Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5401 - 5450 OF 15217 RESULTS

Effectiveness of rituximab for the treatment of rheumatoid arthritis in patients with prior exposure to anti-TNF: Results from the CORRONA registry
Journal of Rheumatology, ISSN: 14992752 0315162X
Leslie R. Harrold; Reed; Ashwini Shewade; Robert Magner; Katherine C. Saunders; Ani John; Joel M. Kremer; Jeffrey D. Greenberg
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Hydrophobic interaction chromatography for antibody drug conjugate drug distribution analysis
American Pharmaceutical Review, ISSN: 10998012
Tao Chen; Kelly Zhang; Jason Gruenhagen; Colin D. Medley
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Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States
British Journal of Haematology, ISSN: 13652141 00071048
Chadi Nabhan; Michelle Byrtek; Ashish Rai; Keith Dawson; Zhou; Brian K. Link; Jonathan W. Friedberg; Zelenetz; Matthew J. Maurer; James R. Cerhan; Christopher R. Flowers
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Changes in asthma control, work productivity, and impairment with omalizumab: 5-year EXCELS study results
Allergy and Asthma Proceedings, ISSN: 15396304 10885412
James L. Zazzali; Karina Raimundo; Benjamin L. Trzaskoma; Karin Rosén; Michael Schatz
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A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma
Journal of the American Academy of Dermatology, ISSN: 10976787 01909622
Howard Sofen; Kenneth G. Gross; Leonard Goldberg; Harry Sharata; Tiffani K. Hamilton; Barbara Egbert; Benjamin Lyons; Jeannie Hou; Ivor Caro
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Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)
British Journal of Haematology, ISSN: 13652141 00071048
Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Brad Kahl; Sandra J. Horning; Ranjana H. Advani
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Risk of corticosteroid-related adverse events in asthma patients with high oral corticosteroid use
Allergy and Asthma Proceedings, ISSN: 15396304 10885412
James L. Zazzali; Michael S. Broder; Theodore A. Omachi; Eunice Chang; Gordon H. Sun; Karina Raimundo
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The Cost-Effectiveness of Ranibizumab for the Treatment of Diabetic Macular Edema
Ophthalmology, ISSN: 15494713 01616420
Gary C. Brown; Melissa M. Brown; Adam Turpcu; Yamina Rajput
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Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice
Diabetologia, ISSN: 14320428 0012186X
Samantha L. Hocking; Rebecca L. Stewart; Amanda E. Brandon; Eurwin Suryana; Ella Stuart; Emily M. Baldwin; Ganesh Kolumam; Zora Modrusan; Jagath R. Junutula; Jenny E. Gunton; Michael Medynskyj; Sinead P. Blaber; Elisabeth Karsten; Benjamin R. Herbert; David E. James; Gregory J. Cooney; Michael M. Swarbrick
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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
Pharmacology and Therapeutics, ISSN: 1879016X 01637258
Deepak Sampath; Tanja S. Zabka; Misner; Thomas O'Brien; Peter Dragovich
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Sulfonic Acid Salts of Donepezil and Stabilization of Amorphous Donepezil via Formation of Amorphous Salts
Crystal Growth and Design, ISSN: 15287505 15287483
Sun Hye Lee; Jae Ho Bae; Yeojin Park; Bishal Raj Adhikari; Chen Mao; Daeyoung Kim; Kyung Im Kim; Sung Kwon Kang; Eun Hee Lee
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Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Lisa Ryner; Yinghui Guan; Ron Firestein; Yuanyuan Xiao; Younjeong Choi; Christina Rabe; Shan Lu; Eloisa Fuentes; Huw; Lackner; Ling Fu; Lukas Amler; Carlos Bais; Wang
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Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
EBioMedicine, ISSN: 23523964
Ganesh Kolumam; Mark Chen; Raymond K. Tong; Jose Zavala-Solorio; Lance Kates; Nicholas Van Bruggen; Ross; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Diana Ronai Dunshee; Ai-Luen Wu; Benjamin Haley; Keith R. Anderson; Søren Warming; Xin Y. Rairdan; Nicholas Lewin-Koh; Yingnan Zhang; Johnny Gutierrez; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Sharmila Rajan; Travis W. Bainbridge; Jean-Michel Vernes; Meng; James Ziai; Robert Soriano; Matthew J. Brauer; Yongmei Chen; Scott Stawicki; Hok Seon Kim; Laetitia Comps-Agrar; Luis; Christoph Spiess; Yan Wu; James A. Ernst; Owen P. McGuinness; Andrew S. Peterson; Junichiro Sonoda
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Intratumoral heterogeneity: From diversity comes resistance
Clinical Cancer Research, ISSN: 15573265 10780432
Ariel Pribluda; Cecile C. de la Cruz; Erica L. Jackson
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Conformational Isomerism in Solid State of AMG 853 - Structure Studies Using Solid-State Nuclear Magnetic Resonance and X-ray Diffraction
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Kiang; Karthik Nagapudi; Tian Wu; Matthew L. Peterson; Janan Jona; Richard J. Staples; Peter W. Stephens
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Use of cassette dosing to enhance the throughput of rat brain microdialysis studies
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Gauri Deshmukh; Kefeng Sun; Bianca M. Liederer; Xiao Ding; Xingrong Liu
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Comparative Study of Analytical Techniques for Determining Protein Charge
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Dana I. Filoti; Steven J. Shire; Sandeep Yadav; Thomas M. Laue
