Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6501 - 6550 OF 15217 RESULTS

December 1, 2013

Learning and confirming with preclinical studies: Modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Harvey Wong; Stephen Gould; Nageshwar Budha; Darbonne; Edward E. Kadel III; Hank La; Bruno Alicke; Jason S Halladay; Rebecca Erickson; Chia C. Portera; Anthony W. Tolcher; Jeffery R. Infante; Michael Mamounas; Flygare; Cornelis E. Hop; Wayne J. Fairbrother

December 1, 2013

Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis

Birth Defects Research Part B - Developmental and Reproductive Toxicology, ISSN: 15429733 15429741

Christopher J. Bowman; William J. Breslin; Anu V. Connor; Pauline L. Martin; Graeme J. Moffat; Lakshmi Sivaraman; M. Belen Tornesi; Simon Chivers

December 1, 2013

A phase 1B study of dulanermin in combination with modified FOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer

Clinical Colorectal Cancer, ISSN: 15330028 19380674

Zev A. Wainberg; Wells A. Messersmith; Parvin F. Peddi; Amy V. Kapp; Avi Ashkenazi; Stephanie Royer-Joo; Chia C. Portera; Kozloff

December 1, 2013

Potential drug interventions for diabetic retinopathy

Drug Discovery Today, ISSN: 13596446 18785832

Qin Shen; Jim Zhen Wu; Jason C. Wong

December 1, 2013

On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay

Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744

Leonid M. Berezhkovskiy; Susan C. Wong; Jason S Halladay

December 1, 2013

Ferumoxytol enhanced resting state fMRI and relative cerebral blood volume mapping in normal human brain

NeuroImage, ISSN: 10538119 10959572

Helen D'Arceuil; Alexandre Coimbra; Pamela Triano; Margaret Dougherty; Julie Mello; Michael Moseley; Gary Glover; Maarten Lansberg; Francis Blankenberg

December 1, 2013

PTEN loss mitigates the response of medulloblastoma to hedgehog pathway inhibition

Cancer Research, ISSN: 00085472 15387445

Ciara Metcalfe; Bruno Alicke; Ailey Crow; Marlea Lamoureux; Gerrit J. P. Dijkgraaf; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage

December 1, 2013

A novel method for high throughput lipophilicity determination by microscale shake flask and liquid chromatography tandem mass spectrometry

Combinatorial Chemistry and High Throughput Screening, ISSN: 13862073 18755402

Baiwei Lin; Joseph H. Pease

December 1, 2013

Endocytosis and cancer

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Ira Mellman; Yarden

December 1, 2013

Pharmacokinetic interactions between lersivirine and zidovudine, tenofovir disoproxil fumarate/ emtricitabine and abacavir/lamivudine

Antiviral Therapy, ISSN: 13596535 20402058

Manoli Vourvahis; John Davis; Grant Langdon; Gary Layton; Juanzhi Fang; Heng Wee Choo; Arne G. Hansson; Margaret Tawadrous

December 1, 2013

Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Stanley A. Roberts; Paul A. Andrews; Diann Blanset; Kelly Flagella; Boris Gorovits; Carmel M. Lynch; Pauline L. Martin; Kimberly Kramer-Stickland; Stephane Thibault; Garvin Warner

November 27, 2013

Process lifecycle validation: Applying risk management

BioPharm International, ISSN: 1542166X 19391862

Anurag S. Rathore; Scott Bozzone; A. Hamid Mollah

November 27, 2013

Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Nandini C. Patel; Jacob B. Schwarz; Xinjun J. Hou; Dennis J. Hoover; Longfei Xie; Anton J. Fliri; Randall J. Gallaschun; John T. Lazzaro; Dianne K. Bryce; William E. Hoffmann; Ashley N. Hanks; Dina F. McGinnis; Eric S. Marr; Justin L. Gazard; Mihály Hajós; Renato J. Scialis; Raymond S. Hurst; Christopher L. Shaffer; Jayvardhan Pandit; Christopher J. O'Donnell

November 26, 2013

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Donald S. Kirkpatrick; Daisy J. Bustos; Taner Dogan; Jocelyn Chan; Lilian Phu; Amy Young; Lori S. Friedman; Marcia Belvin; Qinghua Song; Corey Bakalarski; Klaus P. Hoeflich

November 25, 2013

A Nobel Prize for membrane traffic: Vesicles find their journey's end

Journal of Cell Biology, ISSN: 00219525 15408140

Ira Mellman; Scott D. Emr

November 21, 2013

RASIP1 regulates vertebrate vascular endothelial junction stability through EPAC1-RAP1 signaling

