Genentech: Publications

January 1, 2014

Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - Impact of effector cells

Journal of Immunological Methods, ISSN: 18727905 00221759

Shan Chung; Yuwen L. Lin; Chae Reed; Carl Ng; Zhijie Jey Cheng; Fabio Malavasi; Yang; Quarmby; An Song

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January 1, 2014

Dendritic cells in IBD pathogenesis: An area of therapeutic opportunity?

Journal of Pathology, ISSN: 00223417 10969896

Jennifer Bates; Laurie Diehl

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January 1, 2014

Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants

Cell Reports, ISSN: 22111247

Matt Simon; Peter Sarkies; Kohta Ikegami; Anna-Lisa Doebley; Leonard D. Goldstein; Jacinth Mitchell; Aisa Sakaguchi; Eric A. Miska; Shawn Ahmed

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January 1, 2014

HGF/MET-directed therapeutics in gastroesophageal cancer: A review of clinical and biomarker development

Oncotarget, ISSN: 19492553

Stephen P. Hack; Jean-Marie Bruey; Koeppen

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January 1, 2014

Developing biomarkers to predict benefit from HGF/MET pathway inhibitors

Journal of Pathology, ISSN: 00223417 10969896

Koeppen; Sandra Rost; Robert Yauch

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January 1, 2014

Assay formats: Recommendation for best practices and harmonization from the global bioanalysis consortium harmonization team

AAPS Journal, ISSN: 15507416

Sherri Dudal; Daniel Baltrukonis; Rebecca Crisino; M. Jaya Goyal; Alison Joyce; Karolina Österlund; John Smeraglia; Yoshitaka Taniguchi; Yang

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January 1, 2014

CNS Amyloid-β, Soluble APP-α and-β Kinetics during BACE Inhibition

Journal of Neuroscience, ISSN: 15292401 02706474

Justyna A. Dobrowolska; Maria S. Michener; Guoxin Wu; Bruce W. Patterson; Robert Chott; Vitaliy Ovod; Yuriy Pyatkivskyy; Kristin R. Wildsmith; Tom Kasten; Parker Mathers; Mandy Dancho; Christina Lennox; Brad E. Smith; David Gilberto; Debra McLoughlin; Daniel J. Holder; Andrew W. Stamford; Kevin E. Yarasheski; Matthew E. Kennedy; Mary J. Savage; Randall J. Bateman

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January 1, 2014

Best practices for the development, scale-up, and post-approval change control of IR and MR dosage forms in the current quality-by-design paradigm

AAPS PharmSciTech, ISSN: 15309932

Glenn A. Van Buskirk; Satish Asotra; Christopher Balducci; Prabir Basu; Gerald DiDonato; Angelica Dorantes; W. Mark Eickhoff; Tapash Ghosh; Mario A. González; Theresa Henry; Matthew Howard; Jason Kamm; Steven Laurenz; Ryan MacKenzie; Richard Mannion; Patrick K. Noonan; Terrance Ocheltree; Umesh Pai; Richard P. Poska; Michael L. Putnam; Ramani R. Raghavan; Colleen Ruegger; Eric Sánchez; Vinod Shah; Zezhi Jesse Shao; Russell Somma; Vijay Tammara; Avinash G. Thombre; Bruce Thompson; Robert J. Timko; Satyam Upadrashta; Sivakumar Vaithiyalingam

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January 1, 2014

A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Amita Patnaik; Patricia M. LoRusso; Wells A. Messersmith; Kyriakos P. Papadopoulos; Lia Gore; Muralidhar Beeram; Vanitha Ramakrishnan; Amy H. Kim; Joseph Beyer; Mason Shih; Darbonne; Yan Xin; Ron Yu; Hong Xiang; Rainer Brachmann; Colin D. Weekes

