Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5951 - 6000 OF 15217 RESULTS

Shining LIGHT on functional promiscuity in the TNF and TNFR superfamilies
Structure, ISSN: 18784186 09692126
Daniel M. Whalen; Sarah G. Hymowitz
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Challenges with overall survival as an endpoint for efficacy assessment in first line metastatic breast cancer randomized controlled clinical trials and the investigation of truncated overall survival as an alternative endpoint
Memo - Magazine of European Medical Oncology, ISSN: 18655076 18655041
Neate; Alexander Strasak; Hans Ulrich Burger; Barbara Tong; Lee D. Kaiser
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Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib±onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit
Clinical Cancer Research, ISSN: 10780432
Koeppen; Wei Yu; Jiping Zha; Ajay Pandita; Elicia M. Penuel; Linda Rangell; Rajiv Raja; Sankar Mohan; Rajesh Patel; Rupal Desai; Ling Fu; An Do; Vaishali Parab; Xiaoling Xia; Thomas Januario; Sharianne G. Louie; Ellen H. Filvaroff; David S. Shames; Ignacio I. Wistuba; Marina Lipkind; Jenny Huang; Mirella Lazarov; Vanitha Ramakrishnan; Lukas Amler; See Phan; Premal Patel; Amy Peterson; Robert Yauch
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Genetically engineered knock-in and conditional knock-in mouse models of cancer
Cold Spring Harbor Protocols, ISSN: 15596095 19403402
Amy Rappaport; Leisa Johnson
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Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Shu Lin; Samuel Wein; Michelle Gonzales-Cope; Gabriel L. Otte; Zuo-Fei Yuan; Leila Afjehi-Sadat; Tobias Maile; Shelley L. Berger; John Rush; Jennie R. Lill; David Arnott; Benjamin A. Garcia
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Rapid UHPLC-HRMS peptide mapping for monoclonal antibodies
American Pharmaceutical Review, ISSN: 10998012
Nisana Andersen; Lisa Vampola; Rashmi Jain; Melissa Alvarez; Scott Chamberlain; Amy Hilderbrand
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Trastuzumab emtansine in human epidermal growth factor receptor 2-positive metastatic breast cancer: An integrated safety analysis
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Diéras; Nadia Harbeck; G. Thomas Budd; Joel K. Greenson; Ellie Guardino; Meghna Samant; Nataliya Chernyukhin; Melanie Smitt; Ian E. Krop
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Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge
mAbs, ISSN: 19420870 19420862
Bing Li; Devin B. Tesar; C. Andrew Boswell; Hendry S. Cahaya; Anne Wong; Jianhuan Zhang; Meng; Eigenbrot; Homer Pantua; Jingyu Diao; Sharookh B. Kapadia; Rong Deng; Robert F. Kelley
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Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer
Cancer, ISSN: 10970142 0008543X
Peter A. Kaufman; Kenneth J. Bloom; Howard A. Burris; Julie Gralow; Musa Mayer; Pegram; Hope S. Rugo; Sandra M. Swain; Denise A. Yardley; Miu Chau; Deepa Lalla; Bongin Yoo; Melissa Brammer; Charles L. Vogel
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Whole genome sequencing and analysis of plant growth promoting bacteria isolated from the rhizosphere of plantation crops coconut, cocoa and arecanut
PLoS ONE, ISSN: 19326203
Alka Gupta; Murali Gopal; George Thomas; Vinu Manikandan; John Gajewski; George Thomas; Somasekar Seshagiri; Stephan C. Schuster; Preeti Rajesh; Ravi Gupta
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Accurate analysis of boronic pinacol esters using low residual silanol silica based reversed phase HPLC
Journal of Liquid Chromatography and Related Technologies, ISSN: 1520572X 10826076
Archana Kumar; Tania Ng; Sushant Malhotra; Jason Gruenhagen; Larry Wigman
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Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: A cross-sectional study
Breast Cancer Research, ISSN: 1465542X 14655411
Gretchen L. Gierach; Hui Li; Jennifer T. Loud; Mark H. Greene; Catherine K. Chow; Li Lan; Sheila A. Prindiville; Jennifer Eng-Wong; Peter W. Soballe; Claudia Giambartolomei; Phuong L. Mai; Claudia E. Galbo; Kathryn Nichols; Kathleen A. Calzone; Olufunmilayo I. Olopade; Mitchell H. Gail; Maryellen L. Giger
