Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6551 - 6600 OF 15217 RESULTS

Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum
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Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Glen Giese; Adam Myrold; Gorrell; Josefine Persson
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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak
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Vehicle selection for nonclinical oral safety studies
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
PLoS ONE, ISSN: 19326203
Yaiza Diaz-de-Durana; Janet Lau; Deborah Knee; Christophe Filippi; Marco Londei; Peter McNamara; Marc Nasoff; Michael Didonato; Richard Glynne; Ann E. Herman
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Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Tetrahedron Letters, ISSN: 00404039 18733581
Malcolm P. Huestis; Wendy Liu; Matthew Volgraf; Hans E. Purkey; Christine Yu; Weiru Wang; Darin Smith; Guy Vigers; Darrin Dutcher; Kevin W. Hunt; Michael Siu
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Methylglyoxal Evokes Pain by Stimulating TRPA1
PLoS ONE, ISSN: 19326203
David A. Andersson; Clive Gentry; Emily Light; Nisha Vastani; Julie Vallortigara; Angelika Bierhaus; Thomas Fleming; Stuart Bevan
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Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
Journal of Experimental Medicine, ISSN: 00221007 15409538
Nathan E. Welty; Christopher Staley; Nico Ghilardi; Michael J. Sadowsky; Botond Z. Igyártó; Daniel H. Kaplan
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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells
Journal of Cell Science, ISSN: 00219533 14779137
Abitha Jacob; Jian Jing; James Lee; Pepper Schedin; Simon M. Gilbert; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Journal of Experimental Medicine, ISSN: 00221007 15409538
Adriana Soler; Helena Serra; Wayne Pearce; Ana Angulo; Julie Guillermet-Guibert; Lori S. Friedman; Francesc Viñals; Holger Gerhardt; Oriol Casanovas; Mariona Graupera; Bart Vanhaesebroeck
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Incidence of catheter-related complications in patients with central venous or hemodialysis catheters: A health care claims database analysis
BMC Cardiovascular Disorders, ISSN: 14712261
Pavel Napalkov; Diana M. Felici; Laura Chu; Joan R. Jacobs; Susan M. Begelman
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Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay
BMC Bioinformatics, ISSN: 14712105
Gregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber
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Investigation into temperature-induced aggregation of an antibody drug conjugate
Bioconjugate Chemistry, ISSN: 15204812 10431802
Nia S. Beckley; Kathlyn P. Lazzareschi; Hung-Wei Chih; Vikas Sharma; Heather Flores
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Managing technologies in a global drug substance biotech manufacturing network - A case study
Pharmaceutical Outsourcing, ISSN: 19453337
Michael Pohlscheidt; Eric Fallon; David Chang; Dan Stark; Frank Trach
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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
BMJ Open, ISSN: 20446055
Jianmei Wang; Adam Platt; Ruchi Upmanyu; Søren Germer; Guiyuan Lei; Christina Rabe; Ryma Benayed; Andrew Kenwright; Andrew Hemmings; Mitchell Martin; Olivier Harari
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Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
C. Andrew Boswell; Jan Marik; Michael J. Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Bumbaca; Victor Yip; Eduardo E. Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha N. Goriparthi; Anthony Trias; Herman S. Gill; Simon P. Williams; Jagath R. Junutula; Fielder; Leslie A. Khawli
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EGFR-activating mutations correlate with a fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity
Cancer Research, ISSN: 00085472 15387445
Heike N. Pfaäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H. Benes; Lecia V. Sequist; Lee Zou; Henning Willers
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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Yichin Liu; Yingchun Liu; Shiva Malek; David Peterson; Keith Pitts; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Ivana Yen; Qin Yue
