Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3101 - 3150 OF 15578 RESULTS

February 1, 2020

International standards for the analysis of quality-of-life and patient-reported outcome endpoints in cancer randomised controlled trials: recommendations of the SISAQOL Consortium

The Lancet Oncology, ISSN: 14745488 14702045

Corneel Coens; Madeline Pe; Amylou Dueck; Jeff A. Sloan; Ethan Basch; Melanie Calvert; Alicyn Campbell; Charles S. Cleeland; Kim Cocks; Laurence Collette; Nancy Devlin; Lien Dorme; Hans-Henning Flechtner; Carolyn C. Gotay; Ingolf Griebsch; Mogens Groenvold; Madeleine King; Paul G Kluetz; Michael Koller; Daniel C Malone; Francesca Martinelli; Sandra A Mitchell; Jammbe Musoro; Daniel O'Connor; Kathy Oliver; Elisabeth Piault-Louis; Martine Piccart; Chantal Quinten; Jaap C Reijneveld; Christoph Schürmann; Ashley Wilder Smith; Katherine M Soltys; Martin J. B. Taphoorn; Galina Velikova; Andrew Bottomley

February 1, 2020

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Nicholas P. D. Liau; Timothy J. Wendorff; John Quinn; Micah Steffek; Wilson Phung; Peter S. Liu; Jia Tang; Flaviyan J. Irudayanathan; Saeed Izadi; Andrey S. Shaw; Shiva Malek; Sarah G. Hymowitz; Jawahar Sudhamsu

February 1, 2020

Rituximab utilization for approved and off-label nononcology indications and patients’ experiences with the Patient Alert Card

Pharmacology Research and Perspectives, ISSN: 20521707

Khaled Sarsour; Senam Beckley-Kartey; Simone Melega; Odueyungbo; Petra Kirchner; Natasha Khalife; Joanne Bangs

February 1, 2020

Human cytochrome P450 1A1 adapts active site for atypical nonplanar substrate

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Aaron G. Bart; Ryan Takahashi; Xiaojing Wang; Emily E. Scott

February 1, 2020

Population Pharmacokinetics, Efficacy Exposure-Response Analysis

Pharmaceutical Research, ISSN: 1573904X 07248741

Phyllis Chan; Jiajie Yu; Leslie Chinn; Marita Prohn; Jan Huisman; Brett Matzuka; William D. Hanley; Katie Tuckwell; Angelica Quartino

February 1, 2020

An efficient Bayesian platform trial design for borrowing adaptively from historical control data in lymphoma

Contemporary Clinical Trials, ISSN: 15592030 15517144

James Normington; Jiawen Zhu; Federico Mattiello; Somnath Sarkar; Bradley P. Carlin

February 1, 2020

Atezolizumab in combination with bevacizumab, paclitaxel and carboplatin for the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer, including patients with EGFR mutations

Expert Review of Respiratory Medicine, ISSN: 17476356 17476348

Martin Reck; Geetha Shankar; Lee; Coleman; Mark L. McCleland; Vassiliki A. Papadimitrakopoulou; Mark A. Socinski; Alan Sandler

February 1, 2020

Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration?

Ophthalmology Retina, ISSN: 24686530

Yogin Patel; Daniel M. Miller; Anne E. Fung; Lauren Hill; Philip J. Rosenfeld

February 1, 2020

De Novo Versus Recurrent HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from the SystHERs Registry

Oncologist, ISSN: 1549490X 10837159

Debasish Tripathy; Adam Brufsky; Melody A. Cobleigh; Mohammad Jahanzeb; Peter A. Kaufman; Ginny Mason; O'Shaughnessy; Hope S. Rugo; Sandra M. Swain; Denise A. Yardley; Laura Chu; Haocheng Li; Vincent Antao; Sara A. Hurvitz

February 1, 2020

Ovarian Toxicity Assessment in Histopathological Images Using Deep Learning

Toxicologic Pathology, ISSN: 15331601 01926233

Fangyao Hu; Leah Schutt; Cleopatra Kozlowski; Karen S. Regan; Noel Dybdal; Melissa Schutten

