Scientists / Publications

Publications

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DISPLAYING 7651 - 7700 OF 15656 RESULTS

Open Reconcile: A practical open-sourced ontology-driven webservice
Proceedings of the 2012 IEEE 16th International Enterprise Distributed Object Computing Conference Workshops, EDOCW 2012,
Rebecca Lawler; Hui Yang; Kathryn Woods; Joshua S. Kaminker
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An update on the genomic landscape of breast cancer: New opportunity for personalized therapy?
Translational Cancer Research, ISSN: 22196803 2218676X
Anneleen Daemen
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Early development GMPs for drug-product manufacturing of small molecules: An industry perspective (Part III)
Pharmaceutical Technology, ISSN: 15432521 21507376
Richard Creekmore; Eleni Dokou; Amnon Eylath; Dennis Joiner; Michael Lovdahl; Jackson D. Pellett; Eric Schmitt; John W. Skoug
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Early development gmps for small-molecule specifications
Pharmaceutical Technology, ISSN: 15432521 21507376
Michael Coutant; Zhihong Ge; James S. McElvain; Scott A. Miller; Dennis O'Connor; Frank Swanek; Michael Szulc; Mark D. Trone; Kirby Wong-Moon; Mehran Yazdanian; Peter M. Yehl; Shuhong Zhang
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Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Gordon J. King; Jacqueline Stöckli; Shu-Hong Hu; Brit Winnen; Wilko G. A. Duprez; Christopher C. Meoli; Jagath R. Junutula; Russell J. Jarrott; David E. James; Andrew E. Whitten; Jennifer L. Martin
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Development of an ELISA based bridging assay as a surrogate measure of ADCC
Journal of Immunological Methods, ISSN: 00221759 18727905
Aaron S. Miller; Max L. Tejada; Hélène Gazzano-Santoro
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Discovery of potent and selective pyrazolopyrimidine Janus kinase 2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Emily J. Hanan; Anne Van Abbema; Kathy Barrett; Wade S. Blair; Jeff Blaney; Christine Chang; Eigenbrot; Sean Flynn; Paul Gibbons; Christopher A. Hurley; Jane R. Kenny; Janusz J. Kulagowski; Leslie Lee; Steven Magnuson; Claire Morris; Jeremy Murray; Richard Pastor; Thomas E. Rawson; Michael Siu; Ultsch; Aihe Zhou; Deepak Sampath; Joseph P. Lyssikatos
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Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Anthony A. Estrada; Xingrong Liu; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Bryan K. Chan; Huifen Chen; Xiao Ding; Antonio G. DiPasquale; Sara L. Dominguez; Jennafer Dotson; Jason H. Drummond; Michael Flagella; Sean Flynn; Reina N. Fuji; Andrew Gill; Janet Gunzner; Seth F. Harris; Timothy P. Heffron; Tracy L. Kleinheinz; Donna W. Lee; Claire E. Le Pichon; Joseph P. Lyssikatos; Andrew D. Medhurst; John Moffat; Susmith Mukund; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Thuy Tran; Naimisha Trivedi; Shumei Wang; Shuo Zhang; Xiaolin Zhang; Guiling Zhao; Haitao Zhu; Zachary K. Sweeney
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14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing
Neuron, ISSN: 08966273 10974199
Patricia T. Yam; Christopher B. Kent; Steves Morin; W. Todd Farmer; Ricardo Alchini; Léa Lepelletier; David R. Colman; Marc Tessier-Lavigne; Alyson E. Fournier; Frédéric Charron
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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Chaitali Parikh; Vasantharajan Janakiraman; Wen-I. Wu; Catherine K. Foo; Noelyn Kljavin; Subhra Chaudhuri; Eric Stawiski; Brian Lee; Jie Lin; Hong Li; Maria N. Lorenzo; Yuan; Joseph Guillory; Marlena Jackson; Jesus Rondon; Yvonne Franke; Krista K. Bowman; Meredith Sagolla; Stinson; Thomas D Wu; Jiansheng Wu; David Stokoe; Howard M. Stern; Barbara J. Brandhuber; Kui Lin; Nicholas J. Skelton; Somasekar Seshagiri