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Xiaozhang Zheng; Kenneth W. Bair; Paul Bauer; Timm Baumeister; Krista K. Bowman; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Yezhen Feng; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Hong Li; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Justin Ly; Thomas O'Brien; Jason Oeh; Angela Oh; Dominic J. Reynolds; Deepak Sampath; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jarrod Tremayne; Leslie Wang; Weiru Wang; Zhongguo Wang; Hongxing Wu; Jiansheng Wu; Yang Xiao; Guangxing Yang; Po-Wai Yuen; Mark Zak; Peter Dragovich
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New paradigms for process validation: A practical approach
BioProcess International, ISSN: 15426319
Mire-Sluis; Vijay Chiruvolu; Kelley; Linda Ng; Reb Russell; Chiang Syin; Victor Vinci; Mats Welin; Nathan McKnight; Bob Kuhn; Christian Klock; Ranjit Deshmukh; Siddharth Advant
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Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Elizabeth M. Blackwood; Jennifer A. Epler; Ivana Yen; Michael Flagella; Thomas O'Brien; Marie Evangelista; Stephen Schmidt; Yang Xiao; Jonathan Choi; Kaska Kowanetz; Judi Ramiscal; Kenton Wong; Diana Jakubiak; Sharon Fong Yee; Cain; Lewis Gazzard; Karen Williams; Jason S Halladay; Peter K Jackson; Shiva Malek
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A dual host vector for Fab phage display and expression of native IgG in mammalian cells
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Devin B. Tesar; Isidro Hötzel
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SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Rebecca R. Pferdehirt; Barbara J. Meyer
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Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins
PLoS Pathogens, ISSN: 15537366 15537374
Wouter L. W. Hazenbos; Kimberly K. Kajihara; Richard L. Vandlen; J. Hiroshi Morisaki; Sophie M. Lehar; Mark J. Kwakkenbos; Tim Beaumont; Arjen Q. Bakker; Qui Phung; Lee R. Swem; Satish Ramakrishnan; Janice Kim; Min Xu; Ishita M. Shah; Binh An Diep; Tao Sai; Andrew Sebrell; Yana Khalfin; Angela Oh; Christopher M. Koth; S. Jack Lin; Byoung-Chul Lee; Magnus Strandh; Klaus Koefoed; Peter S. Andersen; Hergen Spits; Eric J. Brown; Man-Wah Tan; Sanjeev Mariathasan
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Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Jane Fridlyand; Richard M. Simon; Jessica C. Walrath; Roach; Richard Buller; David P. Schenkein; Keith Flaherty; Jeff D. Allen; Ellen V. Sigal; Scher
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Spray Drying of Monoclonal Antibodies: Investigating Powder-Based Biologic Drug Substance Bulk Storage
Drying Technology, ISSN: 07373937 15322300
Mayumi Bowen; Robert Turok; Maa
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Pak and Rac GTPases promote oncogenic KIT-induced neoplasms
Journal of Clinical Investigation, ISSN: 00219738 15588238
Holly Martin; Raghuveer Singh Mali; Peilin Ma; Anindya Chatterjee; Baskar Ramdas; Emily Sims; Veerendra Munugalavadla; Joydeep Ghosh; Matringly; Valeria Visconte; Ramon V. Tiu; Cornelis P. Vlaar; Suranganie Dharmawardhane; Reuben Kapur
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The anatomy of successful computational biology software
Nature Biotechnology, ISSN: 10870156 15461696
Stephen Altschul; Barry Demchak; Richard Durbin; Robert Gentleman; Martin Krzywinski; Heng Li; Anton Nekrutenko; James Robinson; Wayne Rasband; James Taylor; Cole Trapnell
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A high-throughput functional complementation assay for classification of BRCA1 missense variants
Cancer Discovery, ISSN: 21598274 21598290
Peter Bouwman; Hanneke van der Gulden; Ingrid van der Heijden; Rinske Drost; Christiaan N. Klijn; Pramudita Prasetyanti; Mark Pieterse; Ellen Wientjens; Jost Seibler; Frans B.L. Hogervorst; Jos Jonkers
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Mass spectrometry of antibody-drug conjugates in plasma and tissue in drug development
Characterization of Protein Therapeutics using Mass Spectrometry,
Surinder Kaur; Keyang Xu; Ola M. Saad; Luna Liu; Tim Slattery; Randall Dere
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Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease
Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036
Gordon; Hamzeh; Pockros; Hoop; Buikema; Korner; Terrault
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Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36-month results from two phase III trials: RISE and RIDE
Ophthalmology, ISSN: 01616420 15494713
David M. Brown; Quan Dong Nguyen; Dennis Marcus; David S. Boyer; Sunil Patel; Leonard Feiner; Patricio G. Schlottmann; Amy Chen Rundle; Jiameng Zhang; Roman G. Rubio; Anthony P. Adamis; Jason S. Ehrlich; J. Jill Hopkins
