Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8001 - 8050 OF 15217 RESULTS

Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala
Journal of Comparative Neurology, ISSN: 00219967 10969861
Bei Wang; Thomas Lufkin; John L. R. Rubenstein
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Preparation of distinct ubiquitin chain reagents of high purity and yield
Structure, ISSN: 09692126 18784186
Ken Dong; Elizabeth Helgason; Christine Yu; Lilian Phu; David Arnott; Ivan Bosanac; Deanne M. Compaan; Oscar W Huang; Anna V. Fedorova; Donald S. Kirkpatrick; Sarah G. Hymowitz; Erin C. Dueber
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Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics
PLoS ONE, ISSN: 19326203
Daniel J Anderson; Jenni K. Durieux; Kyung Song; Ryan Alvarado; Peter K Jackson; Georgia Hatzivassiliou; Mary J. C. Ludlam
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Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Taylor Zhang; Justin Bourret; Tony Cano
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Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes
FEBS Letters, ISSN: 00145793 18733468
Xinxin Gao; Natalia Arenas-Ramirez; Suzie J. Scales; Rami N. Hannoush
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Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: Results of a phase 3b study
Molecular Genetics and Metabolism, ISSN: 10967192 10967206
Barbara K. Burton; Maria Nowacka; Julia B. Hennermann; Mark Lipson; Dorothy K. Grange; Anupam Chakrapani; Friedrich Trefz; Alejandro Dorenbaum; Michael Imperiale; Sun Sook Kim; Paul M. Fernhoff
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Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis
Analytical Chemistry, ISSN: 00032700
X. Christopher Yu; Koman Joe; Yu Zhang; Andrea Adriano; Yaning Wang; Hélène Gazzano-Santoro; Rodney Keck; Galahad Deperalta; Victor Ling
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Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus
Arthritis and Rheumatism, ISSN: 00043591 15290131
Alyssa M. Morimoto; Donna Thibault Flesher; Yang; Kristen Wolslegel; Xiangdan Wang; Ann Brady; Abbas Alexander; Quarmby; Eric Wakshull; Bruce C. Richardson; Michael J. Townsend; Timothy W. Behrens
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A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Richard A. Graham; Bert L. Lum; Morrison; Ilsung Chang; Karin Jorga; Brian J. Dean; Young G. Shin; Qin Yue; Teresa Mulder; Vikram Malhi; Minli Xie; Low; Cornelis E. Hop
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Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: Results of a phase 3b study
Molecular Genetics and Metabolism, ISSN: 10967192 10967206
Barbara K. Burton; Maria Nowacka; Julia B. Hennermann; Mark Lipson; Dorothy K. Grange; Anupam Chakrapani; Friedrich Trefz; Alex Dorenbaum; Michael Imperiale; Sun Sook Kim; Paul M. Fernhoff
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Hedgehog fights back: Mechanisms of acquired resistance against smoothened antagonists
Cancer Research, ISSN: 00085472 15387445
Ciara Metcalfe; Frederic J. De Sauvage
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Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis
Hepatology, ISSN: 02709139 15273350
Henriette E. Meyer Zu Schwabedissen; Joseph A. Ware; David Finkelstein; Amarjit S. Chaudhry; Sara Mansell; Matilde Leon-Ponte; Stephen C. Strom; Hani Zaher; Ute I. Schwarz; David J. Freeman; Erin G. Schuetz; Rommel G. Tirona; Richard B. Kim
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Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells
Cancer Science, ISSN: 13479032 13497006
Tetsunari Hase; Sato; Kenya Yoshida; Girard; Yoshihiro Takeyama; Mihoko Horio; Momen Elshazley; Tomoyo Oguri; Yoshitaka Sekido; David S. Shames; Adi Gazdar; Minna; Masashi Kondo; Yoshinori Hasegawa
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Viscosity analysis of high concentration bovine serum albumin aqueous solutions
Pharmaceutical Research, ISSN: 07248741 1573904X
Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia
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A phase III, open-label, single-arm study of tenecteplase for restoration of function in dysfunctional central venous catheters
Journal of Vascular and Interventional Radiology, ISSN: 10510443 15357732
Cameron Tebbi; John Costanzi; Robert Shulman; Luke Dreisbach; Brian R. Jacobs; Martha Blaney; Ashby; Barbara S. Gillespie; Susan M. Begelman
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Pervasive sharing of genetic effects in autoimmune disease
PLoS Genetics, ISSN: 15537390 15537404
Chris Cotsapas; Benjamin F. Voight; Elizabeth Rossin; Kasper Lage; Neale; Chris Wallace; Gonçalo R. AbecasisGonç; Jeffrey C. Barrett; Timothy W. Behrens; Judy H. Cho; Philip L. De Jager; James T. Elder; Robert R. Graham; Peter K. Gregersen; Lars Klareskog; Katherine A. Siminovitch; David A. van Heel; Cisca Wijmenga; Jane Worthington; John A. Todd; David A. Hafler; Stephen S. Rich; Mark J. Daly
