Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7401 - 7450 OF 15217 RESULTS

Protein microarrays, biosensors, and cell-based methods for secretome-wide extracellular protein-protein interaction mapping
Methods, ISSN: 10462023 10959130
Lino C. Gonzalez Jr.
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Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
American Journal of Neuroradiology, ISSN: 01956108 1936959X
Jose A. Carrillo; Albert Lai; Phioanh L. Nghiemphu; Kim; Phillips; Samir Kharbanda; Moftakhar; Lalaezari; William H. Yong; Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope
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Overcoming soluble target interference in an anti-therapeutic antibody screening assay for an antibody-drug conjugate therapeutic
Bioanalysis, ISSN: 17576180 17576199
Montserrat Carrasco-Triguero; Connie Mahood; Marija Milojic-Blair; Caroline Amaya; Jane Ruppel; Kyu Hong; Joo-Hee Yi; Surinder Kaur
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Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: The phase III FILM trial
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Stohl W.; Juan Gomez-Reino; Ewa Olech; Jean Dudler; Roy Fleischmann; Cristiano A. F. Zerbini; Ashrafzadeh; Susanna M. Grzeschik; Rebecca Bieraugel; Jennifer Green; Steve Francom; Wolfgang Dummer
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DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis, ISSN: 08936692 10982280
Xiao Zhang; Andrew D. Wallace; Pan Du; Warren A. Kibbe; Nadereh Jafari; Hehuang Xie; Simon Lin; Andrea A. Baccarelli; Marcelo Bento Soares; Lifang Hou
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Pcadmix: Principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations
Human Biology, ISSN: 00187143 15346617
Abra Brisbin; Katarzyna Bryc; Jake Byrnes; Fouad Zakharia; Larsson Omberg; Jeremiah D. Degenhardt; Andy Reynolds; Harry Ostrer; Jason G. Mezey; Carlos D. Bustamante
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Validation of a tool to assess medication treatment satisfaction in patients with Type2 diabetes: The Diabetes Medication System Rating Questionnaire (DMSRQ)
Diabetic Medicine, ISSN: 07423071 14645491
Peyrot; Harshaw; Shillington; Yaping Xu; Rubin
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Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting
FASEB Journal, ISSN: 08926638 15306860
Laetitia Comps-Agrar; Julie Kniazeff; Arsten Brock; Eric Trinquet; Jean-Philippe Pin
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Longitudinal changes in asthma control with omalizumab: 2-year interim data from the EXCELS study
Journal of Asthma, ISSN: 02770903 15324303
Mark D. Eisner; James L. Zazzali; Mary K. Miller; Mary S. Bradley; Michael Schatz
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Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
Journal of Pathology, ISSN: 00223417 10969896
Alicia S Chung; Marcin Kowanetz; Xiumin Wu; Guanglei Zhuang; Hai Ngu; David Finkle; László Kömüves; Franklin V. Peale Jr.; Napoleone Ferrara
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Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Nature Neuroscience, ISSN: 10976256 15461726
Erik Mire; Cecilia Mezzera; Eduardo Leyva-Diáz; Ana V. Paternain; Paola Squarzoni; Lisa Bluy; Mar Castillo-Paterna; María José López; Sandra Peregrín; Marc Tessier-Lavigne; Sonia Garel; Joan Galcerán; Juan Lerma; Guillermina López-Bendito
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Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: An open-label, multiple-dose, randomized, crossover study
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Georgina Cirrincione-Dall; Barbara J. Brennan; Rosa M. Ballester-Sanchis; Mercidita T. Navarro; Brian E. Davies
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Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin
Hepatology, ISSN: 02709139 15273350
Stephen A. Harrison; Hamzeh; Jian Han; Prashant K. Pandya; Muhammed Y. Sheikh; John M. Vierling
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The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
Protein Science, ISSN: 09618368 1469896X
Christian N. Cunningham; Daniel R. Southworth; Kristin A. Krukenberg; David A. Agard
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Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Manoli Vourvahis; John Davis; Rong Wang; Gary Layton; Heng Wee Choo; Chew Lan Chong; Margaret Tawadrous
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An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
Aging Cell, ISSN: 14749718 14749726
Kwame Twumasi-Boateng; Tim W. Wang; Linda Tsai; Kuang-Hui Lee; Ali Salehpour; Sudarshan Bhat; Man-Wah Tan; Michael Shapira
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Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function
Methods in Molecular Biology, ISSN: 10643745
Robert F. Kelley; Meng