February 1, 2020

Using Electronic Health Records to Derive Control Arms for Early Phase Single-Arm Lung Cancer Trials: Proof-of-Concept in Randomized Controlled Trials

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Gillis Carrigan; Samuel Whipple; William B. Capra; Michael D. Taylor; Jeffrey S. Brown; Michael W. Lu; Brandon Arnieri; Ryan Copping; Kenneth J. Rothman

February 1, 2020

Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

William W. Busse; Marc Humbert; Tmirah Haselkorn; Benjamin Ortiz; Benjamin L. Trzaskoma; Patricia Stephenson; Lorena Garcia Conde; Farid Kianifard; Stephen Holgate

February 1, 2020

Rituximab utilization for approved and off-label nononcology indications and patients’ experiences with the Patient Alert Card

Pharmacology Research and Perspectives, ISSN: 20521707

Khaled Sarsour; Senam Beckley-Kartey; Simone Melega; Adefowope Odueyungbo; Petra Kirchner; Natasha Khalife; Joanne Bangs

January 29, 2020

Genome-wide analysis of differential gene expression and splicing in excitatory neurons and interneuron subtypes

Journal of Neuroscience, ISSN: 15292401 02706474

Melanie A. Huntley; Karpagam Srinivasan; Brad A. Friedman; Tzu-Ming Wang; Ada X. Yee; Yuanyuan Wang; Joshua S. Kaminker; Morgan Sheng; David V. Hansen; Jesse E. Hanson

January 28, 2020

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration

Cell Reports, ISSN: 22111247

Luz D. Orozco; Hsu-Hsin Chen; Christian Cox; Kenneth J. Katschke Jr.; Rommel Arceo; Carmina Espiritu; Patrick Caplazi; Sarajane Saturnio Nghiem; Ying-Jiun Chen; Zora Modrusan; Amy Dressen; Leonard D. Goldstein; Christine Clarke; Tushar Bhangale; Brian L. Yaspan; Marion Jeanne; Michael J. Townsend; Menno Van Lookeren Campagne; Jason A. Hackney

January 23, 2020

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected Benzoin-Derived Enol Carbonates

Advanced Synthesis and Catalysis, ISSN: 16154169 16154150

Rémi Lavernhe; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz

January 22, 2020

Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease

Alzheimer's Research and Therapy, ISSN: 17589193

Yoshida; Anita Moein; Tobias Bittner; Ostrowitzki; Helen Lin; Lee Honigberg; Jin Y. Jin; Angelica Quartino

January 21, 2020

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Hae-Min Park; Valerie J. Winton; Jared J. Drader; Sheri Manalili Wheeler; Greg A. Lazar; Neil L Kelleher; Yichin Liu; John C. Tran; Philip D. Compton

January 15, 2020

Phase Ia study of anti-NAPI2B antibody–drug conjugate lifastuzumab vedotin DNIB0600A in patients with non–small cell lung cancer and platinum-resistant ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

David E. Gerber; Jeffery R. Infante; Michael S. Gordon; Sarah B. Goldberg; Miguel Martín; Enriqueta Felip; Maria Martinez Garcia; Joan H. Schiller; David Spigel; Julie Cordova; Valerie Westcott; Wang; David S. Shames; Younjeong Choi; Robert S. Kahn; Randall Dere; Divya Samineni; Jian Xu; Kedan Lin; Katie Wood; Stephanie Royer-Joo; Lemahieu; Schuth; Vaze; Daniel Maslyar; Eric W. Humke; Howard A. Burris

January 14, 2020

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models

Cell Reports, ISSN: 22111247

Jesse E. Hanson; Keran Ma; Justin Elstrott; Martin Weber; Sandrine Saillet; Abdullah S. Khan; Jeffrey Simms; Benjamin Liu; Thomas A. Kim; Gui-Qiu Yu; Yelin Chen; Tzu-Ming Wang; Zhiyu Jiang; Bianca M. Liederer; Gauri Deshmukh; Hilda Solanoy; Connie Chan; Benjamin D. Sellers; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Robby M. Weimer; Morgan Sheng; T. Michael Gill; Kimberly Scearce-Levie; Jorge J. Palop

