Scientists / Publications

Publications

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DISPLAYING 5801 - 5850 OF 15217 RESULTS

Asthma biomarkers: What constitutes a 'gold standard'?
Thorax, ISSN: 14683296 00406376
Joseph R. Arron; Kenji Izuhara
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Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies
OncoImmunology, ISSN: 2162402X 21624011
Scot D. Liu; John Lowe
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John T. Stults
The Encyclopedia of Mass Spectrometry: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry,
Stults
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Metal ion interactions with mAbs: Part 1 pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region
mAbs, ISSN: 19420870 19420862
Zephania Kwong Glover; Basa; Benjamin Moore; Jennifer S. Laurence; Alavattam Sreedhara
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Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular Lymphoma
Hematology, ISSN: 16078454 10245332
Zhou; Jianmin Wang; Jessica Zhang; Catherine Copley-Merriman; Yasuhiro Torigoe; Carolina Reyes; John F. Seymour; Fritz C. Offner; Marek Trneny; Gilles Salles
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A comprehensive transcriptional portrait of human cancer cell lines
Nature Biotechnology, ISSN: 15461696 10870156
Christiaan N. Klijn; Durinck; Eric Stawiski; Matthias Peter; Zhaoshi Jiang; Hanbin Liu; Jeremiah D. Degenhardt; Oleg Mayba; Florian Gnad; Jinfeng Liu; Gregoire Pau; Jens Reeder; Yi Cao; Kiran Mukhyala; Suresh K Selvaraj; Mamie Yu; Gregory J Zynda; Matthew J. Brauer; Thomas D Wu; Robert Gentleman; Gerard Manning; Robert Yauch; Richard Bourgon; David Stokoe; Zora Modrusan; Richard M. Neve; Frederic J. De Sauvage; Jeffrey Settleman; Somasekar Seshagiri; Zemin Zhang
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Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development
Bioanalysis, ISSN: 17576199 17576180
Masood U. Khan; Ronald Bowsher; Mark Cameron; Viswanath Devanarayan; Steve Keller; Lindsay King; Jean W. Lee; Alyssa M. Morimoto; Paul Rhyne; Laurie Stephen; Yuling Wu; Tim Wyant; D Richard Lachno
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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; James A. Wells
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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Vikas Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg V. Borisov; Robert F. Kelley; Ilya Chorny; Joe Zhongxiang Zhou; Ken A. Dill; Trevor E. Swartz
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Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio
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Identification of the WNT1 residues required for palmitoylation by Porcupine
FEBS Letters, ISSN: 18733468 00145793
Miranda; Lisa M. Galli; Enriquez; Linda A. Szabo; Xinxin Gao; Rami N. Hannoush; Laura W. Burrus
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Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up
Organic Process Research and Development, ISSN: 1520586X 10836160
Travis Remarchuk; Frederic St-Jean; Diane Carrera; Scott Savage; Herbert M. Yajima; Brian Wong; Srinivasan Babu; Alan Deese; Jeffrey Stults; Michael W. Dong; David Askin; Jonathan W. Lane; Keith L. Spencer
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Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate
Organic Process Research and Development, ISSN: 1520586X 10836160
Jonathan W. Lane; Keith L. Spencer; Sagar R. Shakya; Nicholas C. Kallan; Peter J. Stengel; Travis Remarchuk
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Depletion of the Central Metabolite NAD leads to oncosismediated cell death
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Christopher J. Del Nagro; Yang Xiao; Linda Rangell; Mike Reichelt; Thomas O'Brien
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Preclinical efficacy of MEK inhibition in NRAS-mutant AML
Blood, ISSN: 15280020 00064971
Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li
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Preclinical efficacy of MEK inhibition in NRAS-mutant AML
Blood, ISSN: 15280020 00064971
Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott C. Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li
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Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: Omeprazole and ranitidine
Anti-Cancer Drugs, ISSN: 14735741 09594973
Heidemarie Kletzl; Mylene Giraudon; Patricia Sanwald Ducray; Markus Abt; Marta Hamilton; Bert L. Lum
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Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Lewis Gazzard; Brent A. Appleton; Kerry Chapman; Huifen Chen; Clark; Joy Drobnick; Simon Goodacre; Jason S Halladay; Joseph P. Lyssikatos; Stephen Schmidt; Steve Sideris; Wiesmann; Karen Williams; Ping Wu; Ivana Yen; Shiva Malek
