Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5851 - 5900 OF 15217 RESULTS

2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 2-hybrid LBA/LCMS, ELN & regulatory agencies' input)
Bioanalysis, ISSN: 17576199 17576180
Dawn Dufield; Hendrik Neubert; Fabio Garofolo; Leo Kirkovsky; Lauren Stevenson; Isabelle Dumont; Surinder Kaur; Keyang Xu; Stephen C. Alley; Matthew Szapacs; Mark Arnold; Surendra Bansal; Sam Haidar; Jan Welink; Olivier Le Blaye; Jason Wakelin-Smith; Emma Whale; Akiko Ishii-Watabe; Mark Bustard; Noriko Katori; Lakshmi Amaravadi; Anne-Françoise Aubry; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Jeff Duggan; Eric Fluhler; Boris Gorovits; Swati Gupta; Roger Hayes; Stacy Ho; Benno Ingelse; Lindsay King; Ann Lévesque; Steve Lowes; Mark Ma; Adrien Musuku; Heather Myler; Timothy Olah; Shefali Patel; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Amanda Wilson; Eric Woolf; Li Xue; Tong-Yuan Yang
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Complement inhibition in cynomolgus monkeys by anti-factor D antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Kelly M. Loyet; Jeremy Good; Teresa Davancaze; Lizette Sturgeon; Xiangdan Wang; Yang; Kha Le; Maureen Wong; Hass; Menno Van Lookeren Campagne; Peter Haughney; Alyssa M. Morimoto; Lisa A. Damico; Laura DeForge
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Willingness to pay to avoid metastatic breast cancer treatment side effects: results from a conjoint analysis
SpringerPlus, ISSN: 21931801
Deepa Lalla; Rashad Carlton; Eduardo Santos; Thomas Bramley; Anna D’Souza
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A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease
PLoS ONE, ISSN: 19326203
Kareem L. Graham; Jian V. Zhang; Susanna Lewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C. Butcher; Brian A. Zabel
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TNFR1-activated NF-κB signal transduction: Regulation by the ubiquitin/proteasome system
Current Opinion in Chemical Biology, ISSN: 18790402 13675931
Ingrid E. Wertz
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Ultra-high-pressure liquid chromatography (UHPLC) in method development
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Michael W. Dong; Kelly Zhang
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Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A
FEBS Letters, ISSN: 18733468 00145793
Karen Stanger; Till Maurer; Harini Kaluarachchi; Mary Coons; Yvonne Franke; Rami N. Hannoush
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Single-cell in situ imaging of palmitoylation in fatty-acylated proteins
Nature Protocols, ISSN: 17502799 17542189
Xinxin Gao; Rami N. Hannoush
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Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
Nature, ISSN: 14764687 00280836
Mahesh Yadav; Suchit Jhunjhunwala; Qui Phung; Patrick J. Lupardus; Josh Tanguay; Stephanie M. Bumbaca; Christian Franci; Tommy K. Cheung; Jens Fritsche; Toni Weinschenk; Zora Modrusan; Ira Mellman; Jennie R. Lill; Lélia Delamarre
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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
Nature, ISSN: 14764687 00280836
Thomas Powles; Joseph Paul Eder; Gregg D. Fine; Fadi S. Braiteh; Yohann Loriot; Cristina Cruz; Joaquim Bellmunt; Howard A. Burris; Petrylak; Siew-Leng Teng; Xiaodong Shen; Zachary Boyd; Priti Hegde; Daniel S. Chen; Nicholas J. Vogelzang
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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Nature, ISSN: 14764687 00280836
Roy S. Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D. Fine; Omid Hamid; Michael S. Gordon; Jeffrey A. Sosman; David McDermott; John D. Powderly; Scott Gettinger; Holbrook E. K. Kohrt; Leora Horn; Donald Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Koeppen; Priti Hegde; Ira Mellman; Daniel S. Chen; F. Stephen Hodi
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Molecular simulations of the pairwise interaction of monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga
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The blood-brain barrier's gut check
Science Translational Medicine, ISSN: 19466242 19466234
Nga Bien-Ly; Ryan J. Watts
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Evaluating Source Data Verification as a Quality Control Measure in Clinical Trials
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Nicole Sheetz; Brett Wilson; Joanne Benedict; Esther Huffman; Andy Lawton; Mark Travers; Patrick Nadolny; Stephen Young; Kyle Given; Lawrence Florin
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Drugs for macular degeneration
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
Ivaylo Stoilov; Anne E. Fung; Roman G. Rubio
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Quantification of residual solvents in antibody drug conjugates using gas chromatography
Analytica Chimica Acta, ISSN: 18734324 00032670
Colin D. Medley; Jacob Kay; Yi Li; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn
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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian-Jin Xie; Dinesh Rakheja; Ivan Pedrosa; Thomas Carroll; Renée M. McKay; Payal Kapur; James Brugarolas
