Genentech: Publications

July 1, 2011

Balancing multiple baseline characteristics in randomized clinical trials

Contemporary Clinical Trials, ISSN: 15517144 15592030

Zheng Su

July 1, 2011

Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer

Breast Cancer Research and Treatment, ISSN: 01676806 15737217

Teemu T. Junttila; Guangmin Li; Kathryn Parsons; Gail L. Phillips; Mark X. Sliwkowski

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July 1, 2011

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus

Arthritis and Rheumatism, ISSN: 00043591 15290131

Paula S. Ramos; Adrienne H. Williams; Julie T. Ziegler; Mary E. Comeau; Richard T. Guy; Christopher J. Lessard; He Li; Jeffrey C. Edberg; Raphael Zidovetzki; Lindsey A. Criswell; Patrick M. Gaffney; Deborah S. Cunninghame Graham; Robert R. Graham; Jennifer A. Kelly; Kenneth M. Kaufman; Elizabeth E. Brown; Graciela S. Alarcõn; Michelle Petri; John D. Reveille; Gerald McGwin; Luis M. Vilá; Robert P. Kimberly; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; John B. Harley; Robert P. Kimberly; Marta E. Alarcón-Riquelme; Carl D. Langefeld; Kathy L. Moser

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July 1, 2011

Biopharmaceutical manufacturing using blow-Fill-Seal Technology

BioPharm International, ISSN: 1542166X 19391862

Wei Liu; Philippe Lam; Scott Faulhaber; Samir Sane

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July 1, 2011

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steven T. Staben; Michael Siu; Richard Goldsmith; Alan G. Olivero; Steven Do; Burdick; Timothy P. Heffron; Jennafer Dotson; Daniel P. Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Wiesmann; Ping Wu

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June 30, 2011

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

New England Journal of Medicine, ISSN: 15334406 00284793

Paul B. Chapman; Axel Hauschild; Caroline Robert; John B. Haanen; Paolo A. Ascierto; James Larkin; Reinhard Dummer; Claus Garbe; Alessandro Testori; Michele Maio; Hogg; Paul Lorigan; Celeste Lebbe; Thomas Jouary; Dirk Schadendorf; Antoni Ribas; Steven J. O'Day; Jeffrey A. Sosman; John M. Kirkwood; Alexander M. M. Eggermont; Brigitte Dréno; Keith B. Nolop; Jiang Li; Betty Nelson; Jeannie Hou; Richard J. Lee; Keith Flaherty; McArthur

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June 30, 2011

Rosettascripts: A scripting language interface to the Rosetta Macromolecular modeling suite

PLoS ONE, ISSN: 19326203

Sarel J. Fleishman; Andrew Leaver-Fay; Jacob E. Corn; Eva-Maria Strauch; Sagar D. Khare; Nobuyasu Koga; Justin Ashworth; Paul Murphy; Florian Richter; Gordon Lemmon; Meiler; David Baker

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June 28, 2011

The tubby family proteins

Genome Biology, ISSN: 14747596 1474760X

Saikat Mukhopadhyay; Peter K Jackson

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June 23, 2011

Regulation of angiogenesis by a non-canonical Wnt - Flt1 pathway in myeloid cells

Nature, ISSN: 00280836 14764687

James A. Stefater III; Ian Lewkowich; Sujata Rao; Giovanni Mariggi; April C. Carpenter; Adam R. Burr; Jieqing Fan; Rieko Ajima; Jeffery D. Molkentin; Bart O. Williams; Marsha Wills-Karp; Jeffrey W. Pollard; Terry Yamaguchi; Napoleone Ferrara; Holger Gerhardt; Richard Lang