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Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing
PLoS ONE, ISSN: 19326203
Severine Margeridon-Thermet; Sophie Le Pogam; Lewyn Li; Tommy F. Liu; Nancy Shulman; Robert W. Shafer; Nájera
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Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos
Developmental Biology, ISSN: 1095564X 00121606
Arif Kirmizitas; William Q. Gillis; Haitao Zhu; Gerald H. Thomsen
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Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Peter Dragovich; Benjamin P. Fauber; Jason Boggs; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Chiho Li; Yichin Liu; Yingchun Liu; Shuguang Ma; Shiva Malek; David Peterson; Keith Pitts; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou
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Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-Induced necroptosis in vivo
Journal of Immunology, ISSN: 15506606 00221767
Apostolos Polykratis; Nicole Hermance; Matija Zelic; Justine Roderick; Chun Kim; Trieu-My Van; Thomas H. Lee; Francis K.M. Chan; Manolis Pasparakis; Michelle A. Kelliher
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Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Olivier René; Gladys De Leon Boenig; Brenda Burton; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; Hank La; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Weiru Wang; Harvey Wong
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Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Taylor Zhang; Jennifer Hu; Amanda L. Pace; Wong; Y. John Wang; Kao
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Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Eric Van Cutsem; Cathy Eng; Elzbieta Nowara; Anna Swieboda-Sadlej; Niall C. Tebbutt; Edith Mitchell; Irina Davidenko; Joe Stephenson; Elena Elez; Hans Prenen; Hongjie Deng; Rui Tang; Ian McCaffery; Kelly S. Oliner; Lisa Chen; Jennifer Gansert; Elwyn Loh; Dominic Smethurst; Tabernero
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Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis
Science Translational Medicine, ISSN: 19466242 19466234
Anne L. Fletcher; Jessica S. Elman; Jillian L. Astarita; Ryan Murray; Nima Saeidi; Joshua D'Rozario; Konstantin Knoblich; Flavian D. Brown; Frank A Schildberg; Janice M. Nieves; Tracy S. P. Heng; Richard L. Boyd; Shannon J. Turley; Biju Parekkadan
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Temperature dependence of the complexation mechanism of celecoxib and hydroxyl-β-cyclodextrin in aqueous solution
Pharmaceutics, ISSN: 19994923
Po-Chang Chiang; Yue Shi; Yong Cui
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Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma
British Journal of Cancer, ISSN: 15321827 00070920
Lindi Chen; Zhao; Halliday; Berry; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; Del Bello; Piergentili; David R. Newell; John Lunec; Deborah A. Tweddle
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A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer
British Journal of Cancer, ISSN: 15321827 00070920
Yoon-Koo Kang; Rha; Tassone; Barriuso; Ron Yu; Szado; Amit Garg; Bang
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Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells
Cancer Cell, ISSN: 18783686 15356108
Ho-June Lee; Guanglei Zhuang; Yi Cao; Pan Du; Hyo-Jin Kim; Jeffrey Settleman
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MBASED: Allele-specific expression detection in cancer tissues and cell lines
Genome Biology, ISSN: 1474760X 14747596
Oleg Mayba; Houston N. Gilbert; Jinfeng Liu; Matthias Peter; Suchit Jhunjhunwala; Zhaoshi Jiang; Colin K. Watanabe; Zemin Zhang
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Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
Science Signaling, ISSN: 19379145 19450877
Juliane Mooz; Tripat Kaur Oberoi-Khanuja; Gregory S. Harms; Weiru Wang; Bijay S. Jaiswal; Somasekar Seshagiri; Ritva Tikkanen; Krishnaraj Rajalingam
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Analytical strategies for genotoxic impurities in the pharmaceutical industry
