Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3651 - 3700 OF 15578 RESULTS

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens
Genome Biology, ISSN: 1474760X 14747596
Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin
View on Scopus
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Benjamin D. Sellers; Antonio G. DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; Johnson; C. Lee Robinette; Charles J. Cohen; Brian S. Safina; Daniel P. Sutherlin; Daniel F. Ortwine; Christoph Dehnhardt
View on Scopus
CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer
BMC Cancer, ISSN: 14712407
Zi-Ming Zhao; Susan E. Yost; Katherine E. Hutchinson; Sierra Min Li; Yate-Ching Yuan; Javad Noorbakhsh; Zheng Liu; Charles Warden; Johnson; Xiwei Wu; Jeffrey H. Chuang; Yuan Yuan
View on Scopus
Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 -sp 2 Suzuki Coupling of a Benzyl Carbonate
Organic Process Research and Development, ISSN: 1520586X 10836160
Lauren E. Sirois; Matthew M. Zhao; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu
View on Scopus
Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies
Bioconjugate Chemistry, ISSN: 15204812 10431802
Nicholas Vance; Neelie Zacharias; Ultsch; Guangmin Li; Aimee Fourie; Peter S. Liu; Julien Lafrance-Vanasse; James A. Ernst; Wendy N. Sandoval; Katherine R. Kozak; Gail L. Phillips; Weiru Wang; Jack D. Sadowsky
View on Scopus
Study of a Competing Hydrodefluorination Reaction during the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde
Organometallics, ISSN: 15206041 02767333
Frederic St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Remy Angelaud; Francis Gosselin
View on Scopus
Directed Cp Rh III -Catalyzed Fluorosulfonylvinylation of Arenes
Organometallics, ISSN: 15206041 02767333
Gqwetha Ncube; Malcolm P. Huestis
View on Scopus
Fatty acid recognition in the Frizzled receptor family
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Aaron H Nile; Rami N. Hannoush
View on Scopus
Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines
Journal of the American Chemical Society, ISSN: 15205126 00027863
Seung Wook Kim; Leyah A. Schwartz; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische
View on Scopus
Why Computed Protein Folding Landscapes Are Sensitive to the Water Model
Journal of Chemical Theory and Computation, ISSN: 15499626 15499618
Ramu Anandakrishnan; Saeed Izadi; Alexey V. Onufriev
View on Scopus
Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion
BMC Ophthalmology, ISSN: 14712415
W. Lloyd Clark; Mimi Liu; John Kitchens; Pin-Wen Wang; Zdenka Haskova
View on Scopus
A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology
BMC Pulmonary Medicine, ISSN: 14712466
Tracy Staton; Kun Peng; Ryan Owen; David F. Choy; Christopher R. Cabanski; Alice Fong; Flavia Brunstein; Kathila R. Alatsis; Hubert Chen
View on Scopus
In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability
Molecular Pharmaceutics, ISSN: 15438392 15438384
Stijn H.S. Koshari; Purnendu K. Nayak; Shalini Burra; Isidro E. Zarraga; Karthikan Rajagopal; Yun Liu; Norman J. Wagner; Abraham M. Lenhoff
View on Scopus
Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures
Molecular Pharmaceutics, ISSN: 15438392 15438384
Karthikan Rajagopal; Debby P. Chang; Purnendu K. Nayak; Saeed Izadi; Thomas W. Patapoff; Jennifer Zhang; Robert F. Kelley; Alavattam Sreedhara
View on Scopus
In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches
Molecular Pharmaceutics, ISSN: 15438392 15438384
Kelly M. Loyet; Hass; Wendy N. Sandoval; Ashley Morando; Peter S. Liu; Whitney Shatz; Leslie Dickmann; Margaret Kenrick; Jeremy Good; Teresa Davancaze; Alyssa M. Morimoto; Robert F. Kelley; Justin M. Scheer
View on Scopus
Seeking universal detectors for analytical characterizations