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June 21, 2011

Innate immunity: Unfolding the neuro-immuno connections

Current Biology, ISSN: 09609822

Man-Wah Tan

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June 20, 2011

Confirmatory Immunogenicity Assays

Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations,

Eric Wakshull; Daniel A. Coleman

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June 20, 2011

Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients

Health and Quality of Life Outcomes, ISSN: 14777525

Mark S. Walker; Murad Hasan; Yeun Mi Yim; Elaine B. Yu; Edward J. Stepanski; Lee S. Schwartzberg

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June 17, 2011

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated Death Domain (FADD), and caspase-8

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Aminah Ikner; Avi Ashkenazi

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June 16, 2011

COP1 is a tumour suppressor that causes degradation of ETS transcription factors

Nature, ISSN: 00280836 14764687

Alberto C. Vitari; Kevin G. Leong; Kim Newton; Cindy Yee; Karen M. O'Rourke; Jinfeng Liu; Lilian Phu; Rajesh Vij; Ron Ferrando; Suzana Couto; Sankar Mohan; Ajay Pandita; Hongo; David Arnott; Ingrid E. Wertz; Gao; French; Vishva M. Dixit

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June 14, 2011

TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer

Science Signaling, ISSN: 19450877 19379145

Susanna Y. Stinson; Lackner; Alex T. Adai; Nancy Yu; Hyo-Jin Kim; Carol O'Brien; Jill M. Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Thomas Januario; Robert J. Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard M. Stern; Søren Warming; Frederic J. De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan

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June 10, 2011

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

Science, ISSN: 00368075 10959203

Yonghao Yu; Sang-Oh Yoon; George Poulogiannis; Qian Yang; Xiaoju Max Ma; Judit Villén; Neil Kubica; Gregory R. Hoffman; Lewis C. Cantley; Steven P. Gygi; John Blenis

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June 9, 2011

VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1

Neuron, ISSN: 08966273 10974199

Carmen Ruiz de Almodovar; Pierre J. Fabre; Ellen Knevels; Cathy Coulon; Inmaculada Segura; Patrick C. G. Haddick; Liesbeth Aerts; Nicolas Delattin; Geraldine Strasser; Won-Jong Oh; Christian Lange; Stefan Vinckier; Jody Haigh; Coralie Fouquet; Chenghua Gu; Kari Alitalo; Valerie Castellani; Marc Tessier-Lavigne; Alain Chedotal; Frédéric Charron; Peter Carmeliet

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June 7, 2011

Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Abigail I. Nash; Reginald McNulty; Mary Elizabeth Shillito; Trevor E. Swartz; Roberto A. Bogomolni; Hartmut Luecke; Kevin H. Gardner

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June 7, 2011

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Weiwei Chen; Tracy Tzu-Ling Tang; Jeffrey Eastham-Anderson; Debra Dunlap; Bruno Alicke; Michelle Nannini; Stephen Gould; Robert Yauch; Zora Modrusan; Kelly J. DuPree; Darbonne; Greg D. Plowman; Frederic J. De Sauvage; Christopher A. Callahana

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June 7, 2011

The arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions

Current Biology, ISSN: 09609822

Aakanksha Singhvi; Jerome Teuliere; Karla Talavera; Shaun Cordes; Guangshuo Ou; Ronald D. Vale; Brinda C. Prasad; Clark; Gian Garriga

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June 3, 2011

A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography

Journal of Chromatography A, ISSN: 00219673

Chris Hamman; Mengling Wong; Michael Hayes; Paul Gibbons

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June 2, 2011

Immunology: In command of commensals

Nature, ISSN: 00280836 14764687

Menno Van Lookeren Campagne; Vishva M. Dixit

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June 2, 2011

Improved synthesis of γ-lactones from cyclopropyl cyanoesters

Synthetic Communications, ISSN: 00397911 15322432

Nandini C. Patel; Jacob B. Schwarz; Khondaker Islam; Whitney Miller; Tuan P. Tran; Yunjing Wei