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Health-related quality of life in a randomized phase III study of bevacizumab, temozolomide, and radiotherapy in newly diagnosed glioblastoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Martin J. B. Taphoorn; Roger Henriksson; Andrew Bottomley; Timothy Cloughesy; Wick; Warren Mason; Frank Saran; Ryo Nishikawa; Magalie Hilton; Christina Theodore-Oklota; Arliene Ravelo; Olivier L. Chinot
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Predictors of Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Ranibizumab
Ophthalmology, ISSN: 15494713 01616420
Raafay Sophie; Na Lu; Peter A. Campochiaro
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Vented Spikes Improve Delivery from Intravenous Bags with No Air Headspace
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
William J. Galush; Travis A. Horst
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The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive
Temperature, ISSN: 23328959 23328940
Jun Chen
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Joint modeling of survival and longitudinal non-survival data: Current methods and issues. Report of the DIA Bayesian joint modeling working group
Statistics in Medicine, ISSN: 10970258 02776715
A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois
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Responses to discussants of 'Joint modeling of survival and longitudinal non-survival data: Current methods and issues. report of the DIA Bayesian joint modeling working group'
Statistics in Medicine, ISSN: 10970258 02776715
A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois
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Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling
Journal of Experimental Medicine, ISSN: 15409538 00221007
Derek A. Holmes; Eric Suto; Wyne P. Lee; Qinglin Ou; Qian Gong; Hamish R.C. Smith; Patrick Caplazi; Andrew A. Chan
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The role of FcεRI expressed in dendritic cells and monocytes
Cellular and Molecular Life Sciences, ISSN: 14209071 1420682X
Jeoung-Sook Shin; Alexandra M. Greer
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Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine
Vaccine, ISSN: 18732518 0264410X
Mary Ann Goss; Fabio Lievano; Karyn M. Buchanan; Margaret M. Seminack; Michael L. Cunningham; Adrian Dana
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Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination
Cell Death and Disease, ISSN: 20414889
Maria Cristina De Almagro; Tatiana Goncharov; Kim Newton; Domagoj Vucic
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Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Lewis Gazzard; Karen Williams; Huifen Chen; Lorraine Axford; Elizabeth M. Blackwood; Brenda Burton; Kerry Chapman; Peter H. Crackett; Joy Drobnick; Charles Ellwood; Jennifer A. Epler; Michael Flagella; Emanuela Gancia; Matthew Gill; Simon Goodacre; Jason S Halladay; Joanne F. M. Hewitt; Hazel Hunt; Samuel Kintz; Joseph P. Lyssikatos; Calum Macleod; Sarah Major; Guillaume Médard; Raman Narukulla; Judi Ramiscal; Stephen Schmidt; Eileen Seward; Wiesmann; Ping Wu; Sharon Fong Yee; Ivana Yen; Shiva Malek
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Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
James J. Crawford; Wendy Lee; Ignacio Aliagas; Simon Mathieu; Klaus P. Hoeflich; Wei Zhou; Weiru Wang; Lionel Rouge; Lesley J. Murray; Hank La; Ning Liu; Peter W. Fan; Jonathan Cheong; Christopher E. Heise; Sreemathy Ramaswamy; Robert Mintzer; Yanzhou Liu; Qi Chao; Joachim Rudolph
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Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kanika Bajaj Pahuja; Jinzhi Wang; Anastasia Blagoveshchenskaya; Lillian Lim; Madhusudhan; Peter Mayinger; Randy Schekman
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Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425
Organic Process Research and Development, ISSN: 1520586X 10836160
Andreas Stumpf; Zhigang Cheng; Brian Wong; Mark E. Reynolds; Remy Angelaud; James Girotti; Alan Deese; Christine Gu; Lewis Gazzard
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Drugs versus placebo for dysthymia
Cochrane database of systematic reviews (Online : Update Software), ISSN: 1469493X
Mauricio Silva de Lima; Joanna Moncrieff; Bernardo G. O Soares
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Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer
BMC Genomics, ISSN: 14712164
Florian Gnad; Sophia Doll; Gerard Manning; David Arnott; Zemin Zhang
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Nature Chemical Biology, ISSN: 15524469 15524450
Elayne Chan-Penebre; Kristy G. Kuplast; Christina R. Majer; P Ann Boriack-Sjodin; Tim J. Wigle; L Danielle Johnston; Nathalie Rioux; Michael J. Munchhof; Lei Jin; Suzanne L. Jacques; Kip A. West; Trupti Lingaraj; Kimberly Stickland; Scott A. Ribich; Alejandra Raimondi; Margaret Porter Scott; Nigel J. Waters; Roy M. Pollock; Jesse J. Smith; Olena Barbash; Melissa Pappalardi; Thau F. Ho; Kelvin Nurse; Khyati P. Oza; Kathleen T. Gallagher; Ryan Kruger; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth; Kenneth W. Duncan
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Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress
PLoS ONE, ISSN: 19326203
Andrea D'Osualdo; Veronica G. Anania; Kebing Yu; Jennie R. Lill; Randal J. Kaufman; Shu-Ichi Matsuzawa; John C. Reed
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Histopathology in mouse models of rheumatoid arthritis
Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development,
Patrick Caplazi; Laurie Diehl
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Baculovirus display for discovery of low-affinity extracellular receptor-ligand interactions using protein microarrays
Analytical Biochemistry, ISSN: 10960309 00032697
Irene Tom; Alberto Estevez; Krista K. Bowman; Lino C. Gonzalez Jr.