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Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease
American Journal of Cardiology, ISSN: 00029149 18791913
Lin T. Guey; Clive R. Pullinger; Ishida; Patricia M. O'Connor; Christian Zellner; Omar L. Francone; Jason M. Laramie; Naya-Vigne; Ketevan A. Siradze; Prakash Deedwania; Redberg; Philip H. Frost; Albert B. Seymour; Kane; Malloy
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Molecular subclassification of diffuse gliomas: Seeing order in the chaos
GLIA, ISSN: 08941491 10981136
Jason T. Huse; Phillips; Cameron W. Brennan
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ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer
Genes and Cancer, ISSN: 19476019 19476027
Christopher Mill; Michael D. Zordan; S. Michael Rothenberg; Jeffrey E. Settleman; James F. Leary; David J. Riese II
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Blinded independent central review of progression in cancer clinical trials: Results from a meta-analysis
European Journal of Cancer, ISSN: 09598049 18790852
Amit; Mannino; Stone; Bushnell; Denne; Jeffrey D. Helterbrand; Hans Ulrich Burger
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Research outcomes and recommendations for the assessment of progression in cancer clinical trials from a PhRMA working group
European Journal of Cancer, ISSN: 09598049 18790852
Stone; Bushnell; Denne; Daniel J. Sargent; Amit; Chen; Bailey-Iacona; Jeffrey D. Helterbrand; Williams
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Notch3 signalling promotes tumour growth in colorectal cancer
Journal of Pathology, ISSN: 00223417 10969896
Valentina Serafin; Luca Persano; Lidia Moserle; Giovanni Esposito; Margherita Ghisi; Matteo Curtarello; Laura Bonanno; Massimo Masiero; Domenico Ribatti; Michael Stürzl; Elisabeth Naschberger; Roland S Croner; Adrian M. Jubb; Adrian L. Harris; Koeppen; Alberto Amadori; Stefano Indraccolo
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Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study
Ophthalmology, ISSN: 01616420 15494713
David M. Brown; Peter A. Campochiaro; Robert B. Bhisitkul; Allen C. Ho; Sarah Gray; Namrata Saroj; Anthony P. Adamis; Roman G. Rubio; Wendy Yee Murahashi
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A delicate dance: Host response to mycobacteria
Current Opinion in Immunology, ISSN: 09527915 18790372
Kassidy K. Huynh; Shilpa A. Joshi; Eric J. Brown
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The development of peptide-based tools for the analysis of angiogenesis
Chemistry and Biology, ISSN: 10745521
Anna V. Fedorova; Zobel; Herman S. Gill; Annie Ogasawara; Judith E. Flores; Jeff N. Tinianow; Alexander N. Vanderbilt; Ping Wu; Meng; Simon P. Williams; Wiesmann; Jeremy Murray; Jan Marik; Deshayes
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Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
PLoS ONE, ISSN: 19326203
Marinella G. Callow; Hoanh Tran; Lilian Phu; Ted Lau; James Lee; Wendy N. Sandoval; Peter S. Liu; Sheila Bheddah; Janet Tao; Jennie R. Lill; Hongo; David P. Davis; Donald S. Kirkpatrick; Paul G. Polakis; Michael Costa
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ExpressionPlot: A web-based framework for analysis of RNA-Seq and microarray gene expression data
Genome Biology, ISSN: 14747596 1474760X
Brad A. Friedman; Tom Maniatis
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Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue
PLoS ONE, ISSN: 19326203
Michael J. Devine; Alice Kaganovich; Mina Ryten; Adamantios Mamais; Daniah Trabzuni; Claudia Manzoni; Philip McGoldrick; Diane Chan; Allissa Dillman; Julia Zerle; Susannah Horan; Jan-Willem Taanman; John Hardy; Jose-Felix Marti-Masso; Daniel Healey; Anthony H. Schapira; Benjamin Wolozin; Rina Bandopadhyay; Mark R. Cookson; Marcel P Van Der Brug; Patrick A. Lewis
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Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
Blood, ISSN: 15280020 00064971
Xuan-Hung Nguyen; Philipp A. Lang; Karl S. Lang; Dieter Adam; Gulnar Fattakhova; Niko Föger; Mohammad Azhar Kamal; Patricia Prilla; Sabine Mathieu; Christina Wagner; Tak W. Mak; Andrew A. Chan; Kyeong-Hee Lee
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Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
Shalini Gupta; Viswanath Devanarayan; Deborah Finco-Kent; George R. Gunn; Susan Kirshner; Richards; Bonita Rup; An Song; Subramanyam
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Increased rheumatoid factor interference observed during immunogenicity assessment of an Fc-engineered therapeutic antibody
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
James Araujo; Marcel Zocher; Kristin Wallace; Kun Peng; Saloumeh Kadkhodayan Fischer
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Modulation of inflammasome pathways by bacterial and viral pathogens
Journal of Immunology, ISSN: 00221767 15506606
Lamkanfi; Vishva M. Dixit
