Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6651 - 6700 OF 15217 RESULTS

Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Janet Gunzner; Bianca M. Liederer; Justin Ly; Thomas O'Brien; Angela Oh; Leslie Wang; Weiru Wang; Yang Xiao; Mark Zak; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair
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Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer
Oncogene, ISSN: 09509232 14765594
Sunaga; Kaira; Imai; Shimizu; Nakano; David S. Shames; Girard; Junichi Soh; Sato; Iwasaki; Ishizuka; Adi Gazdar; Minna; Mori
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Development and preclinical characterization of a humanized antibody targeting CXCL12
Clinical Cancer Research, ISSN: 10780432 15573265
Cuiling Zhong; Jianyong Wang; Bing Li; Hong Xiang; Ultsch; Mary Coons; Wong; Nancy Y. Chiang; Suzanna Clark; Robyn Clark; Leah Quintana; Gribling; Eric Suto; Kai H. Barck; Corpuz; Jenny Yao; Rashi Takkar; Wyne P. Lee; Lisa A. Damico; Richard A. D. Carano; Adams; Robert F. Kelley; Weiru Wang; Napoleone Ferrara
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Developing standards for breakthrough therapy designation in oncology
Clinical Cancer Research, ISSN: 10780432 15573265
Sandra J. Horning; Daniel A. Haber; Wendy K.D. Selig; S. Percy Ivy; Samantha A. Roberts; Jeff D. Allen; Ellen V. Sigal; Charles L. Sawyers
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Incorporation of physiologically based pharmacokinetic modeling in the evaluation of solubility requirements for the salt selection process: A case study using phenytoin
AAPS Journal, ISSN: 15507416
Po-Chang Chiang; Harvey Wong
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A Senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
Cancer Cell, ISSN: 18783686 15356108
Ariel Pribluda; Ela Elyada; Zoltan Wiener; Haya Hamza; RobertE. Goldstein; Moshe Biton; Ido Burstain; Yael Morgenstern; Guy Brachya; Hana Billauer; Sharon Biton; Irit Snir-Alkalay; Domagoj Vucic; Katharina Schlereth; Marco Mernberger; Thorsten Stiewe; Moshe Oren; Kari Alitalo; Eli Pikarsky; Yinon Ben-Neriah
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With a favorable side effect profile, tecfidera gains the FDA's approval: With a third oral therapy for multiple sclerosis, clinicians now have more choices to manage the devastating symptoms of the disease
Managed Care, ISSN: 10623388
Thomas Morrow
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The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells
Cancer Letters, ISSN: 03043835 18727980
Célia Rosilio; Nadia Lounnas; Marielle Nebout; Véronique Imbert; Thijs Hagenbeek; Hergen Spits; Vahid Asnafi; Rodolphe Pontier-Bres; Julie Reverso; Jean-François Michiels; Issam Ben Sahra; Fréderic Bost; Jean-François Peyron
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A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
Blood, ISSN: 15280020 00064971
Long Li; Jingli A. Zhang; Marei Dose; Hao Yuan Kueh; Ruzbeh Mosadeghi; Fotini Gounari; Ellen V. Rothenberg
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Sustainable practices in medicinal chemistry: Current state and future directions
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Marian C. Bryan; Barry Dillon; Lawrence G. Hamann; Gregory J. Hughes; Michael E. Kopach; Emily A. Peterson; Mehrnaz Pourashraf; Izzat Raheem; Paul Richardson; Daniel Richter; Helen F. Sneddon
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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Mark Merchant; Xiaolei Ma; Henry R. Maun; Zhong Zheng; Jing Peng; Mally Romero; Arthur Huang; Nai-Ying Yang; Merry C. Nishimura; Joan M. Greve; Santell; Yu-Wen Zhang; Yanli Su; Dafna W. Kaufman; Karen L Billeci; Elaine Mai; Moffat; Lim; Duenas; Phillips; Hong Xiang; Judy Young; George F. Vande Woude; Dennis; Dorothea Reilly; Ralph H. Schwall; Melissa A. Starovasnik; Lazarus; Yansura
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Small-angle neutron scattering characterization of monoclonal antibody conformations and interactions at high concentrations
Biophysical Journal, ISSN: 00063495 15420086
Eric J. Yearley; Isidro E. Zarraga; Steven J. Shire; Thomas M. Scherer; Yatin Gokarn; Norman J. Wagner; Yun Liu