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Ig Repertoire Constructor: A novel algorithm for antibody repertoire construction and immunoproteogenomics analysis
Bioinformatics, ISSN: 14602059 13674803
Yana Safonova; Stefano Bonissone; Eugene Kurpilyansky; Ekaterina Starostina; Alla Lapidus; Stinson; Laura DePalatis; Wendy N. Sandoval; Jennie R. Lill; Pavel A. Pevzner
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Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Ankush Argade; Somasekhar Bhamidipati; Hui Li; Catherine Sylvain; Jeffrey Clough; David Carroll; Holger Keim; Sylvia Braselmann; Vanessa Taylor; Haoran Zhao; Ellen Herlaar; Sarkiz D. Issakani; Brian R. Wong; Esteban S. Masuda; Donald G. Payan; Rajinder Singh
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Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Ankush Argade; Somasekhar Bhamidipati; Hui Li; David Carroll; Jeffrey Clough; Holger Keim; Catherine Sylvain; Alexander B. Rossi; Christina Coquilla; Sarkiz D. Issakani; Esteban S. Masuda; Donald G. Payan; Rajinder Singh
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An integrated suite of modeling tools that empower scientists in structure- and property-based drug design
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Jianwen A. Feng; Ignacio Aliagas; Philippe Bergeron; Jeff Blaney; Erin K. Bradley; Michael F. T. Koehler; Man-Ling Lee; Daniel F. Ortwine; Vickie Tsui; Johnny Wu; Alberto Gobbi
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Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Alberto Gobbi; Kirk D. Robarge; Aihe Zhou; Adrian Barnard; Jianhua Cao; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Arunima Ganguli; Julie Hawkins; Adam R. Johnson; Hank La; Maxine Norman; Gary Salmon; Susan Summerhill; Wenjun Ouyang; Wei Tang; Harvey Wong
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Leveraging the Pre-DFG Residue Thr-406 to Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series
ACS Medicinal Chemistry Letters, ISSN: 19485875
Joachim Rudolph; Ignacio Aliagas; James J. Crawford; Simon Mathieu; Wendy Lee; Qi Chao; Ping Dong; Lionel Rouge; Weiru Wang; Christopher E. Heise; Lesley J. Murray; Hank La; Yanzhou Liu; Gerard Manning; François Diederich; Klaus P. Hoeflich
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Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin
Experimental Cell Research, ISSN: 10902422 00144827
Jeannine Gerhardt; Gulfem D. Guler; Ellen Fanning
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L-type amino-acid transporter 1 (LAT1): A therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia
Leukemia, ISSN: 14765551 08876924
Célia Rosilio; Marielle Nebout; Véronique Imbert; Emmanuel Griessinger; Zouhour Neffati; Benadiba; Thijs Hagenbeek; Hergen Spits; Julie Reverso; Ambrosetti; Jean-François Michiels; Bailly-Maitre; Endou; Wempe; Jean-François Peyron
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SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML
Science Signaling, ISSN: 19379145 19450877
Domenico Fasci; Veronica G. Anania; Jennie R. Lill; Guy S. Salvesen
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Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events
Journal of Molecular Biology, ISSN: 10898638 00222836
Kebing Yu; Lilian Phu; Eugene Varfolomeev; Daisy J. Bustos; Domagoj Vucic; Donald S. Kirkpatrick
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On the analytical superiority of 1D NMR for fingerprinting the higher order structure of protein therapeutics compared to multidimensional NMR methods
Analytical Chemistry, ISSN: 15206882 00032700
Leszek Poppe; John B. Jordan; Gary Rogers; Paul D. Schnier
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A phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Kenneth C. Kalunian; Merrill; Romeo MacIuca; Jacqueline McBride; Michael J. Townsend; Xiaohui Wei; John C. Davis; William P. Kennedy
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Characteristics Associated with Biologic Monotherapy Use in Biologic-Naive Patients with Rheumatoid Arthritis in a US Registry Population
Rheumatology and Therapy, ISSN: 21986584 21986576
Dimitrios A. Pappas; Reed; Katherine C. Saunders; Ani John; Ashwini Shewade; Jeffrey D. Greenberg; Joel M. Kremer
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