Genentech: Publications

January 1, 2014

Systematic review of vismodegib toxicity profile in the treatment of advanced basal cell carcinomas compared to other systemic therapies in dermatology

Journal of Drugs in Dermatology, ISSN: 15459616

Margit L. W. Juhász; Ellen S. Marmur

View on Scopus

January 1, 2014

Real-time asthma outreach reduces excessive short-acting β2-agonist use: A randomized study

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Robert S. Zeiger; Michael Schatz; Qiaowu Li; Paul G. Solari; James L. Zazzali; Wansu Chen

View on Scopus

January 1, 2014

Homozygosity of the autosomal dominant alzheimer disease presenilin 1 E280A mutation

Neurology, ISSN: 1526632X 00283878

Kenneth S. Kosik; Claudia Muñoz; Liliana Lopez; Mary Luz Arcila; Gloria García; Lucía Madrigal; Sonia Moreno; Silvia Ríos Romenets; Hugo Lopez; Madelyn Gutierrez; Jessica B. Langbaum; William Cho; Shehnaaz Suliman; Pierre N. Tariot; Carole Ho; Eric M. Reiman; Francisco Lopera

View on Scopus

January 1, 2014

Internal virus polarization model for virus retention by the Ultipor® VF Grade DV20 membrane

Biotechnology Progress, ISSN: 15206033 87567938

Nigel B. Jackson; Meisam Bakhshayeshi; Andrew Zydney; Amit Mehta; Robert Van Reis; Ralf Kuriyel

View on Scopus

January 1, 2014

Treatment patterns and clinical outcomes for patients with de novo versus recurrent HER2-positive metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Denise A. Yardley; Peter A. Kaufman; Adam Brufsky; Marianne Ulcickas Yood; Hope S. Rugo; Musa Mayer; Quah; Bongin Yoo; Debasish Tripathy

View on Scopus

January 1, 2014

The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine

Drug Development Research, ISSN: 10982299 02724391

Joshua Haznedar; Sebastian A. Moreira; Thomas Marbury; Richard Robson; William Smith; Rohit Kulkarni; Marie L. Munson; James A. Thommes; Annabelle Lemenuel-Diot; Carla Washington; Patrick F. Smith; Ya-Chi Chen

View on Scopus

January 1, 2014

Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials

Ophthalmology, ISSN: 15494713 01616420

Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai

View on Scopus

January 1, 2014

Bispecific therapeutics for ophthalmic indications: Target selection and the optimal molecular format

Expert Review of Ophthalmology, ISSN: 17469902 17469899

Jennifer Le Couter; Justin M. Scheer

View on Scopus

January 1, 2014

Geographic atrophy: Clinical features and potential therapeutic approaches

Ophthalmology, ISSN: 15494713 01616420

Frank G. Holz; Erich C. Strauss; Steffen Schmitz-Valckenberg; Menno Van Lookeren Campagne

View on Scopus

January 1, 2014

Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Amit Garg; Angelica Quartino; Jing Li; Jin Y. Jin; D. Russell Wada; Hanbin Li; Javier Cortés; Virginia McNally; Graham Ross; Jennifer Visich; Bert L. Lum

View on Scopus

January 1, 2014

Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells

Molecular Biotechnology, ISSN: 15590305 10736085

Shirley S. M. Yip; Meixia Zhou; John C. Joly; Snedecor; Amy Shen; Yongping Crawford

View on Scopus

January 1, 2014

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized fab-antigen complexes

mAbs, ISSN: 19420870 19420862

Sherry L. La Porte; Eigenbrot; Ultsch; Ho; Davide Foletti; Alison Forgie; Kevin C. Lindquist; David L. Shelton; Jaume Pons

View on Scopus

January 1, 2014

Genetic markers of bevacizumab-induced hypertension

Angiogenesis, ISSN: 15737209 09696970

Diether Lambrechts; Matthieu Moisse; Paul Delmar; David W. Miles; Natasha Leighl; Bernard Escudier; Eric Van Cutsem; Aruna T. Bansal; Peter Carmeliet; Stefan J. Scherer; Sanne De Haas; Celine Pallaud

View on Scopus

January 1, 2014

Amphiregulin and pten evoke a multimodal mechanism of acquired resistance to PI3k inhibition

