Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7651 - 7700 OF 15217 RESULTS

March 1, 2012

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Cinthia V Pastuskovas; Eduardo E. Mundo; Simon P. Williams; Tapan K. Nayak; Jason Ho; Sheila Ulufatu; Suzanna Clark; Ross; Eric Cheng; Kathryn Parsons; Cain; Marjie Van Hoy; Nicholas Majidy; Sheila Bheddah; Josefa Chuh; Katherine R. Kozak; Nicholas Lewin-Koh; Peter Nauka; Daniela Bumbaca; Mark X. Sliwkowski; Jay Tibbitts; Frank-Peter Theil; Fielder; Leslie A. Khawli; C. Andrew Boswell

March 1, 2012

P21-Activated kinase inhibitors: A patent review

Expert Opinion on Therapeutic Patents, ISSN: 13543776 17447674

James J. Crawford; Klaus P. Hoeflich; Joachim Rudolph

March 1, 2012

A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis

Pediatric Pulmonology, ISSN: 87556863 10990496

Michael S. Stalvey; Ran D. Anbar; Michael W. Konstan; Joan R. Jacobs; Bert Bakker; Barbara M. Lippe; David E. Geller

March 1, 2012

Neogenin regulates sonic hedgehog pathway activity during digit patterning

Developmental Dynamics, ISSN: 10588388 10970177

Mingi Hong; Karen A. Schachter; Guoying Jiang; Robert S. Krauss

February 28, 2012

An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo

PLoS ONE, ISSN: 19326203

Cleopatra Kozlowski; Robby M. Weimer

February 27, 2012

Handling of tautomerism and stereochemistry in compound registration

Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596

Alberto Gobbi; Man-Ling Lee

February 27, 2012

Handling of tautomerism and stereochemistry in compound registration

Journal of Chemical Information and Modeling, ISSN: 15499596 15205142

Alberto Gobbi; Man-Ling Lee

February 26, 2012

Genetic models of sensorimotor gating: Relevance to neuropsychiatric disorders

Current Topics in Behavioral Neurosciences, ISSN: 18663389 18663370

Susan Powell; Martin Weber; Mark A. Geyer

February 24, 2012

Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Shi-Xiong Tan; Ng; Christopher C. Meoli; Ansu Kumar; Poh-Sim Khoo; Daniel J. Fazakerley; Jagath R. Junutula; Shireen Vali; David E. James; Jacqueline Stöckli

February 17, 2012

Engineering upper hinge improves stability and effector function of a human IgG1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Boxu Yan; Daniel Boyd; Timothy Kaschak; Joni Tsukuda; Amy Shen; Yuwen L. Lin; Shan Chung; Priyanka Gupta; Amrita Kamath; Anne Wong; Jean-Michel Vernes; Meng; Klara Totpal; Gabriele Schaefer; Guoying Jiang; Bartek Nogal; Craig Emery; Vanderlaan; Paul J. Carter; Reed J. Harris; Ashraf Amanullah

February 17, 2012

TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers

Cell, ISSN: 10974172 00928674

Anurag Singh; Michael F. Sweeney; Min Yu; Alexa Burger; Patricia Greninger; Cyril H. Benes; Daniel A. Haber; Jeffrey Settleman

February 17, 2012

Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization

Journal of Chromatography A, ISSN: 00219673 18733778

Jace Fogle; Josefine Persson

February 17, 2012

Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. I. Mechanistic evaluation

Journal of Chromatography A, ISSN: 00219673 18733778

Jace Fogle; Nina Mohan; Eric Cheung; Josefine Persson

February 16, 2012

A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome

BMC Pulmonary Medicine, ISSN: 14712466

Peter E. Morris; Jay S. Steingrub; Bee Y. Huang; Shamay Tang; Patrick Liu; Peter R. Rhode; Hing C. Wong

February 15, 2012

Exploring racial differences in outcome and treatment for metastatic colorectal cancer: Results from a large prospective observational cohort study (BRiTE)

Cancer, ISSN: 0008543X 10970142

Blase Polite; Amy Sing; Daniel J. Sargent; Grothey; Jordan Berlin; Kozloff; Shibao Feng

February 14, 2012

Death Receptors DR6 and TROY Regulate Brain Vascular Development

Developmental Cell, ISSN: 15345807 18781551

Stephen Tam; David L. Richmond; Joshua S. Kaminker; Zora Modrusan; Baby Martin-McNulty; Tim C. Cao; Robby M. Weimer; Richard A. D. Carano; Nicholas Vanbruggen; Ryan J. Watts

February 14, 2012

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Johanna I. Partanen; Topi A. Tervonen; Mikko Myllynen; Essi Lind; Misa Imai; Pekka Katajisto; Gerrit J. P. Dijkgraaf; Panu E. Kovanen; Tomi P. Mäkelä; Zena Wer; Juha Klefström

