Genentech: Publications

September 15, 2013

Onartuzumab (MetMab): Using nonclinical pharmacokinetic and concentration-effect data to support clinical development

Clinical Cancer Research, ISSN: 10780432 15573265

Hong Xiang; Brendan C. Bender; Arthur Reyes; Mark Merchant; Nelson L. Shasha Jumbe; Mally Romero; Teresa Davancaze; Ihsan Nijem; Elaine Mai; Judy Young; Amy Peterson; Lisa A. Damico

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September 13, 2013

Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Christoph Spiess; Jack Bevers; Janet Jackman; Nancy Y. Chiang; Nakamura; Michael Dillon; Hongbin Liu; Patricia Molina; J. Michael Elliott; Whitney Shatz; Justin M. Scheer; Glen Giese; Josefine Persson; Yin Zhang; Dennis; James Giulianotti; Prateek Gupta; Dorothea Reilly; Enzo Palma; Jianyong Wang; Stefanich; Heleen Scheerens; Fuh; Lawren C. Wu

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September 12, 2013

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2

PLoS ONE, ISSN: 19326203

Nelson; Morgan Sheng

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September 10, 2013

Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function

PLoS ONE, ISSN: 19326203

John P. Clancy; Rhonda D. Szczesniak; Melissa A. Ashlock; Sarah E. Ernst; Lijuan Fan; Douglas B. Hornick; Philip H. Karp; Umer Khan; James Lymp; Alicia J. Ostmann; Amir Rezayat; Timothy D. Starner; Shajan P. Sugandha; Hongtao Sun; Nancy Quinney; Scott H. Donaldson; Steven M. Rowe; Sherif E. Gabriel

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September 10, 2013

Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Song-Hua Lee; Rui-Rui Wong; Chui-Yoke Chin; Tian-Yeh Lim; Su-Anne Eng; Cin Kong; Nur Afifah Ijap; Ming-Seong Lau; Mei-Perng Lim; Yunn-Hwen Gan; Fang-Lian He; Man-Wah Tan; Sheila Nathan

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September 9, 2013

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

Cancer Cell, ISSN: 18783686 15356108

Krishna P.L. Bhat; Veerakumar Balasubramaniyan; Brian Vaillant; Ravesanker Ezhilarasan; Karlijn Hummelink; Faith Hollingsworth; Khalida Wani; Lindsey Heathcock; Johanna D. James; Lindsey D. Goodman; Siobhan Conroy; Lihong Long; Nina Lelic; Suzhen Wang; Joy Gumin; Divya Raj; Yoshinori Kodama; Aditya Raghunathan; Adriana Olar; Kaushal Joshi; Christopher E. Pelloski; Amy Heimberger; SeHoon Kim; Daniel P. Cahill; Ganesh Rao; Wilfred F. A. DenDunnen; Hendrikus W.G.M. Boddeke; Phillips; Ichiro Nakano; Frederick F. Lang; Howard Colman; Erik P. Sulman; Kenneth D. Aldape

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September 9, 2013

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region

Journal of Molecular Biology, ISSN: 10898638 00222836

Kittichoat Tiyanont; Thomas E. Wales; Christian W. Siebel; John R. Engen; Stephen C. Blacklow

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September 5, 2013

CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice

Journal of Virology, ISSN: 0022538X 10985514

Kevin B. Walsh; John Sidney; Megan J. Welch; Daniel M. Fremgen; Alessandro Sette; Michael B.A. Oldstone

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September 5, 2013

A Role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway

Cell Stem Cell, ISSN: 19345909 18759777

Kai Kessenbrock; Gerrit J. P. Dijkgraaf; Devon A. Lawson; Laurie E. Littlepage; Payam Shahi; Ursula Pieper; Zena Werb

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September 4, 2013

A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb

Journal of General Physiology, ISSN: 00221295 15407748

Tamer M. Gamal El-Din; Gilbert Q. Martinez; Jian Payandeh; Todd Scheuer; William A. Catterall

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September 3, 2013

Protein microarrays for identification of novel extracellular protein-protein interactions

Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343655 19343663

Irene Tom; Nicholas Lewin-Koh; Sree R. Ramani; Lino C. Gonzalez Jr.