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A microRNA upregulated in asthma airway T cells promotes T H 2 cytokine production
Nature Immunology, ISSN: 15292916 15292908
Laura J. Simpson; Sana Patel; Nirav R. Bhakta; David F. Choy; Hans D. Brightbill; Xin Ren; Yanli Wang; Heather H. Pua; Dirk Baumjohann; Misty M. Montoya; Marisella Panduro; Kelly A. Remedios; Xiaozhu Huang; John V. Fahy; Joseph R. Arron; Prescott G. Woodruff; K. Mark Ansel
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Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
New England Journal of Medicine, ISSN: 15334406 00284793
James Larkin; Paolo A. Ascierto; Brigitte Dréno; Victoria Atkinson; Gabriella Liszkay; Michele Maio; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Mika A. Sovak; Ilsung Chang; Nicholas Choong; Stephen P. Hack; McArthur; Antoni Ribas
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Regulation of neuronal gene expression and survival by basal NMDA receptor activity: A role for histone deacetylase 4
Journal of Neuroscience, ISSN: 15292401 02706474
Yelin Chen; Yuanyuan Wang; Zora Modrusan; Morgan Sheng; Joshua S. Kaminker
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Direct medical costs and resource use for treating central and branch retinal vein occlusion in commercially insured working-age and medicare populations
Retina, ISSN: 15392864 0275004X
Ivan J. Suñer; Jay Margolis; Kimberly Ruiz; Irwin Tran; Paul P. Lee
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Collateral vessel presence in branch and central retinal vein occlusions and their impact on visual acuity and anatomical gains: A retrospective analysis
Retina, ISSN: 15392864 0275004X
Rishi Singh; Tamara Lee; Linda Yau; Roman G. Rubio
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HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme
Developmental Cell, ISSN: 18781551 15345807
Marco Osterwalder; Dario Speziale; Malak Shoukry; Rajiv Mohan; Robert Ivanek; Manuel Kohler; Christian Beisel; Xiaohui Wen; Suzie J. Scales; Vincent M. Christoffels; Axel Visel; Javier Lopez-Rios; Rolf Zeller
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Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Wilson; Yuanyuan Xiao; Jill M. Spoerke; Jane Fridlyand; Koeppen; Eloisa Fuentes; Huw; Ilma Abbas; Arjan Gower; Erica Schleifman; Rupal Desai; Ling Fu; Teiko Sumiyoshi; Joyce A. O’Shaughnessy; Garret M. Hampton; Lackner
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Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Janice Maloney; Travis W. Bainbridge; Amy Gustafson; Shuo Zhang; Roxanne Kyauk; Pascal Steiner; Marcel P Van Der Brug; Yichin Liu; James A. Ernst; Ryan J. Watts; Jasvinder K. Atwal
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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Science Translational Medicine, ISSN: 19466242 19466234
Y. Joy Yu; Jasvinder K. Atwal; Yin Zhang; Raymond K. Tong; Kristin R. Wildsmith; Christine Tan; Nga Bien-Ly; Maria Hersom; Janice Maloney; William J. Meilandt; Daniela Bumbaca; Kapil Gadkar; Kwame Hoyte; Wilman Luk; Yanmei Lu; James A. Ernst; Kimberly Scearce-Levie; Jessica A. Couch; Dennis; Ryan J. Watts
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Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib
Molecular Pharmaceutics, ISSN: 15438392 15438384
Edna F. Choo; Justin Ly; Jocelyn Chan; Sheerin Shahidi-Latham; Kirsten Messick; Emile G. Plise; Cristine Quiason; Lulu Yang
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Subcutaneous Tocilizumab Versus Placebo in Combination With Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Alan Kivitz; Ewa Olech; Michael Borofsky; Beatriz M. Zazueta; Federico Navarro-Sarabia; Sebastião C. Radominski; Merrill; Lucy Rowell; Clare Nasmyth-Miller; Bao; Stephen Wright; Janet E. Pope
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Associations Between Preterm Birth, Low Birth Weight, andPostpartum Health in a Predominantly Hispanic WICPopulation
Journal of Nutrition Education and Behavior, ISSN: 14994046
Stephanie A. Leonard; Denise Gee; Yuda Zhu; Catherine M. Crespi; Shannon E. Whaley
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An antimesothelin-monomethyl auristatin E conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Suzie J. Scales; Nidhi Gupta; Glenn Pacheco; Ron Firestein; French; Koeppen; Linda Rangell; Vivian Barry-Hamilton; Luis; Josefa Chuh; Yin Zhang; Gladys S. Ingle; Aimee Fourie-O'Donohue; Katherine R. Kozak; Ross; Dennis; Spencer
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A generic UHPLC-UV-MS method for cleaning verification of highly potent drugs
American Pharmaceutical Review, ISSN: 10998012
Syed Salman Lateef; Vinayak Ak; Michael W. Dong; Christine Gu
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It's time to regulate: Coping with product-induced nongenetic clonal instability in CHO cell lines via regulated protein expression
Biotechnology Progress, ISSN: 15206033 87567938
Shahram Misaghi; Chang; Snedecor
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Standardized extractables testing protocol for single-use systems in biomanufacturing
Pharmaceutical Engineering, ISSN: 02738139
Weibing Ding; Gary Madsen; Ekta Mahajan; Seamus O'Connor; Ken Wong
