Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5551 - 5600 OF 15217 RESULTS

Incidence of liver injury among cancer patients receiving chemotherapy in an integrated health system
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Marianne Ulcickas Yood; Michele Bortolini; Deborah Casso; Jean G. Beck; Susan A. Oliveria; Karen E. Wells; Kimberley J. Woodcroft; Lisa I. Wang
View on Scopus
Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7
Journal of Immunology, ISSN: 15506606 00221767
Gimano D. Amatngalim; Yolanda Van Wijck; Yvonne De Mooij-Eijk; Renate M. Verhoosel; Jürgen Harder; Annemarie N. Lekkerkerker; Richard A. J. Janssen; Pieter S. Hiemstra
View on Scopus
Feasibility and cardiac safety of trastuzumab emtansine after anthracycline-based chemotherapy as (neo)adjuvant therapy for human epidermal growth factor receptor 2-positive early-stage breast cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Ian E. Krop; Suter; Chau T. Dang; Luc Dirix; Romieu; Claudio Zamagni; Marc L. Citron; Mario Campone; Xu; Melanie Smitt; Luca Gianni
View on Scopus
Clinical outcomes in elderly patients with advanced non-small cell lung cancer: Results from ARIES, a bevacizumab observational cohortstudy
Clinical Oncology, ISSN: 14332981 09366555
Antoinette J. Wozniak; Michael Kosty; Mohammad Jahanzeb; Julie Brahmer; David Spigel; Larry Leon; Susan Fish; E. Dawn Flick; Sebastien J. Hazard; Thomas J. Lynch
View on Scopus
Immunohistochemical Detection of FLAG-Tagged Endogenous Proteins in Knock-In Mice
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Ron Ferrando; Kim Newton; Felix Chu; Webster; French
View on Scopus
The quintessence of immunogenicity reporting for biotherapeutics
Nature Biotechnology, ISSN: 15461696 10870156
Gopi Shankar; Arkin; Viswanath Devanarayan; Kromminga; Quarmby; Richards; Subramanyam; Steven J. Swanson
View on Scopus
Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: The OLIVIA multinational randomised phase II trial
Annals of Oncology, ISSN: 15698041 09237534
Thomas Gruenberger; Bridgewater; Chau; Garcia Alfonso; Rivoire; Mudan; Susan F. Lasserre; Frank Hermann; Waterkamp; Adam
View on Scopus
Contribution of metabolites to P450 inhibition-Based Drug-Drug interactions: Scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hongbin Yu; Suresh K. Balani; Weichao Chen; Donghui Cui; Ling He; W. Griffith Humphreys; Jialin Mao; W. George Lai; Anthony J. Lee; Heng-Keang Lim; Christopher MacLauchlin; Chandra Prakash; Sekhar Surapaneni; Susanna Tse; Alana Upthagrove; Robert L. Walsky; Bo Wen; Zhaopie Zeng
View on Scopus
Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing
Journal of Molecular Biology, ISSN: 10898638 00222836
Thomas Van Blarcom; Andrea Rossi; Davide Foletti; Purnima Sundar; Steven Pitts; Christine Bee; Jody Melton Witt; Zea Melton; Adela Hasa-Moreno; Lee Shaughnessy; Dilduz Telman; Lora Zhao; Wai Ling Cheung; Jan Berka; Wenwu Zhai; Pavel Strop; Javier Chaparro-Riggers; David L. Shelton; Jaume Pons; Arvind Rajpal
View on Scopus
MAP4K4 regulates integrin-FERM binding to control endothelial cell motility
Nature, ISSN: 14764687 00280836
Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeffrey Eastham-Anderson; Stephen Gould; Seth F. Harris; Chudi O. Ndubaku; Weilan Ye
View on Scopus
Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues
PLoS ONE, ISSN: 19326203
Scott D. Patterson; John M. Rossi; Katherine L. Paweletz; Dan Fitzpatrick; C. Glenn Begley; Leigh Busse; Steve Elliott; Ian McCaffery
View on Scopus
Atom-Atom-Path similarity and Sphere Exclusion clustering: Tools for prioritizing fragment hits
Journal of Cheminformatics, ISSN: 17582946
Alberto Gobbi; Anthony M. Giannetti; Huifen Chen; Man-Ling Lee
View on Scopus
A novel Respiratory Syncytial Virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models
PLoS ONE, ISSN: 19326203
Stacie L. Lambert; Shahin Aslam; Elizabeth Stillman; Mia MacPhail; Christine Nelson; Bodrey Ro; Rosemary Sweetwood; Yuk Man Lei; Jennifer C. Woo; Roderick S. Tang
View on Scopus
An industry statistician's perspective on personalized health care drug development
