Scientists / Publications

Publications

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DISPLAYING 7851 - 7900 OF 15217 RESULTS

Phase I study evaluating the safety and pharmacokinetics of MDX-1303, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers
Clinical and Vaccine Immunology, ISSN: 15566811 1556679X
Valerie Riddle; Phillip Leese; Diann Blanset; Melany Adamcio; Matthew Meldorf; Israel Lowy
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Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment
Arthritis and Rheumatism, ISSN: 00043591 15290131
Preeti Lal; Zheng Su; Cécile T.J. Holweg; Gregg J. Silverman; Sergio Schwartzman; Ariella Kelman; Simon J. Read; Spaniolo; John G. Monroe; Timothy W. Behrens; Michael J. Townsend
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Durable complete response of metastatic gastric cancer with anti-met therapy followed by resistance at recurrence
Cancer Discovery, ISSN: 21598274 21598290
Daniel V.T. Catenacci; Les Henderson; Shu-Yuan Xiao; Premal Patel; Robert Yauch; Priti Hegde; Jiping Zha; Ajay Pandita; Amy Peterson; Ravi Salgia
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Therapeutic promise and challenges of targeting DLL4/NOTCH1
Vascular Cell, ISSN: 2045824X
Minhong Yan
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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
Biochimica et Biophysica Acta - Proteins and Proteomics, ISSN: 15709639 18781454
David Meininger; Leeanne Zalameda; Yichin Liu; Lara P. Stepan; Luis Borges; John D. McCarter; Claire L. Sutherland
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Preclinical assessment of novel BRAF inhibitors: Integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Bruno Alicke; Jason Boggs; Victoria Dinkel; Stephen Gould; Jonas Grina; Kristina West; Kapil Menghrajani; Yingqing Ran; Joachim Rudolph; Steve Wenglowsky
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The Bcl-2/Bcl-X L/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jun Chen; Sha Jin; Vivek Abraham; Xiaoli Huang; Bernard Liu; Michael J. Mitten; Paul M. Nimmer; Xiaoyu Lin; Morey L. Smith; Yu Shen; Alexander R. Shoemaker; Stephen K. Tahir; Haichao Zhang; Scott L. Ackler; Saul H. Rosenberg; Heather Maecker; Deepak Sampath; Joel D. Leverson; Chris Tse; Steven W. Elmore
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Chung; Lisa Tuomi; Jason S. Ehrlich
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Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure
European Journal of Cancer, ISSN: 09598049 18790852
Nizar M. Tannir; Yu-Ning Wong; Christian K. Kollmannsberger; Marc S. Ernstoff; David J. Perry; Leonard J. Appleman; Edwin M. Posadas; Daniel Cho; Toni K. Choueiri; Andrew Coates; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Jihong Chen; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Dror Michaelson
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Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome
Dermatology Reports, ISSN: 20367392 20367406
Glen J. Weiss; Raoul Tibes; Lisa Blaydorn; Gayle Jameson; Molly Downhour; Erica White; Ivor Caro; Daniel D. Von Hoff
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Y. Chung; Lisa Tuomi; Jason S. Ehrlich
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Vanadium bromoperoxidase from Delisea pulchra: Enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing
Chemical Communications, ISSN: 1364548X 13597345
Moriah Sandy; Jayme N. Carter-Franklin; Jessica D. Martin; Alison Butler
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Different mechanisms for resistance to trastuzumab versus lapatinib in HER2- positive breast cancers -- role of estrogen receptor and HER2 reactivation
Breast Cancer Research, ISSN: 14655411 1465542X
Yen-Chao Wang; Gladys Morrison; Ryan Gillihan; Jun Guo; Robin M. Ward; Xiaoyong Fu; Maria F. Botero; Nuala A. Healy; Susan G. Hilsenbeck; Gail L. Phillips; Gary C. Chamness; Mothaffar F. Rimawi; C.Kent Osborne; Rachel Schiff
