Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7801 - 7850 OF 15217 RESULTS

Effects of commercial air travel on patients with pulmonary hypertension
Chest, ISSN: 19313543 00123692
Nareg Roubinian; C. Gregory Elliott; Christopher F. Barnett; Paul D. Blanc; Joan Chen; Teresa De Marco; Hubert Chen
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Determination of hepatic clearance with the account of drug-protein binding kinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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A phase i study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Sarah B. Goldberg; Jeffrey G. Supko; Joel W. Neal; Alona Muzikansky; Subba Digumarthy; Panos Fidias; Jennifer S. Temel; Rebecca S. Heist; Alice T. Shaw; Patricia O. McCarthy; Thomas J. Lynch; Sreenath Sharma; Jeffrey Settleman; Lecia V. Sequist
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Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin
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Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny
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Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler
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Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
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Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Variable selection in multivariate modeling of drug product formula and manufacturing process
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie
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Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Mayumi Bowen; Nick Armstrong; Maa
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Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma
Investigational New Drugs, ISSN: 15730646 01676997
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
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Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach
Drug Metabolism Letters, ISSN: 18723128
Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny
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A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Jeff Blaney
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SpeCond: A method to detect condition-specific gene expression
Genome Biology, ISSN: 14747596 1474760X
Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe
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The A-MYSM Power of Deubiquitinases
Immunity, ISSN: 10747613 10974180
Ignacio A. Demarco; Harinder Singh
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The authors reply
New England Journal of Medicine, ISSN: 00284793 15334406
Joseph R. Arron; Jonathan Corren; Matthews
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Cancer immunotherapy comes of age
Nature, ISSN: 14764687 00280836
Ira Mellman; George Coukos; Glenn Dranoff
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Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria
PLoS ONE, ISSN: 19326203
Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder
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TRAF2 and cellular IAPs: A critical link in TNFR family signaling
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
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Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
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Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
Science Translational Medicine, ISSN: 19466242 19466234
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition
PLoS ONE, ISSN: 19326203
Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens
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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Science Translational Medicine, ISSN: 19466242
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
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Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
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Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
British Journal of Cancer, ISSN: 00070920 15321827
Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland
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Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha
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On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format
Analytical Biochemistry, ISSN: 10960309 00032697
Melissa Alvarez; Guillaume Tremintin; Jennifer Wang; Eng; Kao; Justin Jeong; Victor Ling; Oleg V. Borisov
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Role of MetMAb (OA-5D5) in c-MET active lung malignancies
Expert Opinion on Biological Therapy, ISSN: 14712598
Mosmi Surati; Premal Patel; Amy Peterson; Ravi Salgia
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The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
Genes and Immunity, ISSN: 14664879 14765470
Paola G. Bronson; Goldstein; Ramsay; Beckman; Janelle A. Noble; Lane; Michael F. Seldin; Jennifer A. Kelly; John B. Harley; Kathy L. Moser; Patrick M. Gaffney; Timothy W. Behrens; Lindsey A. Criswell; Lisa F. Barcellos
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IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
Nature Immunology, ISSN: 15292908 15292916
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Luis; Zhongua Lin; Surinc Er Jeet; Justin Lesch; Jason A. Hackney; Janice Kim; Meijuan Zhou; Joyce Lai; Zora Modrusan; Tao Sai; Wyne P. Lee; Min Xu; Patrick Caplazi; Laurie Diehl; Jason De Voss; Mercedesz Balazs; Lino C. Gonzalez Jr.; Harinder Singh; Wenjun Ouyang; Rajita Pappu
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Proposal for a new protein therapeutic immunogenicity titer assay cutpoint
Bioanalysis, ISSN: 17576180 17576199
Eric Wakshull; Robert Hendricks; Caroline Amaya; Daniel A. Coleman
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Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T H17 cells