Genes and Cancer, ISSN: 19476027 19476019

Kyle A. Edgar; Lisa Crocker; Eric Cheng; Marie-Claire Wagle; Matthew Wongchenko; Yibing Yan; Wilson; Nicholas A. Dompe; Richard M. Neve; Marcia Belvin; Deepak Sampath; Lori S. Friedman; Jeffery J. Wallin

View on Scopus

January 1, 2014

In vivo antigen-driven plasmablast enrichment in combination with antigen-specific cell sorting to facilitate the isolation of rare monoclonal antibodies from human B cells

Nature Protocols, ISSN: 17502799 17542189

Zhonghua Lin; Nancy Y. Chiang; Ning Chai; Dhaya Seshasayee; Wyne P. Lee; Mercedesz Balazs; Nakamura; Lee R. Swem

View on Scopus

January 1, 2014

Immunomodulation and lymphoma in humans

Journal of Immunotoxicology, ISSN: 1547691X

Rafael Ponce; Thomas R. Gelzleichter; Helen G. Haggerty; Shawn Heidel; Matthew S. Holdren; Herve Lebrec; R. Daniel Mellon; Marc Pallardy

View on Scopus

January 1, 2014

Tailoring small molecules for an allosteric site on procaspase-6

ChemMedChem, ISSN: 18607179 18607187

Jeremy Murray; Anthony M. Giannetti; Micah Steffek; Paul Gibbons; Brian R. Hearn; Frederick Cohen; Christine Tam; Christine D. Pozniak; Brandon Bravo; Joe Lewcock; Priyadarshini Jaishankar; Cuong Q. Ly; Xianrui Zhao; Yinyan Tang; Preeti Chugha; Michelle R. Arkin; Flygare; Adam R. Renslo

View on Scopus

January 1, 2014

Investigation of adverse-event-related costs for patients with metastatic breast cancer in a real-world setting

Oncologist, ISSN: 1549490X 10837159

Sara A. Hurvitz; Annie Guérin; Melissa Brammer; Ellie Guardino; Zheng-Yi Zhou; Dominick Latremouille Viau; Eric Q. Wu; Deepa Lalla

View on Scopus

January 1, 2014

Comparison of treatment patterns and economic outcomes in metastatic breast cancer patients initiated on trastuzumab versus lapatinib: A retrospective analysis

SpringerPlus, ISSN: 21931801

Annie Guérin; Deepa Lalla; Geneviève Gauthier; Amy Styles; Eric Q. Wu; Anthony Masaquel; Melissa Brammer

View on Scopus

January 1, 2014

IAP family of cell death and signaling regulators

Methods in Enzymology, ISSN: 15577988 00766879

John Silke; Domagoj Vucic

View on Scopus

January 1, 2014

Interrogation of in vivo protein-protein interactions using transgenic mouse models and stable isotope labeling

Methods in Molecular Biology, ISSN: 10643745

Anwesha Dey; Jiansheng Wu; Donald S. Kirkpatrick

View on Scopus

January 1, 2014

Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Daruka Mahadevan; Gregory Ryan Sutton; Rafael Arteta-Bulos; Chris J. Bowden; Paul J. E. Miller; Rachel Elizabeth Swart; Mark S. Walker; Paul Haluska; Pamela N. Münster; John Marshall; Omid Hamid; Razelle Kurzrock

View on Scopus

January 1, 2014

AKT-induced tamoxifen resistance is overturned by RRM2 inhibition

Molecular Cancer Research, ISSN: 15573125 15417786

Khyati N. Shah; Kshama R. Mehta; David Peterson; Marie Evangelista; John C. Livesey; Jesika S. Faridi

View on Scopus

January 1, 2014

A new player on the psoriasis block: IL-17A- and IL-22-producing innate lymphoid cells

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Nicole L. Ward; Dale T. Umetsu

View on Scopus

January 1, 2014

Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake

Science China Life Sciences, ISSN: 16747305

LiLi Qian; ChangZu Cai; PengFei Yuan; Sun-Young Jeong; XiaoZhou Yang; Venita I. DeAlmeida; James A. Ernst; Michael Costa; Stanley N. Cohen; WenSheng Wei

View on Scopus

January 1, 2014

Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Erika H. De Boever; Claire Ashman; Anthony P. Cahn; Nicholas W. Locantore; Phil Overend; Isabelle J. Pouliquen; Adrian P. Serone; Tracey J. Wright; Mair M. Jenkins; Inderpal S. Panesar; Sivayogan S. Thiagarajah; Sally E. Wenzel