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September 3, 2013

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition

Oncogenesis, ISSN: 21579024

Osborne; Larsen; Gonzales; David S. Shames; Sato; Ignacio I. Wistuba; Girard; Minna; Cobb

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September 3, 2013

Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

Journal of Clinical Investigation, ISSN: 15588238 00219738

Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Anthony Lima; Stacey Yeung; Jason H. Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yin Zhang; Dennis; Jeffrey Eastham-Anderson; Adrian M. Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai H. Barck; Richard A. D. Carano; William F. Forrest; Qinghua Song; Daniel S. Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde

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September 1, 2013

Go with the flow

Innovations in Pharmaceutical Technology, ISSN: 14717204

Juan Colberg; Stefan G. Koenig; David Leahy; Peter Poechlauer

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September 1, 2013

Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Barbara J. Brennan; Sebastian A. Moreira; Peter N. Morcos; Mercidita T. Navarro; Jiney Asthappan; Petra Goelzer; Paul Weigl; Patrick F. Smith

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September 1, 2013

Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection

Journal of Separation Science, ISSN: 16159306 16159314

Kelly Zhang; Yi Li; Midco Tsang; Nik P. Chetwyn

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September 1, 2013

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Nature Immunology, ISSN: 15292908 15292916

Ansuman T. Satpathy; Carlos G. Briseño; Jacob S. Lee; Dennis Ng; Nicholas A. Manieri; Wumesh Kc; Xiaodi Wu; Stephanie R. Thomas; Wan-Ling Lee; Mustafa Turkoz; Keely G. McDonald; Matthew M. Meredith; Christina Song; Cynthia J. Guidos; Rodney D. Newberry; Wenjun Ouyang; Theresa L. Murphy; Thaddeus S. Stappenbeck; Jennifer L. Gommerman; Michel Nussenzweig; Marco Colonna; Raphael Kopan; Kenneth M. Murphy

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September 1, 2013

Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: Results from a randomized, double-blind, phase III study

Arthritis and Rheumatism, ISSN: 15290131 00043591

Eduardo F. Mysler; Alberto J. Spindler; Renato Guzman; Marc Bijl; David Jayne; Richard A. Furie; Frédéric A. Houssiau; Jorn Drappa; David Close; Romeo MacIuca; Kajal Rao; Saba Shahdad; Paul Brunetta

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September 1, 2013

Dendritic cells: master regulators of the immune response

Cancer immunology research, ISSN: 23266074

Ira Mellman

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September 1, 2013

PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma

Brain Pathology, ISSN: 10156305 17503639

Joanna J. Phillips; Derick Aranda; David W. Ellison; Alexander R. Judkins; Sidney E. Croul; Daniel J. Brat; Keith L. Ligon; Craig Horbinski; Sriram Venneti; Gelareh Zadeh; Mariarita Santi; Shengmei Zhou; Christina L. Appin; Stefano Sioletic; Lisa M. Sullivan; Maria Martinez-Lage; Aaron E. Robinson; William H. Yong; Timothy Cloughesy; Albert Lai; Phillips; Roxanne Marshall; Sabine Mueller; Daphne A. Haas-Kogan; Annette M. Molinaro; Arie Perry

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September 1, 2013

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

Nature Medicine, ISSN: 10788956 1546170X

Alicia S Chung; Xiumin Wu; Guanglei Zhuang; Hai Ngu; Ian Kasman; Jianhuan Zhang; Jean-Michel Vernes; Zhaoshi Jiang; Meng; Franklin V. Peale Jr.; Wenjun Ouyang; Napoleone Ferrara