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Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jae H. Chang; Emile G. Plise; Jonathan Cheong; Quynh Ho; Molly Lin
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Identification of a potential conformationally disordered mesophase in a small molecule: Experimental and computational approaches
Molecular Pharmaceutics, ISSN: 15438384 15438392
Paroma Chakravarty; Simon Bates; Leonard Thomas
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A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: Suppression of CYP3A by IL-6
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
MacHavaram; Lisa M. Almond; Amin Rostami-Hodjegan; Iain Gardner; Masoud Jamei; Suzanne Tay; Susan C. Wong; Amita Joshi; Jane R. Kenny
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Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
Nature Immunology, ISSN: 15292908 15292916
Ian A. Myles; Natalia M. Fontecilla; Patricia A. Valdez; Paul J. Vithayathil; Shruti Naik; Yasmine Belkaid; Wenjun Ouyang; Sandip K. Datta
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Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on QTc interval in healthy subjects: Results from a thorough QT study
Drug Development Research, ISSN: 02724391 10982299
Peter N. Morcos; Rohit Kulkarni; Sally Scoon; Patrick F. Smith; Barbara J. Brennan
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Barth syndrome: Cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN: 09254439 1879260X
François Gonzalvez; Marilena D'Aurelio; Marie Boutant; Aoula Moustapha; Jean-Philippe Puech; Thomas Landes; Laeticia Arnauné-Pelloquin; Guillaume Vial; Nellie Taleux; Christian Slomianny; Ronald J. Wanders; Riekelt H. Houtkooper; Pascale Bellenguer; Ian Max Møller; Eyal Gottlieb; Frederic M. Vaz; Giovanni Manfredi; Patrice X. Petit
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SM30 protein function during sea urchin larval spicule formation
Journal of Structural Biology, ISSN: 10478477 10958657
Fred Wilt; Christopher E. Killian; Lindsay Croker; Patricia Hamilton
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Corroboration of claims algorithm for second-line costs of metastatic colorectal cancer treatment with targeted agents
Journal of Medical Economics, ISSN: 13696998 1941837X
Stacey Dacosta Byfield; Elaine B. Yu; Rob Morlock; Dana Evans; April Teitelbaum
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An integrated multiple-analyte pharmacokinetic model to characterize trastuzumab emtansine (T-DM1) clearance pathways and to evaluate reduced pharmacokinetic sampling in patients with HER2-positive metastatic breast cancer
Clinical Pharmacokinetics, ISSN: 03125963 11791926
Dan Lu; Amita Joshi; Wang; Steve Olsen; Joo-Hee Yi; Ian E. Krop; Howard A. Burris; Sandhya Girish
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FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthew R. Ramsey; Catherine Wilson; Benjamin Ory; S. Michael Rothenberg; William Faquin; Alea A. Mills; Leif W. Ellisen
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Death receptor 5 agonistic antibody PRO95780: Preclinical pharmacokinetics and concentration-effect relationship support clinical dose and regimen selection
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Hong Xiang; Arthur Reyes; Stephen M. Eppler; Kelley; Lisa A. Damico
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Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis
Arthritis and Rheumatism, ISSN: 00043591 15290131
Miloslavsky; Specks; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Tchao; Viviano; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; Iklé; Brett Jepson; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; John H. Stone
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Depletion of regulatory T cells by targeting folate receptor 4 enhances the potency of a GM-CSF-secreting tumor cell immunotherapy
Clinical Immunology, ISSN: 15216616 15217035
Spencer C. Liang; Marina Moskalenko; Melinda Van Roey; Karin Jooss
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Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques
Molecular Metabolism, ISSN: 22128778