Design and Analysis of Clinical Trials for Predictive Medicine,
Jane Fridlyand; Ru-Fang Yeh; Howard M. Mackey; Thomas Bengtsson; Paul Delmar; Spaniolo; Lieberman
View on Scopus
GPU-accelerated compartmental modeling analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
PLoS ONE, ISSN: 19326203
Yu-Han H. Hsu; Ziyin Huang; Gregory Z. Ferl; Chee Ng
View on Scopus
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Science Translational Medicine, ISSN: 19466242 19466234
Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers
View on Scopus
Regulation of the oncoprotein Smoothened by small molecules
Nature Chemical Biology, ISSN: 15524469 15524450
Hayley J. Sharpe; Weiru Wang; Rami N. Hannoush; Frederic J. De Sauvage
View on Scopus
TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation
Journal of Immunology, ISSN: 15506606 00221767
Jarod A. Zepp; Ling Wu; Wen Qian; Wenjun Ouyang; Mark Aronica; Serpil Erzurum; Xiaoxia Li
View on Scopus
Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation
Journal of Immunology, ISSN: 15506606 00221767
Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard
View on Scopus
Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
View on Scopus
A probabilistic method to report predictions from a human liver microsomes stability QSAR model: A practical tool for drug discovery
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh
View on Scopus
Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
View on Scopus
Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients
Drugs in R and D, ISSN: 11796901 11745886
Marta Boffito; Akil Jackson; Anton Pozniak; Mylene Giraudon; Rohit Kulkarni; Maria Connie Abelardo; Indravadan H. Patel; Peter N. Morcos
View on Scopus
Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Scot D. Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
View on Scopus
Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology, ISSN: 19353456 19330219
Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl
View on Scopus
Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Jacomijn P. Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O. Sercan; Yun Ji; Osler Andres; Jeffrey S. Rubin; Rami N. Hannoush; Gunnar Schulte
View on Scopus
Rapid antidepressants stimulate the decoupling of GABA B receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η
Molecular Psychiatry, ISSN: 14765578 13594184
Workman; Patrick C. G. Haddick; Bush; Dilly; Niere; Zemelman; Raab-Graham
View on Scopus
Developmental and Reproductive Toxicity Testing
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Gerhard F. Weinbauer; Christopher J. Bowman; Wendy Halpern; Gary Chellman
View on Scopus
Opportunities for Implementing the 3 Rs in Drug Development and Safety Assessment Studies Using Nonhuman Primates
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Kathryn Chapman; Kathryn Bayne; Jessica A. Couch; Thierry Decelle; John Finch; Lolke de Haan; Tina Koban; Lars Fris Mikkelsen; Wolfgang Müller; Helen Palmer; Mark Prescott
View on Scopus
Gaps and Future Challenges
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Joerg Bluemel; Sven Korte; Emanuel Schenck; Gerhard F. Weinbauer
View on Scopus
Minor structural change to tertiary sulfonamide RORC ligands led to opposite mechanisms of action
ACS Medicinal Chemistry Letters, ISSN: 19485875
Olivier René; Benjamin P. Fauber; Gladys De Leon Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; James R. Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi J. A. Wallweber; Harvey Wong
View on Scopus
Considerations on Immunogenicity
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,
Thomas R. Gelzleichter; Eric Wakshull
View on Scopus
IgE/FcεRI-mediated antigen cross-presentation by dendritic cells enhances anti-tumor immune responses
Cell Reports, ISSN: 22111247
Barbara Platzer; KutluG. Elpek; Viviana Cremasco; Kristi Baker; MadeleineM. Stout; Cornelia Schultz; Eleonora Dehlink; Kai-TingC. Shade; RobertM. Anthony; Blumberg; Shannon J. Turley; Edda Fiebiger
View on Scopus
Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Cancer Cell, ISSN: 18783686 15356108
Hayley J. Sharpe; Gregoire Pau; Gerrit J. P. Dijkgraaf; Nicole Basset-Seguin; Zora Modrusan; Thomas Januario; Vickie Tsui; Alison B. Durham; Andrzej A. Dlugosz; Matthias Peter; Richard Bourgon; Jean Y. Tang; Kavita Y. Sarin; Luc Dirix; David C. Fisher; Charles M. Rudin; Howard Sofen; Michael R. Migden; Robert Yauch; Frederic J. De Sauvage
View on Scopus
β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björn E. Clausen; Ira Mellman; Aimin Jiang
View on Scopus
Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T
Current Biology, ISSN: 18790445 09609822
Florencia Rago; Karen Gascoigne; Iain M. Cheeseman
View on Scopus
Investigation of Drug-Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy
Molecular Pharmaceutics, ISSN: 15438392 15438384
Yang Song; Xinghao Yang; Xin Chen; Haichen Nie; Stephen Byrn; Joseph W. Lubach
View on Scopus
Mixing monoclonal antibody formulations using bottom-mounted mixers: impact of mechanism and design on drug product quality
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Benson Gikanga; Yufei Chen; Oliver B. Stauch; Maa
View on Scopus
In-use physicochemical and microbiological stability of biological parenteral products
American Journal of Health-System Pharmacy, ISSN: 15352900 10792082
Margaret Ricci; Michelle Frazier; Jamie M. R. Moore; Cromwell; William J. Galush; Ankit Patel; Michael Adler; Ulrike Altenburger; Ulla Grauschopf; Pierre Goldbach; Jonas L. Fast; Irene Krämer; Hanns-Christian Mahler
View on Scopus
What patients need
American Pharmaceutical Review, ISSN: 10998012
Larry Wigman
View on Scopus
Metrics that give voice to quality
Pharmaceutical Engineering, ISSN: 02738139
Joseph Famulare
View on Scopus
Differential effects of targeting Notch receptors in a mouse model of liver cancer
Hepatology, ISSN: 15273350 02709139
Erik G. Huntzicker; Kathy Hötzel; Lisa Choy; Li Che; Ross; Gregoire Pau; Neeraj Sharma; Christian W. Siebel; Xin Chen; French
View on Scopus
Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox)
American Journal of Cardiology, ISSN: 18791913 00029149
Vanessa S. Reddy; Quang T. Bui; Joan R. Jacobs; Susan M. Begelman; Dave P. Miller; William J. French
View on Scopus
Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase
Toxicological Sciences, ISSN: 10960929 10966080
Tanja S. Zabka; Jatinder Singh; Preeti Dhawan; Bianca M. Liederer; Jason Oeh; Ariel Kauss; Yang Xiao; Mark Zak; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Joseph Beyer; Cindy A. Farman; Hirdesh Uppal; Peter Dragovich; Thomas O'Brien; Deepak Sampath; Misner
View on Scopus
Necroptosis: Pathway diversity and characteristics
Seminars in Cell and Developmental Biology, ISSN: 10963634 10849521
Maria Cristina De Almagro; Domagoj Vucic
View on Scopus
Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Laura M. Paulin; Gregory B. Diette; Paul D. Blanc; Nirupama Putcha; Mark D. Eisner; Richard E. Kanner; Andrew J. Belli; Stephanie Christenson; Donald P. Tashkin; MeiLan Han; Graham Barr; Nadia N. Hansel
View on Scopus
The Consequences of Diminishing Industry Support on the Independent Education Landscape: An Evidence-Based Analysis of the Perceived and Realistic Impact on Professional Development and Patient Care Among Oncologists
Journal of Cancer Education, ISSN: 15430154 08858195
Caroline Robinson; John Ruggiero; Mazi Abdolrasulnia; B. Stephen Burton
View on Scopus
Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis
Value in Health, ISSN: 15244733 10983015
Josh J. Carlson; Sarika Ogale; Fred Dejonckheere; Sean D. Sullivan
View on Scopus
Incidence of giant cell arteritis and characteristics of patients: Data-driven analysis of comorbidities
Arthritis Care and Research, ISSN: 21514658 2151464X
Hans Petri; Alan Nevitt; Khaled Sarsour; Pavel Napalkov; Neil Collinson
View on Scopus
Author reply
Ophthalmology, ISSN: 15494713 01616420
Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai
View on Scopus
© 2024 Genentech, Inc. All rights reserved. This site is intended for US residents only.