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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Chaitali Parikh; Vasantharajan Janakiraman; Wen-I. Wu; Catherine K. Foo; Noelyn Kljavin; Subhra Chaudhuri; Eric Stawiski; Brian B. Lee; Jie Lin; Hong Li; Maria N. Lorenzo; Yuan; Joseph Guillory; Marlena Jackson; Jesus Rondon; Yvonne Franke; Krista K. Bowman; Meredith Sagolla; Stinson; Thomas D Wu; Jiansheng Wu; David Stokoe; Howard M. Stern; Barbara J. Brandhuber; Kui Lin; Nicholas J. Skelton; Somasekar Seshagiri
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Characterization of rat liver proteins adducted by reactive metabolites of menthofuran
Chemical Research in Toxicology, ISSN: 0893228X 15205010
S. Cyrus Khojasteh; Dylan P. Hartley; Kevin A. Ford; Hirdesh Uppal; Shimako Oishi; Sidney D. Nelson
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A genomic regulatory element that directs assembly and function of immune-specific AP-1 - IRF complexes
Science, ISSN: 10959203 00368075
Elke Glasmacher; Smita Agrawal; Abraham B. Chang; Theresa L. Murphy; Wenwen Zeng; Bryan Vander Lugt; Aly A. Khan; Maria Ciofani; Chauncey J. Spooner; Sascha Rutz; Jason A. Hackney; Roza Nurieva; Carlos R. Escalante; Wenjun Ouyang; Dan R. Littman; Kenneth M. Murphy; Harinder Singh
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Airway epithelial miRNA expression is altered in asthma
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Owen D. Solberg; Edwin J. Ostrin; Michael I. Love; Jeffrey C. Peng; Nirav R. Bhakta; Lydia Hou; Christine Nguyen; Margaret Solon; Cindy Nguyen; Andrea J. Barczak; Lorna T. Zlock; Denitza P. Blagev; Walter E. Finkbeiner; K. Mark Ansel; Joseph R. Arron; David J. Erle; Prescott G. Woodruff
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Targeting the PI3K pathway in the brain - Efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier
Clinical Cancer Research, ISSN: 10780432 15573265
Laurent Salphati; Timothy P. Heffron; Bruno Alicke; Merry C. Nishimura; Kai H. Barck; Richard A. D. Carano; Jonathan Cheong; Kyle A. Edgar; Joan M. Greve; Samir Kharbanda; Koeppen; Shari Lau; Leslie Lee; Jodie Pang; Emile G. Plise; Jenny L. Pokorny; Hani Bou-Reslan; Jann N. Sarkaria; Jeffery J. Wallin; Xiaolin Zhang; Stephen Gould; Alan G. Olivero; Phillips
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FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
Cancer Research, ISSN: 00085472 15387445
Xiangnan Du; Qian-Rena Wang; Emily Chan; Mark Merchant; Jinfeng Liu; French; Avi Ashkenazi; Jing Qing
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An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer
Cancer Research, ISSN: 00085472 15387445
Mark L. McCleland; Adam S. Adler; Yonglei Shang; Thomas Hunsaker; Tom Truong; David Peterson; Eric Torres; Li Li; Benjamin Haley; Jean-Philippe Stephan; Marcia Belvin; Georgia Hatzivassiliou; Elizabeth M. Blackwood; Laura B. Corson; Marie Evangelista; Jiping Zha; Ron Firestein
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p21-activated kinase 1 is required for efficient tumor formation and progression in a ras-mediated skin cancer model
Cancer Research, ISSN: 00085472 15387445
Hoi Yee Chow; Adrian M. Jubb; Jennifer N. Koch; Zahara M. Jaffer; Dina Stepanova; David Campbell; Sergio G. Duron; Marie O'Farrell; Kathy Q. Cai; Andres J. P. Klein-Szanto; J. Silvio Gutkind; Klaus P. Hoeflich; Jonathan Chernoff
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Real-time quantification of antibody-short interfering RNA conjugate in serum by antigen capture reverse transcription-polymerase chain reaction
Analytical Biochemistry, ISSN: 10960309 00032697
Martha Tan; Jean-Michel Vernes; Joyce Chan; Trinna L. Cuellar; Aarati Asundi; Nelson; Victor Yip; Shen; Richard L. Vandlen; Christian W. Siebel; Meng
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Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Roland Pfoh; Angela Li; Nilmadhab Chakrabarti; Jian Payandeh; Reǵis Pomès; Emil F. Pai
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TTBK2 kinase: Linking primary cilia and cerebellar ataxias