January 9, 2020

Log D Contributions of Substituents Commonly Used in Medicinal Chemistry

ACS Medicinal Chemistry Letters, ISSN: 19485875

Matthew L. Landry; James J. Crawford

January 9, 2020

A brief history of human disease genetics

Nature, ISSN: 14764687 00280836

Melina Claussnitzer; Judy H. Cho; Rory Collins; Nancy J. Cox; Emmanouil T. Dermitzakis; Matthew E. Hurles; Sekar Kathiresan; Eimear E. Kenny; Cecilia M. Lindgren; Daniel G. MacArthur; Kathryn N. North; Sharon E. Plon; Heidi L. Rehm; Neil Risch; Charles Rotimi; Jay Shendure; Nicole Soranzo; Mark I. McCarthy

January 7, 2020

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Analytical Chemistry, ISSN: 15206882 00032700

Peilu Liu; Xuan Gao; Victor Lundin; Catherine Shi; Yilma T. Adem; Kevin Lin; Guoying Jiang; Kao; Feng Yang; David A. Michels; Alan G. Marshall; Hui-Min Zhang

January 7, 2020

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

ChemMedChem, ISSN: 18607187 18607179

Thomas H. Pillow; Pragya Adhikari; Robert A. Blake; Jinhua Chen; Geoffrey Del Rosario; Gauri Deshmukh; Isabel Figueroa; Karen Gascoigne; Amrita Kamath; Susan Kaufman; Tracy L. Kleinheinz; Katherine R. Kozak; Brandon Latifi; Douglas Leipold; Chun Sing Li; Ruina Li; Melinda M. Mulvihill; Aimee O'Donohue; Rebecca K. Rowntree; Jack D. Sadowsky; John Wai; Xinxin Wang; Cong Wu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Richard Zang; Hongyan Zhang; Hao Zhou; Xiaoyu Zhu; Peter Dragovich

January 5, 2020

Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy

Chemico-Biological Interactions, ISSN: 18727786 00092797

Genualdi; Stuart C. Feinstein; Wilson; Jordan; Nicola J. Stagg

January 3, 2020

Dual photoredox/nickel-catalyzed conversion of aryl halides to aryl aminooxetanes: Computational evidence for a substrate-dependent switch in mechanism

ACS Catalysis, ISSN: 21555435

Kavoos Kolahdouzan; Ryan Khalaf; Jessica M. Grandner; Yongsheng Chen; Jack A. Terrett; Malcolm P. Huestis

January 2, 2020

Exposure–response analysis of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia: pooled results from a phase 1b study and the phase 3 MURANO study

Leukemia and Lymphoma, ISSN: 10292403 10428194

Rong Deng; Leonid Gibiansky; Tong Lu; Xiaobin Li; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Noopur Shankar; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles

January 2, 2020

Cost-effectiveness of omalizumab for the treatment of moderate-to-severe uncontrolled allergic asthma in the United States

Current Medical Research and Opinion, ISSN: 14734877 03007995

Patrick W. Sullivan; Qianyi Li; S. Pinar Bilir; Joseph Dang; Abhishek Kavati; Ming Yang; Yamina Rajput

January 1, 2020

The Role of Futility Analyses in Alzheimer’s Disease Clinical Trials

Journal of Prevention of Alzheimer's Disease, ISSN: 24260266 22745807

Rachelle S. Doody

January 1, 2020

Combined vaccination with NY-ESO-1 protein, poly-ICLC, and montanide improves humoral and cellular immune responses in patients with high-risk melanoma

Cancer immunology research, ISSN: 23266074 23266066

Anna Pavlick; Ana B. Blazquez; Marcia Meseck; Michael Lattanzi; Patrick A. Ott; Thomas U. Marron; Rose Marie Holman; John Mandeli; Andres M. Salazar; Christopher B. McClain; Gustavo Gimenez; Sreekumar Balan; Sacha Gnjatic; Rachel L. Sabado; Nina Bhardwaj

January 1, 2020

Importance of drying in small molecule drug product development

Drying Technologies for Biotechnology and Pharmaceutical Applications,

Paroma Chakravarty; Karthik Nagapudi

January 1, 2020

Sensitive detection of therapeutic efficacy with the etdrs diabetic retinopathy severity scale

