Genentech: Publications

January 1, 2020

Diabetic population-based model to estimate impact of ranibizumab on diabetic retinopathy severity in patients with diabetic macular edema

Clinical Ophthalmology, ISSN: 11775483 11775467

Rohit Varma; Neil M. Bressler; Quan V. Doan; Ivan J. Suñer; Mark Danese; Chantal M. Dolan; Abraham Lee; Jason S. Ehrlich; Yamina Rajput

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January 1, 2020

Chapter 11: Particles in Biopharmaceuticals: Causes, Characterization, and Strategy

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Steven Messick; Miguel Saggu; Anacelia Ríos Quiroz

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January 1, 2020

Chapter 24: Considerations and Challenges When Filling High-Concentration Monoclonal Antibody Formulations into Prefilled Syringes

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Wendy Shieu; Maa

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January 1, 2020

Chapter 4: Production Strategies and Challenges with IgG-Based Bispecific Ab Formats

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Chen Gu; Diego Ellerman

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January 1, 2020

Chapter 15: Drug Product Formulation Development and Formulation Robustness Criteria for a mAb in a Pre-filled Syringe

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Gregory Downing; Karen Rutherford

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January 1, 2020

Impact of genetic and nongenetic factors on body mass index and waist-hip ratio change in HIV-infected individuals initiating antiretroviral therapy

Open Forum Infectious Diseases, ISSN: 23288957

Catalina Barceló; Monia Guidi; Christian W. Thorball; Christian Hammer; Aziz Chaouch; Sebastian Haubitz; Bernasconi; Thierry Buclin; Philip E. Tarr; Chantal Csajka; Anagnostopoulos; Battegay; Bernasconi; Böni; Braun; Bucher; Alexandra Calmy; Cavassini; Ciuffi; Dollenmaier; Egger; Elzi; Fehr; Jacques Fellay; Hansjakob Furrer; Fux; Günthard; Haerry; Barbara Hasse; Hirsch; Hoffmann; Hösli; Huber; Christian Kahlert; Kaiser; Keiser; Klimkait; Kouyos; Kovari; Ledergerber; Martinetti; Martinez de Tejada; Marzolini; Metzner; Müller; Nicca; Paioni; Pantaleo; Perreau; Rauch; Rudin; Alexandra U. Scherrer; Schmid; Speck; Stöckle; Tarr; Trkola; Vernazza; Wandeler; Weber; Yerly

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January 1, 2020

MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity

Science immunology, ISSN: 24709468

Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Hélène Capietto; Lélia Delamarre; Kevin B. Walsh; Weilan Ye

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January 1, 2020

Visual Function Decline Resulting from Geographic Atrophy: Results from the Chroma and Spectri Phase 3 Trials

Ophthalmology Retina, ISSN: 24686530

Jeffrey S. Heier; Dante Joseph Pieramici; Usha Chakravarthy; Sunil Patel; Sunil Gupta; Andrew Lotery; Eleonora M. Lad; David Silverman; Erin C. Henry; Majid Anderesi; Elizabeth Tschosik; Sarah Gray; Daniela Ferrara; Robyn H. Guymer

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January 1, 2020

MicrobiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Justin Williams; Hector Corrada Bravo; Jennifer A. Tom; Joseph N. Paulson

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January 1, 2020

Risk stratification biomarkers for Staphylococcus aureus bacteraemia

Clinical and Translational Immunology, ISSN: 20500068

Yi Cao; Alessander O. Guimaraes; Melicent Peck; Oleg Mayba; Felicia Ruffin; Kyu Hong; Montserrat Carrasco-Triguero; Vance G. Fowler; Stacey A. Maskarinec; Carrie M. Rosenberger

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January 1, 2020

A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction

PLoS ONE, ISSN: 19326203

Beyza Bulutoglu; Camilo Rey-Bedón; Safak Mert; Lipeng Tian; Yoon-Young Jang; Martin L. Yarmush; Berk Usta

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January 1, 2020

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

eLife, ISSN: 2050084X

Mable Lam; Scot A. Marsters; Avi Ashkenazi; Peter Walter

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January 1, 2020

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

eLife, ISSN: 2050084X

Agata Wesolowska-Andersen; Grace Zhuo Yu; Vibe Nylander; Fernando Abaitua; Matthias Thurner; Jason M. Torres; Anubha Mahajan; Anna L. Gloyn; Mark I. McCarthy