Cell, ISSN: 10974172 00928674
Peter K Jackson
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To respond or not to respond to CD40 agonism: That is the prediction
OncoImmunology, ISSN: 21624011 2162402X
Xiaoyan Shi; David Dornan
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Nature, ISSN: 00280836 14764687
Samuel Huber; Nicola Gagliani; Lauren A. Zenewicz; Francis J. Huber; Lidia Bosurgi; Bo Hu; Matija Hedl; Wei Zhang; William O'Connor; Andrew J. Murphy; David M. Valenzuela; Yancopoulos; Carmen J. Booth; Judy H. Cho; Wenjun Ouyang; Clara Abraham; Richard A. Flavell
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Trastuzumab emtansine for HER2-positive advanced breast cancer
New England Journal of Medicine, ISSN: 15334406 00284793
Sunil Verma; David W. Miles; Luca Gianni; Ian E. Krop; Manfred Welslau; Baselga; Pegram; Do-Youn Oh; Diéras; Ellie Guardino; Liang Fang; Michael W. Lu; Steve Olsen; Kimberly Blackwell
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Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
Molecular Systems Biology, ISSN: 17444292
Jacek R. Wiśniewski; Paweł Ostasiewicz; Kamila Duś; Dorota F. Zielińska; Florian Gnad; Matthias Mann
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Improving risk assessment
Science Translational Medicine, ISSN: 19466234 19466242
Donna M. Dambach; Hirdesh Uppal
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Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
American Journal of Human Genetics, ISSN: 00029297 15376605
Folkert W. Asselbergs; Yiran Guo; Erik P.A. Van Iperen; Suthesh Sivapalaratnam; Vinicius Tragante; Matthew B. Lanktree; Leslie A. Lange; Berta Almoguera; Yolande E. Appelman; John Barnard; Jens Baumert; Amber L. Beitelshees; Tushar Bhangale; Yii-Der Ida Chen; Tom R. Gaunt; Yan Gong; Jemma C. Hopewell; Toby Johnson; Marcus E. Kleber; Taimour Y. Langaee; Mingyao Li; Yun R. Li; Kiang Liu; Caitrin W. McDonough; Matthijs FL Meijs; Rita P.S. Middelberg; Kiran Musunuru; Christopher P. Nelson; Jeffrey R. O'Connell; Sandosh Padmanabhan; James S. Pankow; Nathan Pankratz; Suzanne Rafelt; Ramakrishnan Rajagopalan; Simon P.R. Romaine; Nicholas J. Schork; Jonathan Shaffer; Haiqing Shen; Erin N. Smith; Sam Tischfield; Peter J. Van Der Most; Jana V. Van Vliet-Ostaptchouk; Niek Verweij; Kelly A. Volcik; Li Zhang; Kent R. Bailey; Kristian M. Bailey; Florianne Bauer; Jolanda M.A. Boer; Peter S. Braund; Amber Burt; Paul R. Burton; Sarah G. Buxbaum; Wei Chen; Rhonda M. Cooper-DeHoff; L. Adrienne Cupples; Jonas S. Dejong; Christian Delles; David Duggan; Myriam Fornage; Clement E. Furlong; Nicole Glazer; John G. Gums; Claire Hastie; Michael V. Holmes; Thomas Illig; Susan A. Kirkland; Mika Kivimaki; Ronald Klein; Barbara E.K. Klein; Charles Kooperberg; Kandice Kottke-Marchant; Meena Kumari; Andrea Lacroix; Laya Mallela; Gurunathan Murugesan; Jose Ordovas; Willem H. Ouwehand; Wendy S. Post; Thomas Meitinger; Hubert Scharnagl; Pamela J. Schreiner; Tina Shah; Denis C. Shields; Daichi Shimbo; Sathanur R. Srinivasan; Ronald P. Stolk; Daniel I. Swerdlow; Herman Taylor; Eric Topol; Elina Toskala; Joost L. Van Pelt; Jessica Van Setten; Salim Yusuf; John C. Whittaker; Aeilko H. Zwinderman; Sonia S. Anand; Anthony J. Balmforth; Gerald S. Berenson; Connie R. Bezzina; Bernhard O. Boehm; Eric Boerwinkle; Juan P. Casas; Mark Caulfield; Robert Clarke; John M. Connell; Karen J. Cruickshanks; Karina W. Davidson; Ian N. Day; Paul I. W. De Bakker; Pieter A. Doevendans; Anna Dominiczak; Alistair S. Hall; Catharina A. Hartman; Christian Hengstenberg; Hans L. Hillege; Marten H. Hofker; Steve E. Humphries; Gail P. Jarvik; Julie A. Johnson; Bernhard M. Kaess; Sekar Kathiresan; Wolfgang Koenig; Debbie A. Lawlor; Winfried März; Olle Melander; Braxton D. Mitchell; Grant W. Montgomery; Patricia B. Munroe; Sarah S. Murray; Stephen J. Newhouse; N. Charlotte Onland-Moret; Neil Poulter; Bruce M. Psaty; Susan Redline; Stephen S. Rich; Jerome I. Rotter; Heribert Schunkert; Peter Sever; Alan R. Shuldiner; Roy L. Silverstein; Alice Stanton; Barbara Thorand; Mieke Trip; Michael Y. Tsai; Pim Van Der Harst; Ellen Van Der Schoot; Yvonne T. Van Der Schouw; W.M. Monique Verschuren; Hugh Watkins; Arthur A.M. Wilde; Bruce H.R. Wolffenbuttel; John B. Whitfield; G. Kees Hovingh; Christie M. Ballantyne; Cisca Wijmenga; Muredach P. Reilly; Nicholas G. Martin; James G. Wilson; Daniel J. Rader; Nilesh J. Samani; Alex Reiner; Robert A. Hegele; John J.P. Kastelein; Aroon D. Hingorani; Philippa J. Talmud; Hakon Hakonarson; Clara C. Elbers; Brendan J. Keating; Fotios Drenos