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January 1, 2014

The other randomization - methods for labeling drug kits

Contemporary Clinical Trials, ISSN: 15592030 15517144

Daniel A. Coleman; Ron Yu

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January 1, 2014

Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling

Cell Adhesion and Migration, ISSN: 19336926 19336918

Christopher W. Wilson; Weilan Ye

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January 1, 2014

Understanding the effect of the HCV polymerase inhibitor mericitabine on early viral kinetics in the phase 2 JUMP-C and PROPEL studies

British Journal of Clinical Pharmacology, ISSN: 13652125 03065251

Ya-Chi Chen; Coen A. Bernaards; Rohit Kulkarni; Sebastian A. Moreira; Yonghong Zhu; Anna Chan; Ethan Badman; Andrew Ackrill; James A. Thommes; Patrick F. Smith

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January 1, 2014

Evaluation of the effect of mericitabine at projected therapeutic and supratherapeutic doses on cardiac repolarization in healthy subjects: A thorough QT/QTc study

Clinical Pharmacology in Drug Development, ISSN: 21607648 2160763X

Ya-Chi Chen; Joshua Haznedar; Rohit Kulkarni; Christelle Vistuer; Carla Washington; Mei Liu; Patrick F. Smith

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January 1, 2014

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Karin Rosén; William W. Busse

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January 1, 2014

Follow your gut: Relaying information from the site of left-right symmetry breaking in the mouse

Genesis, ISSN: 1526968X 1526954X

Yukio Saijoh; Manuel Viotti; Anna-Katerina Hadjantonakis

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January 1, 2014

For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

Toxicology Research, ISSN: 20454538 2045452X

Chenghong Zhang; Shuguang Ma; Erlie Marie Delarosa; Suzanne Tay; Jasleen K. Sodhi; Vivek Musinipally; Patricia Chang; Rama Pai; Jason S Halladay; Misner; Jane R. Kenny; Cornelis E. Hop; S. Cyrus Khojasteh

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January 1, 2014

Health care utilization and costs by site of service for nonmetastatic breast cancer patients treated with trastuzumab

Journal of Managed Care Pharmacy, ISSN: 10834087

Anju Parthan; Eduardo Santos; Laura Becker; Art Small; Deepa Lalla; Melissa Brammer; April Teitelbaum

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January 1, 2014

Distribution of the phosphatidylinositol 3-kinase inhibitors pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models - Assessment by matrix-assisted laser desorption ionization imaging

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Laurent Salphati; Sheerin Shahidi-Latham; Cristine Quiason; Kai H. Barck; Merry C. Nishimura; Bruno Alicke; Jodie Pang; Richard A. D. Carano; Alan G. Olivero; Phillips

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January 1, 2014

OX40L blockade and allergen-induced airway responses in subjects with mild asthma

Clinical and Experimental Allergy, ISSN: 09547894 13652222

Gauvreau; Boulet; Cockcroft; Fitzgerald; Mayers; Carlsten; Laviolette; Killian; Davis; Larché; Kipling; Dua; Mosesova; Wendy Putnam; Zheng; Heleen Scheerens; Mcclintock; Matthews; O'Byrne

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January 1, 2014

Assessing health-related quality of life for advanced basal cell carcinoma and basal cell carcinoma nevus syndrome development of the first disease-specific patient-reported outcome questionnaires

JAMA Dermatology, ISSN: 21686068

Susan D. Mathias; Mary-Margaret Chren; Hilary H. Colwell; Yeun Mi Yim; Carolina Reyes; Diana M. Chen; Scott W. Fosko

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January 1, 2014

Combinatorial approach for large-scale identification of linked peptides from tandem mass spectrometry spectra

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Jian Wang; Veronica G. Anania; Jeff Knott; John Rush; Jennie R. Lill; Philip E. Bourne; Nuno Bandeira

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January 1, 2014

A comparison of health-related quality of life in idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis

Chest, ISSN: 19313543 00123692

Molly Lubin; Hubert Chen; Brett Elicker; Kirk D. Jones; Harold R. Collard; Joyce S. Lee

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January 1, 2014

Patients' willingness to trade off between the duration and frequency of rheumatoid arthritis treatments