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Kelly Zhang; Kenji L. Kurita; Venkatramani; David J. Russell
View on Scopus
Macrolactamization Approaches to Arylomycin Antibiotics Core
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
View on Scopus
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury
Science, ISSN: 10959203 00368075
Oliver J. Harrison; Jonathan L. Linehan; Han-Yu Shih; Nicolas Bouladoux; Seong-Ji Han; Margery Smelkinson; Shurjo K. Sen; Allyson L. Byrd; Michel Enamorado; Chen Yao; Samira Tamoutounour; Francois Van Laethem; Charlotte Hurabielle; Nicholas Collins; Andrea Paun; Rosalba Salcedo; John J. O'Shea; Yasmine Belkaid
View on Scopus
Cellular Plasticity in Intestinal Homeostasis and Disease
Cell Stem Cell, ISSN: 18759777 19345909
Felipe de Sousa e Melo; Frederic J. De Sauvage
View on Scopus
A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles
Tetrahedron Letters, ISSN: 18733581 00404039
Kyle Clagg; Sara Hold; Archana Kumar; Stefan G. Koenig; Remy Angelaud
View on Scopus
Borrowing From Historical Control Data in Cancer Drug Development: A Cautionary Tale and Practical Guidelines
Statistics in Biopharmaceutical Research, ISSN: 19466315
Connor Jo Lewis; Somnath Sarkar; Jiawen Zhu; Bradley P. Carlin
View on Scopus
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Structure, ISSN: 18784186 09692126
Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang
View on Scopus
Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Chengfeng Ren; Aaron O. Bailey; Erica Vanderporten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth F. Harris; Yichin Liu; Guanghui Han; Wendy N. Sandoval
View on Scopus
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
mAbs, ISSN: 19420870 19420862
Robert G. Brinson; John P. Marino; Frank Delaglio; Luke W. Arbogast; Ryan M. Evans; Anthony Kearsley; Geneviève Gingras; Houman Ghasriani; Yves Aubin; Gregory K. Pierens; Xinying Jia; Mehdi Mobli; Hamish G. Grant; David W. Keizer; Kristian Schweimer; Jonas Ståhle; Göran Widmalm; Edward R. Zartler; Chad W. Lawrence; Patrick N. Reardon; John R. Cort; Ping Xu; Feng Ni; Saeko Yanaka; Koichi Kato; Stuart R. Parnham; Desiree Tsao; Andreas Blomgren; Torgny Rundlöf; Nils Trieloff; Peter Schmieder; Ross; Ken Skidmore; Kang Chen; David Keire; Darón I. Freedberg; Thea Suter-Stahel; Gerhard Wider; Gregor Ilc; Janez Plavec; Scott A. Bradley; Donna M. Baldisseri; Mauricio Luis Sforça; Ana Carolina de Mattos Zeri; Julie Yu Wei; Christina M. Szabo; Carlos A. Amezcua; John B. Jordan; Mats Wikström
View on Scopus
Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning
Analytical Chemistry, ISSN: 15206882 00032700
Jordan Baker; Dana McDaniel; David Cain; Paula Lee Tao; Charlene Li; Yuting Huang; Hongbin Liu; Judith Zhu-Shimoni; Milady Ninonuevo
View on Scopus
Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases
Expert Opinion on Drug Delivery, ISSN: 17447593 17425247
Whitney Shatz; Jeffrey Aaronson; Stefan T. Yohe; Robert F. Kelley; Yogeshvar N. Kalia
View on Scopus
High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies
mAbs, ISSN: 19420870 19420862
T. Noelle Lombana; Marissa L. Matsumoto; Amy M. Berkley; Evangeline Toy; Ryan Cook; Yutian Gan; Du; Paul D. Schnier; Wendy N. Sandoval; Zhengmao Ye; Jill Schartner; Kim; Christoph Spiess
View on Scopus
Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Multiple Sclerosis Journal - Experimental, Translational and Clinical,
Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers
View on Scopus
Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers
View on Scopus
Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Erin L MacMillan; Julia J Schubert; Irene Vavasour; Roger Tam; Alexander Rauscher; Carolyn Taylor; Rick White; Hideki Garren; David Clayton; Victoria Levesque; David K. B. Li; Shannon Kolind; Traboulsee