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Unraveling multiple MHC gene associations with systemic lupus erythematosus: Model choice indicates a role for HLA alleles and non-HLA genes in europeans
American Journal of Human Genetics, ISSN: 00029297 15376605
David L. Morris; Kimberly E. Taylor; Michelle M.A. Fernando; Joanne Nititham; Marta E. Alarcón-Riquelme; Lisa F. Barcellos; Timothy W. Behrens; Chris Cotsapas; Patrick M. Gaffney; Robert R. Graham; Bernardo A. Pons-Estel; Peter K. Gregersen; John B. Harley; Stephen L. Hauser; Geoffrey Hom; Carl D. Langefeld; Janelle A. Noble; John D. Rioux; Michael F. Seldin; Lindsey A. Criswell; Timothy J. Vyse
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Non-clinical toxicological considerations for pharmaceutical salt selection
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Vanessa E. Hogan; Cécile T.J. Holweg; David F. Choy; Sarah K. Kummerfeld; Jason A. Hackney; Y. K. Onno Teng; Michael J. Townsend; Jacob M. Van Laar
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A DNA-conjugated magnetic nanoparticle assay for assessing genotoxicity
Analytical and Bioanalytical Chemistry, ISSN: 16182642 16182650
Colin D. Medley; Joshua E. Smith; Larry Wigman; Nik P. Chetwyn
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Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: A translational toxicokinetic/toxicodynamic analysis
Toxicological Sciences, ISSN: 10966080 10960929
Harvey Wong; Nageshwar Budha; Kristina West; Elizabeth M. Blackwood; Joseph A. Ware; Ron Yu; Darbonne; Stephen Gould; Ronald Steigerwalt; Rebecca Erickson; Cornelis E. Hop; Patricia M. LoRusso; Gail Eckhardt; Andrew Wagner; Iris Chan; Michael Mamounas; Flygare; Wayne J. Fairbrother
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Treatment rationale study design for the MetLung trial: A randomized, double-blind phase III study of onartuzumab (MetMAb) in combination with erlotinib versus erlotinib alone in patients who have received standard chemotherapy for stage IIIB or IV met-positive non-small-cell lung cancer
Clinical Lung Cancer, ISSN: 15257304 19380690
David Spigel; Martin J. Edelman; Tony Mok; Kenneth O'Byrne; Luis Paz-Ares; Wei Yu; Karen Rittweger; Holger Thurm
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Quantitation and characterization of process impurities and extractables in protein-containing solutions using proton NMR as a general tool
Biotechnology Progress, ISSN: 87567938 15206033
Ken Skidmore; Daniel Hewitt; Kao
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Impact of disease severity on healthcare costs in patients with chronic hepatitis C (CHC) virus infection
Hepatology, ISSN: 02709139 15273350
Gordon; Pockros; Terrault; Hoop; Buikema; David Nerenz; Hamzeh
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Characterization of Hepatitis C Virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Sophie Le Pogam; Yan; Chhabra; Ilnicka; Kang; Kosaka; Ali; Chin; Nancy Shulman; Patrick F. Smith; Klumpp; Nájera
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Robustness of iCIEF methodology for the analysis of monoclonal antibodies: An interlaboratory study
Journal of Separation Science, ISSN: 16159306 16159314
Oscar Salas-Solano; Babu Kennel; Park; Kelly Roby; Zoran Sosic; Boris Boumajny; Sarah Free; Angelia Reed-Bogan; David A. Michels; Will McElroy; Pauline Bonasia; Mingfang Hong; Xiaoping Z. He; Margaret Ruesch; Frank Moffatt; Steffen Kiessig; Brian Nunnally
