Genentech: Publications

January 15, 2012

Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; David Moreno; Joachim Rudolph; Yingqing Ran; Kateri Ahrendt; Alisha Arrigo; Ben Colson; Susan L. Gloor; Gregg Hastings

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January 15, 2012

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Li Ren; Ellen R. Laird; Alexandre J. Buckmelter; Victoria Dinkel; Susan L. Gloor; Jonas Grina; Bradley J. Newhouse; Kevin Rasor; Gregg Hastings; Stefan Gradl; Joachim Rudolph

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January 15, 2012

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen- deprivation therapy

Cancer Research, ISSN: 00085472 15387445

Yuting Sun; Bu-Er Wang; Kevin G. Leong; Peng Yue; Li Li; Suchit Jhunjhunwala; Darrell Chen; Kyounghee Seo; Zora Modrusan; Gao; Jeffrey Settleman; Leisa Johnson

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January 14, 2012

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

BMC Cancer, ISSN: 14712407

Carolyn D. Britten; Antoinette S. Gomes; Zev A. Wainberg; David Elashoff; Rafael Amado; Yan Xin; Ronald W. Busuttil; Dennis J. Slamon; Richard S. Finn

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January 13, 2012

Separation-Based Analytical Methods for Measuring Protein Aggregation

Analysis of Aggregates and Particles in Protein Pharmaceuticals,

Jun Liu; Barthélemy Demeule; Steven J. Shire

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January 12, 2012

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

PLoS ONE, ISSN: 19326203

Robert Mintzer; Sreemathy Ramaswamy; Kinjalkumar Shah; Rami N. Hannoush; Christine D. Pozniak; Frederick Cohen; Xianrui Zhao; Emile G. Plise; Joe Lewcock; Christopher E. Heise

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January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

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January 11, 2012

Genetic analysis of DSCAM'S role as a netrin-1 receptor in vertebrates

Journal of Neuroscience, ISSN: 02706474 15292401

Elena Palmesino; Patrick C. G. Haddick; Marc Tessier-Lavigne; Artur Kania

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January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Alan R. Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

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January 8, 2012

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: Results of a phase I randomized, placebo-controlled trial

Arthritis Research and Therapy, ISSN: 14786354 14786362

Brinda Emu; Diana Luca; Carolyn Offutt; Jane L. Grogan; Bernadette Rojkovich; Marna Williams; Meina Tao Tang; Jim J. Xiao; June H. Lee; John C. Davis

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January 6, 2012

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold

Journal of Molecular Biology, ISSN: 10898638 00222836

Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel

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January 6, 2012

Capillary size exclusion chromatography with picogram sensitivity for analysis of monoclonal antibodies purified from harvested cell culture fluid

Journal of Chromatography A, ISSN: 18733778 00219673

Jennifer C. Rea; G. Tony Moreno; Lisa Vampola; Yun Lou; Bjorn Van Haan; Guillaume Tremintin; Laura C. Simmons; Adrian Nava; Yajun Jennifer Wang; Dell Farnan

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January 6, 2012

Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis

Science, ISSN: 10959203 00368075

Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin

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January 5, 2012

Regulation of mitosis and taxane response by Daxx and Rassf1

Oncogene, ISSN: 09509232 14765594

Giovinazzi; Lindsay; Morozov; Escobar-Cabrera; Matthew K. Summers; Han; McIntosh; Ishov

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January 1, 2012

DEGAS: Sharing and tracking target compound ideas with external collaborators

Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596

Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron

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January 1, 2012

ggbio: an R package for extending the grammar of graphics for genomic data

Genome Biology, ISSN: 14656914

Tengfei Yin; Dianne Cook; Michael Lawrence

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January 1, 2012

Randomized and balancing allocation schemes for clinical trials: Computational perspectives on design and deployment

Designs for Clinical Trials: Perspectives on Current Issues,

Vincent J. Carey; Robert Gentleman

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January 1, 2012

Anti-angiogenesis therapy in melanoma

Targeted Therapeutics in Melanoma,

Daniel S. Chen

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January 1, 2012

Pioneers of oncology nursing.

ONS connect, ISSN: 19351623

Bertie Ford

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January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951

Jeff Blaney

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January 1, 2012

Influence of the compound selection process on the performance of human clearance prediction methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop

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January 1, 2012

Targeting a cystic fibrosis mutation opens door for personalized treatment.

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2012

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Science Translational Medicine, ISSN: 19466242

Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu

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January 1, 2012

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

Mucosal Immunology, ISSN: 19330219 19353456

Jennifer Cox; Noelyn Kljavin; Naruhisa Ota; Leonard; Merone Roose-Girma; Laurie Diehl; Wenjun Ouyang; Nico Ghilardi

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January 1, 2012

Noninvasive optical sensor technology in shake flasks

BioProcess International, ISSN: 15426319

Wen-Lin Tsai; Jennifer Autsen; Julie Ma; Terry Hudson; Jun Luo

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January 1, 2012

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

David F. Choy; Daniel K. Hsu; Dhaya Seshasayee; Maxwell A. Fung; Zora Modrusan; Flavius Martin; Fu-Tong Liu; Joseph R. Arron

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January 1, 2012

In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Jane R. Kenny; Cornelis E. Hop; Sami Haddad