American Pharmaceutical Review, ISSN: 10998012
Venkatramani; Mohammad Al-Sayah
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Investigation of excipient compatibility and associated degradations for the formulation development of a small molecule pharmaceutical compound
American Pharmaceutical Review, ISSN: 10998012
Jane Li; Hong Lin; Christine Gu; Priscilla Mantik; Stefanie Gee; Peter M. Yehl
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Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function
Toxicological Sciences, ISSN: 10960929
Thomas R. Gelzleichter; Wendy Halpern; Roy Erwin; Amos Baruch; Maya Leabman; Abigail S. Forrest; Christina Satterwhite; Kun Peng; Jennifer Chilton; Dale Stevens
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PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia
Blood, ISSN: 15280020 00064971
Martin Weisser; Ru-Fang Yeh; Guillemette Duchateau-Nguyen; Palermo; Tri Quang Nguyen; Xiaoyan Shi; Susanna Y. Stinson; Nancy Yu; Annika Dufour; Tadeusz Robak; Galina Salogub; Anna Dmoszynska; Philippe Solal-Celigny; Krzysztof Warzocha; Javier Loscertales; John Catalano; Loree Larratt; Viktor A. Rossiev; Isabelle Bence-Bruckler; Christian H. Geisler; Marco Montillo; Kirsten Fischer; Anna-Maria Fink; Michael Hallek; Johannes Bloehdorn; Raymonde Busch; Axel Benner; Hartmut Doḧner; Nancy Valente; Michael Wenger; Stephan Stilgenbauer; David Dornan
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Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons
Neuron, ISSN: 10974199 08966273
Yelin Chen; Yuanyuan Wang; Ali Ertürk; Dara Y. Kallop; Zhiyu Jiang; Robby M. Weimer; Joshua S. Kaminker; Morgan Sheng
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Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains
PLoS ONE, ISSN: 19326203
Travis W. Bainbridge; Venita I. DeAlmeida; Anita Izrael-Tomasevic; Cecile Chalouni; Borlan Pan; Joshua Goldsmith; Alia P. Schoen; Gabriel Quinones; Ryan Kelly; Jennie R. Lill; Wendy N. Sandoval; Michael Costa; Paul G. Polakis; David Arnott; Bonnee Rubinfeld; James A. Ernst
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Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate
Bioconjugate Chemistry, ISSN: 15204812 10431802
Michael Kim; Yan Chen; Joseph C. Marhoul; Fred Jacobson
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PILRα negatively regulates mouse inflammatory arthritis
Journal of Immunology, ISSN: 15506606 00221767
Yonglian Sun; Patrick Caplazi; Juan Zhang; Anita Mazloom; Sarah K. Kummerfeld; Gabriel Quinones; Kate Senger; Justin Lesch; Ivan Peng; Andrew Sebrell; Wilman Luk; Yanmei Lu; Zhonghua Lin; Kai H. Barck; Judy Young; Mariela Del Rio; Sophie M. Lehar; Vida Asghari; Wei Yu Lin; Sanjeev Mariathasan; Jason Devoss; Shahram Misaghi; Mercedesz Balazs; Tao Sai; Benjamin Haley; Hass; Min Xu; Wenjun Ouyang; Flavius Martin; Wyne P. Lee; Ali A. Zarrin
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VariantAnnotation: A Bioconductor package for exploration and annotation of genetic variants
Bioinformatics, ISSN: 14602059 13674803
Valerie Obenchain; Michael Lawrence; Vincent J. Carey; Stephanie M. Gogarten; Paul Shannon; Martin Morgan
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MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein
Genes and Development, ISSN: 15495477 08909369
Monica S. Guo; Taylor B. Updegrove; Emily Gogol; Svetlana A. Shabalina; Carol A. Gross; Gisela Storz
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Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex
Journal of Neurophysiology, ISSN: 15221598 00223077
Justin Elstrott; Kelly B. Clancy; Haani Jafri; Igor Akimenko; Daniel E. Feldman
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Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible t-cell kinase inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Jason D. Burch; Kevin Lau; John J. Barker; Frederick A. Brookfield; Yong Chen; Yuan Chen; Eigenbrot; Claire Ellebrandt; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Daniel Kordt; Colin H. Mackinnon; Paul A. McEwan; Daniel F. Ortwine; Daniel B. Stein; Xiaolu Wang; Dirk Winkler; Po-Wai Yuen; Yamin Zhang; Ali A. Zarrin; Zhonghua Pei