Shijie Li; Paul Kievit; Anna-Karin Robertson; Ganesh Kolumam; Xiumin Li; Karin von Wachenfeldt; Christine Valfridsson; Sherron Bullens; Ilhem Messaoudi; Lindsay Bader; Kyra J. Cowan; Amrita Kamath; Nicholas Van Bruggen; Bunting; Björn Frendéus; Kevin L. Grove
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A randomised phase i study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
Gut, ISSN: 00175749 14683288
Paul J. Rutgeerts; Richard N. Fedorak; Daan W. Hommes; Andreas Sturm; Daniel C. Baumgart; Brian Bressler; Stefan Schreiber; John C Mansfield; Marna Williams; Meina Tao Tang; Jennifer Visich; Xiaohui Wei; Mary E. Keir; Diana Luca; Dimitry Danilenko; Jackson G. Egen; Sharon O'Byrne
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Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages
Immunology and Cell Biology, ISSN: 08189641 14401711
Amitabha Chaudhuri; Nicholas S. Wilson; Becky Yang; Andres Paler Martinez; Jinfeng Liu; Catherine Zhu; Nicole Bricker; Suzana Couto; Zora Modrusan; French; James Cupp; Avi Ashkenazi
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Risk of infections in rheumatoid arthritis patients switching from anti-TNF agents to rituximab, abatacept, or another anti-TNF agent, a retrospective administrative claims analysis
Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X
Stephen S. Johnston; Adam Turpcu; Nianwen Shi; Robert Fowler; Bong-Chul Chu; Kimberly Alexander
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FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer
Cancer Biology and Therapy, ISSN: 15384047 15558576
Bora Lim; Angelique Scicchitano; Cheryl Beachler; Niraj Gusani; Nabeel Sarwani; Zhaohai Yang; Kevin Staveley-O'Carroll; Avi Ashkenazi; Chia C. Portera; Wafik S. El-Deiry
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Software for Computing and Annotating Genomic Ranges
PLoS Computational Biology, ISSN: 1553734X 15537358
Michael Lawrence; Wolfgang Huber; Hervé Pagès; Patrick Aboyoun; Marc Carlson; Robert Gentleman; Martin Morgan; Vincent J. Carey
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JUMP-C: A randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients
Hepatology, ISSN: 02709139 15273350
Pockros; Donald Jensen; Naoky Tsai; Ryan Taylor; Alnoor Ramji; Curtis Cooper; Rolland Dickson; Alan Tice; Rohit Kulkarni; John M. Vierling; Marie L. Munson; Ya-Chi Chen; Nájera; James A. Thommes
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PROPEL: A randomized trial of mericitabine plus peginterferon alpha-2a/ribavirin therapy in treatment-naïve HCV genotype 1/4 patients
Hepatology, ISSN: 02709139 15273350
Heiner Wedemeyer; Donald Jensen; Robert Herring; Peter Ferenci; Mang-Ming Ma; Stefan Zeuzem; Maribel Rodriguez-Torres; Natalie Bzowej; Pockros; John M. Vierling; David Ipe; Marie L. Munson; Ya-Chi Chen; Nájera; James A. Thommes
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Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Florian Gnad; Amy Young; Wei Zhou; Karen Lyle; Christy C. Ong; Matthew P. Stokes; Jeffrey C. Silva; Marcia Belvin; Lori S. Friedman; Koeppen; Audrey Minden; Klaus P. Hoeflich
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Expression of a dominant negative mutant innexin in identified neurons and glial cells reveals selective interactions among gap junctional proteins
Developmental Neurobiology, ISSN: 19328451 10974695
Neema Yazdani; Constantine P. Firme; Eduardo R. Macagno; Michael W. Baker
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TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma
Science Translational Medicine, ISSN: 19466234 19466242
Ryan B. Corcoran; S. Michael Rothenberg; Aaron N. Hata; Anthony C. Faber; Adriano Piris; Rosalynn M. Nazarian; Ronald D. Brown; Jason T. Godfrey; Daniel Winokur; John Walsh; Mari Mino-Kenudson; Shyamala Maheswaran; Jeffrey Settleman; Jennifer A. Wargo; Keith Flaherty; Daniel A. Haber; Jeff A. Engelman
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IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Carlene L. Zindl; Jen-Feng Lai; Yun Kyung Lee; Craig L. Maynard; Stacey N. Harbour; Wenjun Ouyang; David D. Chaplin; Casey T. Weaver
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SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition
PLoS ONE, ISSN: 19326203
Jesse E. Hanson; Hank La; Emile G. Plise; Yunghsiang Chen; Xiao Ding; Taleen Hanania; Emily V. Sabath; Vadim Alexandrov; Dani Brunner; Emer Leahy; Pascal Steiner; Lichuan Liu; Kimberly Scearce-Levie; Qiang Zhou
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Phosphorylation of threonine-19 of PSD-95 by GSK-3β isrequired for PSD-95 mobilization and long-term depression
Journal of Neuroscience, ISSN: 02706474 15292401
Nelson; Myung Jong Kim; Honor Hsin; Yelin Chen; Morgan Sheng
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The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity
Immunity, ISSN: 10747613 10974180
Yaya Wang; Iftach Shaked; Stephanie M. Stanford; Wenbo Zhou; JulieM. Curtsinger; Zbigniew Mikulski; ZacharyR. Shaheen; Genhong Cheng; Kristy Sawatzke; AmandaM. Campbell; JenniferL. Auger; Hatice Bilgic; FernandaM. Shoyama; DavidO. Schmeling; HenryH. Balfour; Kiminori Hasegawa; Andrew A. Chan; JohnA. Corbett; BryceA. Binstadt; MatthewF. Mescher; Klaus Ley; Nunzio Bottini; Erik J. Peterson
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Oncology meets immunology: The cancer-immunity cycle
Immunity, ISSN: 10747613 10974180
Daniel S. Chen; Ira Mellman
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Evidence for impaired amyloid β clearance in Alzheimer's disease
Alzheimer's Research and Therapy, ISSN: 17589193
Kristin R. Wildsmith; Monica Holley; Julie C Savage; Rebecca Skerrett; Gary E Landreth
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Histamine H3 Receptor Integrates Peripheral Inflammatory Signals in the Neurogenic Control of Immune Responses and Autoimmune Disease Susceptibility
PLoS ONE, ISSN: 19326203
Dimitry N. Krementsov; Emma H. Wall; Rebecca A. Martin; Meenakumari Subramanian; Rajkumar Noubade; Roxana Del Rio; Gary M. Mawe; Jeffrey P. Bond; Matthew E. Poynter; Elizabeth P. Blankenhorn; Cory Teuscher
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Chemoselective sp 2-sp3 cross-couplings: Iron-catalyzed alkyl transfer to dihaloaromatics
Organic Letters, ISSN: 15237060 15237052
Sushant Malhotra; Pamela S. Seng; Stefan G. Koenig; Alan Deese; Kevin A. Ford
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An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies
Cell Host and Microbe, ISSN: 19346069 19313128
Nakamura; Ning Chai; Summer Park; Nancy Y. Chiang; Zhonghua Lin; Chiu; Rina Fong; Donghong Yan; Janice Kim; Juan Zhang; Wyne P. Lee; Alberto Estevez; Mary Coons; Min Xu; Patrick J. Lupardus; Mercedesz Balazs; Lee R. Swem
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Trisulfide modification impacts the reduction step in antibody-drug conjugation process
Bioconjugate Chemistry, ISSN: 15204812 10431802
Katherine Cumnock; Timothy Tully; Christopher Cornell; Matthew Hutchinson; Gorrell; Ken Skidmore; Yan Chen; Fred Jacobson
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Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis
PLoS ONE, ISSN: 19326203
Alvin Gogineni; Maresa Caunt; Ailey Crow; Chingwei V. Lee; Fuh; Nicholas Van Bruggen; Weilan Ye; Robby M. Weimer
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Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hao Chen; John B.B. Ridgway; Tao Sai; Joyce Lai; Søren Warming; Hanying Chen; Merone Roose-Girma; Gu Zhang; Weinian Shou; Minhong Yan
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Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States
Molecular Vision, ISSN: 10900535
Louis R. Pasquale; Stephanie J. Loomis; Robert N. Weinreb; Jae H. Kang; Brian L. Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; William K. Scott; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Brian W. Kunkle; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Janey L. Wiggs
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A phase II study of sorafenib (BAY 43-9006) in recurrent diffuse large B cell lymphoma: An eastern cooperative oncology group study (E1404)
Journal of Hematology and Oncology, ISSN: 17568722
Daniel R. Greenwald; Hailun Li; Selina M. Luger; Ronald S. Go; David King; Taral Patel; Randy D. Gascoyne; Jill Kolesar; Brad Kahl; Sandra J. Horning
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