View on Scopus

January 1, 2014

Profiling cancer genemutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing

Oncologist, ISSN: 1549490X 10837159

Liangxuan Zhang; Liangjing Chen; Sachin Sah; Gary J. Latham; Rajesh Patel; Qinghua Song; Koeppen; Rachel Tam; Erica Schleifman; Haider Mashhedi; Sreedevi Chalasani; Ling Fu; Teiko Sumiyoshi; Rajiv Raja; William F. Forrest; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia

View on Scopus

January 1, 2014

Protein crystallization image classification with elastic net

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN: 16057422

Jeffrey Hung; John Collins; Mehari Weldetsion; Oliver Newland; Eric Chiang; Steve Guerrero; Kazunori Okada

View on Scopus

January 1, 2014

Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: A pooled analysis of individual patient data from four randomised controlled trials

The Lancet Oncology, ISSN: 14745488 14702045

Hans-Joachim Schmoll; Chris Twelves; Sun; Michael J O'Connell; Cartwright; Edward McKenna; Muhammad Saif; Lee; Greg Yothers; Daniel Haller

View on Scopus

January 1, 2014

Population pharmacokinetics and exposure-response analyses of trastuzumab in patients with advanced gastric or gastroesophageal junction cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Valérie F. Cosson; Vivian W. Ng; Michaela Lehle; Bert L. Lum

View on Scopus

January 1, 2014

Pathology in drug discovery and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Koeppen; Jorge S. Reis-Filho

View on Scopus

January 1, 2014

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

Nature Chemical Biology, ISSN: 15524469 15524450

Xinxin Gao; Rami N. Hannoush

View on Scopus

January 1, 2014

New challenges and opportunities in nonclinical safety testing of biologics

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Andreas Baumann; Kelly Flagella; Roy Forster; Lolke de Haan; Sven Kronenberg; Mathias Locher; Wolfgang F. Richter; Frank-Peter Theil; Marque Todd

View on Scopus

January 1, 2014

Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway

Methods in Enzymology, ISSN: 15577988 00766879

Jean-Philippe Stephan

View on Scopus

January 1, 2014

The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling

Molecular and Cellular Biology, ISSN: 10985549 02707306

Bo Cen; Ying Xiong; Jin H. Song; Sandeep Mahajan; Rachel DuPont; Kristen McEachern; Daniel J. DeAngelo; Jorge E. Cortes; Mark D. Minden; Allen Ebens; Alice Mims; Amanda LaRue; Andrew S. Kraft

View on Scopus

January 1, 2014

Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: A literature-based meta-analysis from 91 trials

Neuro-Oncology, ISSN: 15235866 15228517

Kelong Han; Melanie Ren; Wick; Lauren E. Abrey; Asha Das; Jin Y. Jin; David A. Reardon

View on Scopus

January 1, 2014

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Journal of Cellular Physiology, ISSN: 10974652 00219541

Jikui Shen; David F. Choy; Tsunehiko Yoshida; Takeshi Iwase; Gulnar Hafiz; Bing Xie; Sean F. Hackett; Joseph R. Arron; Peter A. Campochiaro

View on Scopus

January 1, 2014

Emerging technologies in extracellular vesicle-based molecular diagnostics

Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159

Shidong Jia; Davide Zocco; Michael L. Samuels; Michael F. Chou; Roger Chammas; Johan Skog; Natasa Zarovni; Fatemeh Momen-Heravi; Winston Patrick Kuo

View on Scopus

January 1, 2014

Whole-Slide Imaging and Automated Image Analysis: Considerations and Opportunities in the Practice of Pathology

Veterinary Pathology, ISSN: 03009858 15442217

Webster; Dunstan

View on Scopus

January 1, 2014

Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Arthur; Turnbull; Renshaw; Keys; Thomas; Wilson; Lackner; Sims; Dixon

View on Scopus

January 1, 2014

Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: A double-blind, randomized, controlled trial

Chest, ISSN: 19313543 00123692

Abdullah A. Alangari; Nidal Malhis; Mohamed Mubasher; Najwa Al-Ghamedi; Mohamad Al-Tannir; Muhammad Riaz; Dale T. Umetsu; Saleh Al-Tamimi