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June 1, 2011

Rituximab's new therapeutic target: The podocyte actin cytoskeleton

Science Translational Medicine, ISSN: 19466234 19466242

Andrew A. Chan

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June 1, 2011

Free versus total ligand-binding assays: Points to consider in biotherapeutic drug development

Bioanalysis, ISSN: 17576180 17576199

Yang; Quarmby

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June 1, 2011

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

Journal of Neuroscience Research, ISSN: 03604012 10974547

Guoxin Wu; Sethu Sankaranarayanan; Sidney H.-K. Hsieh; Adam J. Simon; Mary J. Savage

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June 1, 2011

Absorption, distribution, metabolism, and excretion of [ 14C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: A unique metabolic pathway via pyridine ring opening

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Qin Yue; Yunghsiang Chen; Teresa Mulder; Alan Deese; Ryan Takahashi; Patrick J. Rudewicz; Mark E. Reynolds; Eric G. Solon; Cornelis E. Hop; Harvey Wong; S. Cyrus Khojasteh

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June 1, 2011

Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: Results from the SALUTE trial

Journal of Clinical Oncology, ISSN: 0732183X 15277755

David Spigel; Peter Townley; David M. Waterhouse; Liang Fang; Ibrahim Adiguzel; Jane E. Huang; David A. Karlin; Leonardo Faoro; Frank A. Scappaticci; Mark A. Socinski

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June 1, 2011

Antibody delivery of drugs and radionuclides: Factors influencing clinical pharmacology

Therapeutic Delivery, ISSN: 20415990 20416008

Saileta Prabhu; C. Andrew Boswell; Douglas Leipold; Leslie A. Khawli; Dongwei Li; Dan Lu; Frank-Peter Theil; Amita Joshi; Bert L. Lum

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June 1, 2011

Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in patients with advanced Non-small Cell Lung Cancer (NSCLC)

Investigational New Drugs, ISSN: 01676997

Hai T. Tran; Ralph G. Zinner; George R. Blumenschein; Yun W. Oh; Vassiliki A. Papadimitrakopoulou; Edward S. Kim; Charles Lu; Mubashira Malik; Bert L. Lum; Roy S. Herbst

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June 1, 2011

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation

Journal of Immunology, ISSN: 00221767 15506606

Yan Qu; Shahram Misaghi; Kim Newton; Laurie L. Gilmour; Salina Louie; James Cupp; George R. Dubyak; David Hackos; Vishva M. Dixit

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June 1, 2011

Intercompany study to evaluate the robustness of capillary isoelectric focusing technology for the analysis of monoclonal antibodies

Chromatographia, ISSN: 00095893 16121112

Oscar Salas-Solano; Kunnel Babu; Park; Xinfeng Zhang; Li Zhang; Zoran Sosic; Boris Boumajny; Ming Zeng; Cheng; Angelia Reed-Bogan; Stacey Cummins-Bitz; David A. Michels; Monica Parker; Pauline Bonasia; Mingfang Hong; Steven Cook; Margaret Ruesch; David Lamb; Dora Bolyan; Steffen Kiessig; Darren Allender; Brian Nunnally

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June 1, 2011

Glycosylation of therapeutic proteins: Current understanding of structure-function relationships

BioProcess International, ISSN: 15426319

Joseph Siemiatkoski; Stacey Ma; Jun Park; Kurt Brorson; Patrick Swann; Lorna McLeod

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June 1, 2011

Regulation of hemocytes in Drosophila requires dappled cytochrome b5

Biochemical Genetics, ISSN: 00062928 15734927

Kurt Kleinhesselink; Corinna Conway; David Sholer; Irvin Huang; Deborah A. Kimbrell

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June 1, 2011

Non-oxime pyrazole based inhibitors of B-Raf kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Bradley J. Newhouse; Joshua D. Hansen; Jonas Grina; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Matthew Martinson; Sarah Galbraith; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero

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June 1, 2011

Clinical use of dornase alfa is associated with a slower rate of FEV 1 decline in cystic fibrosis