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VEGF modulates synaptic activity in the developing spinal cord
Developmental Neurobiology, ISSN: 1932846X 19328451
Sylvaine Guérit; Anne-Emilie Allain; Céline Léon; William Cazenave; Napoleone Ferrara; Pascal Branchereau; Andréas Bikfalvi
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Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis
Arthritis and Rheumatology, ISSN: 23265205 23265191
Miloslavsky; Specks; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Tchao; Viviano; Linna Ding; Iklé; Villarreal; Brett Jepson; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; John H. Stone
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Assessing stability-indicating methods for coelution by two-dimensional liquid chromatography with mass spectrometric detection
Journal of Separation Science, ISSN: 16159314 16159306
Venkatramani; James Girotti; Larry Wigman; Nicholas Chetwyn
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Treatment patterns and outcomes among patients with metastatic melanoma treated in community practice
International Journal of Dermatology, ISSN: 13654632 00119059
Mark S. Walker; Carolina Reyes; Jiandong Kerr; Sacha Satram-Hoang; Edward J. Stepanski
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Prevalence of and risk factors for diabetic macular edema in the United States
JAMA Ophthalmology, ISSN: 21686165
Rohit Varma; Neil M. Bressler; Quan V. Doan; Michelle Gleeson; Mark Danese; Julie K. Bower; Elizabeth Selvin; Chantal M. Dolan; Jennifer T. Fine; Shoshana Colman; Adam Turpcu
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Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
Ophthalmology, ISSN: 15494713 01616420
Allen C. Ho; Brandon G. Busbee; Carl D. Regillo; Mark R. Wieland; Sherri A. Van Everen; Zhengrong Li; Roman G. Rubio; Phillip Lai
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Pharmacokinetics of ranibizumab after intravitreal administration in patients with retinal vein occlusion or diabetic macular edema
Ophthalmology, ISSN: 15494713 01616420
Yi Zhang; Zhenling Yao; Nitin Kaila; Peter Kuebler; Jennifer Visich; Mauricio Maia; Lisa Tuomi; Jason S. Ehrlich; Roman G. Rubio; Peter A. Campochiaro
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Characterizing monoclonal antibody structure by carbodiimide/GEE footprinting
mAbs, ISSN: 19420870 19420862
Parminder Kaur; Sara Tomechko; Janna Kiselar; Wuxian Shi; Galahad Deperalta; Aaron T. Wecksler; Giridharan Gokulrangan; Victor Ling; Mark R. Chance
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Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3
Cell Death and Differentiation, ISSN: 14765403 13509047
Koenig; Naik; Rohrbeck; Herold; Trounson; Bouillet; Thomas; Voss; Andreas Strasser; Coultas
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IAP proteins and their therapeutic potential
Cell Death: Mechanism and Disease,
Domagoj Vucic
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Ubiquitination in disease pathogenesis and treatment
Nature Medicine, ISSN: 1546170X 10788956
Doris Popovic; Domagoj Vucic; Ivan Dikic
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Critical role of bioanalytical strategies in investigation of clinical PK observations, a phase I case study
mAbs, ISSN: 19420870 19420862
Kun Peng; Keyang Xu; Luna Liu; Robert Hendricks; Reginald Delarosa; Erickson; Nageshwar Budha; Maya Leabman; An Song; Surinder Kaur; Saloumeh Kadkhodayan Fischer
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HAM-5 Functions As a MAP Kinase Scaffold during Cell Fusion in Neurospora crassa
PLoS Genetics, ISSN: 15537404 15537390
Wilfried Jonkers; Abigail C. Leeder; Charles Ansong; Yuexi Wang; Feng Yang; Trevor L. Starr; David G. Camp; Richard D. Smith; N. Louise Glass
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The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation
Fungal Genetics and Biology, ISSN: 10960937 10871845
Yi Xiong; Samuel T. Coradetti; Xin Li; Marina A. Gritsenko; Therese Clauss; Vlad Petyuk; David G. Camp; Richard D. Smith; Jamie H.D. Cate; Feng Yang; N. Louise Glass
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Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice
mAbs, ISSN: 19420870 19420862
Amrita Kamath; Victor Yip; Priyanka Gupta; C. Andrew Boswell; Daniela Bumbaca; Peter Haughney; Joni Castro; Siao Ping Tsai; Glenn Pacheco; Ross; Minhong Yan; Lisa A. Damico; Leslie A. Khawli; Shen
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Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: A head-to-head phase 2 randomized controlled study (The ALTARA Study)
Arthritis Research and Therapy, ISSN: 14786362 14786354
William P. Kennedy; J. Abraham Simon; Carolyn Offutt; Priscilla Horn; Ann E. Herman; Michael J. Townsend; Meina Tao Tang; Jane L. Grogan; Frank Hsieh; John C. Davis
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Assessment of HER 2 testing patterns, HER 2+ disease, and the utilization of HER 2-directed therapy in early breast cancer
Breast Cancer: Targets and Therapy, ISSN: 11791314
David D. Stenehjem; Minkyoung Yoo; Sudhir K. Unni; Mukul Singhal; Hillevi Bauer; Kim Saverno; Quah; Anthony Masaquel; Diana I. Brixner
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