Arthritis Care and Research, ISSN: 21514658 2151464X

Christine Poulos; A. Brett Hauber; Juan Marcos González; Adam Turpcu

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January 1, 2014

Development of a tripartite solvent blend for sustainable chromatography

Green Chemistry, ISSN: 14639270 14639262

Florence M. Chardon; Nicole Blaquiere; Georgette M. Castanedo; Stefan G. Koenig

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January 1, 2014

Resource utilization and cost in a commercially insured population with schizophrenia

American Health and Drug Benefits, ISSN: 19422970 19422962

Kathryn Fitch; Kosuke Iwasaki; Kathleen F. Villa

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January 1, 2014

Viral clearance using traditional, well-understood unit operations (session I): Low-pH inactivation

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124

Qi Chen

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January 1, 2014

The effects of tocilizumab on osteitis, synovitis and erosion progression in rheumatoid arthritis: Results from the ACT-RAY MRI substudy

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Philip G. Conaghan; Charles G. Peterfy; Ewa Olech; Jeffrey Kaine; David Ridley; Julie DiCarlo; Josh Friedman; Jenny Devenport; Orrin Troum

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January 1, 2014

Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells

Annals of Neurology, ISSN: 03645134 15318249

Dimitry N. Krementsov; Rajkumar Noubade; Julie A. Dragon; Kinya Otsu; Mercedes Rincon; Cory Teuscher

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January 1, 2014

Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy

Pharmacotherapy, ISSN: 02770008

Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Núria Bech; Patrick F. Smith; Barbara J. Brennan

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January 1, 2014

HPLC for characterization and quality control of therapeutic monoclonal antibodies

LC-GC Europe, ISSN: 14716577

Taylor Zhang; Quan; Michael W. Dong

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January 1, 2014

Superficially porous particles: Perspectives, practices, and trends

LCGC North America, ISSN: 15275949

Michael W. Dong; Szabolcs Fekete; Davy Guillarme

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January 1, 2014

Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Abdelkader Rahmaoui; Kenneth J. Rothman; Eva Guinan; Mark D. Eisner; Mary S. Bradley; Carlos Iribarren; Hubert Chen; Gillis Carrigan; Karin Rosén; Stanley J. Szefler

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January 1, 2014

Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: Final analysis from the PROPHESYS cohort

Journal of Viral Hepatitis, ISSN: 13652893 13520504

Aronsohn; Ancuta; Caruntu; Coppola; Delic; Digiacomo; Dusheiko; Lengyel; Marcellin; Orlandini; Pruthi; Silva; Tallarico; Schmitz; Tatsch; Korner; Cheinquer

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January 1, 2014

The use of phase 2 interim analysis to expedite drug development decisions

Contemporary Clinical Trials, ISSN: 15592030 15517144

Jie Huang; Asha Das; Hans Ulrich Burger; Wei Zhong; Wenwen Zhang; Lieberman

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January 1, 2014

Comparison of hospital length of stay, costs, and readmissions of alteplase versus catheter replacement among patients with occluded central venous catheters

Journal of Hospital Medicine, ISSN: 15535606 15535592

Frank R. Ernst; Er Chen; Craig Lipkin; Darren Tayama; Alpesh N. Amin

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January 1, 2014

Dendritic cell-targeted vaccines

Frontiers in Immunology, ISSN: 16643224

Lillian Cohn; Lélia Delamarre

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January 1, 2014

Maximum likelihood estimation of GEVD: Applications in bioinformatics

IEEE/ACM Transactions on Computational Biology and Bioinformatics, ISSN: 15455963

Minta Thomas; Anneleen Daemen; Bart De Moor

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January 1, 2014

Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema

Ophthalmology, ISSN: 15494713 01616420

Peter A. Campochiaro; Charles C. Wykoff; Howard Shapiro; Roman G. Rubio; Jason S. Ehrlich