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Identification of Asp isomerization in proteins by 18O labeling and tandem mass spectrometry
Methods in Molecular Biology, ISSN: 10643745
Jennifer Zhang; Viswanatham Katta
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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Nature, ISSN: 00280836 14764687
Wilson; Jane Fridlyand; Yibing Yan; Elicia M. Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P. Sutherlin; Koeppen; Mark Merchant; Richard M. Neve; Jeffrey Settleman
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The development of small-molecule IAP antagonists for the treatment of cancer
Topics in Medicinal Chemistry, ISSN: 18622461 1862247X
Deshayes; Jeremy Murray; Domagoj Vucic
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Inefficiency of randomization methods that balance on stratum margins and improvements with permuted blocks and a sequential method
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
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Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Anuj Chaudhri; Isidro E. Zarraga; Tim J. Kamerzell; J. Paul Brandt; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth
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CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Blood, ISSN: 15280020 00064971
Sebastian Willenborg; Tina Lucas; Geert Van Loo; Johanna A. Knipper; Thomas Krieg; Ingo Haase; Bent Brachvogel; Matthias Hammerschmidt; Andras Nagy; Napoleone Ferrara; Manolis Pasparakis; Sabine A. Eming
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Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Blood, ISSN: 15280020 00064971
Pichika Chantrathammachart; Nigel Mackman; Erica Sparkenbaugh; Jian-Guo Wang; Leslie V. Parise; Daniel Kirchhofer; Nigel S. Key; Rafal Pawlinski
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GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death In Vitro and In Vivo
Clinical Cancer Research, ISSN: 10780432 15573265
Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Leslie Lee; Berry; Lisa D. Belmont; Koeppen; Marcia Belvin; Lori S. Friedman; Deepak Sampath
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Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
Cancer Research, ISSN: 00085472 15387445
Meilan He; Wei Zhang; Thomas Bakken; Melissa Schutten; Zsolt Toth; Jae U. Jung; Parkash Gill; Mark Cannon; Shou-Jiang Gao
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Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
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The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Youjun Chen; Cecile Chalouni; Christine Tan; Robyn Clark; Rayna Venook; Rachana Ohri; Helga Raab; Ron Firestein; William Mallet; Paul G. Polakis
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Structure and conservation of the periplasmic targeting factor Tic22 protein from plants and cyanobacteria
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Joanna Tripp; Alexander Hahn; Patrick Koenig; Nadine Flinner; Daniela Bublak; Eva M. Brouwer; Franziska Ertel; Oliver Mirus; Irmgard Sinning; Ivo Tews; Enrico Schleiff
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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Rohan Mendonca; Mercedesz Balazs; Kathy Barrett; Philippe Bergeron; Wade S. Blair; Christine Chang; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Chris Hamman; Emily J. Hanan; Eric Harstad; Peter R. Hewitt; Christopher A. Hurley; Tian Jin; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Janusz J. Kulagowski; Sharada Labadie; Jiangpeng Liao; Marya Liimatta; Zhonghua Lin; Patrick J. Lupardus; Robert J. Maxey; Jeremy Murray; Rebecca Pulk; Madeleine Rodriguez; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Ling Xiao; Yisong Xiao
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique Aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Journal of Neuroscience, ISSN: 02706474 15292401
Oskar Adolfsson; Maria Pihlgren; Nicolas Toni; Yvan Varisco; Anna Lucia Buccarello; Katia Antoniello; Sophie Lohmann; Kasia Piorkowska; Valerie Gafner; Jasvinder K. Atwal; Janice Maloney; Mark Chen; Alvin Gogineni; Robby M. Weimer; Deborah L. Mortensen; Michel Friesenhahn; Carole Ho; Robert Paul; Andrea Pfeifer; Andreas Muhs; Ryan J. Watts
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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth
Cancer Cell, ISSN: 18783686 15356108
Nicholas S. Wilson; Annie Yang; Becky Yang; Suzana Couto; Howard M. Stern; Alvin Gogineni; Pitti; Scot A. Marsters; Robby M. Weimer; Mallika Singh; Avi Ashkenazi
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Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Taejin Yoon; Henriette Macmillan; Sarah E. Mortimer; Wei Jiang; Rinderknecht; Lawrence J. Stern; Mellins
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PiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Cell, ISSN: 10974172 00928674
