. Zon; Charles Lee
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Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma
Respiratory Medicine, ISSN: 09546111
Tmirah Haselkorn; James E. Fish; Bradley E. Chipps; Dave P. Miller; Hubert Chen; Weiss
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Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
Journal of Comparative Neurology, ISSN: 00219967 10969861
Jason E. Long; Christo Swan; Winnie S. Liang; Inma Cobos; Gregory B. Potter; John L. R. Rubenstein
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