View on Scopus
HPLC and UHPLC for biopharmaceutical analysis
HPLC and UHPLC for Practicing Scientists,
Jennifer C. Rea; Taylor Zhang
View on Scopus
Process validation
Comprehensive Biotechnology,
David H. Reifsnyder; Nathan McKnight; Kelley
View on Scopus
Disposable bioreactors
Comprehensive Biotechnology,
Oosterhuis; Terry Hudson; Alberto D’Avino; Zijlstra; Ashraf Amanullah
View on Scopus
Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study
Nature Methods, ISSN: 15491676 15491277
Michael Wainberg; Anubha Mahajan; Anshul Kundaje; Mark I. McCarthy; Erik Ingelsson; Nasa Sinnott-Armstrong; Manuel Rivas
View on Scopus
Cisplatin Ineligibility for Patients with Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives among US Oncologists
Bladder Cancer, ISSN: 23523735 23523727
Matthew D. Galsky; Esprit Ma; Bijal Shah-Manek; Rosalina Mills; Long Ha; Craig Krebsbach; Eric Blouin; Darren Tayama; Sarika Ogale
View on Scopus
Healthcare costs of potential glucocorticoid-associated adverse events in patients with giant cell arteritis
ClinicoEconomics and Outcomes Research, ISSN: 11786981
Jennie Best; Amanda M. Kong; David Smith; Ibrahim Abbass; Margaret Michalska
View on Scopus
Phase i Study of DSTP3086S, an antibody-drug conjugate targeting six-transmembrane epithelial antigen of prostate 1, in metastatic castration-resistant prostate cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Daniel C. Danila; Russell Z. Szmulewitz; Ulka Vaishampayan; Celestia S. Higano; Ari Baron; Houston N. Gilbert; Flavia Brunstein; Marija Milojic-Blair; Wang; Omar Kabbarah; Michael Mamounas; Bernard M. Fine; Daniel Maslyar; Alexander Ungewickell; Scher
View on Scopus
Immunoaffinity LC-MS/MS to quantify a PEGylated anti-Factor D Fab biotherapeutic in cynomolgus monkey serum
Bioanalysis, ISSN: 17576199 17576180
Luna Liu; Yanqiu Liu; Lu Dai; Cinzia Stella; Morse Faria; Junlong Shao; Jamie L Hicks; Diego F. Cortes; William R. Mylott; Eric Wakshull; Surinder Kaur; Keyang Xu
View on Scopus
2019 White Paper on Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2-Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Brian Booth; Lauren Stevenson; Renuka Pillutla; Michael H. Buonarati; Chris Beaver; Daniela Fraier; Fabio Garofolo; Sam Haidar; Rafiqul Islam; Christopher James; John Kadavil; Olga Kavetska; Li; Christina Satterwhite; Natasha Savoie; Sriram Subramaniam; Nilufer Tampal; Theingi Thway; Eric Woolf; Olivier Le Blaye; Matthew Andisik; Chad Briscoe; Stephanie Cape; Arindam Dasgupta; Saloumeh Kadkhodayan Fischer; Roger Hayes; John Kamerud; Gustavo Mendes Lima Santos; Corey Nehls; Catherine Soo; Stephen Vinter; Emma Whale; Keyang Xu; Seongeun Julia Cho; Anna Edmison; Sean Kassim; Thais Correa Rocha; Jan Welink; Shashi Amur; Abbas Bandukwala; Elana Cherry; Shirley Hopper; Akiko Ishii-Watabe; Susan Kirshner; Kevin Maher; Joao Pedras-Vasconcelos; Yoshiro Saito; Therese Solstad Saunders; Venke Skibeli; Verthelyi; Yow-Ming C. Wang; Haoheng Yan
View on Scopus
2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)
Bioanalysis, ISSN: 17576199 17576180
Steven Piccoli; Devangi Mehta; Alessandra Vitaliti; John Allinson; Shashi Amur; Steven Eck; Cherie Green; Michael Hedrick; Shirley Hopper; Allena Ji; Alison Joyce; Virginia Litwin; Kevin Maher; Joel Mathews; Kun Peng; Afshin Safavi; Yow-Ming C. Wang; Yan Zhang; Lakshmi Amaravadi; Nisha Palackal; Sai Thankamony; Chris Beaver; Eris Bame; Thomas Emrich; Grimaldi; Jonathan Haulenbeek; Vellalore Kakkanaiah; David Lanham; Andrew Mayer; Paul C Trampont; Laurent Vermet; Naveen Dakappagari; Catherine Aversa Fleener; Fabio Garofolo; Cynthia Rogers; Shabnam Tangri; Yuanxin Xu; Meina Liang; Manoj Rajadhyaksha; Susan Richards; Becky Schweighardt; Shobha Purushothama; Daniel Baltrukonis; Jochen Brumm; Elana Cherry; Jason Delcarpini; Carol Gleason; Susan Kirshner; Robert J Kubiak; Luying Pan; Michael A. Partridge; Joao Pedras-Vasconcelos; Qiang Qu; Venke Skibeli; Therese Solstad Saunders; Roland F Staack; Kay Stubenrauch; Albert Torri; Verthelyi; Haoheng Yan; Boris Gorovits; Rachel Palmer; Milton; Brian Long; Bart Corsaro; Vahid Farrokhi; Michele Fiscella; Neil Henderson; Vibha Jawa; Jim McNally; Rocio Murphy; Hanspeter Waldner; Tong-Yuan Yang