Blood, ISSN: 15280020 00064971

Christopher W. Wilson; Leon Parker; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Merone Roose-Girma; Søren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye

November 12, 2013

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christian S. Lobsiger; Severine Boillée; Christine Pozniake; Amir M. Khan; Melissa McAlonis-Downes; Joe Lewcock; Don W. Cleveland

November 12, 2013

Subcutaneous versus intravenous administration of rituximab: Pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys

PLoS ONE, ISSN: 19326203

Cheng-Ping Mao; Martin R. Brovarney; Karim Dabbagh; Herbert F. Birnböck; Wolfgang F. Richter; Christopher J. Del Nagro

November 10, 2013

Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer

Journal of Clinical Oncology, ISSN: 15277755

David Spigel; Thomas J. Ervin; Rodryg Ramlau; Davey B Daniel; Jerome H Goldschmidt; George R. Blumenschein; Maciej J Krzakowski; Gilles Robinet; Benoit Godbert; Fabrice Barlesi; Ramaswamy Govindan; Taral Patel; Sergey Orlov; Michael Wertheim; Wei Yu; Jiping Zha; Robert Yauch; Premal Patel; See Phan; Amy Peterson

November 5, 2013

Improved crystallographic structures using extensive combinatorial refinement

Structure, ISSN: 09692126 18784186

Jerome C. Nwachukwu; Mark R. Southern; James R. Kiefer; Pavel V. Afonine; Paul D. Adams; Thomas C. Terwilliger; Kendall W. Nettles

November 4, 2013

Systemic concentrations can limit the oral absorption of poorly soluble drugs: An investigation of non-sink permeation using physiologically based pharmacokinetic modeling

Molecular Pharmaceutics, ISSN: 15438384 15438392

Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong

November 4, 2013

Characterization of a water-solid interaction in a partially ordered system

Molecular Pharmaceutics, ISSN: 15438384 15438392

Paroma Chakravarty; Joseph W. Lubach

November 4, 2013

Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects

Molecular Pharmaceutics, ISSN: 15438384 15438392

Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser

November 4, 2013

Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria

Molecular Pharmaceutics, ISSN: 15438384 15438392

Marc R. Yago; Adam Frymoyer; Gillian S. Smelick; Lynda A. Frassetto; Nageshwar Budha; Mark J. Dresser; Joseph A. Ware; Leslie Z. Benet

November 4, 2013

Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans

Molecular Pharmaceutics, ISSN: 15438384 15438392

Joseph W. Lubach; Jacob Z. Chen; Jonathan Hau; Jose Imperio; Melis Coraggio; Lichuan Liu; Harvey Wong

November 4, 2013

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development

Molecular Pharmaceutics, ISSN: 15438384 15438392

Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware

November 4, 2013

Physical chemical drug-drug interactions from drug discovery to registration: New opportunities for the pharmaceutical scientist to impact drug development

Molecular Pharmaceutics, ISSN: 15438384 15438392

Joseph A. Ware; Gena Dalziel

November 4, 2013

Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: Bench to bedside investigation of pH-dependent solubility

Molecular Pharmaceutics, ISSN: 15438384 15438392

Joseph A. Ware; Gena Dalziel; Jin Y. Jin; Jackson D. Pellett; Gillian S. Smelick; David A. West; Laurent Salphati; Xiao Ding; Rebecca Sutton; Jane Fridyland; Mark J. Dresser; Glenn Morrisson; Scott N. Holden

November 4, 2013

Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs - Reversing the effect of elevated gastric pH with betaine HCl

Molecular Pharmaceutics, ISSN: 15438384 15438392

Jodie Pang; Gena Dalziel; Brian J. Dean; Joseph A. Ware; Laurent Salphati

November 1, 2013

More myths in ultrahigh-pressure liquid chromatography

LC-GC Europe, ISSN: 14716577

Michael W. Dong

November 1, 2013

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Journal of Experimental Medicine, ISSN: 00221007 15409538

Omar Abdel-Wahab; Jie Gao; Mazhar Adli; Anwesha Dey; Thomas Trimarchi; Young Rock Chung; Cem Kuscu; Todd Hricik; Delphine Ndiaye-Lobry; Lindsay M. LaFave; Richard Koche; Alan H. Shih; Olga A. Guryanova; Eunhee Kim; Sheng Li; Suveg Pandey; Joseph Y. Shin; Leon Telis; Jinfeng Liu; Parva K. Bhatt; Sebastien Monette; Xinyang Zhao; Christopher E Mason; Christopher Y. Park; Bradley E. Bernstein; Iannis Aifantis; Ross L. Levine