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Imaging cleared intact biological systems at a cellular level by 3DISCO
Journal of Visualized Experiments, ISSN: 1940087X
Ali Ertürk; Daniel Lafkas; Cecile Chalouni
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Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides
Organic Letters, ISSN: 15237052 15237060
Olivier René; Benjamin P. Fauber; Sushant Malhotra; Herbert M. Yajima
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Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs - a systematic review and network meta-analysis
Health and Quality of Life Outcomes, ISSN: 14777525
Jeroen P. Jansen; Felicity Buckley; Fred Dejonckheere; Sarika Ogale
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Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
Science Translational Medicine, ISSN: 19466242 19466234
Gauvreau; Harris; Boulet; Heleen Scheerens; Fitzgerald; Wendy Putnam; Cockcroft; Davis; Richard Leigh; Zheng; Barbro Dahlén; Yehong Wang; Romeo MacIuca; Mayers; X. Charlene Liao; Lawren C. Wu; Matthews; O'Byrne
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The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation
Cancer Research, ISSN: 15387445 00085472
Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman
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Development of a comprehensive near infrared spectroscopy calibration model for rapid measurements of moisture content in multiple pharmaceutical products
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
Dipak Mainali; Jane Li; Peter M. Yehl; Nicholas Chetwyn
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Asymmetric stereodivergent strategy towards aminocyclitols
Chemistry - A European Journal, ISSN: 15213765 09476539
Barry M. Trost; Sushant Malhotra
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Balancing benefit and risk of medicines: A systematic review and classification of available methodologies
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Shahrul Mt-Isa; Christine Hallgreen; Nan Wang; Georgy Genov; Ian Hirsch; Davide Luciani; Lawrence D. Phillips; George Quartey; Sinan B. Sarac; Isabelle Stoeckert; Ioanna Tzoulaki; Alain Micaleff; Deborah Ashby; Billy Amzal; Simon Ashworth; Alex Asiimwe; Johan Bring; Torbjorn Callreus; Edmond Kakit Chan; Christoph Dierig; Gerald Downey; David Gelb; Alesia Goginsky; Richard Hermann; Steve Hobbiger; Kimberley S. Hockley; Diana Hughes; Juhaeri Juhaeri; Silvia Kuhls; Alfons Lieftucht; Marilyn Metcalf; Jeremiah Mwangi; Richard Nixon; Rebecca Noel; John Pears; Ruth Peters; Lawrence Phillips; Susan Shepherd; Elizabeth Swain J.; Andrew Thomson; Laurence Titeux; Rianne van den Ham; Tjeerd van Staa; Edward Waddingham; Lesley Wise
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Predicting Discontinuation of Pegylated Interferon as a Result of Lack of Efficacy in United States Veterans With Chronic Hepatitis C on Dual Therapy
Annals of Pharmacotherapy, ISSN: 15426270 10600280
Richard E. Nelson; Hoop; Korner; Scott L. Duvall; Candace Hayden; Kristin Knippenberg; Timothy Morgan; Prashant K. Pandya; Jian Han; Joanne Lafleur
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Endogenously expressed IL-13Rα2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts
Journal of Immunology, ISSN: 15506606 00221767
Sanjay Chandriani; Daryle J. DePianto; Elsa N. N'Diaye; Abbas Alexander; Janet Jackman; Jack Bevers; Vladimir Ramirez-Carrozzi; Rajita Pappu; Steven E. Kauder; Toy; Connie Ha; Zora Modrusan; Lawren C. Wu; Harold R. Collard; Paul J. Wolters; Jackson G. Egen; Joseph R. Arron
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Treatment emergent suicidal ideation and behavior
Suicide: Phenomenology and Neurobiology,
Sian Ratcliffe; Phillip B. Chappell; Janel Boyce-Rustay; Svetlana Gloukhova; Denise M. Oleske
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Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration
Haematologica, ISSN: 15928721 03906078
James B. Bussel; Christina S. Lee; Caroline Seery; Allison A. Imahiyerobo; Michaela V. Thompson; Diane Catellier; Ithamar G. Turenne; Vivek L. Patel; Paul A. Basciano; Rebecca Elstrom; Waleed Ghanima
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