February 9, 2012

Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats

Brain Research, ISSN: 00068993 18726240

Wei-Li Chang; Martin Weber; Michelle R. Breier; Richard L. Saint Marie; Samantha R. Hines; Neal R. Swerdlow

February 7, 2012

Global kinetic analysis of proteolysis via quantitative targeted proteomics

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Nick Agard; Sami Mahrus; Jonathan C. Trinidad; Aenoch Lynn; Alma Burlingame; James A. Wells

February 1, 2012

Phosphorylation-dependent activity of the deubiquitinase DUBA

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Oscar W Huang; Xiaolei Ma; Jianping Yin; Jeremy Flinders; Till Maurer; Nobuhiko Kayagaki; Qui Phung; Ivan Bosanac; David Arnott; Vishva M. Dixit; Sarah G. Hymowitz; Melissa A. Starovasnik; Andrea G Cochran

February 1, 2012

A risk-based approach to transferring a mature biopharmaceutical process

BioPharm International, ISSN: 1542166X 19391862

Jean Harms; Purav Dave

February 1, 2012

Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Yazici; Jeffrey R. Curtis; Ince; Baraf; Raymond L. Malamet; Lichen L. Teng; Arthur Kavanaugh

February 1, 2012

Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis

Current Opinion in Genetics and Development, ISSN: 0959437X 18790380

Robert Yauch; Jeffrey Settleman

February 1, 2012

Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Journal of Clinical Investigation, ISSN: 00219738 15588238

A. Phillip Owens III; Freda H. Passam; Silvio Antoniak; Stephanie M. Marshall; Allison L. McDaniel; Lawrence Rudel; Julie C. Williams; Brian K. Hubbard; Julie-Ann Dutton; Jian-Guo Wang; Peter S. Tobias; Linda K. Curtiss; Alan Daugherty; Daniel Kirchhofer; James P. Luyendyk; Patrick M. Moriarty; Shanmugam Nagarajan; Barbara C. Furie; Bruce Furie; Douglas G. Johns; Ryan E. Temel; Nigel Mackman

February 1, 2012

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation

Journal of Virology, ISSN: 0022538X 10985514

Sungyong Won; Celine Eidenschenk; Carrie N. Arnold; Owen M. Siggs; Lei Sun; Katharina Brandl; Tina-Marie Mullen; Glen R. Nemerow; Eva Marie Y. Moresco; Bruce Beutler

February 1, 2012

Cost-effectiveness of adding rituximab to fludarabine and cyclophosphamide for the treatment of previously untreated chronic lymphocytic leukemia

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Ashwini Shewade; Susan Lerner; Mark Friedmann; Leona Han; Hialy Gutierrez; Sacha Satram-Hoang; Michael J. Keating

February 1, 2012

Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

James L. Zazzali; Michael S. Broder; Eunice Chang; Melvin W. Chiu; Daniel J. Hogan

February 1, 2012

Pharmacokinetic effects of coadministration of lersivirine with raltegravir or maraviroc in healthy subjects

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Manoli Vourvahis; Grant Langdon; Robert R. LaBadie; Gary Layton; Marie-Noella Ndongo; Subhashis Banerjee; John Davis

February 1, 2012

Purification and characterization of novel sperm motility-related proteins

Protein Purification,

Gopal C. Majumder; Kaushik Das; Sudipta Saha; Debjani Nath; Arunima Maiti; Sujoy Das; Nabina Dey; Saswati Banerjee; Madhabi Barua; Mahitosh Mandal; Bijay S. Jaiswal; Rupamanjari Biswas; Arpita Bhoumik; Debarun Roy; Souvik Dey; Jharna Som; Debdas Bhattacharyya; Sandhya Rekha Dungdung

February 1, 2012

Targeting IAP proteins for therapeutic intervention in cancer

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Fulda; Domagoj Vucic

February 1, 2012

Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

William F. Rigby; Tony; Oelke; Bernard Combe; Laster; Von Muhlen; Fisheleva; Carmen Martin; Travers; Wolfgang Dummer

February 1, 2012

Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

Paul P. Tak; Philip J. Mease; Mark C. Genovese; Joel M. Kremer; Haraoui; Tanaka; Bingham; Ashrafzadeh; Travers; Safa-Leathers; Kumar; Wolfgang Dummer

February 1, 2012

Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: Pharmacogenetic implications

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Laetitia Dahan; Joseph Ciccolini; Alexandre Evrard; Litaty Mbatchi; Jay Tibbitts; Pauline Ries; Emmanuelle Norguet; Cedric Mercier; Athanassios Iliadis; L'Houcine Ouafik; Bruno Lacarelle; Jean-Francois Seitz

February 1, 2012

Monoclonal antibodies: What are the pharmacokinetic and pharmacodynamic considerations for drug development?