View on Scopus
2019 white paper on recent issues in bioanalysis: Chromatographic assays (part 1 - Innovation in small molecules and oligonucleotides & mass spectrometric method development strategies for large molecule bioanalysis)
Bioanalysis, ISSN: 17576199 17576180
Christine Fandozzi; Christopher Evans; Amanda Wilson; Dian Su; Melanie Anderson; Valerie Clausen; Lieve Dillen; Fabio Garofolo; Chris Holliman; Elliott Nickbarg; Timothy Olah; Ragu Ramanathan; Hui Zhang; Surinder Kaur; Renuka Pillutla; Hongbin Yu; Kevin Bateman; Lorella Di Donato; Shawna Hengel; Wenying Jian; Barry Jones; John Kellie; Anita Lee; Joe Palandra; Natasha Savoie; Petia Shipkova; Susan Spitz; Matthew Szapacs; Jian Wang; Katherine Wright; Jianing Zeng
View on Scopus
Microglia in Brain Development, Homeostasis, and Neurodegeneration
Annual Review of Genetics, ISSN: 15452948 00664197
Christopher J. Bohlen; Brad A. Friedman; Borislav Dejanovic; Morgan Sheng
View on Scopus
Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer
Oncotarget, ISSN: 19492553
C. Andrew Boswell; Daniela Bumbaca Yadav; Eduardo E. Mundo; Shang-Fan Yu; Jennifer A. Lacap; Aimee Fourie-O’Donohue; Katherine R. Kozak; Gregory Z. Ferl; Crystal Zhang; Jason Ho; Sheila Ulufatu; Leslie A. Khawli; Kedan Lin
View on Scopus
Streamlined Characterization of an Antibody-Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Alexandre Goyon; Michael Kim; Lu Dai; Christopher Cornell; Fred Jacobson; Davy Guillarme; Cinzia Stella
View on Scopus
Immunogenicity of antibody-drug conjugates: Observations across 8 molecules in 11 clinical trials
Bioanalysis, ISSN: 17576199 17576180
Montserrat Carrasco-Triguero; Randall Dere; Marija Milojic-Blair; Ola M. Saad; Denise Nazzal; Kyu Hong; Surinder Kaur
View on Scopus
Evaluation of in-study cut points to enable appropriate interpretation of clinical immunogenicity results
Bioanalysis, ISSN: 17576199 17576180
Jochen Brumm; Kun Peng
View on Scopus
Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals
Organic and Biomolecular Chemistry, ISSN: 14770520
Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Daniel F. Ortwine; Antonio G. DiPasquale; Jun Liang; Xiaojing Wang; Jason R. Zbieg; Jun Li
View on Scopus
Imaging patients with metastatic castration-resistant prostate cancer using 89Zr-DFO-MSTP2109A anti-STEAP1 antibody
Journal of Nuclear Medicine, ISSN: 2159662X 01615505
Jorge A. Carrasquillo; Bernard M. Fine; Neeta Pandit-Taskar; Steven M. Larson; Stephen E. Fleming; Josef J. Fox; Sarah M. Cheal; Joseph A. O’Donoghue; Shutian Ruan; Govind Ragupathi; Serge K. Lyashchenko; John L. Humm; Scher; Mithat Gonen; Simon P. Williams; Daniel C. Danila; Michael J. Morris
View on Scopus
A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Bushra Husain; Sree R. Ramani; Eugene Y. Chiang; Isabelle Lehoux; Sairupa Paduchuri; Tia A. Arena; Patel; Blair Wilson; Pamela Chan; Yvonne Franke; Athena W. Wong; Jennie R. Lill; Shannon J. Turley; Lino C. Gonzalez Jr.; Jane L. Grogan; Nadia Martinez-Martin
View on Scopus
Comparative effectiveness of first-line nab-paclitaxel versus paclitaxel monotherapy in triple-negative breast cancer
Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305
Patricia Luhn; Chui; Angela Hsieh; Jingbo Yi; Almut Mecke; Preeti S. Bajaj; Waseem Hasnain; Adeline Falgas; Thanh G.N. Ton; Allison W. Kurian
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.