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January 1, 2012

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

Nature Cell Biology, ISSN: 14657392 14764679

Ben Chih; Peter S. Liu; Yvonne Chinn; Cecile Chalouni; László Kömüves; Hass; Wendy N. Sandoval; Andrew S. Peterson

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January 1, 2012

Transferrin antibodies into the brain

Neuropsychopharmacology, ISSN: 0893133X 1740634X

Dennis; Ryan J. Watts

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January 1, 2012

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

mAbs, ISSN: 19420870 19420862

Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter

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January 1, 2012

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

mAbs, ISSN: 19420862 19420870

Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu

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January 1, 2012

Effect of sulfobutyl ether beta-cyclodextrin modifier on selectivity of reversed phase hplc separations

Journal of Liquid Chromatography and Related Technologies, ISSN: 10826076 1520572X

Kenley K. Ngim; Qiqing Zhong; Kavita Mistry; Nik P. Chetwyn

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January 1, 2012

Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Alavattam Sreedhara; Cordoba; Qing Zhu; Jeanne Kwong; Jun Liu

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January 1, 2012

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Suman A. Luthra; Marcel Utz; Eric M. Gorman; Michael J. Pikal; Eric Munson; Joseph W. Lubach

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January 1, 2012

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Dange V. Kumar; Roopa Rai; Ken A. Brameld; Jennifer Riggs; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Huiyong Hu; Isabelle Lehoux; Joseph D. Ho; Wendy B. Young; Barry Hart; Michael J. Green

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January 1, 2012

Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture

Journal of Biotechnology, ISSN: 01681656 18734863

Kristen L. Koterba; Trissa Borgschulte; Mike Laird

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January 1, 2012

BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Kevin B. Kim; Jeffrey A. Sosman; John P. Fruehauf; Gerald Linette; Svetomir N. Markovic; David McDermott; Jeffrey S. Weber; Hoa Nguyen; Peter Cheverton; Daniel S. Chen; Amy Peterson; William E. Carson III; Steven J. O'Day

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January 1, 2012

Hybridization of conditional and predictive power for futility assessment in sequential clinical trials with time-to-event outcomes: A resampling approach

Contemporary Clinical Trials, ISSN: 15517144 15592030

Jing Yi; Liang Fang; Zheng Su

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January 1, 2012

Editorial

Contemporary Clinical Trials, ISSN: 15517144 15592030

Zheng Su

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January 1, 2012

Assessing and improving asymmetric flow field-flow fractionation of therapeutic proteins

Field-Flow Fractionation in Biopolymer Analysis,

Jun Liu; Qing Zhu; Steven J. Shire; Barthélemy Demeule

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January 1, 2012

Treatment of HER2-positive breast cancer: Current status and future perspectives

Nature Reviews Clinical Oncology, ISSN: 17594774 17594782

Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni

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January 1, 2012

Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini

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January 1, 2012

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus

Infection and Immunity, ISSN: 00199567 10985522

Melissa A. Gessner; Jessica L. Werner; Lauren M. Lilly; Michael P. Nelson; Allison E. Metz; Chad W. Dunaway; Yvonne R. Chan; Wenjun Ouyang; Gordon D. Brown; Casey T. Weaver; Chad Steele

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January 1, 2012

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

Pancreatology, ISSN: 14243911 14243903

Rebecca J. Brais; Susan E. Davies; Maria O'Donovan; Ben W. Simpson; Natalie Cook; Darbonne; Sian Chilcott; Martijn P. Lolkema; Albrecht Neesse; Michelle Lockley; Pippa G. Corrie; Duncan I. Jodrell; Raaj K. Praseedom; Emmanuel L. Huguet; Asif Jah; Neville V. Jamieson; Frederic J. De Sauvage; David Tuveson; Nicholas R. Carroll

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January 1, 2012

Erratum: Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres (Bioorganic and Medicinal Chemistry Letters (2010) 20 (2229-2233))

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

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January 1, 2012

Tenecteplase for the improvement of blood flow rate in dysfunctional hemodialysis catheters

Clinical Nephrology, ISSN: 03010430

Jesse Goldman; Steven Fishbane; Matthew J. Oliver; Martha Blaney; Joan R. Jacobs; Susan M. Begelman

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January 1, 2012

Differentiation programs in development and cancer

Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing,

Hosein Kouros-Mehr

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January 1, 2012

Neuropilin-1 expression in cancer and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Laura A. Strickland; Scot D. Liu; Judy Mak; Maike Schmidt; Koeppen

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January 1, 2012

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency

PLoS Genetics, ISSN: 15537390 15537404

Ricardo C. Ferreira; Qiang Pan-Hammarström; Robert R. Graham; Gumersindo Fontán; Annette T. Lee; Ward Ortmann; Ning Wang; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R. Ludviksson; Sinikka Koskinen; Katri Haimila; Leonid Padyukov; Peter K. Gregersen; Lennart Hammarström; Timothy W. Behrens

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January 1, 2012

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

Nucleic Acids Research, ISSN: 03051048 13624962

Emily C. Knouf; Kavita Garg; Jason D. Arroyo; Yesenia Correa; Deepayan Sarkar; Rachael K. Parkin; Kaitlyn Wurz; Kathy C. O'Briant; Andrew K. Godwin; Nicole D. Urban; Walter L. Ruzzo; Robert Gentleman; Charles W. Drescher; Elizabeth M. Swisher; Muneesh Tewari

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