Clinical Ophthalmology, ISSN: 11775483 11775467

Jiameng Zhang; Erich C. Strauss

January 1, 2020

Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Hany S. Girgis; Cory D. DuPai; Jessica Lund; Janina Reeder; Joseph Guillory; Durinck; Yuxin Liang; Joshua S. Kaminker; Peter A. Smith; Elizabeth Skippington

January 1, 2020

Five-year patterns of diabetic retinopathy progression in us clinical practice

Clinical Ophthalmology, ISSN: 11775483 11775467

Andrew A. Moshfeghi; Vincent Garmo; Daniel Sheinson; Avanti Ghanekar; Ibrahim Abbass

January 1, 2020

Comment on 'Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab'

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Attila Pethoe-Schramm; Jenny Devenport; William Reiss

January 1, 2020

Long-Term Stability of Anti-Vascular Endothelial Growth Factor (a-VEGF) Biologics Under Physiologically Relevant Conditions and Its Impact on the Development of Long-Acting Delivery Systems

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Debby P. Chang; Shalini Burra; Eric S. Day; Joyce Chan; Laetitia Comps-Agrar; Thierry Nivaggioli; Karthikan Rajagopal

January 1, 2020

Circulating tumor DNA and biomarker analyse from the lotus randomized trial of first-line ipatasertib and paclitaxel for metastatic triple-negative breast cancer

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Sung-Bae Kim; Saura; Oliveira; Doron Lipson; Mark Kennedy; Mandy Greene; Virginia Breese; Aruna Mani; Xu; Rebecca Dent

January 1, 2020

Development of deep learning models to predict best-corrected visual acuity from optical coherence tomography

Translational Vision Science and Technology, ISSN: 21642591

Michael G. Kawczynski; Thomas Bengtsson; Jian Dai; J. Jill Hopkins; Simon S. Gao; Jeffrey R. Willis

January 1, 2020

Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma

OncoImmunology, ISSN: 2162402X 21624011

Alexandra Drakaki; Preet K. Dhillon; Heather A. Wakelee; Chui; Jinjoo Shim; Matthew Kent; Viraj Degaonkar; Tien Hoang; Virginia McNally; Patricia Luhn; Ralf Gutzmer

January 1, 2020

microbiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Jennifer A. Tom; Joseph N. Paulson; Justin Williams; Hector Corrada Bravo

January 1, 2020

Targeted IgMs agonize ocular targets with extended vitreal exposure

mAbs, ISSN: 19420870 19420862

Chen; Maciej Paluch; Julie A. Zorn; Sharmila Rajan; Brandon Leonard; Alberto Estevez; John Brady; Chiu; Wilson Phung; Amin Famili; Minhong Yan; Claudio Ciferri; Marissa L. Matsumoto; Greg A. Lazar; Susan R. Crowell; Hass; Nick Agard

January 1, 2020

Using artificial intelligence for improving stroke diagnosis in emergency departments: a practical framework

Therapeutic Advances in Neurological Disorders, ISSN: 17562864 17562856

Vida Abedi; Ayesha Khan; Durgesh Chaudhary; Debdipto Misra; Venkatesh Avula; Dhruv Mathrawala; Chadd Kraus; Kyle A. Marshall; Nayan Chaudhary; Xiao Li; Clemens M. Schirmer; Fabien Scalzo; Jiang Li; Ramin Zand

January 1, 2020

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, ISSN: 19420870 19420862

Yue Sun; Alberto Estevez; Tilman Schlothauer; Aaron T. Wecksler

January 1, 2020

Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer's Disease Treated with Escalating Doses for up to 133 Weeks

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Heather Guthrie; Lawrence S. Honig; Helen Lin; Kaycee M. Sink; Kathleen Blondeau; Angelica Quartino; Michael J. Dolton; Montserrat Carrasco-Triguero; Qinshu Lian; Tobias Bittner; David Clayton; Jillian Smith; Ostrowitzki

January 1, 2020

Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Ariel Muliadi; Alamelu Banda; Chen Mao

January 1, 2020

Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019)

Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776

Huifen Chen; Jack A. Terrett

January 1, 2020

Modeling colorectal cancer progression through orthotopic implantation of organoids