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Community-wide assessment of protein-interface modeling suggests improvements to design methodology
Journal of Molecular Biology, ISSN: 10898638 00222836
Sarel J. Fleishman; Timothy A. Whitehead; Eva-Maria Strauch; Jacob E. Corn; Sanbo Qin; Huan-Xiang Zhou; Julie C. Mitchell; Omar N.A. Demerdash; Mayuko Takeda-Shitaka; Genki Terashi; Iain H. Moal; Xiaofan Li; Paul A. Bates; Martin Zacharias; Hahnbeom Park; Jun-Su Ko; Hasup Lee; Chaok Seok; Thomas Bourquard; Julie Bernauer; Anne Poupon; Jérôme Azé; Seren Soner; Şefik Kerem Ovali; Pemra Ozbek; Nir Ben Tal; Türkan Haliloglu; Howook Hwang; Thom Vreven; Brian G. Pierce; Zhi-Ping Weng; Laura Pérez-Cano; Carles Pons; Juan Fernández-Recio; Fan Jiang; Feng Yang; Xinqi Gong; Libin Cao; Xianjin Xu; Bin Liu; Panwen Wang; Chunhua Li; Cunxin Wang; Charles H. Robert; Mainak Guharoy; Shiyong Liu; Yangyu Huang; Lin Li; Dachuan Guo; Ying Chen; Yi Xiao; Nir London; Zohar Itzhaki; Ora Schueler-Furman; Yuval Inbar; Vladimir Potapov; Mati Cohen; Gideon Schreiber; Yuko Tsuchiya; Eiji Kanamori; Daron M. Standley; Haruki Nakamura; Kengo Kinoshita; Camden M. Driggers; Robert G. Hall; Jessica L. Morgan; Victor L. Hsu; Jian Zhan; Yuedong Yang; Yaoqi Zhou; Panagiotis L. Kastritis; Alexandre M.J.J. Bonvin; Weiyi Zhang; Carlos J. Camacho; Krishna P. Kilambi; Aroop Sircar; Jeffrey J. Gray; Masahito Ohue; Nobuyuki Uchikoga; Yuri Matsuzaki; Takashi Ishida; Yutaka Akiyama; Raed Khashan; Stephen Bush; Denis Fouches; Alexander Tropsha; Juan Esquivel-Rodríguez; Daisuke Kihara; P. Benjamin Stranges; Ron Jacak; Brian Kuhlman; Sheng-You Huang; Xiaoqin Zou; Shoshana J. Wodak; Joel Janin; David Baker
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Rational design of phosphoinositide 3-kinase inhibitors that exhibit selectivity over the phosphoinositide 3-kinase isoform
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Binqing Wei; Alan G. Olivero; Steven T. Staben; Vickie Tsui; Steven Do; Jennafer Dotson; Adrian J. Folkes; Paul Goldsmith; Richard Goldsmith; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Daniel P. Sutherlin; Nan Chi Wan; Shumei Wang; Wiesmann; Bing-Yan Zhu
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Lymphangiogenesis is required for pancreatic islet inflammation and diabetes
PLoS ONE, ISSN: 19326203
Na Yin; Nan Zhang; Girdhari Lal; Jiangnan Xu; Minhong Yan; Yaozhong Ding; Jonathan S. Bromberg
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Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jean-Charles Soria; Zsuzsanna Márk; Petr Zatloukal; Barna Szima; István Albert; Erzsébet Juhász; Jean-Louis Pujol; Jerzy Kozielski; Nigel Baker; Dominic Smethurst; Yong-Jiang Hei; Avi Ashkenazi; Howard M. Stern; Lukas Amler; Pan; Fiona Blackhall
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An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
Genes and Development, ISSN: 08909369 15495477
Kevin J. Wright; Lisa M. Baye; Anique Olivier-Mason; Saikat Mukhopadhyay; Liyun Sang; Mandy Kwong; Weiru Wang; Pamela R. Pretorius; Val C. Sheffield; Piali Sengupta; Diane C. Slusarski; Peter K Jackson
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The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P 3
Biochemistry, ISSN: 00062960 15204995
Carissa Pilling; Kyle E. Landgraf; Joseph J. Falke
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Hotspot-centric de novo design of protein binders
Journal of Molecular Biology, ISSN: 10898638 00222836
Sarel J. Fleishman; Jacob E. Corn; Eva-Maria Strauch; Timothy A. Whitehead; John Karanicolas; David Baker
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RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Adam Brufsky; Sara A. Hurvitz; Edith A. Perez; Raji Swamy; Vicente Valero; Vincent O'Neill; Hope S. Rugo