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Characterization of ML-IAP protein stability and physiological role in vivo
Biochemical Journal, ISSN: 02646021 14708728
Eugene Varfolomeev; Elham Moradi; Jasmin N. Dynek; Jiping Zha; Anna V. Fedorova; Deshayes; Wayne J. Fairbrother; Kim Newton; Jennifer Le Couter; Domagoj Vucic
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Long-term outcomes after high dose therapy and autologous haematopoietic cell rescue for refractory/relapsed Hodgkin lymphoma
British Journal of Haematology, ISSN: 00071048 13652141
Ann Y. Minn; Elyn Riedel; Jerry Halpern; Laura J. Johnston; Sandra J. Horning; Richard T. Hoppe; Karyn A. Goodman
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A strategy for risk mitigation of antibodies with fast clearance
mAbs, ISSN: 19420862 19420870
Isidro Hötzel; Frank-Peter Theil; Lisa J. Bernstein; Saileta Prabhu; Rong Deng; Leah Quintana; Jeff Lutman; Renuka Sibia; Pamela Chan; Daniela Bumbaca; Fielder; Paul J. Carter; Robert F. Kelley
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Can quality solve the equation? ↓ pricing ↓ a health authority expectations ↑ a supply chain complexity ↑ a counterfeiting ↑ quality drugs to patients + an engaged workforce
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Jennifer Magnani; Anders Vinther
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Immune complex therapies for treatment of immune thrombocytopenia
Development of Antibody-Based Therapeutics: Translational Considerations,
Rong Deng; Joseph P. Balthasar
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Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro
Environmental Toxicology and Pharmacology, ISSN: 13826689 18727077
Xiao Zhang; Andrew D. Wallace; Pan Du; Simon Lin; Andrea A. Baccarelli; Hongmei Jiang; Nadereh Jafari; Yinan Zheng; Hehuang Xie; Marcelo Bento Soares; Warren A. Kibbe; Lifang Hou
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Caspase-3 in the central nervous system: Beyond apoptosis
Trends in Neurosciences, ISSN: 01662236 1878108X
Marcello D'Amelio; Morgan Sheng; Francesco Cecconi
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Dicer-dependent and -independent argonaute2 protein interaction networks in mammalian cells
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Anne Frohn; H. Christian Eberl; Julia Stöhr; Elke Glasmacher; Sabine Rüdel; Vigo Heissmeyer; Matthias Mann; Gunter Meister
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Targeting the apoptotic pathway in chondrosarcoma using recombinant human Apo2L/TRAIL (dulanermin), a dual proapoptotic receptor (DR4/DR5) agonist
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Vivek Subbiah; Robert E. Brown; Jamie Buryanek; Jonathan Trent; Avi Ashkenazi; Roy S. Herbst; Razelle Kurzrock
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Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism
Molecules, ISSN: 14203049
Robert St. Onge; Ulrich Schlecht; Curt Scharfe; Marie Evangelista
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Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany
mAbs, ISSN: 19420862 19420870
Alain Beck; John M. Lambert; Michael Sun; Kedan Lin
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Highlights from a recent BIO survey on therapeutic protein - Drug interactions
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Peter Lloyd; Honghui Zhou; Frank-Peter Theil; Tarundeep Kakkar; Ivan Nestorov; Stanley A. Roberts
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Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: Results of a phase I, placebo-controlled, double-blind, dose-escalation study
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jacqueline McBride; Jenny Jiang; Abbas Alexander; Alyssa M. Morimoto; Jing Li; Romeo MacIuca; Michael J. Townsend; Daniel J. Wallace; William P. Kennedy; Jorn Drappa
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