View on Scopus

January 1, 2014

Risk of hospitalized bacterial infections associated with biologic treatment among US veterans with rheumatoid arthritis

Arthritis Care and Research, ISSN: 21514658 2151464X

Jeffrey R. Curtis; Yang; Patkar; Chen; Jasvinder A. Singh; Cannon; Ted R. Mikuls; Delzell; Saag; Safford; Scott L. Duvall; Kimberly Alexander; Pavel Napalkov; Kevin L. Winthrop; Burton; Kamauu; Baddley

View on Scopus

January 1, 2014

Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers

Journal of Pharmacy and Pharmacology, ISSN: 00223573 20427158

Peter N. Morcos; Sebastian A. Moreira; Mercidita T. Navarro; Núria Bech; Amanda Quatkemeyer; Patrick F. Smith; Barbara J. Brennan

View on Scopus

January 1, 2014

The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marta Hamilton; Julie Wolf; Drolet; Scott Fettner; Ashok Rakhit; Karsten Witt; Bert L. Lum

View on Scopus

January 1, 2014

A Homozygous PDE6D Mutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

Human Mutation, ISSN: 10597794 10981004

Sophie Thomas; Kevin J. Wright; Stéphanie Le Corre; Alessia Micalizzi; Marta Romani; Avinash Abhyankar; Julien Saada; Isabelle Perrault; Jeanne Amiel; Julie Litzler; Emilie Filhol; Nadia Elkhartoufi; Mandy Kwong; Jean-Laurent Casanova; Nathalie Boddaert; Wolfgang Baehr; Stanislas Lyonnet; Arnold Munnich; Lydie Burglen; Nicolas Chassaing; Ferechté Encha-Ravazi; Michel Vekemans; Joseph G. Gleeson; Enza Maria Valente; Peter K Jackson; Iain A. Drummond; Sophie Saunier; Tania Attié-Bitach

View on Scopus

January 1, 2014

Use of anti-malarial drugs and the risk of developing eye disorders

Travel Medicine and Infectious Disease, ISSN: 14778939 18730442

Cornelia Schneider; Miriam Adamcova; Susan S. Jick; Patricia Schlagenhauf; Mary K. Miller; Hans-Georg Rhein; Christoph R. Meier

View on Scopus

January 1, 2014

Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies

Clinical Cancer Research, ISSN: 15573265 10780432

Ravi Salgia; Premal Patel; John Bothos; Wei Yu; Stephen M. Eppler; Priti Hegde; Shuang Bai; Surinder Kaur; Ihsan Nijem; Daniel V.T. Catenacci; Amy Peterson; Ratain; Blase Polite; Janice M. Mehnert; Rebecca A. Moss

View on Scopus

January 1, 2014

Genomic landscape of metastatic colorectal cancer

Nature Communications, ISSN: 20411723

Josien C. Haan; Mariette Labots; Christian Rausch; Miriam Koopman; Jolien Tol; Leonie J. M. Mekenkamp; Mark A. Van De Wiel; Danielle Israeli; Hendrik F. Van Essen; Nicole C. T. Van Grieken; Quirinus J. M. Voorham; Linda J. W. Bosch; Xueping Qu; Omar Kabbarah; Henk M. W. Verheul; Iris D. Nagtegaal; Cornelis J. A. Punt; Bauke Ylstra; Gerrit A. Meijer

View on Scopus

January 1, 2014

Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance

Oncotarget, ISSN: 19492553

Shih-Min A. Huang; Anlai Wang; Rita Greco; Zhifang Li; Claude Barberis; Michel Tabart; Vinod Patel; Laurent Schio; Raelene Hurley; Hong Cheng; Christoph Lengauer; Jack Pollard; James Watters; Carlos Garcia-Echeverria; Dmitri Wiederschain; Francisco Adrian; JingXin Zhang

View on Scopus

January 1, 2014

Implementing high-temperature short-time media treatment in commercial-scale cell culture manufacturing processes

Applied Microbiology and Biotechnology, ISSN: 14320614 01757598

Michael Pohlscheidt; Salim Charaniya; Fikret Kulenovic; Mahalia Corrales; Masaru Shiratori; Justin Bourret; Steven Meier; Eric Fallon; Robert Kiss

View on Scopus

Attention: This page may not render properly. The browser you are using, Internet Explorer 10, is no longer supported.

Publications

Join Our Team

Two Scientists Walk Into a Bar