November 1, 2013

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

Nature Neuroscience, ISSN: 10976256 15461726

David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein

November 1, 2013

Two-dimensional HPLC in pharmaceutical analysis

American Pharmaceutical Review, ISSN: 10998012

Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn

November 1, 2013

Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation

Biotechnology Progress, ISSN: 87567938 15206033

Joseph Wood; Ekta Mahajan; Masaru Shiratori

November 1, 2013

Clinical applications of palifermin: Amelioration of oral mucositis and other potential indications

Journal of Cellular and Molecular Medicine, ISSN: 15821838

Saroj Vadhan-Raj; Jenna D. Goldberg; Miguel-Angel Perales; Dietmar P. Berger; Marcel R.M. van den Brink

November 1, 2013

Erratum: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (Journal of Inherited Metabolic Disease DOI: 10.1007/s10545-012-9561-3)

Journal of Inherited Metabolic Disease, ISSN: 01418955 15732665

Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales

November 1, 2013

Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct

Developmental Dynamics, ISSN: 10588388 10970177

Yoko Inès Nozawa; Erica Yao; Chuwen Lin; Jehn-Hsiahn Yang; Christopher W. Wilson; Rhodora Gacayan; Pao-Tien Chuang

November 1, 2013

A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail

European Journal of Clinical Pharmacology, ISSN: 00316970 14321041

Peter N. Morcos; Linda Chang; Rohit Kulkarni; Mylene Giraudon; Nancy Shulman; Barbara J. Brennan; Patrick F. Smith; Jonathan Q. Tran

November 1, 2013

Age distribution of patients with advanced non-melanoma skin cancer in the United States

Archives of Dermatological Research, ISSN: 03403696 1432069X

Stacey Dacosta Byfield; Diana M. Chen; Yeun Mi Yim; Carolina Reyes

November 1, 2013

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Bradley J. Newhouse; Steve Wenglowsky; Jonas Grina; Ellen R. Laird; Walter C. Voegtli; Li Ren; Kateri Ahrendt; Alexandre J. Buckmelter; Susan L. Gloor; Nathalie Klopfenstein; Joachim Rudolph; Zhaoyang Wen; Xianfeng Li; Bainian Feng

November 1, 2013

A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials

Contemporary Clinical Trials, ISSN: 15517144 15592030

Wei Zhong; Joseph S. Koopmeiners; Bradley P. Carlin

November 1, 2013

Using registries to identify adverse events in rheumatic diseases

Pediatrics, ISSN: 00314005 10984275

Geraldina Lionetti; Yukiko Kimura; Laura E. Schanberg; Timothy Beukelman; Carol A. Wallace; Norman T. Ilowite; Jane Winsor; Kathleen Fox; Marc Natter; John S. Sundy; Eric Brodsky; Jeffrey R. Curtis; Vincent Del Gaizo; Solomon Iyasu; Angelika Jahreis; Ann Meeker-O'connell; Barbara B. Mittleman; Bernard M. Murphy; Eric D. Peterson; Sandra C. Raymond; Soko Setoguchi; Jeffrey N. Siegel; Rachel E. Sobel; Daniel Solomon; Taunton R. Southwood; Richard Vesely; Patience H. White; Nico M. Wulffraat; Christy I. Sandborg

November 1, 2013

Population pharmacokinetic analysis from phase i and phase ii studies of the humanized monovalent antibody, onartuzumab (metmab), in patients with advanced solid tumors

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Yan Xin; Denise Jin; Stephen M. Eppler; Lisa A. Damico; Amita Joshi; John Davis; Surinder Kaur; Ihsan Nijem; John Bothos; Amy Peterson; Premal Patel; Shuang Bai

November 1, 2013

Sample size and threshold estimation for clinical trials with predictive biomarkers

Contemporary Clinical Trials, ISSN: 15517144 15592030

Howard M. Mackey; Thomas Bengtsson

November 1, 2013

Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel

Anti-Cancer Drugs, ISSN: 09594973 14735741

Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga

November 1, 2013

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

Acta Neuropathologica, ISSN: 00016322 14320533

Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus

November 1, 2013

Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography

Biotechnology Progress, ISSN: 87567938 15206033

Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel

November 1, 2013

Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments

Journal of Chromatography A, ISSN: 18733778 00219673

Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete

November 1, 2013

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

Journal of Experimental Medicine, ISSN: 00221007 15409538

Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock

November 1, 2013

ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller

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