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Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Yuzhong Deng; Harvey Wong; Richard A. Graham; Wenbin Liu; Heuy-Shin Shen; Yao Shi; Laixin Wang; Meng; Vikram Malhi; Xiao Ding; Brian J. Dean
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Central nervous system metastases in patients with HER2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registHER
Clinical Cancer Research, ISSN: 10780432 15573265
Adam Brufsky; Musa Mayer; Hope S. Rugo; Peter A. Kaufman; Elizabeth Tan-Chiu; Debasish Tripathy; Iulia Cristina Tudor; Lisa I. Wang; Melissa Brammer; Mona Shing; Marianne Ulcickas Yood; Denise A. Yardley
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Modulation of the thermodynamic stability of proteins by polyols: Significance of polyol hydrophobicity and impact on the chemical potential of water
International Journal of Pharmaceutics, ISSN: 03785173 18733476
Vineet Kumar; Ravi Chari; Vikas Sharma; Devendra S. Kalonia
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Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Bruno Alicke; Kristina West; Patricia Pacheco; Hank La; Thomas Januario; Robert Yauch; Frederic J. De Sauvage; Stephen Gould
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Distinct apoptotic signaling characteristics of the anti-CD40 monoclonal antibody dacetuzumab and rituximab produce enhanced antitumor activity in non-Hodgkin lymphoma
Clinical Cancer Research, ISSN: 10780432 15573265
Timothy S. Lewis; Renee S. McCormick; Kim Emmerton; Jeffrey Lau; Shang-Fan Yu; Julie A. McEarchern; Iqbal S. Grewal; Che-Leung Law
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Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jenny Yao; Xiumin Wu; Guanglei Zhuang; Ian Kasman; Tobias Vogt; Vernon T. Phan; Masabumi Shibuya; Napoleone Ferrara; Carlos Bais
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Development and evolution of the human neocortex
Cell, ISSN: 10974172 00928674
Jan H. Lui; David V. Hansen; Arnold R. Kriegstein
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Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Miki Susanto Park; Jae H. Chang
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Efflux of Drugs via Transporters-The Antiabsorption Pathway
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Jae H. Chang; James A. Uchizono; Miki Susanto Park
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Fewer recurrent infections of C. difficile seen with fidaxomicin. This new class of antibiotic--the macrocycles--has a greater sustained response against re-infection than vancomycin.
Managed Care, ISSN: 10623388
Thomas Morrow
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Investigating liquid leak from pre-filled syringes upon needle shield removal: Effect of air bubble pressure
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Edwin K. Chan; Maa; David E. Overcashier; Chung C. Hsu
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An improved method for visualizing the morphology of lyophilized product cakes
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Philippe Lam; Thomas W. Patapoff
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Danoprevir monotherapy decreases inflammatory markers in patients with chronic hepatitis C virus infection
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Caralee J. Schaefer; Karl Kossen; Sharlene R. Lim; Jiing-Huey Lin; Lin Pan; Williamson Bradford; Patrick F. Smith; Scott D. Seiwert
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Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies
Pharmaceutical Research, ISSN: 07248741 1573904X
Sandeep Yadav; Alavattam Sreedhara; Sonoko Kanai; Jun Liu; Samantha Lien; Henry B. Lowman; Devendra S. Kalonia; Steven J. Shire
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Preview: A program for surveying shotgun proteomics tandem mass spectrometry data
Analytical Chemistry, ISSN: 00032700
Yong J. Kil; Christopher Becker; Wendy N. Sandoval; David Goldberg; Marshall Bern
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Structure determination by MALDI-IRMPD mass spectrometry and exoglycosidase digestions of O-linked oligosaccharides from Xenopus borealis egg jelly
Glycobiology, ISSN: 09596658 14602423
Bensheng Li; Scott C. Russell; Jinhua Zhang; Jerry L. Hedrick; Carlito B. Lebrilla
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A class of designs for phase I cancer clinical trials combining Bayesian and likelihood approaches
Journal of Applied Statistics, ISSN: 02664763 13600532
Zheng Su
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Antiarthritis effect of a novel Bruton's Tyrosine Kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/ pharmacodynamic modeling: Relationships between inhibition of BTK phosphorylation and efficacy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Lichuan Liu; Julie Di Paolo; Jim Barbosa; Hong Rong; Karin Reif; Harvey Wong
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