Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7101 - 7150 OF 16605 RESULTS

January 1, 2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

January 1, 2015

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress, ISSN: 15206033 87567938

Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu

January 1, 2015

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron

January 1, 2015

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li

January 1, 2015

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina

January 1, 2015

Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis

Journal of Managed Care Pharmacy, ISSN: 10834087

Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher

January 1, 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, ISSN: 15928721 03906078

Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski

January 1, 2015

Performance bounds for particle filters using the optimal proposal

Monthly Weather Review, ISSN: 15200493 00270644

Chris Snyder; Thomas Bengtsson; Mathias Morzfeld

January 1, 2015

Using lysine-reactive fluorescent dye for surface characterization of a mAb

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ming Lei; Kao; Christian Schöneich

January 1, 2015

Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh

January 1, 2015

Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

Oncologist, ISSN: 1549490X 10837159

Shidong Jia; Liangxuan Zhang; Gary J. Latham

January 1, 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

January 1, 2015

Cell-specific aptamer characterization

Aptamers Selected by Cell-SELEX for Theranostics,

Tao Chen; Cuichen Wu; Weihong Tan

January 1, 2015

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system

Journal of Managed Care Pharmacy, ISSN: 10834087

Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel

January 1, 2015

New HPLC systems and products introduced at Pittcon 2015: A brief review

LC-GC Europe, ISSN: 14716577

Michael W. Dong

January 1, 2015

miRNAs in Transitions: EMT, MET, and EndoMT

MicroRNA in Regenerative Medicine,

Sato; David S. Shames; Yoshinori Hasegawa

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric W. Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N Kinch; Nick V Grishin; Peter M. Haverty; Bernard Chow; Julian S Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Stromal infrastructure of the lymph node and coordination of immunity

Trends in Immunology, ISSN: 14714981 14714906

Jonathan Chang; Shannon J. Turley

January 1, 2015

Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells

Receptor Tyrosine Kinases: Methods and Protocols, ISSN: 10643745

Inhee Chung; Ira Mellman

January 1, 2015

Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins

Methods in Enzymology, ISSN: 15577988 00766879

Jun Liu; Sandeep Yadav; Andya; Barthélemy Demeule; Steven J. Shire

January 1, 2015

Cytokines

Rheumatology: Sixth Edition,

John J. O'Shea; Massimo Gadina; Richard M. Siegel; Joshua Farber

January 1, 2015

Biosimilars in rheumatology

Rheumatology: Sixth Edition,

Jeffrey N. Siegel

January 1, 2015

Principles and techniques in molecular biology

Rheumatology: Sixth Edition,

Elaine F. Remmers; Michael J. Ombrello; Richard M. Siegel

January 1, 2015

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice

Gastroenterology, ISSN: 15280012 00165085

Nikè V.J.A. Büller; Sanne L. Rosekrans; Ciara Metcalfe; Jarom Heijmans; Willemijn A. Van Dop; Evelyn Fessler; Marnix Jansen; Christina Ahn; Jacqueline L.M. Vermeulen; B. Florien Westendorp; Els C. Robanus-Maandag; G. Johan Offerhaus; Jan Paul Medema; Geert R.A.M. D'Haens; Manon E. Wildenberg; Frederic J. De Sauvage; Vanesa Muncan; Gijs R. Van Den Brink

January 1, 2015

DUBs, the regulation of cell identity and disease

Biochemical Journal, ISSN: 14708728 02646021

Johanna Heideker; Ingrid E. Wertz

January 1, 2015

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses

OncoImmunology, ISSN: 2162402X 21624011

Robert J. Johnston; Xin Yu; Jane L. Grogan

January 1, 2015

Separation science in drug development, Part 2: High‑throughput characterization

LC-GC Europe, ISSN: 14716577

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

TRPA1 as a drug target - Promise and challenges

Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN: 14321912 00281298

Jun Chen; David Hackos

January 1, 2015

Effects of copper on CHO cells: Cellular requirements and product quality considerations

Biotechnology Progress, ISSN: 15206033 87567938

Inn H. Yuk; Stephen Russell; Yun Tang; Wei-Ting Hsu; Brad Mauger; Rigzen P. S. Aulakh; Jun Luo; Martin Gawlitzek; John C. Joly

January 1, 2015

p21-activated kinase 2 regulates endothelial development and function through the Bmk1/Erk5 pathway

Molecular and Cellular Biology, ISSN: 10985549 02707306

Maria Radu; Karen Lyle; Klaus P. Hoeflich; Olga Villamar-Cruz; Koeppen; Jonathan Chernoff

January 1, 2015

Group I Paks as therapeutic targets in NF2-deficient meningioma

Oncotarget, ISSN: 19492553

Hoi Yee Chow; Biao Dong; Sergio G. Duron; David Campbell; Christy C. Ong; Klaus P. Hoeflich; Long-Sheng Chang; D. Bradley Welling; Zeng-Jie Yang; Jonathan Chernoff

January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

January 1, 2015

Orchestrating high-throughput genomic analysis with Bioconductor

Nature Methods, ISSN: 15487105 15487091

Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc Carlson; Benilton S. Carvalho; Hector Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; Raphael Gottardo; Florian Hahne; Kasper D. Hansen; Rafael A. Irizarry; Michael Lawrence; Michael I. Love; James MacDonald; Valerie Obenchain; Andrzej K. Oles̈; Hervé Pagès; Alejandro Reyes; Paul Shannon; Gordon K. Smyth; Dan Tenenbaum; Levi Waldron; Martin Morgan

January 1, 2015

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Immunity, ISSN: 10974180 10747613

Natalia B. Pikor; Jillian L. Astarita; Leslie Summers-Deluca; Georgina Galicia; Joy Qu; Lesley A. Ward; Susan Armstrong; Claudia X. Dominguez; Deepali Malhotra; Brendan Heiden; Robert Kay; Valera Castanov; Hanane Touil; Louis Boon; Paul O'Connor; Amit Bar-Or; Alexandre Prat; Valeria Ramaglia; Samuel Ludwin; Shannon J. Turley; Jennifer L. Gommerman

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