Methods in Molecular Biology, ISSN: 19406029 10643745

Felipe de Sousa e Melo; Jonathan M. Harnoss; Noelyn Kljavin; Ryan Scott; Catherine Sohn; Kevin G. Leong; Frederic J. De Sauvage

January 1, 2020

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Human Brain Mapping, ISSN: 10970193 10659471

Christopher R. K. Ching; Derrek P. Hibar; Tiril P. Gurholt; Abraham Nunes; Sophia I. Thomopoulos; Christoph Abé; Ingrid Agartz; Rachel M. Brouwer; Dara M. Cannon; Sonja M C de Zwarte; Lisa T. Eyler; Pauline Favre; Tomas Hajek; Unn K. Haukvik; Josselin Houenou; Mikael Landén; Tristram A. Lett; Colm McDonald; Leila Nabulsi; Yash Patel; Melissa E. Pauling; Tomas Paus; Joaquim Radua; Marcio G. Soeiro-de-Souza; Giulia Tronchin; Neeltje E. M. Van Haren; Eduard Vieta; Henrik Walter; Ling-Li Zeng; Martin Alda; Jorge Almeida; Dag Alnæs; Silvia Alonso-Lana; Cara Altimus; Michael Bauer; Bernhard T. Baune; Carrie E. Bearden; Marcella Bellani; Francesco Benedetti; Michael Berk; Amy C. Bilderbeck; Hilary P. Blumberg; Erlend Bøen; Irene Bollettini; Caterina del Mar Bonnin; Paolo Brambilla; Erick J. Canales-Rodríguez; Xavier Caseras; Orwa Dandash; Udo Dannlowski; Giuseppe Delvecchio; Ana M. Díaz-Zuluaga; Danai Dima; Édouard Duchesnay; Torbjørn Elvsåshagen; Scott C. Fears; Sophia Frangou; Janice M. Fullerton; David C. Glahn; Jose M. Goikolea; Melissa J. Green; Dominik Grotegerd; Oliver Gruber; Bartholomeus C. M. Haarman; Chantal Henry; Fleur M. Howells; Victoria Ives-Deliperi; Andreas Jansen; Tilo T.J. Kircher; Christian Knöchel; Bernd Krämer; Beny Lafer; Carlos López-Jaramillo; Rodrigo Machado-Vieira; Bradley J. MacIntosh; Elisa M. T. Melloni; Philip B. Mitchell; Igor Nenadic; Fabiano Nery; Allison C. Nugent; Viola Oertel; Roel A. Ophoff; Miho Ota; Bronwyn J. Overs; Daniel L. Pham; Mary L. Phillips; Julian A. Pineda-Zapata; Sara Poletti; Mircea Polosan; Edith Pomarol-Clotet; Arnaud Pouchon; Yann Quidé; Maria M. Rive; Gloria Roberts; Henricus G. Ruhe; Raymond Salvador; Salvador Sarró; Theodore D. Satterthwaite; Aart H. Schene; Kang Sim; Jair C. Soares; Michael Stäblein; Dan J. Stein; Christian K. Tamnes; Georgios V. Thomaidis; Cristian Vargas Upegui; Dick J. Veltman; Michèle Wessa; Lars T. Westlye; Heather C. Whalley; Daniel H. Wolf; Mon-Ju Wu; Lakshmi N. Yatham; Carlos A. Zarate; Paul M. Thompson; Ole A. Andreassen

January 1, 2020

Mechanistic modeling of soluble Aβ dynamics and target engagement in the brain by anti-Aβ mAbs in Alzheimer’s disease

Current Alzheimer Research, ISSN: 18755828 15672050

Gregory Z. Ferl; Reina N. Fuji; Jasvinder K. Atwal; Tony Sun; Ramanujan; Angelica Quartino

January 1, 2020

Predictors of early diabetic retinopathy regression with ranibizumab in the ride and rise clinical trials

Clinical Ophthalmology, ISSN: 11775483 11775467

Michael Singer; Mimi Liu; Patricio G. Schlottmann; Arshad M. Khanani; Miranda Hemphill; Lauren Hill; Lisa Tuomi; Zdenka Haskova

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