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607

Rong Deng; Feng Jin; Saileta Prabhu; Suhasini Iyer

February 1, 2012

Characterization of nonrapid virologic response patients infected with HCV genotype 1 who may relapse after standard therapy with peginterferon plus ribavirin

Journal of Viral Hepatitis, ISSN: 13520504 13652893

Reau; Hamzeh; Lentz; Zhou; Donald Jensen

February 1, 2012

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates

Journal of Biomolecular Screening, ISSN: 10870571 1552454X

Yichin Liu; Beresini; Adam R. Johnson; Robert Mintzer; Kinjalkumar Shah; Clark; Stephen Schmidt; Lewis; Marya Liimatta; Linda O. Elliott; Amy Gustafson; Christopher E. Heise

February 1, 2012

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

Nature Cell Biology, ISSN: 14657392 14764679

Nevena V. Dimova; Nathaniel A. Hathaway; Byung-Hoon Lee; Donald S. Kirkpatrick; Marie Lea Berkowitz; Steven P. Gygi; Daniel Finley; Randall W. King

February 1, 2012

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development (Cambridge), ISSN: 09501991 14779129

Kelli L. VanDussen; Alexis J. Carulli; Theresa M. Keeley; Sanjeevkumar R. Patel; Brent J. Puthoff; Scott T. Magness; Ivy T. Tran; Ivan Maillard; Christian W. Siebel; Åsa Kolterud; Ann S. Grosse; Deborah L. Gumucio; Stephen A. Ernst; Yu-Hwai Tsai; Peter J. Dempsey; Linda C. Samuelson

January 31, 2012

Thermodynamics of coupled folding in the interaction of archaeal RNase P proteins RPP21 and RPP29

Biochemistry, ISSN: 00062960 15204995

Yiren Xu; Sri Vidya Oruganti; Venkat Gopalan; Mark P. Foster

January 30, 2012

Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus

Brain Research, ISSN: 00068993 18726240

Joel C. Selcher; Weifeng Xu; Jesse E. Hanson; Robert C. Malenka; Daniel V. Madison

January 24, 2012

Oncogene addiction

Current Biology, ISSN: 09609822

Jeffrey Settleman

January 23, 2012

A guide to rational dosing of monoclonal antibodies

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Shuang Bai; Karin Jorga; Yan Xin; Denise Jin; Zheng; Lisa A. Damico; Manish Gupta; Meina Tao Tang; David E. Allison; Dan Lu; Yi Zhang; Amita Joshi; Mark J. Dresser

January 22, 2012

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Nature Medicine, ISSN: 1546170X 10788956

Clara Montagut; Alba Dalmases; Beatriz Bellosillo; Marta Crespo; Silvia Pairet; Mar Iglesias; Marta Salido; Manuel Gallen; Scot A. Marsters; Siao Ping Tsai; André Minoche; Somasekar Seshagiri; Sergi Serrano; Heinz Himmelbauer; Joaquim Bellmunt; Ana Rovira; Jeffrey Settleman; Francesc Bosch; Joan Albanell

January 22, 2012

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Nature Biotechnology, ISSN: 15461696 10870156

Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula

January 19, 2012

Heteroarylation of azine N-oxides

Organic Letters, ISSN: 15237052 15237060

Francis Gosselin; Scott Savage; Nicole Blaquiere; Steven T. Staben

January 17, 2012

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

Developmental Cell, ISSN: 15345807 18781551

Linda N. Geng; Zizhen Yao; Lauren Snider; Abraham P. Fong; Jennifer N. Cech; Janet M. Young; Silvere M. vanderMaarel; Walter L. Ruzzo; Robert Gentleman; Rabi Tawil; Stephen J. Tapscott

January 16, 2012

NMDA receptors and BAX are essential for Aβ impairment of LTP

Scientific Reports, ISSN: 20452322

Kimberly Moore Olsen; Morgan Sheng

January 16, 2012

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

NeuroImage, ISSN: 10538119 10959572

Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope; Taryar M. Zaw; Phillips; Shadi Lalezari; Phioanh L. Nghiemphu; Hassana Ibrahim; Kourosh M. Naeini; Robert J. Harris; Albert Lai

January 15, 2012

A secreted protein microarray platform for extracellular protein interaction discovery

Analytical Biochemistry, ISSN: 10960309 00032697

Sree R. Ramani; Irene Tom; Nicholas Lewin-Koh; Bernd Wranik; Laura DePalatis; Jianjun Zhang; Dan L. Eaton; Lino C. Gonzalez Jr.

January 15, 2012

Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Baselga; Javier Cortés; Sung-Bae Kim; Seock-Ah Im; Roberto Hegg; Im; Laslo Roman; José Luiz Pedrini; Tadeusz Pienkowski; Adam Knott; Emma Clark; Benyunes; Graham Ross; Sandra M. Swain

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