Alyson Ashe; Alexandra Sapetschnig; Eva-Maria Weick; Jacinth Mitchell; Marloes P. Bagijn; Amy C. Cording; Anna-Lisa Doebley; Leonard D. Goldstein; Nicolas J. Lehrbach; Jérémie Le Pen; Greta Pintacuda; Aisa Sakaguchi; Peter Sarkies; Shawn Ahmed; Eric A. Miska
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A conserved role of IQGAP1 in regulating TOR complex 1
Journal of Cell Science, ISSN: 00219533 14779137
Yemsrach K. Tekletsadik; Robert Sonn; Mahasin A. Osman
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Weak interactions govern the viscosity of concentrated antibody solutions: High-throughput analysis using the diffusion interaction parameter
Biophysical Journal, ISSN: 00063495 15420086
Brian D. Connolly; Chris Petry; Sandeep Yadav; Barthélemy Demeule; Natalie Ciaccio; Jamie M. R. Moore; Steven J. Shire; Yatin Gokarn
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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Journal of Clinical Investigation, ISSN: 00219738 15588238
Azeb Tadesse Argaw; Linnea Asp; Jingya Zhang; Kristina Navrazhina; Trinh Pham; John N. Mariani; Sean Mahase; Dipankar J. Dutta; Jeremy Seto; Elisabeth G. Kramer; Napoleone Ferrara; Michael V. Sofroniew; Gareth R. John
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Considerations in the development of circulating tumor cell technology for clinical use
Journal of Translational Medicine, ISSN: 14795876
David R. Parkinson; Nicholas Dracopoli; Brenda G. Petty; Carolyn Compton; Massimo Cristofanilli; Albert Deisseroth; Daniel F. Hayes; Gordon Kapke; Prasanna Kumar; Jerry S.H. Lee; Minetta C. Liu; Robert McCormack; Stanislaw Mikulski; Larry Nagahara; Klaus Pantel; Sonia Pearson-White; Elizabeth A. Punnoose; Lori T. Roadcap; Andrew E. Schade; Scher; Caroline C. Sigman; Gary J. Kelloff
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A novel method to calculate mean survival time for time-to-event data
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Zheng Su; Liang Fang
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Reply to "On the differentiation of mouse IgE + cells"
Nature Immunology, ISSN: 15292908 15292916
Oezcan Talay; Donghong Yan; Hans D. Brightbill; Elizabeth E. M. Straney; Meijuan Zhou; Ena Ladi; Wyne P. Lee; Jackson G. Egen; Cary D. Austin; Min Xu; Lawren C. Wu
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Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Gregory Z. Ferl; Ruediger E. Port
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Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity
Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851
Meng-Yun Chou; Cary D. Austin; Kim
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC
Nature Immunology, ISSN: 15292908 15292916
Jianming Xie; Johannes B. Huppa; Evan W. Newell; Jun Huang; Peter J. R. Ebert; Qi-Jing Li; Mark M. Davis
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Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Clement L. Ren; Michael W. Konstan; Ashley Yegin; Lawrence Rasouliyan; Benjamin L. Trzaskoma; Morgan; Warren E. Regelmann
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Antibodies against the gh/gl/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (Anti-CMV) neutralizing antibody response in CMV hyperimmune globulin
Journal of Virology, ISSN: 0022538X 10985514
Ashley Fouts; Pamela Chan; Jean-Philippe Stephan; Richard L. Vandlen; Becket Feierbach
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The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients
British Journal of Pharmacology, ISSN: 00071188 14765381
Andrew G. Polson; Reina N. Fuji
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Androgen hormone action in prostatic carcinogenesis: Stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis
Carcinogenesis, ISSN: 01433334 14602180
Emily A. Ricke; Karin Williams; Yi-Fen Lee; Suzana Couto; Yuzhuo Wang; Simon W. Hayward; Gerald R. Cunha; William A. Ricke
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Ultrasensitive detection of cellular protein interactions using bioluminescence resonance energy transfer quantum dot-based nanoprobes
Journal of Cellular Biochemistry, ISSN: 07302312 10974644
Gabriel Quinones; Steven C. Miller; Sukanta Bhattacharyya; Daniel Sobek; Jean-Philippe Stephan
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The effect of fellow eye visual acuity on visual acuity of study eyes receiving ranibizumab for age-related macular degeneration
Retina, ISSN: 0275004X 15392864
Sandrine A. Zweifel; Namrata Saroj; Howard Shapiro; K. Bailey Freund
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Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans
mAbs, ISSN: 19420862 19420870
Marcella Yu; Darren Brown; Chae Reed; Shan Chung; Jeff Lutman; Stefanich; Anne Wong; Jean-Philippe Stephan; Robert Bayer
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