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Discovery of a potent, selective, and orally available class i phosphatidylinositol 3-kinase (PI3K)/Mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Linda Bao; Megan Berry; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian Folks; Lori S. Friedman; Richard Goldsmith; Janet Gunzner; Timothy P. Heffron; John Lesnick; Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Wiesmann; Ping Wu; Bing-Yan Zhu; Alan G. Olivero
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Non-canonical inflammasome activation targets caspase-11
Nature, ISSN: 00280836 14764687
Nobuhiko Kayagaki; Søren Warming; Lamkanfi; Lieselotte Vande Walle; Salina Louie; Jennifer Dong; Kim Newton; Yan Qu; Jinfeng Liu; Sherry Heldens; Juan Zhang; Wyne P. Lee; Merone Roose-Girma; Vishva M. Dixit
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Broadening our expectations for viral safety risk mitigation
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Ivar Kljavin
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Breakout session A: Elimination or treatment of high-risk raw materials
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Robert Kiss; Roman Drews
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Practicing safe cell culture: Applied process designs for minimizing virus contamination risk
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Robert Kiss
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Human IL-25-and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
Nature Immunology, ISSN: 15292908 15292916
Jenny M. Mjösberg; Sara Trifari; Natasha K Crellin; Charlotte P. Peters; Cornelis M. Van Drunen; Berber Piet; Wytske J. Fokkens; Tom Cupedo; Hergen Spits
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Selective IgA deficiency in autoimmune diseases
Molecular Medicine, ISSN: 10761551
Ning Wang; Nan Shen; Timothy J. Vyse; Vidya Anand; Iva Gunnarson; Gunnar Sturfelt; Solbritt Rantapää-Dahlqvist; Kerstin Elvin; Lennart Truedsson; Bengt A. Andersson; Charlotte Dahle; Eva Örtqvist; Peter K. Gregersen; Timothy W. Behrens; Lennart Hammarström
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Cataract surgery in ranibizumab-treated patients with neovascular age-related macular degeneration from the phase 3 ANCHOR and MARINA trials
American Journal of Ophthalmology, ISSN: 00029394 18791891
Philip J. Rosenfeld; Howard Shapiro; Jason S. Ehrlich; Pamela Wong
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Selective MMP13 inhibitors
Medicinal Research Reviews, ISSN: 01986325 10981128
Jie Jack Li; Adam R. Johnson
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Infused therapy and survival in older patients diagnosed with metastatic breast cancer who received trastuzumab
Cancer Investigation, ISSN: 07357907 15324192
Robert I. Griffiths; Deepa Lalla; Robert J. Herbert; Justin Doan; Melissa Brammer; Mark Danese
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Controlling glycation of recombinant antibody in fed-batch cell cultures
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Inn H. Yuk; Boyan Zhang; Yi Yang; George Dutina; Kimberly D. Leach; Natarajan Vijayasankaran; Amy Shen; Dana C. Andersen; Snedecor; John C. Joly
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A phase i study of tasisulam sodium (LY573636 sodium), a novel anticancer compound in patients with refractory solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
George R. Simon; Robert L. Ilaria Jr.; Mika A. Sovak; Charles C. Williams; Eric B. Haura; Ann L. Cleverly; Amanda K. Sykes; Margaret M. Wagner; Dinesh P. De Alwis; Christopher A. Slapak; Mary A. Miller; David R. Spriggs
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Inhibition of GSK3 by Wnt signalling - Two contrasting models
Journal of Cell Science, ISSN: 00219533 14779137
Ciara Metcalfe; Mariann Bienz
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The heart endocardium is derived from vascular endothelial progenitors
Development (Cambridge), ISSN: 09501991 14779129
Michal Milgrom-Hoffman; Zachary Harrelson; Napoleone Ferrara; Elazar Zelzer; Sylvia M. Evans; Eldad Tzahor