Pediatric Pulmonology, ISSN: 87556863 10990496

Michael W. Konstan; Wagener; David J. Pasta; Stefanie J. Millar; Joan R. Jacobs; Ashley Yegin; Morgan

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June 1, 2011

The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians

Clinical Endocrinology, ISSN: 03000664 13652265

Anand Vaidya; Bei Sun; Forman; Paul N. Hopkins; Nancy J. Brown; Nikheel S. Kolatkar; Gordon H. Williams; Jonathan S. Williams

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June 1, 2011

B cell immunotherapy in autoimmunity - 2010 update

Molecular Immunology, ISSN: 01615890 18729142

Andrew A. Chan

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June 1, 2011

Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab

Neuro-Oncology, ISSN: 15228517 15235866

Jeffrey S. Wefel; Timothy Cloughesy; James L. Zazzali; Maoxia Zheng; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S. Friedman

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June 1, 2011

Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)

Lupus, ISSN: 09612033 14770962

Merrill; Jill P. Buyon; Richard A. Furie; Latinis; Gordon; Hsin-Ju Hsieh; Paul Brunetta

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June 1, 2011

Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411

Daugherty; Linda Rangell; Eckert; Jose Zavala-Solorio; Franklin V. Peale Jr.; Mrsny

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June 1, 2011

Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: Non-hispanic white population in the United States with age-related macular degeneration

Archives of Ophthalmology, ISSN: 00039950 15383601

Neil M. Bressler; Quan V. Doan; Rohit Varma; Paul P. Lee; Ivan J. Suñer; Chantal M. Dolan; Mark Danese; Elaine B. Yu; Irwin Tran; Shoshana Colman

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June 1, 2011

Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study

Journal of Hepatology, ISSN: 01688278 01688278

Nicole Forestier; Dominique Larrey; Dominique Guyader; Marcellin; Régine Rouzier; Alain Patat; Patrick F. Smith; Williamson Bradford; Steven Porter; Lawrence Blatt; Scott D. Seiwert; Stefan Zeuzem

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June 1, 2011

Streamlining downstream process development

BioProcess International, ISSN: 15426319

Brian Kluck; Binh Thai; Jim Furey; Dennis Annarelli

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June 1, 2011

Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: Anticipated thyroid effects and unique pituitary gland findings

Toxicologic Pathology, ISSN: 01926233 15331601

Tanja S. Zabka; Mark Fielden; Rosario Garrido; Jianhua Tao; Adrian J. Fretland; Jennifer Fretland; Mudher Albassam; Thomas Singer; Kolaja

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June 1, 2011

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

Biochemical Journal, ISSN: 02646021 14708728

Mislav Oreb; Anja Höfle; Patrick Koenig; Maik S. Sommer; Irmgard Sinning; Fei Wang; Ivo Tews; Danny J. Schnell; Enrico Schleiff

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June 1, 2011

Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death

Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080

Domagoj Vucic; Vishva M. Dixit; Ingrid E. Wertz

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May 30, 2011

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse

Journal of Cell Biology, ISSN: 00219525 00219525

Deanna G. Wilson; Khanhky Phamluong; Li Li; Mei Sun; Tim C. Cao; Peter S. Liu; Zora Modrusan; Wendy N. Sandoval; Linda Rangell; Richard A. D. Carano; Andrew S. Peterson; Mark J. Solloway

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May 27, 2011

Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas

Immunity, ISSN: 10747613 10974180

Jackson G. Egen; Antonio Gigliotti Rothfuchs; Carl G. Feng; Marcus A. Horwitz; Alan Sher; Ronald N. Germain

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May 27, 2011

Murine Insulin Growth Factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Adrian A. Lobito; Sree R. Ramani; Irene Tom; J.Fernando Bazan; Luis; Wayne J. Fairbrother; Wenjun Ouyang; Lino C. Gonzalez Jr.

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