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Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Hope S. Rugo; Adam Brufsky; Marianne Ulcickas Yood; Debasish Tripathy; Peter A. Kaufman; Musa Mayer; Bongin Yoo; Oyewale Abidoye; Denise A. Yardley
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Bevacizumab confers additional advantage to the combination of trastuzumab plus pertuzumab in trastuzumab-refractory breast cancer model
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Yuliang Sun; Nandini Dey; Melissa Brammer; Pradip De; Brian R. Leyland-Jones
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In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release
Nature Medicine, ISSN: 10788956 1546170X
Richard H. Scheller
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B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Rajasekaran; Nan Wang; Hang; Macaubas; Rinderknecht; Beilhack; Shizuru; Mellins
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The structure and regulation of magnesium selective ion channels
Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736 18792642
Jian Payandeh; Roland Pfoh; Emil F. Pai
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The RosettaCon 2012 Special Collection: Code Writ on Water, Documentation Writ in Stone
PLoS ONE, ISSN: 19326203
Ingemar André; Jacob E. Corn
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Influence of tumour micro-environment heterogeneity on therapeutic response
Nature, ISSN: 00280836 14764687
Melissa Junttila; Frederic J. De Sauvage
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Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; Wei Yu Lin; Zhonghua Lin; Maria N. Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary D. Austin; Mercedesz Balazs; Merone Roose-Girma; Laura DeForge; Søren Warming; Wyne P. Lee; Vishva M. Dixit; Ali A. Zarrin
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Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies
Journal of Experimental Medicine, ISSN: 00221007 15409538
Kim; Avi Ashkenazi
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Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control
BMC Genomics, ISSN: 14712164
Emanuele De Rinaldis; Patrycja Gazinska; Anca Mera; Zora Modrusan; Grazyna Fedorowicz; Brian Burford; Cheryl Gillett; Pierfrancesco Marra; Anita Grigoriadis; David Dornan; Lars Holmberg; Sarah Pinder; Andrew Tutt
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Journal of Cell Biology, ISSN: 00219525 15408140
Sarah Huntwork-Rodriguez; Bei Wang; Trent A. Watkins; Arundhati Sengupta Ghosh; Christine D. Pozniak; Daisy J. Bustos; Kim Newton; Donald S. Kirkpatrick; Joe Lewcock
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Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Manishkumar D. Joshi; Tianhao Li; Qiqing Zhong; Jared L. Anderson
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Differential Host Response, Rather Than Early Viral Replication Efficiency, Correlates with Pathogenicity Caused by Influenza Viruses
PLoS ONE, ISSN: 19326203
Peter S. Askovich; Catherine J. Sanders; Carrie M. Rosenberger; Alan H. Diercks; Pradyot Dash; Garnet Navarro; Peter Vogel; Peter C. Doherty; Paul G. Thomas; Alan Aderem
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Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
Frontiers in Immunology, ISSN: 16643224
Yili Li; Yiyuan Yin; Roy A. Mariuzza
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Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells
Nature Immunology, ISSN: 15292908 15292916
Kamalakannan Rajasekaran; Pawan Kumar; Kristina M. Schuldt; Erik J. Peterson; Bart Vanhaesebroeck; Vishva M. Dixit; Monica S. Thakar; Subramaniam Malarkannan
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Peripherally induced Tregs-role in immune homeostasis and autoimmunity
Frontiers in Immunology, ISSN: 16643224
Mahesh Yadav; Stephen Stephan; Jeffrey A. Bluestone
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SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin
Gene, ISSN: 03781119 18790038
Mariano Oppikofer; Stephanie Kueng; Susan M. Gasser
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A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Wendy Lee; Daniel F. Ortwine; Philippe Bergeron; Kevin Lau; Lichuan Liu; Shiva Malek; Jim Nonomiya; Zhonghua Pei; Kirk D. Robarge; Stephen Schmidt; Steve Sideris; Joseph P. Lyssikatos
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