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Comparison of metabolic soft spot predictions of CYP3A4, CYP2C9 and CYP2D6 substrates using MetaSite and starDrop
Combinatorial Chemistry and High Throughput Screening, ISSN: 13862073 18755402
Young G. Shin; Hoa Le; S. Cyrus Khojasteh; Cornelis E. Hop
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Ascl2 and 11p15.5 amplification in colorectal cancer
Gut, ISSN: 00175749 14683288
Adrian M. Jubb; Klaus P. Hoeflich; Matthias Peter; Yajun Jennifer Wang; Koeppen
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Preparation of 18 F-labeled peptides using the copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition
Nature Protocols, ISSN: 17542189 17502799
Herman S. Gill; Jan Marik
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Economic impact of disease progression in follicular non-Hodgkin lymphoma
Leukemia and Lymphoma, ISSN: 10428194 10292403
Roy Beveridge; Sacha Satram-Hoang; Kavita Sail; Joseph Darragh; Clara Chen; Michael Forsyth; Carolina Reyes
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Clinical development of 2NME-based oncology treatment regimens
Contemporary Clinical Trials, ISSN: 15517144 15592030
Jones; Lieberman; Lee D. Kaiser
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Optimal Allocation of Prognostic Factors in Randomized Preclinical Animal Studies
Drug Information Journal, ISSN: 00928615
Zheng Su
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Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone-induced lung tumorigenesis
Cancer Prevention Research, ISSN: 19406207 19406215
Sharon E. Murphy; Linda B. Von Weymarn; Melissa Schutten; Fekadu Kassie; Jaime F. Modiano
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The impact of glycosylation on monoclonal antibody conformation and stability
mAbs, ISSN: 19420862 19420870
Kai Zheng; Christopher Bantog; Robert Bayer
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Imaged capillary isoelectric focusing for charge-variant analysis of biopharmaceuticals
BioProcess International, ISSN: 15426319
David A. Michels; Oscar Salas-Solano; Chantal Felten
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Validation of ICD-9-CM codes to identify gastrointestinal perforation events in administrative claims data among hospitalized rheumatoid arthritis patients
Pharmacoepidemiology and Drug Safety, ISSN: 10538569 10991557
Jeffrey R. Curtis; Shih-Yin Chen; Winifred Werther; Ani John; David A. Johnson
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Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37
Chemistry and Biology, ISSN: 10745521
Thomas B. Sundberg; Nicole Darricarrere; Pasquale Cirone; Xia Li; Lucy McDonald; Xue Mei; Christopher J. Westlake; Diane C. Slusarski; Robert J. Beynon; Craig M. Crews
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Retrospective. Ralph M. Steinman (1943-2011).
Science, ISSN: 10959203
Ira Mellman; Michel Nussenzweig
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Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl- piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Vito Guagnano; Pascal Furet; Carsten Spanka; Vincent Bordas; Mickaël Le Douget; Christelle Stamm; Josef Brueggen; Michael R. Jensen; Christian Schnell; Herbert Schmid; Markus Wartmann; Joerg Berghausen; Peter Drueckes; Alfred Zimmerlin; Dirksen Bussiere; Jeremy Murray; Diana Graus Porta
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MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments
Arthritis Research and Therapy, ISSN: 14786354 14786362
Heleen Scheerens; Zheng Su; Bryan Irving; Michael J. Townsend; Zheng; Stefanich; Vishala Chindalore; Bingham; John C. Davis
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A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Nicholas A. Dompe; Rivers; Li Li; Shaun Cordes; Martin Schwickart; Elizabeth A. Punnoose; Lukas Amler; Somasekar Seshagiri; Zhijun Tang; Zora Modrusan; David P. Davis
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