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September 1, 2013

Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Brian S. Safina; Zachary K. Sweeney; Jun Li; Bryan K. Chan; Angelina Bisconte; Diane Carrera; Georgette M. Castanedo; Michael Flagella; Robert Heald; Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Steve Price; Karin Reif; Laurent Salphati; Eileen Seward; Binqing Wei; Daniel P. Sutherlin

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September 1, 2013

The association of cytopenias and weight loss with hepatitis C virus virologic response in HIV/HCV-coinfected patients treated with PEG-IFN and RBV

Journal of the International Association of Providers of AIDS Care, ISSN: 23259574 23259582

Jihad Slim; Donna Mildvan; Jian Han; Korner

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September 1, 2013

Comparison of standard laminectomy with an optimized ejection method for the removal of spinal cords from rats and mice

Journal of Histotechnology, ISSN: 01478885 20460236

Heather S. Kennedy; Charles Jones III; Patrick Caplazi

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September 1, 2013

Impact of MET expression on outcome in BRAFV600E/K advanced melanoma

Histopathology, ISSN: 03090167 13652559

Adrian M. Jubb; Antoni Ribas; Jeffrey A. Sosman; McArthur; Yibing Yan; Sandra Rost; Sherry Zhao; Koeppen

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September 1, 2013

Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer

Clinical Colorectal Cancer, ISSN: 15330028 19380674

Bendell; Thomas J. Ervin; David Gallinson; Jaswinder Singh; James A. Wallace; Mansoor Saleh; Marcy Vallone; See Phan; Stephen P. Hack

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September 1, 2013

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Peter Dragovich; Kenneth W. Bair; Timm Baumeister; Yen-Ching Ho; Bianca M. Liederer; Xiongcai Liu; Yongbo Liu; Thomas O'Brien; Jason Oeh; Deepak Sampath; Nicholas J. Skelton; Leslie Wang; Weiru Wang; Hongxing Wu; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng

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September 1, 2013

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Michael Siu; Richard Pastor; Wendy Liu; Kathy Barrett; Megan Berry; Wade S. Blair; Christine Chang; Jacob Z. Chen; Eigenbrot; Nico Ghilardi; Paul Gibbons; Haiying He; Christopher A. Hurley; Jane R. Kenny; S. Cyrus Khojasteh; Hoa Le; Leslie Lee; Joseph P. Lyssikatos; Steven Magnuson; Rebecca Pulk; Vickie Tsui; Ultsch; Yisong Xiao; Bing-Yan Zhu; Deepak Sampath

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September 1, 2013

A hybrid approach to achieving both marginal and conditional balances for stratification variables in sequential clinical trials

Pharmaceutical Statistics, ISSN: 15391604 15391612

Yunzhi Lin; Zheng Su

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September 1, 2013

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

European Journal of Human Genetics, ISSN: 10184813 14765438

Chuan Wang; Annika Ahlford; Tiina M. Järvinen; Gunnel Nordmark; Maija-Leena Eloranta; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Christopher Sjöwall; Heikki Julkunen; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Juha Kere; Lars Rönnblom; Ann-Christine Syvänen; Johanna K. Sandling

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September 1, 2013

Restricted access media as a streamlined approach toward on-line sample preparation: Recent advancements and applications

Journal of Separation Science, ISSN: 16159306 16159314

Samuel H. Yang; Hui Fan; Robert J. Classon; Kevin A. Schug

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September 1, 2013

Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways

Microbes and Infection, ISSN: 12864579 1769714X

Tamara Veiga-Parga; Fernanda Giménez; Sachin Mulik; Eugene Y. Chiang; Jane L. Grogan; Barry T. Rouse

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September 1, 2013

Commentary: Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C - Authors' reply

Alimentary Pharmacology and Therapeutics, ISSN: 02692813 13652036

Talal; Joanne Lafleur; Hoop; Prashant K. Pandya; Martin; Ira M. Jacobson; Jian Han; Korner