Nature Immunology, ISSN: 15292908 15292916
Sascha Rutz; Rajkumar Noubade; Celine Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason A. Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
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It takes two to tango: A new couple in the family of ubiquitin-editing complexes
Nature Immunology, ISSN: 15292908 15292916
Ingrid E. Wertz
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A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
PLoS Genetics, ISSN: 15537390 15537404
Paula S. Ramos; Lindsey A. Criswell; Kathy L. Moser; Mary E. Comeau; Adrienne H. Williams; Nicholas M. Pajewski; Sharon A. Chung; Robert R. Graham; Raphael Zidovetzki; Jennifer A. Kelly; Kenneth M. Kaufman; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; Robert P. Kimberly; Patrick M. Gaffney; Marta E. Alarcón-Riquelme; John B. Harley; Carl D. Langefeld
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The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors
Endocrinology, ISSN: 00137227 19457170
Erik R. Nelson; Carolyn D. DuSell; Xiaojuan Wang; Matthew K. Howe; Glenda Evans; Ryan D. Michalek; Michihisa Umetani; Jeffrey C. Rathmell; Sundeep Khosla; Diane Gesty-Palmer; Donald P. McDonnell
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Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects
AAPS Journal, ISSN: 15507416
Nageshwar Budha; Andreas Kovar; Bernd Meibohm
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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Albert Lai; Samir Kharbanda; Whitney B. Pope; Anh Tran; Orestes E. Solis; Franklin V. Peale Jr.; William F. Forrest; Kanan Pujara; Jose A. Carrillo; Ajay Pandita; Benjamin M. Ellingson; Chauncey W. Bowers; Robert Soriano; Nils-Ole Schmidt; Sankar Mohan; William H. Yong; Somasekar Seshagiri; Zora Modrusan; Zhaoshi Jiang; Kenneth D. Aldape; Paul S. Mischel; Linda M. Liau; Cameron J. Escovedo; Weidong Chen; Phioanh L. Nghiemphu; C. David James; Michael D. Prados; Manfred Westphal; Katrin Lamszus; Timothy Cloughesy; Phillips
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Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans
Psychopharmacology, ISSN: 00333158 14322072
William Cho; Paul Maruff; John Connell; Cindy Gargano; Nicole Calder; Scott Doran; Sabrina Fox-Bosetti; Aizza Hassan; John Renger; Gary Herman; Christopher Lines; Ajay Verma
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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human
Xenobiotica, ISSN: 00498254 13665928
Laurent Salphati; Jodie Pang; Emile G. Plise; Bilin Chou; Jason S Halladay; Alan G. Olivero; Patrick J. Rudewicz; Qingping Tian; Susan C. Wong; Xiaolin Zhang
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Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Isaias Noel Gendrano III; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Identification of aberrant pathway and network activity from high-throughput data-workshop introduction
Pacific Symposium on Biocomputing 2011, PSB 2011,
Ochs; Karchin; Ressom; Robert Gentleman
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Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3- dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery
Nanoscale Research Letters, ISSN: 19317573 1556276X
Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Harvey Wong
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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jeffery J. Wallin; Kyle A. Edgar; Zhengyu Guan; Megan Berry; Wei Wei Prior; Leslie Lee; John Lesnick; Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan G. Olivero; Daniel P. Sutherlin; Carol O'Brien; Jill M. Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Berry; Lackner; Deepak Sampath; Marcia Belvin; Lori S. Friedman
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Concomitant asthma medication use by patients receiving omalizumab 20032008
Journal of Asthma, ISSN: 02770903 15324303
Michael S. Broder; James L. Zazzali; Eunice Chang; Ashley Yegin
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Kilogram-scale asymmetric ruthenium-catalyzed hydrogenation of a tetrasubstituted fluoroenamide
Advanced Synthesis and Catalysis, ISSN: 16154150 16154169
Andreas Stumpf; Mark E. Reynolds; Daniel P. Sutherlin; Srinivasan Babu; Erhard Bappert; Felix Spindler; Michael Welch; John J. Gaudino
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An introduction to wnt signaling
Targeting the Wnt Pathway in Cancer,
Paul G. Polakis
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Single-versus dual-infusion of B-cell-depleting antibody ocrelizumab in rheumatoid arthritis: Results from the phase III FEATURE trial
International Journal of Clinical Rheumatology, ISSN: 17584272 17584280
Joseph E. Huffstutter; James Taylor; Joy Schechtman; Piotr Leszczynski; Marek Brzosko; Farhad Sedarati; Dalia Moawad; Amy V. Kapp; Rebecca Sudlow; Wolfgang Dummer
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Dissecting cancer heterogeneity
Nature Biotechnology, ISSN: 10870156 15461696
David Dornan; Jeffrey Settleman
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Towards BioDBcore: A community-defined information specification for biological databases
Database, ISSN: 17580463
Pascale Gaudet; Amos Bairoch; Dawn Field; Susanna-Assunta Sansone; Chris Taylor; Teresa K. Attwood; Alex Bateman; Judith A. Blake; Carol J. Bult; J. Michael Cherry; Rex L. Chisholm; Guy Cochrane; Charles E. Cook; Janan T. Eppig; Michael Y. Galperin; Robert Gentleman; Carole A. Goble; Takashi Gojobori; John M. Hancock; Douglas G. Howe; Tadashi Imanishi; Janet Kelso; David Landsman; Suzanna E. Lewis; Ilene Karsch-Mizrachi; Sandra Orchard; B.F. Francis Ouellette; Shoba Ranganathan; Lorna Richardson; Philippe Rocca-Serra; Paul N. Schofield; Damian Smedley; Christopher Southan; Tin W. Tan; Tatiana Tatusova; Patricia L. Whetzel; Owen White; Chisato Yamasaki
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