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January 1, 2020

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires

mAbs, ISSN: 19420870 19420862

Yi-Chun Hsiao; Ying-Jiun J. Chen; Leonard D. Goldstein; Jia Wu; Zhonghua Lin; Kellen Schneider; Subhra Chaudhuri; Aju Antony; Kanika Bajaj Pahuja; Zora Modrusan; Dhaya Seshasayee; Somasekar Seshagiri; Isidro Hötzel

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January 1, 2020

Intestinal Stem Cell Aging: Origins and Interventions

Annual Review of Physiology, ISSN: 15451585 00664278

Heinrich Jasper

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January 1, 2020

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

mAbs, ISSN: 19420870 19420862

Aimee Fourie-O’Donohue; Phillip Chu; Josefa Dela Cruz Chuh; Robert Tchelepi; Siao Ping Tsai; John C. Tran; William S. Sawyer; Dian Su; Carl Ng; Keyang Xu; Shang-Fan Yu; Thomas H. Pillow; Jack D. Sadowsky; Peter Dragovich; Yichin Liu; Katherine R. Kozak

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January 1, 2020

Survey of Customers Requesting Medical Information: Preferences and Information Needs of Patients and Health Care Professionals to Support Treatment Decisions

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Stacey M. Fung; Cheryl Sud; Matt Suchodolski

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January 1, 2020

In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Jinze Li; Mayur S. Mitra; Gautham K. Rao

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January 1, 2020

Burden of illness in geographic atrophy: A study of vision-related quality of life and health care resource use

Clinical Ophthalmology, ISSN: 11775483 11775467

Praveen J. Patel; Focke Ziemssen; Eugene Ng; Anushini Muthutantri; David Silverman; Elizabeth Tschosik; Ronald A. Cantrell

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January 1, 2020

Macular atrophy in neovascular age-related macular degeneration: A pilot post Hoc analysis of patients with pigment epithelial detachments

Retina, ISSN: 15392864 0275004X

Carl B. Rebhun; Carlos Moreira-Neto; Shamika Gune; Lauren Hill; Jay S. Duker; Nadia K. Waheed

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January 1, 2020

Predictive and pharmacodynamic biomarkers of response to the phosphatidylinositol 3-kinase inhibitor taselisib in breast cancer preclinical models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Heather M. Moore; Heidi Savage; Carol O'Brien; Wei Zhou; Ethan S. Sokol; Michael E. Goldberg; Ciara Metcalfe; Lori S. Friedman; Lackner; Wilson

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January 1, 2020

Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv600 mutation–positive melanoma receiving adjuvant vemurafenib

Annals of Oncology, ISSN: 15698041 09237534

Paolo A. Ascierto; Karl Lewis; Anna Maria Di Giacomo; Lev Demidov; Mario Mandala; Igor Bondarenko; Christopher Herbert; Andrzej Mackiewicz; Piotr Rutkowski; Alexander Guminski; Brian Simmons; Chenglin Ye; Gregory Hooper; Matthew Wongchenko; Grant R. Goodman; Yibing Yan; Dirk Schadendorf

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January 1, 2020

A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells

Cancer Research, ISSN: 15387445 00085472

Kenneth J. Finn; Scott E. Martin; Jeffrey Settleman

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January 1, 2020

Polatuzumab vedotin in relapsed or refractory diffuse large B-cell lymphoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Laurie H. Sehn; Alex F. Herrera; Christopher R. Flowers; Manali K. Kamdar; Andrew McMillan; Mark Hertzberg; Sarit E. Assouline; Kim; Won Seog Kim; Muhit Ozcan; Jamie Hirata; Elicia M. Penuel; Joseph N. Paulson; Ji Cheng; Grace Ku; Matthew Matasar

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January 1, 2020

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

Nature Genetics, ISSN: 15461718 10614036

Kushal Suryamohan; Sajesh P. Krishnankutty; Joseph Guillory; Matthew Jevit; Markus S. Schröder; Meng Wu; Boney Kuriakose; Oommen K. Mathew; Rajadurai C. Perumal; Ivan Koludarov; Leonard D. Goldstein; Kate Senger; Mandumpala Davis Dixon; Dinesh Velayutham; Derek Vargas; Subhra Chaudhuri; Megha Muraleedharan; Ridhi Goel; Ying-Jiun J. Chen; Aakrosh Ratan; Peter S. Liu; Brendan Faherty; Guillermo de la Rosa; Hiroki Shibata; Miriam Baca; Meredith Sagolla; James Ziai; Gus A. Wright; Domagoj Vucic; Sangeetha Mohan; Aju Antony; Stinson; Donald S. Kirkpatrick; Rami N. Hannoush; Durinck; Zora Modrusan; Eric Stawiski; Kristen Wiley; Terje Raudsepp; R. Manjunatha Kini; Arun Zachariah; Somasekar Seshagiri