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Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Sharada Labadie; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Aihe Zhou
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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Giancarlo Trani; John J. Barker; Steven M. Bromidge; Frederick A. Brookfield; Jason D. Burch; Yuan Chen; Eigenbrot; Alexander Heifetz; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Thomas M. Krülle; Colin H. Mackinnon; Rosemary Maghames; Paul A. McEwan; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Darshan G. Vaidya; Xiaolu Wang; Ali A. Zarrin; Zhonghua Pei
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A reversed sulfonamide series of selective RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Monique B. Van Niel; Benjamin P. Fauber; Matthew W. Cartwright; Simon Gaines; Jonathan C. Killen; Olivier René; Stuart I. Ward; Gladys De Leon Boenig; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Emanuela Gancia; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; James R. Kiefer; Hank La; Peter Lockey; Maxine Norman; Wenjun Ouyang; Ann R. Qin; Nicole Wakes; Bohdan Waszkowycz; Harvey Wong
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MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing
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Internal motions prime cIAP1 for rapid activation
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother
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The IL-20 subfamily of cytokines-from host defence to tissue homeostasis
Nature Reviews Immunology, ISSN: 14741741 14741733
Sascha Rutz; Xiaoting Wang; Wenjun Ouyang
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Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily J. Hanan; Eigenbrot; Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Jennafer Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Jianping Yin; Christine Yu; Inna Zilberleyb; Timothy P. Heffron
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8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Allen A. Thomas; Kevin W. Hunt; Bradley J. Newhouse; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Susan P. Rhodes; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Jiangpeng Liao; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos
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A septin-dependent diffusion barrier at dendritic spine necks
PLoS ONE, ISSN: 19326203
Helge Ewers; Tomoko Tada; Jennifer D. Petersen; Bence Racz; Morgan Sheng; Daniel Choquet
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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Cancer Cell, ISSN: 18783686 15356108
Robert J. Johnston; Laetitia Comps-Agrar; Jason A. Hackney; Xin Yu; Mahrukh Huseni; Yagai Yang; Summer Park; Vincent Javinal; Chiu; Bryan Irving; Dan L. Eaton; Jane L. Grogan
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Gutsy moves in mice: Cellular and molecular dynamics of endoderm morphogenesis
Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 14712970 09628436
Manuel Viotti; Ann C. Foley; Anna-Katerina Hadjantonakis
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Obinutuzumab (Gazyva®), a Novel Glycoengineered Type II CD20 Antibody for the Treatment of Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma
Handbook of Therapeutic Antibodies: Second Edition,
Christian Klein; Marina Bacac; Pablo Umaña; Michael Wenger
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Rituximab (Rituxan®)
Handbook of Therapeutic Antibodies: Second Edition,
Axel Böhnke; Michael Wenger
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Response to Biologic Disease-Modifying Anti-Rheumatic Drugs after Discontinuation of Anti-Tumor Necrosis Factor Alpha Agents for Rheumatoid Arthritis
Rheumatology and Therapy, ISSN: 21986584 21986576
Martin J. Bergman; Eric P. Elkin; Sarika Ogale; Tripthi V. Kamath; Max I. Hamburger
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Editorial
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Davy Guillarme; Michael W. Dong
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Comparison of survival and hospitalization rates between Medicare patients with advanced NSCLC treated with bevacizumab-carboplatin-paclitaxel and carboplatin-paclitaxel: A retrospective cohort study
Lung Cancer, ISSN: 18728332 01695002
Corey Langer; Arliene Ravelo; Sebastien J. Hazard; Annie Guérin; Raluca Ionescu-Ittu; Dominick Latremouille-Viau; Eric Q. Wu; Suresh Ramalingam
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Host cell protein testing by ELISAs and the use of orthogonal methods
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Judith Zhu-Shimoni; X. Christopher Yu; Julie C. Nishihara; Robert Ming Wong; Feny Gunawan; Margaret Lin; Denise C. Krawitz; Peter S. Liu; Wendy N. Sandoval; Vanderlaan
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Breast cancer resistance protein substrate and inhibition evaluation: Why, when, and how?