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September 1, 2013

DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues

Regulatory Peptides, ISSN: 01670115 18731686

Eric Harstad; Jonathan S. Rosenblum; Mark D. Gorrell; William E. Achanzar; Lauro Minimo; Jiangyue Wu; Laura Rosini-Marthaler; Russell Gullo; Nicole D. Ordway; Mark S. Kirby; Kristina D. Chadwick; Gregory N. Cosma; Carolyn F. Moyer

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September 1, 2013

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

Journal of Immunology, ISSN: 00221767 15506606

Sue J. Sohn; Kathy Barrett; Anne Van Abbema; Christine Chang; Pawan Bir Kohli; Hidenobu Kanda; Janice Smith; Yingjie Lai; Aihe Zhou; Birong Zhang; Wenqian Yang; Karen Williams; Calum Macleod; Christopher A. Hurley; Janusz J. Kulagowski; Nicholas Lewin-Koh; Hart S. Dengler; Adam R. Johnson; Nico Ghilardi; Mark Zak; Jun Liang; Wade S. Blair; Steven Magnuson; Lawren C. Wu

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September 1, 2013

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

Nature Chemical Biology, ISSN: 15524450 15524469

Paola Magnaghi; Roberto D'Alessio; Barbara Valsasina; Nilla Avanzi; Simona Rizzi; Daniela Asa; Fabio Gasparri; Liviana Cozzi; Ulisse Cucchi; Christian Orrenius; Paolo Polucci; Dario Ballinari; Claudia Perrera; Antonella Leone; Giovanni Cervi; Elena Casale; Yang Xiao; Wong; Daniel J Anderson; Arturo Galvani; Daniele Donati; Thomas O'Brien; Peter K Jackson; Antonella Isacchi

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September 1, 2013

High resolution reversed phase analysis of recombinant monoclonal antibodies by ultra-high pressure liquid chromatography column coupling

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X

Szabolcs Fekete; Michael W. Dong; Taylor Zhang; Davy Guillarme

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September 1, 2013

Assessing the potential cost-effectiveness of retesting IHC0, IHC1+, or FISH-negative early stage breast cancer patients for HER2 status

Cancer, ISSN: 0008543X 10970142

Louis P. Garrison Jr.; Deepa Lalla; Melissa Brammer; Joseph B. Babigumira; Bruce Wang; Edith A. Perez

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September 1, 2013

Demonstrating measurement equivalence of the electronic and paper formats of the urticaria patient daily diary in patients with chronic idiopathic urticaria

Patient, ISSN: 11781653 11781661

Emuella M. Flood; James L. Zazzali; Jennifer Devlen

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September 1, 2013

Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies

Biotechnology Progress, ISSN: 87567938 15206033

Yongping Crawford; Michelle Zhou; Zhilan Hu; John C. Joly; Snedecor; Amy Shen; Albert Gao

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September 1, 2013

Pharmaco-economic analysis of direct medical costs of metastatic colorectal cancer therapy with XELOX or modified FOLFOX-6 regimens: Implications for health-care utilization in Australia

Asia-Pacific Journal of Clinical Oncology, ISSN: 17437555 17437563

Giao Tran; Stephen P. Hack; Annette Kerr; Leanne Stokes; Peter Gibbs; Timothy Price; Carlene Todd

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September 1, 2013

Effect of cell culture medium components on color of formulated monoclonal antibody drug substance

Biotechnology Progress, ISSN: 87567938 15206033

Natarajan Vijayasankaran; Sharat Varma; Yi Yang; Melissa Mun; Silvana Arevalo; Martin Gawlitzek; Trevor E. Swartz; Lim; Feng Li; Boyan Zhang; Steven Meier; Robert Kiss

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August 31, 2013

Preface

Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry,

Stefan G. Koenig

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August 31, 2013

Scalable green chemistry: Case studies from the pharmaceutical industry

Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry,

Stefan G. Koenig

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August 31, 2013