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January 1, 2020

Extended 5-year follow-up results of a phase Ib study (BRIM7) of vemurafenib and cobimetinib in BRAF-mutant melanoma A C

Clinical Cancer Research, ISSN: 15573265 10780432

Antoni Ribas; Adil Daud; Anna Pavlick; Rene Gonzalez; Karl Lewis; Omid Hamid; Thomas F. Gajewski; Igor Puzanov; Matthew Wongchenko; Isabelle Rooney; Jessie Hsu; Yibing Yan; Erica Park; McArthur

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January 1, 2020

Atezolizumab for children and young adults with previously treated solid tumours, non-Hodgkin lymphoma, and Hodgkin lymphoma (iMATRIX): a multicentre phase 1–2 study

The Lancet Oncology, ISSN: 14745488 14702045

Birgit Geoerger; C Michel Zwaan; Lynley V. Marshall; Jean Michon; Franck Bourdeaut; Michela Casanova; Nadège Corradini; Gianluca Rossato; Mufiza Farid-Kapadia; Colby S. Shemesh; Katherine E. Hutchinson; Francis Donaldson; Minlei Liao; Hubert Caron; Tanya Trippett

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January 1, 2020

Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial

Arthritis and Rheumatology, ISSN: 23265205 23265191

Jon T. Giles; Naveed Sattar; Sherine Gabriel; Paul M Ridker; Steffen Gay; Charles Warne; David Musselman; Laura Brockwell; Emma Shittu; Micki Klearman; Thomas Fleming

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January 1, 2020

Rate of Adverse Events and Associated Health Care Costs for the Management of Inflammatory Bowel Disease in Germany

Clinical Therapeutics, ISSN: 1879114X 01492918

Thomas Wilke; Antje Groth; Gráinne H. Long; Amanda R. Tatro; Diana Sun

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January 1, 2020

Changes in organic anion transporting polypeptide uptake in HEK293 overexpressing cells in the presence and absence of human plasma

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Christine M. Bowman; Eugene C. Chen; Liuxi Chen; Yi-Chen Chen; Xiaorong Liang; Matthew Wright; Yuan Chen; Jialin Mao

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January 1, 2020

A Multicompany Assessment of Submicron Particle Levels by NTA and RMM in a Wide Range of Late-Phase Clinical and Commercial Biotechnology-Derived Protein Products

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Mario Hubert; Dennis T. Yang; Stanley C. Kwok; Anacelia Rios; Tapan K. Das; Ankit Patel; Klaus Wuchner; Valentyn Antochshuk; Friederike Junge; George M. Bou-Assaf; Shawn Cao; Miguel Saggu; Luis Montrond; Nataliya Afonina; Parag Kolhe; Vakhtang Loladze; Linda O. Narhi

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January 1, 2020

Integrated Two-Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non-Hodgkin Lymphoma

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Tong Lu; Leonid Gibiansky; Xiaobin Li; Chunze Li; Priya Agarwal; Colby S. Shemesh; Rong Shi; Randall Dere; Jamie Hirata; Dale Miles; Pascal Chanu; Sandhya Girish; Jin Yan Jin

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January 1, 2020

Harnessing MerTK agonism for targeted therapeutics

mAbs, ISSN: 19420870 19420862

Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Jovencio Borneo; Yan Wu; Minhong Yan

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January 1, 2020

Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

mAbs, ISSN: 19420870 19420862

Chunze Li; Cindy Zhang; Zao Li; Divya Samineni; Dan Lu; Wang; Shang-Chiung Chen; Rong Zhang; Priya Agarwal; Bernard M. Fine; Sandhya Girish

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January 1, 2020

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies

Medicinal Research Reviews, ISSN: 10981128 01986325

Iris Dotan; Matthieu Allez; Silvio Danese; Mary E. Keir; Swati Tole; Jacqueline McBride