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Joseph A. Ware; Bradley L. Urquhart; Yuichi Sugiyama; Zamek-Gliszczynski
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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Nature Medicine, ISSN: 1546170X 10788956
Monica K. Wetzel-Smith; Julie Hunkapiller; Tushar Bhangale; Karpagam Srinivasan; Janice Maloney; Jasvinder K. Atwal; Susan Sa; Murat Yaylaoglu; Oded Foreman; Ward Ortmann; Nisha Rathore; David V. Hansen; Marc Tessier-Lavigne; Richard Mayeux; Brian W. Kunkle; Jonathan L. Haines; Lindsay A. Farrer; Gerard D. Schellenberg; Alison M. Goate; Timothy W. Behrens; Paul K. Crane; Ryan J. Watts; Robert R. Graham
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Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Yuzhong Deng; Luna Musib; Edna F. Choo; Matthew Chapple; Sarah Burke; James Johnson; Stephen M. Eppler; Brian J. Dean
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Monthly versus as-needed ranibizumab injections in patients with retinal vein occlusion: The SHORE study
Ophthalmology, ISSN: 15494713 01616420
Peter A. Campochiaro; Charles C. Wykoff; Michael Singer; Robert Johnson; Dennis Marcus; Linda Yau; Gary Sternberg
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Lupus nephritis susceptibility loci in women with systemic lupus erythematosus
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Sharon A. Chung; Elizabeth E. Brown; Adrienne H. Williams; Paula S. Ramos; Celine C. Berthier; Tushar Bhangale; Marta E. Alarcón-Riquelme; Timothy W. Behrens; Lindsey A. Criswell; Deborah S. Cunninghame Graham; F. Yesim Demirci; Jeffrey C. Edberg; Patrick M. Gaffney; John B. Harley; Chaim O. Jacob; M. Ilyas Kamboh; Jennifer A. Kelly; Susan Manzi; Kathy L. Moser-Sivils; Laurie P. Russell; Michelle Petri; Betty P. Tsao; Timothy J. Vyse; Raphael Zidovetzki; Matthias Kretzler; Robert P. Kimberly; Barry I. Freedman; Robert R. Graham; Carl D. Langefeld
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PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition
Journal of Pathology, ISSN: 10969896 00223417
Wei Zhou; Adrian M. Jubb; Karen Lyle; Qian Xiao; Christy C. Ong; Rupal Desai; Ling Fu; Florian Gnad; Qinghua Song; Matthias Peter; Daniela Aust; Robert Grützmann; Mally Romero; Klara Totpal; Richard M. Neve; Yibing Yan; William F. Forrest; Wang; Rajiv Raja; Christian Pilarsky; Ana De Jesus-Acosta; Marcia Belvin; Lori S. Friedman; Mark Merchant; Elizabeth M. Jaffee; Lei Zheng; Koeppen; Klaus P. Hoeflich
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Treatment Patterns and Comparative Effectiveness in Elderly Diffuse Large B-Cell Lymphoma Patients: A Surveillance, Epidemiology, and End Results-Medicare Analysis
Oncologist, ISSN: 1549490X 10837159
Paul A. Hamlin; Sacha Satram-Hoang; Carolina Reyes; Khang Q. Hoang; Sridhar R. Guduru; Sandra Skettino
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SOX17 links gut endoderm morphogenesis and germ layer segregation
Nature Cell Biology, ISSN: 14764679 14657392
Manuel Viotti; Sonja Nowotschin; Anna-Katerina Hadjantonakis
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Proteome-wide light/dark modulation of thiol oxidation in cyanobacteria revealed by quantitative site-specific redox proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Jia Guo; Amelia Y. Nguyen; Ziyu Dai; Dian Su; Matthew J. Gaffrey; Ronald J. Moore; Jon M. Jacobs; Matthew E. Monroe; Richard D. Smith; David W. Koppenaal; Himadri B. Pakrasi; Wei-Jun Qian
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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery
Future Medicinal Chemistry, ISSN: 17568927 17568919
Peter W. Fan; Yang Song; Leonid M. Berezhkovskiy; Jonathan Cheong; Emile G. Plise; S. Cyrus Khojasteh
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Visualization of protein sequence features using JavaScript and SVG with pViz.js
Bioinformatics, ISSN: 14602059 13674803
Kiran Mukhyalay; Alexandre Masselot
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Vision-related function after ranibizumab treatment for diabetic macular edema: Results from RIDE and RISE
Ophthalmology, ISSN: 15494713 01616420
Neil M. Bressler; Rohit Varma; Ivan J. Suñer; Chantal M. Dolan; James Ward; Jason S. Ehrlich; Shoshana Colman; Adam Turpcu
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Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular amd
British Journal of Ophthalmology, ISSN: 14682079 00071161
Robert L. Avery; Alessandro A. Castellarin; Nathan C. Steinle; Dilsher S. Dhoot; Dante Joseph Pieramici; Robert See; Stephen Couvillion; MA'An A. Nasir; Melvin D. Rabena; Kha Le; Mauricio Maia; Jennifer Visich
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2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 3-LBA and immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Lauren Stevenson; Lakshmi Amaravadi; Heather Myler; Laura Salazar-Fontana; Boris Gorovits; Susan Kirshner; Li Xue; Fabio Garofolo; Stephen C. Alley; Theingi Thway; Alison Joyce; Surendra Bansal; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Isabelle Dumont; Eric Fluhler; Stephanie Fraser; Dominique Gouty; Swati Gupta; Sam Haidar; Roger Hayes; Benno Ingelse; Akiko Ishii-Watabe; Surinder Kaur; Lindsay King; Omar Laterza; Sheldon Leung; Ann Lévesque; Mark Ma; Corinne Petit-Frere; Renuka Pillutla; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Jason Wakelin-Smith; Amanda Wilson; Eric Woolf; Tong-Yuan Yang
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Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study
Breast, ISSN: 15323080 09609776
Charles S. Cleeland; Musa Mayer; Nancy A. Dreyer; Yeun Mi Yim; Elaine B. Yu; Zhaohui Su; Yong Mun; Jeff A. Sloan; Peter A. Kaufman
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