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January 1, 2014

DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid

Inflammatory Bowel Diseases, ISSN: 15364844 10780998

Tammie S. MacFie; Richard Poulsom; Alexandra Parker; Gary Warnes; Tatjana Boitsova; Anke Nijhuis; Nirosha Suraweera; Angela Poehlmann; Jaroslaw Szary; Roger Feakins; Rosemary Jeffery; Richart W. Harper; Adrian M. Jubb; James O. Lindsay; Andrew Silver

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January 1, 2014

A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study

Bioanalysis, ISSN: 17576199 17576180

Keyang Xu; Luna Liu; Mauricio Maia; Jenny Li; John Lowe; An Song; Surinder Kaur

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January 1, 2014

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

Nature, ISSN: 00280836 14764687

Lin Tang; Tamer M. Gamal El-Din; Jian Payandeh; Gilbert Q. Martinez; Teresa M. Heard; Todd Scheuer; Ning Zheng; William A. Catterall

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January 1, 2014

Online integrity monitoring in the Protein A step of mAb Production Processes-increasing reliability and process robustness

Biotechnology Progress, ISSN: 15206033 87567938

Christopher Bork; Sarah Holdridge; Mark Walter; Eric Fallon; Michael Pohlscheidt

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January 1, 2014

Incidence and relevance of proteinuria in bevacizumab-treated patients: Pooled analysis from randomized controlled trials

American Journal of Nephrology, ISSN: 14219670 02508095

Richard A. Lafayette; Bruce Mccall; Nicole F. Li; Laura Chu; Patricia Werner; Asha Das; Richard Glassock

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January 1, 2014

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: A proof-of-principle

Annals of Oncology, ISSN: 15698041 09237534

De Mattos-Arruda; Weigelt; Javier Cortés; Won; Ng; Nuciforo; Bidard; Aura; Saura; Peg; Piscuoglio; Oliveira; Smolders; Premal Patel; Norton; Tabernero; Berger; Seoane; Jorge S. Reis-Filho

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January 1, 2014

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Laurent Salphati; Xiaoyan Chu; Liangfu Chen; Bhagwat Prasad; Shannon Dallas; Raymond Evers; Donna Mamaril-Fishman; Ethan G. Geier; Jonathan Kehler; Jeevan Kunta; Mario Mezler; Loic Laplanche; Jodie Pang; Anja Rode; Matthew G. Soars; Jashvant D. Unadkat; Robert A. B. Van Waterschoot; Jocelyn Yabut; Alfred H. Schinkel; Nico Scheer

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January 1, 2014

1-Aminobenzotriazole coincubated with (s)-warfarin results in potent inactivation of CYP2C9s

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jasleen K. Sodhi; Kevin A. Ford; Sophie Mukadam; Susan C. Wong; Cornelis E. Hop; S. Cyrus Khojasteh; Jason S Halladay

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January 1, 2014

The use of FDG-PET in diffuse large B cell lymphoma (DLBCL): Predicting outcome following first line therapy

Cancer Imaging, ISSN: 14707330

Monica Coughlan; Rebecca Elstrom

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January 1, 2014

Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib

Journal of the American Academy of Dermatology, ISSN: 01909622 10976787

Anne Lynn S. Chang; James A. Solomon; John Hainsworth; Leonard Goldberg; Edward McKenna; Bann-Mo Day; Diana M. Chen; Glen J. Weiss

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January 1, 2014

Prediction of overall survival or progression free survival by disease control rate at week 8 is independent of ethnicity: Western versus Chinese patients with first-line non-small cell lung cancer treated with chemotherapy with or without bevacizumab

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Laurent Claret; Manish Gupta; Kelong Han; Amita Joshi; Nenad Sarapa; Jing He; Bob Powell; Rene Bruno

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January 1, 2014

Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy

Journal of Virology, ISSN: 10985514 0022538X

Kevin B. Walsh; John R. Teijaro; Linda G. Brock; Daniel M. Fremgen; Peter L. Collins; Hugh Rosen; Michael B.A. Oldstone

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