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January 1, 2020

Fiery Cell Death: Pyroptosis in the Central Nervous System

Trends in Neurosciences, ISSN: 1878108X 01662236

Brienne A. McKenzie; Vishva M. Dixit; Christopher Power

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January 1, 2020

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

mAbs, ISSN: 19420870 19420862

Cholpon Tilegenova; Saeed Izadi; Jianping Yin; Christine S. Huang; Jiansheng Wu; Diego Ellerman; Sarah G. Hymowitz; Benjamin T. Walters; Cleo M. Salisbury; Paul J. Carter

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January 1, 2020

Challenges of Using Closed System Transfer Devices With Biological Drug Products: An Industry Perspective

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Alavattam Sreedhara; Camellia Zamiri; Sirj Goswami; Sarah Weiser; Michael Cram; Twinkle R. Christian; Bharat Jagannathan

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January 1, 2020

Real-world practice patterns in veterans with metastatic castration-resistant prostate cancer

Urologic Oncology: Seminars and Original Investigations, ISSN: 18732496 10781439

Ahmad S. Halwani; Kelli M. Rasmussen; Vikas Patil; Catherine C. Li; Christina M. Yong; Zachary Burningham; Sumati Gupta; Sujata Narayanan; Shih Wen Lin; Susheela Carroll; Shivani K. Mhatre; Julie N. Graff; Robert Dreicer; Brian C. Sauer

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January 1, 2020

Physical Stability Studies of Antibody-Drug Conjugates (ADCs) Under Stressed Conditions

Methods in Molecular Biology, ISSN: 19406029 10643745

Yilma T. Adem

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January 1, 2020

Spectral-Domain OCT Predictors of Visual Outcomes after Ranibizumab Treatment for Macular Edema Resulting from Retinal Vein Occlusion

Ophthalmology Retina, ISSN: 24686530

Glenn Yiu; R. Joel Welch; Yinwen Wang; Zhe Wang; Pin-Wen Wang; Zdenka Haskova

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January 1, 2020

High-Resolution Characterization of ADCs by Orbitrap LCMS

Methods in Molecular Biology, ISSN: 19406029 10643745

Jintang He; Surinder Kaur; Keyang Xu

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January 1, 2020

The great escape: tumour cell plasticity in resistance to targeted therapy

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

Soufiane Boumahdi; Frederic J. De Sauvage

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January 1, 2020

Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Tapan K. Das; Linda O. Narhi; Alavattam Sreedhara; Tim Menzen; Christoph Grapentin; Danny Chou; Valentyn Antochshuk; Vasco Filipe

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January 1, 2020

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Nicholas Steven Jones; Yoshida; Laurent Salphati; Jane R. Kenny; Matthew Durk; Leslie Chinn

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January 1, 2020

Unobstructed Multiscale Imaging of Tissue Sections for Ultrastructural Pathology Analysis by Backscattered Electron Scanning Microscopy

Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554

Mike Reichelt; Meredith Sagolla; Anand K. Katakam; Webster

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January 1, 2020

The Value of Prior Response to Anti–Vascular Endothelial Growth Factor for Age-Related Macular Degeneration: A HARBOR Subanalysis

Kidney International Reports, ISSN: 24686530

Rahul N. Khurana; Louis K. Chang; Lauren Hill; Avanti Ghanekar; Ivaylo Stoilov

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January 1, 2020

Nasal gene expression changes with inhaled corticosteroid treatment in asthma

Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538

Ilse M. Boudewijn; Andy Lan; Alen Faiz; Claire A. Cox; Sharon Brouwer; Siebrig Schokker; Sebastiaan J. Vroegop; Nawijn; Prescott G. Woodruff; Stephanie Christenson; Paul Hagedoorn; Henderik W. Frijlink; David F. Choy; Uilke Brouwer; Marissa Wisman; Dirkje S. Postma; James Fingleton; Beasley; van den Berge; Victor Guryev

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January 1, 2020

Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic Pathology, ISSN: 15331601 01926233

Mark T. Butt; Reina N. Fuji; Mike Reichelt; Alok K. Sharma; Sarah Cramer

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January 1, 2020

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice

Journal of Cellular Physiology, ISSN: 10974652 00219541

Jungeun Yu; Christian W. Siebel; Lauren Schilling; Ernesto Canalis

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